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The map label for this gene is lytC [H]

Identifier: 126698013

GI number: 126698013

Start: 521848

End: 523008

Strand: Direct

Name: lytC [H]

Synonym: CD0440

Alternate gene names: 126698013

Gene position: 521848-523008 (Clockwise)

Preceding gene: 126698012

Following gene: 126698014

Centisome position: 12.16

GC content: 28.25

Gene sequence:

>1161_bases
ATGAAATTAAACAAAACACTATTGGCAATAGGGATGTCTGTTTCATTATTGATTGCTAGTTGTCCAACATCAAACGCTCT
TAGTTCTATTAATTCAATAAAAGGTACAAATAAGTATGAAACAGCAGGTTTAATAGCAGATAAACAAAATTATGATATTG
CAATACTTATTAATTCTGAAAATGGATTATCTGATGGATTGTCAGCAAGTGGATTGTCAGGAGCTAAAAATGCCCCAATA
TTGTTAACTAAGAAAGATACAATCCCTTCAGAAACATTAAAAAGATTAGAAAAGGTAAAAGAAGTATATCTAATCGGAGG
AAAAAATTCGATAGGAGCATCAGTTCAGAAAATATTAAGTGATAAAAAAATAAGCATAAATAGAATAAGTGGAACTGATA
GAATAGATACAAGTCATAAAGTTGCAAAAGAAATAGGAAGAGTAAGTACGGTTAAAAAAGTAATATTAACTAATGCTTTT
AAAGGTGAACCAGATGCTATGAGTGTTGCTTCTATAGCAGTTAGAGATAAATCTCCAATAGTATTAACTGATGGAAACAC
TACAAGTTTTGCTACAGATGGATTAGAAACTTATGCAATTGGTGGAAAAGTCAGTATTAGTGATAAGTTAATAAATGAAA
CTAAAGCAACAAGAATAGGTGGAGTAGATAGATACGATACAAATAAACAAATAATAAATAAATTTTATAATGGCTCAAAA
GAATTTTACATAGCAAGTGGGACTGATTTAGTTTATTCTTTAGTTGGTTCTACAATTGCACAAAAAACACCTATAGTGTT
AGTTGGAAATGGAAGTAATAAGAGTATATTAAAAAATGCAAGTAAAATAACTGCTATTGGAAATATTGATGATGTTGTTA
TAAAACAATGTTTAAATATAACTAATAATGTTGGGGATTCAAATACAGGTATTGTAAAAGATACTAATTCAAATAATACG
AACAAACCAAGTAATGAGCCTAGCTCTAATAATCCTGGATTAACTGATAAAAGTACAGTATATGTAACTCCTAATGGAAA
ATCATATCATCTAACAAAAAATTGTTCTACACTAAAAAGAAGTAAAACAATAAATAAAGTAACATTAAAACAAGCTAAGT
CACAAGGTAAAATAGACCCTTGTAATGTTTGTGTAAAATAA

Upstream 100 bases:

>100_bases
AAAATTTTGAAATATAAACTAATTTCATAAAGGAAAATATTCTTTTATGTAGAATTATAATATTTAAGTAATATTATAAA
ATTTATAGGAGGATTTCATT

Downstream 100 bases:

>100_bases
TGTATTAGCCAAATATATATTAAAAAAGACAATTAATTAAGATTGTCTTTTTTATTGAAGAAATATAAATTTATATTATG
TATTATTAAAAAGAAAATTA

Product: cell surface protein

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MKLNKTLLAIGMSVSLLIASCPTSNALSSINSIKGTNKYETAGLIADKQNYDIAILINSENGLSDGLSASGLSGAKNAPI
LLTKKDTIPSETLKRLEKVKEVYLIGGKNSIGASVQKILSDKKISINRISGTDRIDTSHKVAKEIGRVSTVKKVILTNAF
KGEPDAMSVASIAVRDKSPIVLTDGNTTSFATDGLETYAIGGKVSISDKLINETKATRIGGVDRYDTNKQIINKFYNGSK
EFYIASGTDLVYSLVGSTIAQKTPIVLVGNGSNKSILKNASKITAIGNIDDVVIKQCLNITNNVGDSNTGIVKDTNSNNT
NKPSNEPSSNNPGLTDKSTVYVTPNGKSYHLTKNCSTLKRSKTINKVTLKQAKSQGKIDPCNVCVK

Sequences:

>Translated_386_residues
MKLNKTLLAIGMSVSLLIASCPTSNALSSINSIKGTNKYETAGLIADKQNYDIAILINSENGLSDGLSASGLSGAKNAPI
LLTKKDTIPSETLKRLEKVKEVYLIGGKNSIGASVQKILSDKKISINRISGTDRIDTSHKVAKEIGRVSTVKKVILTNAF
KGEPDAMSVASIAVRDKSPIVLTDGNTTSFATDGLETYAIGGKVSISDKLINETKATRIGGVDRYDTNKQIINKFYNGSK
EFYIASGTDLVYSLVGSTIAQKTPIVLVGNGSNKSILKNASKITAIGNIDDVVIKQCLNITNNVGDSNTGIVKDTNSNNT
NKPSNEPSSNNPGLTDKSTVYVTPNGKSYHLTKNCSTLKRSKTINKVTLKQAKSQGKIDPCNVCVK
>Mature_386_residues
MKLNKTLLAIGMSVSLLIASCPTSNALSSINSIKGTNKYETAGLIADKQNYDIAILINSENGLSDGLSASGLSGAKNAPI
LLTKKDTIPSETLKRLEKVKEVYLIGGKNSIGASVQKILSDKKISINRISGTDRIDTSHKVAKEIGRVSTVKKVILTNAF
KGEPDAMSVASIAVRDKSPIVLTDGNTTSFATDGLETYAIGGKVSISDKLINETKATRIGGVDRYDTNKQIINKFYNGSK
EFYIASGTDLVYSLVGSTIAQKTPIVLVGNGSNKSILKNASKITAIGNIDDVVIKQCLNITNNVGDSNTGIVKDTNSNNT
NKPSNEPSSNNPGLTDKSTVYVTPNGKSYHLTKNCSTLKRSKTINKVTLKQAKSQGKIDPCNVCVK

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 41021; Mature: 41021

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNKTLLAIGMSVSLLIASCPTSNALSSINSIKGTNKYETAGLIADKQNYDIAILINSE
CCCCCCCEECCCEEEEEEEECCCHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEEEECC
NGLSDGLSASGLSGAKNAPILLTKKDTIPSETLKRLEKVKEVYLIGGKNSIGASVQKILS
CCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHEEEEECCCCCHHHHHHHHHC
DKKISINRISGTDRIDTSHKVAKEIGRVSTVKKVILTNAFKGEPDAMSVASIAVRDKSPI
CCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCE
VLTDGNTTSFATDGLETYAIGGKVSISDKLINETKATRIGGVDRYDTNKQIINKFYNGSK
EEECCCCCEEECCCCEEEEECCEEEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCC
EFYIASGTDLVYSLVGSTIAQKTPIVLVGNGSNKSILKNASKITAIGNIDDVVIKQCLNI
EEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCEEEECCHHHHHHHHHHHH
TNNVGDSNTGIVKDTNSNNTNKPSNEPSSNNPGLTDKSTVYVTPNGKSYHLTKNCSTLKR
HCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEECCHHHHHH
SKTINKVTLKQAKSQGKIDPCNVCVK
HHCHHHHHHHHHHHCCCCCHHHCCCC
>Mature Secondary Structure
MKLNKTLLAIGMSVSLLIASCPTSNALSSINSIKGTNKYETAGLIADKQNYDIAILINSE
CCCCCCCEECCCEEEEEEEECCCHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEEEECC
NGLSDGLSASGLSGAKNAPILLTKKDTIPSETLKRLEKVKEVYLIGGKNSIGASVQKILS
CCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHEEEEECCCCCHHHHHHHHHC
DKKISINRISGTDRIDTSHKVAKEIGRVSTVKKVILTNAFKGEPDAMSVASIAVRDKSPI
CCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCE
VLTDGNTTSFATDGLETYAIGGKVSISDKLINETKATRIGGVDRYDTNKQIINKFYNGSK
EEECCCCCEEECCCCEEEEECCEEEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCC
EFYIASGTDLVYSLVGSTIAQKTPIVLVGNGSNKSILKNASKITAIGNIDDVVIKQCLNI
EEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCEEEECCHHHHHHHHHHHH
TNNVGDSNTGIVKDTNSNNTNKPSNEPSSNNPGLTDKSTVYVTPNGKSYHLTKNCSTLKR
HCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEECCHHHHHH
SKTINKVTLKQAKSQGKIDPCNVCVK
HHCHHHHHHHHHHHCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]