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The map label for this gene is trpB [H]

Identifier: 126698018

GI number: 126698018

Start: 527476

End: 528888

Strand: Direct

Name: trpB [H]

Synonym: CD0444

Alternate gene names: 126698018

Gene position: 527476-528888 (Clockwise)

Preceding gene: 126698017

Following gene: 126698019

Centisome position: 12.29

GC content: 32.48

Gene sequence:

>1413_bases
ATGAAAGATATGAGTTATCAAGCTGTTATGGGAAGAAATAACGAAATAATGAAAAATGCAATCGGATTGGATTATTCTTC
TTTTGAACAAGAGGGAATAGGGTTTGATTATGAGAAAATGATGAGTGAAACAGGATATACATTACAAGATATTGAAGCAA
TTCAATCACAGTATGCTGTTGGAAATACTCCTTTAATAGAGCTTAAAAATTTGACTAAATTAGCTAGAAAATGTGCTAAA
GAAGGTAAAGGAGCTAGAATATTTGTAAAAGATGAAGCAATGAATGCATCTGGTAGTTTTAAAGCAAGAAGAGCAGCTAC
TGCAGTATATCATGCCAAACAAATGGGATATAAAGGTGTAATAGCAGCTACTAGTGGTAACTATGGTGCAGCTGTAGCAT
CACAAGCGGCAATGCAGGGATTAAAATGTATAATAGTTCAAGAATGTTATGATTCTAATGGTGTAGGTCAACCTGAAATT
ATAGAAAAAGCACGAAAATGTGAGGCATATGGAGCAGAAGTTGTTCAGTTAACTGTTGGACCAGAGTTATTTTATACGTT
CTTAGTTTTATTAGAAGAAACAGGCTATTTTAACGCATCATTATATTCACCATTTGGAATTGCAGGTGTAGAAACTTTAG
GTTATGAGTTAGCTATCCAATTTAGAGAAAAGTATAAAAAAGACCCTGATATAGTTGTTTGTACAAATGCAGGTGGTGGT
AATCTTACTGGAACTGCAAGAGGATTGATAAAAGCTGGTTCTATTAATACTAAAGTAGTAGGAGCAAGTGTAGATTTAAA
AGGATTACACATGGCTAGTGATAATCAATTTAATAAAAAATCATTTACAACAGGACATACAGGTTTTGGGATACCATACT
GTACATGGCCTGATAGGTCAGATGTACCTAGGTCTGCAGCTAGACCACTTAGATATATGGATAGATATGTATTAGTAAAA
CAAGGAGAAGTTTTTTATACAACTGAATTATTGGCACAGCTAGAAGGTATAGAAAGAGGTCCAGCAGGAAATACATCTTT
AGCAGCAGCATTCTCTTTAGCTCAAGAGCTAGATGAGGATAAAGCTATAGTGGTACAAGAAACAGAATATACGGGTGCAG
GTAAACATATATGTCCACAACTTACCTTTGCAAGAGAAAATGGAATAGATATAAAATTTGGAAATCCAAGAGAAGAAATT
GCAGGAGTAAACTTAATATTACCAGAAAGACCAGAATTATTGAAATGTGTTGATATTGATATGAATAAAATAAGAAACTC
ATTTATAAAAAATTGTATATCTAATAATCACATTGATAATATTGATAAGCTAAGCAATCGAGATATAGAATTTTTAATGG
AAGAAGTAAAAAGTTCAAGAGATTTTGTTGTTGATGTATTAAATAATTTATAG

Upstream 100 bases:

>100_bases
ACTCATGATTATGGTAAATGTATACCAGAGTTACTCCAAATAGGAATCCAAGCTAAAGAAATATTATTTGGAGGTGTATA
TAATGAATAATTCAACATCA

Downstream 100 bases:

>100_bases
TAATTATTGTTTTTTAATTTAATATAAAATAAAAATTCAGAAAATTCGATTAAATCGATACGGATGGAGGAATGTTCATG
AAAAAAAGAGAGGATGATTT

Product: pyridoxal-phosphate dependent enzyme

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MKDMSYQAVMGRNNEIMKNAIGLDYSSFEQEGIGFDYEKMMSETGYTLQDIEAIQSQYAVGNTPLIELKNLTKLARKCAK
EGKGARIFVKDEAMNASGSFKARRAATAVYHAKQMGYKGVIAATSGNYGAAVASQAAMQGLKCIIVQECYDSNGVGQPEI
IEKARKCEAYGAEVVQLTVGPELFYTFLVLLEETGYFNASLYSPFGIAGVETLGYELAIQFREKYKKDPDIVVCTNAGGG
NLTGTARGLIKAGSINTKVVGASVDLKGLHMASDNQFNKKSFTTGHTGFGIPYCTWPDRSDVPRSAARPLRYMDRYVLVK
QGEVFYTTELLAQLEGIERGPAGNTSLAAAFSLAQELDEDKAIVVQETEYTGAGKHICPQLTFARENGIDIKFGNPREEI
AGVNLILPERPELLKCVDIDMNKIRNSFIKNCISNNHIDNIDKLSNRDIEFLMEEVKSSRDFVVDVLNNL

Sequences:

