| Definition | Clostridium difficile 630 chromosome, complete genome. |
|---|---|
| Accession | NC_009089 |
| Length | 4,290,252 |
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The map label for this gene is cadA [H]
Identifier: 126697885
GI number: 126697885
Start: 374368
End: 376755
Strand: Direct
Name: cadA [H]
Synonym: CD0313
Alternate gene names: 126697885
Gene position: 374368-376755 (Clockwise)
Preceding gene: 126697884
Following gene: 126697886
Centisome position: 8.73
GC content: 30.78
Gene sequence:
>2388_bases ATGGAAGCAAATAATTCAATTAAAAAAGAATTTATACTAGGAGGATTAAATTGTGCTCACTGTGCAGAGGAGATTAATAA TAAAGTTTCTAAACTACAAGAAGTTAAATCTTCCAATTTAAATTTTATAAATAAAAAACTTACAGTAAATATAAAGGAAA GTTTTAATGAGGATACTACTATAGAAAAGATAATAGATATAATAGATTCAACAGAGCCAGGTCTTGATATACAAATAAGT TCTAAAGAAAATGCAGCTAGTAAAACATCAATTAAAAAAGAGCTTATATTAGGAGGATTAAACTGTGCTCATTGTGCAGA AGAGATTAATAACAAAGTTTCTAAATTAAAAGAAGTTGAATCTTCTAATTTAAACTTTGTAAATAAAAAACTTACAGTAA ATATAAGTAATAACTTTGAAGAGGATGATGTTATAAATAAAATAAAAGAAATAATAAATTCAACAGAGCCAGGGCTTGAT ATACAAGTAGGGTCTACTGACAAAGTAAAAGGGAGAACTACTGAAAAATCAGGAGCTGTAAATGATACAAATAAGAAAGA ATTAATTCCACTTATAATTGGAGCACTTGTATATATATTTGGTATATATCAAACAGCTACAGGTTATGAAAGTCAGTTTA GCAATATAGTATTTATAGTTGCCTATGTAATAGTAGGTGGTGATGTGCTTTTAAGAGCAATAAGAAATATATCAAAAGGA AGAGTATTTGATGAGAACTTTTTGATGGCTCTAGCAACAGTAGGAGCATTAGCAATAGGGGAGTTATCAGAAGCAGTAGG GGTTATGCTTTTCTATAAAGTAGGAGAGTATTTACAAGGTGTTGCAGTTGGTAAATCCAGAAAGTCTATAACTTCACTTA TGCAAATAAGACCAGACTATGCAAATCTAAAAGTTAATTCTGAAGTTAAGGTGGTGTCACCAGAAGAGGTAAATGTAGGT GATATAATAGTAGTAAAACCTGGTGAAAAAGTACCATTAGATGGTGTAGTAGTAGATGGAGTTTCTATGTTAGATACTTC TGCACTTACAGGAGAGTCAGTGCTGAGAGAAGTTGAAAAAGGAGATGAAATCTTATCAGGTGTTATAAATAAAAATGCTT TATTGAGTATTGAAGTTACAAAGAGTTTTGGAGAATCAACAGTTTCTAAGATTCTTGACCTTGTTGAAAATTCTAGCATT AAAAAATCAAAGACAGAAAACTTTATATCTAAGTTTTCAAGATACTATACTCCAATAGTAGTAATAGCTGCTTTATTAAT AGCATTTGTGCCACCACTTGTAATCTCAGGTGAGGTATTTAGTGATTGGTTATATAGAGGATTGATATTCTTAGTCGTTT CTTGCCCTTGTGCATTAGTTTTATCAATACCACTTAGTTTCTTTAGTGGAATTGGGTTTGCATCTAAAAATGGTATCCTT ATTAAAGGAAGTAACTATTTAGAAGCTTTAAGAAGTGTAGATACAGTAGTATTTGATAAAACAGGAACACTTACTAAAGG TGTGTTCAATGTAACTAAGTTAAATCCTGAAGGTATATCAGATGAAGAATTATTAGAATATGCAGCTATTGCGGAGGTAA ATTCAAATCATCCAATAGCAAAGTCTATATTAAGTTACTATAATAAAAAAATTGATTTAGATACAATAGACAGTTATGAG GAAATAGCAGCTTATGGAATTAGAGTAAAGCATAATGGCAATTTTATATTAGCAGGTAATGAGAAACTTATGAAAAAAGA AAATATATCTTATTCATCAGCTAAAGAAGTAGGCACAGTAGTCTATATTGCTGTTGATAAAGTATATAGAGGTTATATAG TTATCTCTGATGAAGTAAAAGAAGATAGTAAAAATGCCATAAGAAGCTTAAAAGAAATAGGGGTAAAAGAAGTTGTAATG TTAACAGGAGATAATGAGAAAGTAGCAAAAAATATTGCTCAAGAATTAGAATTGGATACAGTTTACTCAAATTTACTTCC TAATGAAAAGGTAGATAGATTAGAAGATTTATATGAAGGAAGAACTGAAAAAGAGAAAATAGCATTTGTAGGTGATGGAA TAAATGATGCTCCAGTATTAGCTCGTGCTGATGTTGGTATAGCTATGGGAGGCTTAGGTTCAGATGCTGCTATTGAAGCT GCAGATGTAGTGCTTATGACAGATGAGCCTAGCAAGATATCTAAAGCAATTGAAATAGCAAACAAGACTAATAAGATAGT GTGGCAAAACATAATATTTGCTCTAGGAGTAAAAATTATAGTTATGATACTAGGTGCTGGAGGAGTAGCTACTATGTGGG AAGCTATATTTGCTGATGTAGGTGTGGCACTTATAGCAGTAGTAAATGCTATGAGAGCTATGAGATAA
Upstream 100 bases:
>100_bases TATTACTCATTAGATGATAGTCATATAAGTCAGATATTTGATTGTGGATTAAATCATATTAGAGAGACTTATAAATGATA AATGAGAGGAGTGAATATAT
Downstream 100 bases:
>100_bases GGGATAAATGTAAATCCATACTATTTAAAAAACTTATAATTATATATTGAAGTATGTAATAATGAAAGGTATCAATAAGT TTCTTTTAACTTTATTGGTA
Product: heavy-metal-transporting ATPase
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 795; Mature: 795
Protein sequence:
>795_residues MEANNSIKKEFILGGLNCAHCAEEINNKVSKLQEVKSSNLNFINKKLTVNIKESFNEDTTIEKIIDIIDSTEPGLDIQIS SKENAASKTSIKKELILGGLNCAHCAEEINNKVSKLKEVESSNLNFVNKKLTVNISNNFEEDDVINKIKEIINSTEPGLD IQVGSTDKVKGRTTEKSGAVNDTNKKELIPLIIGALVYIFGIYQTATGYESQFSNIVFIVAYVIVGGDVLLRAIRNISKG RVFDENFLMALATVGALAIGELSEAVGVMLFYKVGEYLQGVAVGKSRKSITSLMQIRPDYANLKVNSEVKVVSPEEVNVG DIIVVKPGEKVPLDGVVVDGVSMLDTSALTGESVLREVEKGDEILSGVINKNALLSIEVTKSFGESTVSKILDLVENSSI KKSKTENFISKFSRYYTPIVVIAALLIAFVPPLVISGEVFSDWLYRGLIFLVVSCPCALVLSIPLSFFSGIGFASKNGIL IKGSNYLEALRSVDTVVFDKTGTLTKGVFNVTKLNPEGISDEELLEYAAIAEVNSNHPIAKSILSYYNKKIDLDTIDSYE EIAAYGIRVKHNGNFILAGNEKLMKKENISYSSAKEVGTVVYIAVDKVYRGYIVISDEVKEDSKNAIRSLKEIGVKEVVM LTGDNEKVAKNIAQELELDTVYSNLLPNEKVDRLEDLYEGRTEKEKIAFVGDGINDAPVLARADVGIAMGGLGSDAAIEA ADVVLMTDEPSKISKAIEIANKTNKIVWQNIIFALGVKIIVMILGAGGVATMWEAIFADVGVALIAVVNAMRAMR
Sequences:
>Translated_795_residues MEANNSIKKEFILGGLNCAHCAEEINNKVSKLQEVKSSNLNFINKKLTVNIKESFNEDTTIEKIIDIIDSTEPGLDIQIS SKENAASKTSIKKELILGGLNCAHCAEEINNKVSKLKEVESSNLNFVNKKLTVNISNNFEEDDVINKIKEIINSTEPGLD IQVGSTDKVKGRTTEKSGAVNDTNKKELIPLIIGALVYIFGIYQTATGYESQFSNIVFIVAYVIVGGDVLLRAIRNISKG RVFDENFLMALATVGALAIGELSEAVGVMLFYKVGEYLQGVAVGKSRKSITSLMQIRPDYANLKVNSEVKVVSPEEVNVG DIIVVKPGEKVPLDGVVVDGVSMLDTSALTGESVLREVEKGDEILSGVINKNALLSIEVTKSFGESTVSKILDLVENSSI KKSKTENFISKFSRYYTPIVVIAALLIAFVPPLVISGEVFSDWLYRGLIFLVVSCPCALVLSIPLSFFSGIGFASKNGIL IKGSNYLEALRSVDTVVFDKTGTLTKGVFNVTKLNPEGISDEELLEYAAIAEVNSNHPIAKSILSYYNKKIDLDTIDSYE EIAAYGIRVKHNGNFILAGNEKLMKKENISYSSAKEVGTVVYIAVDKVYRGYIVISDEVKEDSKNAIRSLKEIGVKEVVM LTGDNEKVAKNIAQELELDTVYSNLLPNEKVDRLEDLYEGRTEKEKIAFVGDGINDAPVLARADVGIAMGGLGSDAAIEA ADVVLMTDEPSKISKAIEIANKTNKIVWQNIIFALGVKIIVMILGAGGVATMWEAIFADVGVALIAVVNAMRAMR >Mature_795_residues MEANNSIKKEFILGGLNCAHCAEEINNKVSKLQEVKSSNLNFINKKLTVNIKESFNEDTTIEKIIDIIDSTEPGLDIQIS SKENAASKTSIKKELILGGLNCAHCAEEINNKVSKLKEVESSNLNFVNKKLTVNISNNFEEDDVINKIKEIINSTEPGLD IQVGSTDKVKGRTTEKSGAVNDTNKKELIPLIIGALVYIFGIYQTATGYESQFSNIVFIVAYVIVGGDVLLRAIRNISKG RVFDENFLMALATVGALAIGELSEAVGVMLFYKVGEYLQGVAVGKSRKSITSLMQIRPDYANLKVNSEVKVVSPEEVNVG DIIVVKPGEKVPLDGVVVDGVSMLDTSALTGESVLREVEKGDEILSGVINKNALLSIEVTKSFGESTVSKILDLVENSSI KKSKTENFISKFSRYYTPIVVIAALLIAFVPPLVISGEVFSDWLYRGLIFLVVSCPCALVLSIPLSFFSGIGFASKNGIL IKGSNYLEALRSVDTVVFDKTGTLTKGVFNVTKLNPEGISDEELLEYAAIAEVNSNHPIAKSILSYYNKKIDLDTIDSYE EIAAYGIRVKHNGNFILAGNEKLMKKENISYSSAKEVGTVVYIAVDKVYRGYIVISDEVKEDSKNAIRSLKEIGVKEVVM LTGDNEKVAKNIAQELELDTVYSNLLPNEKVDRLEDLYEGRTEKEKIAFVGDGINDAPVLARADVGIAMGGLGSDAAIEA ADVVLMTDEPSKISKAIEIANKTNKIVWQNIIFALGVKIIVMILGAGGVATMWEAIFADVGVALIAVVNAMRAMR
Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper [H]
COG id: COG2217
COG function: function code P; Cation transport ATPase
Gene ontology:
Cell location: Cell membrane; Multi-pass membrane protein [H]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 HMA domain [H]
Homologues:
Organism=Homo sapiens, GI115529486, Length=931, Percent_Identity=26.4232008592911, Blast_Score=266, Evalue=5e-71, Organism=Homo sapiens, GI55743071, Length=892, Percent_Identity=25.7847533632287, Blast_Score=263, Evalue=7e-70, Organism=Homo sapiens, GI55743073, Length=563, Percent_Identity=28.9520426287744, Blast_Score=226, Evalue=1e-58, Organism=Homo sapiens, GI48762685, Length=174, Percent_Identity=28.735632183908, Blast_Score=68, Evalue=4e-11, Organism=Homo sapiens, GI48762687, Length=174, Percent_Identity=28.735632183908, Blast_Score=68, Evalue=4e-11, Organism=Homo sapiens, GI48762689, Length=174, Percent_Identity=28.735632183908, Blast_Score=68, Evalue=4e-11, Organism=Homo sapiens, GI48762691, Length=174, Percent_Identity=28.735632183908, Blast_Score=67, Evalue=5e-11, Organism=Escherichia coli, GI1789879, Length=705, Percent_Identity=33.9007092198582, Blast_Score=354, Evalue=1e-98, Organism=Escherichia coli, GI1786691, Length=848, Percent_Identity=26.4150943396226, Blast_Score=261, Evalue=2e-70, Organism=Escherichia coli, GI1786914, Length=582, Percent_Identity=26.4604810996564, Blast_Score=128, Evalue=1e-30, Organism=Escherichia coli, GI2367363, Length=515, Percent_Identity=24.6601941747573, Blast_Score=90, Evalue=7e-19, Organism=Caenorhabditis elegans, GI17556548, Length=883, Percent_Identity=26.3873159682899, Blast_Score=207, Evalue=1e-53, Organism=Caenorhabditis elegans, GI71997269, Length=180, Percent_Identity=30, Blast_Score=74, Evalue=2e-13, Organism=Caenorhabditis elegans, GI71997262, Length=168, Percent_Identity=30.3571428571429, Blast_Score=74, Evalue=2e-13, Organism=Caenorhabditis elegans, GI71997275, Length=168, Percent_Identity=30.3571428571429, Blast_Score=74, Evalue=3e-13, Organism=Saccharomyces cerevisiae, GI6320475, Length=543, Percent_Identity=32.2283609576427, Blast_Score=247, Evalue=4e-66, Organism=Saccharomyces cerevisiae, GI6319772, Length=597, Percent_Identity=25.2931323283082, Blast_Score=174, Evalue=7e-44, Organism=Saccharomyces cerevisiae, GI6321430, Length=556, Percent_Identity=23.3812949640288, Blast_Score=89, Evalue=2e-18, Organism=Saccharomyces cerevisiae, GI6321271, Length=159, Percent_Identity=33.3333333333333, Blast_Score=81, Evalue=6e-16, Organism=Saccharomyces cerevisiae, GI6321432, Length=183, Percent_Identity=32.7868852459016, Blast_Score=71, Evalue=7e-13, Organism=Drosophila melanogaster, GI221329854, Length=633, Percent_Identity=25.1184834123223, Blast_Score=155, Evalue=2e-37, Organism=Drosophila melanogaster, GI24668708, Length=157, Percent_Identity=30.5732484076433, Blast_Score=73, Evalue=6e-13, Organism=Drosophila melanogaster, GI281366617, Length=157, Percent_Identity=30.5732484076433, Blast_Score=73, Evalue=6e-13, Organism=Drosophila melanogaster, GI24668704, Length=157, Percent_Identity=30.5732484076433, Blast_Score=73, Evalue=7e-13, Organism=Drosophila melanogaster, GI24668696, Length=157, Percent_Identity=30.5732484076433, Blast_Score=73, Evalue=8e-13, Organism=Drosophila melanogaster, GI161085803, Length=157, Percent_Identity=30.5732484076433, Blast_Score=72, Evalue=1e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR008250 - InterPro: IPR001366 - InterPro: IPR006404 - InterPro: IPR006416 - InterPro: IPR001757 - InterPro: IPR018303 - InterPro: IPR005834 - InterPro: IPR023214 - InterPro: IPR017969 - InterPro: IPR006121 [H]
Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]
EC number: =3.6.3.3; =3.6.3.5 [H]
Molecular weight: Translated: 86396; Mature: 86396
Theoretical pI: Translated: 4.85; Mature: 4.85
Prosite motif: PS00154 ATPASE_E1_E2 ; PS50846 HMA_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 1.6 %Met (Mature Protein) 2.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEANNSIKKEFILGGLNCAHCAEEINNKVSKLQEVKSSNLNFINKKLTVNIKESFNEDTT CCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEHHHCCCCHH IEKIIDIIDSTEPGLDIQISSKENAASKTSIKKELILGGLNCAHCAEEINNKVSKLKEVE HHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH SSNLNFVNKKLTVNISNNFEEDDVINKIKEIINSTEPGLDIQVGSTDKVKGRTTEKSGAV CCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCC NDTNKKELIPLIIGALVYIFGIYQTATGYESQFSNIVFIVAYVIVGGDVLLRAIRNISKG CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC RVFDENFLMALATVGALAIGELSEAVGVMLFYKVGEYLQGVAVGKSRKSITSLMQIRPDY CEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCH ANLKVNSEVKVVSPEEVNVGDIIVVKPGEKVPLDGVVVDGVSMLDTSALTGESVLREVEK HCEEECCEEEEECCCCCCCCCEEEECCCCCCCCCCEEECCHHHHHHHHCCHHHHHHHHHH GDEILSGVINKNALLSIEVTKSFGESTVSKILDLVENSSIKKSKTENFISKFSRYYTPIV HHHHHHHHHCCCEEEEEEEHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH VIAALLIAFVPPLVISGEVFSDWLYRGLIFLVVSCPCALVLSIPLSFFSGIGFASKNGIL HHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE IKGSNYLEALRSVDTVVFDKTGTLTKGVFNVTKLNPEGISDEELLEYAAIAEVNSNHPIA EECCHHHHHHHHHHHEEECCCCCHHHCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHH KSILSYYNKKIDLDTIDSYEEIAAYGIRVKHNGNFILAGNEKLMKKENISYSSAKEVGTV HHHHHHHCCCCCCCCCCCHHHHHHHCEEEEECCCEEEECCHHHHHHCCCCCCCHHCCCEE VYIAVDKVYRGYIVISDEVKEDSKNAIRSLKEIGVKEVVMLTGDNEKVAKNIAQELELDT EEEEEECHHCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHH VYSNLLPNEKVDRLEDLYEGRTEKEKIAFVGDGINDAPVLARADVGIAMGGLGSDAAIEA HHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEECCCCEEECCCCCCCCCCE ADVVLMTDEPSKISKAIEIANKTNKIVWQNIIFALGVKIIVMILGAGGVATMWEAIFADV EEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH GVALIAVVNAMRAMR HHHHHHHHHHHHHCC >Mature Secondary Structure MEANNSIKKEFILGGLNCAHCAEEINNKVSKLQEVKSSNLNFINKKLTVNIKESFNEDTT CCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEHHHCCCCHH IEKIIDIIDSTEPGLDIQISSKENAASKTSIKKELILGGLNCAHCAEEINNKVSKLKEVE HHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH SSNLNFVNKKLTVNISNNFEEDDVINKIKEIINSTEPGLDIQVGSTDKVKGRTTEKSGAV CCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCC NDTNKKELIPLIIGALVYIFGIYQTATGYESQFSNIVFIVAYVIVGGDVLLRAIRNISKG CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC RVFDENFLMALATVGALAIGELSEAVGVMLFYKVGEYLQGVAVGKSRKSITSLMQIRPDY CEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCH ANLKVNSEVKVVSPEEVNVGDIIVVKPGEKVPLDGVVVDGVSMLDTSALTGESVLREVEK HCEEECCEEEEECCCCCCCCCEEEECCCCCCCCCCEEECCHHHHHHHHCCHHHHHHHHHH GDEILSGVINKNALLSIEVTKSFGESTVSKILDLVENSSIKKSKTENFISKFSRYYTPIV HHHHHHHHHCCCEEEEEEEHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH VIAALLIAFVPPLVISGEVFSDWLYRGLIFLVVSCPCALVLSIPLSFFSGIGFASKNGIL HHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE IKGSNYLEALRSVDTVVFDKTGTLTKGVFNVTKLNPEGISDEELLEYAAIAEVNSNHPIA EECCHHHHHHHHHHHEEECCCCCHHHCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHH KSILSYYNKKIDLDTIDSYEEIAAYGIRVKHNGNFILAGNEKLMKKENISYSSAKEVGTV HHHHHHHCCCCCCCCCCCHHHHHHHCEEEEECCCEEEECCHHHHHHCCCCCCCHHCCCEE VYIAVDKVYRGYIVISDEVKEDSKNAIRSLKEIGVKEVVMLTGDNEKVAKNIAQELELDT EEEEEECHHCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHH VYSNLLPNEKVDRLEDLYEGRTEKEKIAFVGDGINDAPVLARADVGIAMGGLGSDAAIEA HHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEECCCCEEECCCCCCCCCCE ADVVLMTDEPSKISKAIEIANKTNKIVWQNIIFALGVKIIVMILGAGGVATMWEAIFADV EEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH GVALIAVVNAMRAMR HHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 9384377 [H]