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The map label for this gene is gatD [H]

Identifier: 126698067

GI number: 126698067

Start: 580547

End: 581599

Strand: Direct

Name: gatD [H]

Synonym: CD0490

Alternate gene names: 126698067

Gene position: 580547-581599 (Clockwise)

Preceding gene: 126698065

Following gene: 126698068

Centisome position: 13.53

GC content: 34.19

Gene sequence:

>1053_bases
GTGAAGTCAGTTAGATTCTATGGTATAAGAGACACAAGAGTGGAGGATGTGGATGTACCAAAAATATTAGAAAAAGATGA
TGTAATAATTAAAGTAAAAGTAGCTGGAATATGTGGTTCTGATATATCAAAATATTCAAAGACAGGTCCACATATGGTTG
GAGAAATTTTAGGGCATGAATTTTCTGGAGAAGTGGCACAGGTTGGTAAAGAAGTAAGGAGTTTTAAAATAGGAGATAGA
GTTGCTGTTTGTCCAGCTATGCCATGTTTTGAATGTGATGAATGTAAAAAAGGCTTGTATTCAAGATGTAATAATGTAGC
AATAATAGGAAATAAAGAACTTGGAGGTTGTTTTGCAGAGTATACAAAGGTGAAAGAGAGAAATTTAATAAAAATACCAG
ATGAGATAAGTTATGAGACTGCCGCTGCGCTAGAACCAGTATGTATAGCAGGACATGGTCTTTTTAGGTCAGAAGCTAAA
GTTGGAGATACAGTTGTAGTACTTGGTACAGGTCCAATAGGATTATTTTCAATACAATGGGCAAAAATATTTGGTTCTAC
AAAAATAATAGCTGTGGATGTATTTGATGAGAAGTTAGACTTGGCAAAAGAGTTAGGGGCAGATATTTGTATAAATGCAA
AAGAAAAGAATATTGTAGAAGAAATAAAAAGGTTAACTGATGGAGATGGTGCAGATATTGTTATTGAATCGGCTGGTACT
CCACTGACATGTGGTCAAGTACTGTTGCTAGCTAAAAAGGGAGGTACAGTATTGTATGCAGGTGTACCATATGGGGATGT
AGCTTTGACTAGAGAGCAATTTGAAAAGATAGTAAGAAGTGAATTAACTGTAAAGGGAACTTGGTTTGGAAACTCCTTTC
CATTCCCAGGAAAAGAATGGAGTGCTGGATTGTATCATATGCAAAAGGGTGATATGAATGTTGAAAAATTAGTAACACAT
AGAATAAATTTAGAAGAAGCACCAGCTTATTTTGAAAAAGTATACAAAAGGGATATTTTCTTTGGTAAGATAATGATTAA
TATAGATAATTAG

Upstream 100 bases:

>100_bases
GAATACAATGCTTACATATATTGGCATGAAAGTTGCTTTAGATATTTAACATATAAACAATAGGGATATATTCTCAAATA
AAAAGTAGGGGTGGTTAATA

Downstream 100 bases:

>100_bases
ATTAGAGTACTAAATAATAATCCATATAAAAAAGGTTAAGAAAGGTATGATTCATATGGCAGGAATAATTATAGCCACAC
ATGGAAATATGGCTAAAGCA

Product: sugar-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MKSVRFYGIRDTRVEDVDVPKILEKDDVIIKVKVAGICGSDISKYSKTGPHMVGEILGHEFSGEVAQVGKEVRSFKIGDR
VAVCPAMPCFECDECKKGLYSRCNNVAIIGNKELGGCFAEYTKVKERNLIKIPDEISYETAAALEPVCIAGHGLFRSEAK
VGDTVVVLGTGPIGLFSIQWAKIFGSTKIIAVDVFDEKLDLAKELGADICINAKEKNIVEEIKRLTDGDGADIVIESAGT
PLTCGQVLLLAKKGGTVLYAGVPYGDVALTREQFEKIVRSELTVKGTWFGNSFPFPGKEWSAGLYHMQKGDMNVEKLVTH
RINLEEAPAYFEKVYKRDIFFGKIMINIDN

Sequences:

>Translated_350_residues
MKSVRFYGIRDTRVEDVDVPKILEKDDVIIKVKVAGICGSDISKYSKTGPHMVGEILGHEFSGEVAQVGKEVRSFKIGDR
VAVCPAMPCFECDECKKGLYSRCNNVAIIGNKELGGCFAEYTKVKERNLIKIPDEISYETAAALEPVCIAGHGLFRSEAK
VGDTVVVLGTGPIGLFSIQWAKIFGSTKIIAVDVFDEKLDLAKELGADICINAKEKNIVEEIKRLTDGDGADIVIESAGT
PLTCGQVLLLAKKGGTVLYAGVPYGDVALTREQFEKIVRSELTVKGTWFGNSFPFPGKEWSAGLYHMQKGDMNVEKLVTH
RINLEEAPAYFEKVYKRDIFFGKIMINIDN
>Mature_350_residues
MKSVRFYGIRDTRVEDVDVPKILEKDDVIIKVKVAGICGSDISKYSKTGPHMVGEILGHEFSGEVAQVGKEVRSFKIGDR
VAVCPAMPCFECDECKKGLYSRCNNVAIIGNKELGGCFAEYTKVKERNLIKIPDEISYETAAALEPVCIAGHGLFRSEAK
VGDTVVVLGTGPIGLFSIQWAKIFGSTKIIAVDVFDEKLDLAKELGADICINAKEKNIVEEIKRLTDGDGADIVIESAGT
PLTCGQVLLLAKKGGTVLYAGVPYGDVALTREQFEKIVRSELTVKGTWFGNSFPFPGKEWSAGLYHMQKGDMNVEKLVTH
RINLEEAPAYFEKVYKRDIFFGKIMINIDN

Specific function: Converts galactitol 1-phosphate to tagatose 6-phosphate [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=355, Percent_Identity=29.0140845070423, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI4501929, Length=356, Percent_Identity=32.0224719101124, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI34577061, Length=359, Percent_Identity=31.4763231197772, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI71565152, Length=351, Percent_Identity=29.3447293447293, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4501933, Length=347, Percent_Identity=31.700288184438, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI156523966, Length=347, Percent_Identity=30.5475504322767, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI4501939, Length=348, Percent_Identity=30.4597701149425, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI262073058, Length=338, Percent_Identity=28.4023668639053, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI71743840, Length=338, Percent_Identity=28.4023668639053, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI71565154, Length=359, Percent_Identity=27.8551532033426, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI194239674, Length=272, Percent_Identity=25.7352941176471, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI13236495, Length=272, Percent_Identity=25.7352941176471, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788407, Length=350, Percent_Identity=34.5714285714286, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1788073, Length=342, Percent_Identity=34.2105263157895, Blast_Score=181, Evalue=8e-47,
Organism=Escherichia coli, GI1790045, Length=343, Percent_Identity=31.1953352769679, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1788075, Length=353, Percent_Identity=28.8951841359773, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1787863, Length=343, Percent_Identity=30.6122448979592, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI87082125, Length=362, Percent_Identity=32.3204419889503, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786825, Length=391, Percent_Identity=28.6445012787724, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI226510992, Length=322, Percent_Identity=28.5714285714286, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786552, Length=352, Percent_Identity=31.25, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790718, Length=315, Percent_Identity=24.7619047619048, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI87081918, Length=226, Percent_Identity=32.7433628318584, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787572, Length=203, Percent_Identity=30.0492610837438, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786518, Length=253, Percent_Identity=28.0632411067194, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=347, Percent_Identity=32.8530259365994, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17562878, Length=345, Percent_Identity=29.5652173913043, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25146526, Length=340, Percent_Identity=29.7058823529412, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17562584, Length=335, Percent_Identity=28.3582089552239, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17565904, Length=330, Percent_Identity=29.3939393939394, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71997431, Length=354, Percent_Identity=29.0960451977401, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71988145, Length=261, Percent_Identity=30.2681992337165, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17562582, Length=330, Percent_Identity=27.8787878787879, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=347, Percent_Identity=31.1239193083574, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6322619, Length=347, Percent_Identity=31.1239193083574, Blast_Score=172, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6323099, Length=328, Percent_Identity=30.4878048780488, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6319258, Length=329, Percent_Identity=29.1793313069909, Blast_Score=126, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6319257, Length=362, Percent_Identity=24.3093922651934, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320033, Length=356, Percent_Identity=29.7752808988764, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323729, Length=301, Percent_Identity=27.2425249169435, Blast_Score=92, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=286, Percent_Identity=26.9230769230769, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=304, Percent_Identity=26.3157894736842, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=350, Percent_Identity=26.8571428571429, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6319520, Length=253, Percent_Identity=32.0158102766798, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319949, Length=311, Percent_Identity=29.5819935691318, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6323980, Length=156, Percent_Identity=30.7692307692308, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17137530, Length=351, Percent_Identity=31.3390313390313, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI17737897, Length=351, Percent_Identity=30.7692307692308, Blast_Score=164, Evalue=8e-41,
Organism=Drosophila melanogaster, GI17737895, Length=365, Percent_Identity=29.3150684931507, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI45550770, Length=326, Percent_Identity=23.3128834355828, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI221457811, Length=327, Percent_Identity=23.5474006116208, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45551930, Length=327, Percent_Identity=23.5474006116208, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.251 [H]

Molecular weight: Translated: 38458; Mature: 38458

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVRFYGIRDTRVEDVDVPKILEKDDVIIKVKVAGICGSDISKYSKTGPHMVGEILGHE
CCCEEEEECCCCCCCCCCCCHHCCCCCEEEEEEEECCCCCHHHHHHCCCCHHHHHHHCCC
FSGEVAQVGKEVRSFKIGDRVAVCPAMPCFECDECKKGLYSRCNNVAIIGNKELGGCFAE
CCCHHHHHHHHHHHEECCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHH
YTKVKERNLIKIPDEISYETAAALEPVCIAGHGLFRSEAKVGDTVVVLGTGPIGLFSIQW
HHHHHCCCEEECCCCCCCHHHHHCCCEEEECCCCCCCCCCCCCEEEEEECCCCEEEEEEE
AKIFGSTKIIAVDVFDEKLDLAKELGADICINAKEKNIVEEIKRLTDGDGADIVIESAGT
HHHHCCCEEEEEEECCHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCCCEEEEECCCC
PLTCGQVLLLAKKGGTVLYAGVPYGDVALTREQFEKIVRSELTVKGTWFGNSFPFPGKEW
CCCCCEEEEEEECCCEEEEECCCCCCCEECHHHHHHHHHHCEEEEEEECCCCCCCCCCCC
SAGLYHMQKGDMNVEKLVTHRINLEEAPAYFEKVYKRDIFFGKIMINIDN
CCCEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHCCEEEEEEEEEECC
>Mature Secondary Structure
MKSVRFYGIRDTRVEDVDVPKILEKDDVIIKVKVAGICGSDISKYSKTGPHMVGEILGHE
CCCEEEEECCCCCCCCCCCCHHCCCCCEEEEEEEECCCCCHHHHHHCCCCHHHHHHHCCC
FSGEVAQVGKEVRSFKIGDRVAVCPAMPCFECDECKKGLYSRCNNVAIIGNKELGGCFAE
CCCHHHHHHHHHHHEECCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHH
YTKVKERNLIKIPDEISYETAAALEPVCIAGHGLFRSEAKVGDTVVVLGTGPIGLFSIQW
HHHHHCCCEEECCCCCCCHHHHHCCCEEEECCCCCCCCCCCCCEEEEEECCCCEEEEEEE
AKIFGSTKIIAVDVFDEKLDLAKELGADICINAKEKNIVEEIKRLTDGDGADIVIESAGT
HHHHCCCEEEEEEECCHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCCCEEEEECCCC
PLTCGQVLLLAKKGGTVLYAGVPYGDVALTREQFEKIVRSELTVKGTWFGNSFPFPGKEW
CCCCCEEEEEEECCCEEEEECCCCCCCEECHHHHHHHHHHCEEEEEEECCCCCCCCCCCC
SAGLYHMQKGDMNVEKLVTHRINLEEAPAYFEKVYKRDIFFGKIMINIDN
CCCEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]