>Translated_470_residues
MKDMSYQAVMGRNNEIMKNAIGLDYSSFEQEGIGFDYEKMMSETGYTLQDIEAIQSQYAVGNTPLIELKNLTKLARKCAK
EGKGARIFVKDEAMNASGSFKARRAATAVYHAKQMGYKGVIAATSGNYGAAVASQAAMQGLKCIIVQECYDSNGVGQPEI
IEKARKCEAYGAEVVQLTVGPELFYTFLVLLEETGYFNASLYSPFGIAGVETLGYELAIQFREKYKKDPDIVVCTNAGGG
NLTGTARGLIKAGSINTKVVGASVDLKGLHMASDNQFNKKSFTTGHTGFGIPYCTWPDRSDVPRSAARPLRYMDRYVLVK
QGEVFYTTELLAQLEGIERGPAGNTSLAAAFSLAQELDEDKAIVVQETEYTGAGKHICPQLTFARENGIDIKFGNPREEI
AGVNLILPERPELLKCVDIDMNKIRNSFIKNCISNNHIDNIDKLSNRDIEFLMEEVKSSRDFVVDVLNNL
>Mature_470_residues
MKDMSYQAVMGRNNEIMKNAIGLDYSSFEQEGIGFDYEKMMSETGYTLQDIEAIQSQYAVGNTPLIELKNLTKLARKCAK
EGKGARIFVKDEAMNASGSFKARRAATAVYHAKQMGYKGVIAATSGNYGAAVASQAAMQGLKCIIVQECYDSNGVGQPEI
IEKARKCEAYGAEVVQLTVGPELFYTFLVLLEETGYFNASLYSPFGIAGVETLGYELAIQFREKYKKDPDIVVCTNAGGG
NLTGTARGLIKAGSINTKVVGASVDLKGLHMASDNQFNKKSFTTGHTGFGIPYCTWPDRSDVPRSAARPLRYMDRYVLVK
QGEVFYTTELLAQLEGIERGPAGNTSLAAAFSLAQELDEDKAIVVQETEYTGAGKHICPQLTFARENGIDIKFGNPREEI
AGVNLILPERPELLKCVDIDMNKIRNSFIKNCISNNHIDNIDKLSNRDIEFLMEEVKSSRDFVVDVLNNL

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine [H]

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6321412, Length=329, Percent_Identity=24.9240121580547, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 51647; Mature: 51647

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDMSYQAVMGRNNEIMKNAIGLDYSSFEQEGIGFDYEKMMSETGYTLQDIEAIQSQYAV
CCCCCCHHHHCCCHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHCC
GNTPLIELKNLTKLARKCAKEGKGARIFVKDEAMNASGSFKARRAATAVYHAKQMGYKGV
CCCCEEEHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEE
IAATSGNYGAAVASQAAMQGLKCIIVQECYDSNGVGQPEIIEKARKCEAYGAEVVQLTVG
EEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEC
PELFYTFLVLLEETGYFNASLYSPFGIAGVETLGYELAIQFREKYKKDPDIVVCTNAGGG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
NLTGTARGLIKAGSINTKVVGASVDLKGLHMASDNQFNKKSFTTGHTGFGIPYCTWPDRS
CCCHHHHCEEEECCCCEEEEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCCEECCCCCC
DVPRSAARPLRYMDRYVLVKQGEVFYTTELLAQLEGIERGPAGNTSLAAAFSLAQELDED
CCCHHHHHHHHHHHHEEEEECCCEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
KAIVVQETEYTGAGKHICPQLTFARENGIDIKFGNPREEIAGVNLILPERPELLKCVDID
CEEEEEECCCCCCCCCCCCCEEEECCCCCEEEECCCHHHHCCCEEECCCCCCCEEEECCC
MNKIRNSFIKNCISNNHIDNIDKLSNRDIEFLMEEVKSSRDFVVDVLNNL
HHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MKDMSYQAVMGRNNEIMKNAIGLDYSSFEQEGIGFDYEKMMSETGYTLQDIEAIQSQYAV
CCCCCCHHHHCCCHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHCC
GNTPLIELKNLTKLARKCAKEGKGARIFVKDEAMNASGSFKARRAATAVYHAKQMGYKGV
CCCCEEEHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEE
IAATSGNYGAAVASQAAMQGLKCIIVQECYDSNGVGQPEIIEKARKCEAYGAEVVQLTVG
EEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEC
PELFYTFLVLLEETGYFNASLYSPFGIAGVETLGYELAIQFREKYKKDPDIVVCTNAGGG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
NLTGTARGLIKAGSINTKVVGASVDLKGLHMASDNQFNKKSFTTGHTGFGIPYCTWPDRS
CCCHHHHCEEEECCCCEEEEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCCEECCCCCC
DVPRSAARPLRYMDRYVLVKQGEVFYTTELLAQLEGIERGPAGNTSLAAAFSLAQELDED
CCCHHHHHHHHHHHHEEEEECCCEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
KAIVVQETEYTGAGKHICPQLTFARENGIDIKFGNPREEIAGVNLILPERPELLKCVDID
CEEEEEECCCCCCCCCCCCCEEEECCCCCEEEECCCHHHHCCCEEECCCCCCCEEEECCC
MNKIRNSFIKNCISNNHIDNIDKLSNRDIEFLMEEVKSSRDFVVDVLNNL
HHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA