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The map label for this gene is dhaT [H]

Identifier: 126697846

GI number: 126697846

Start: 335742

End: 336872

Strand: Direct

Name: dhaT [H]

Synonym: CD0274

Alternate gene names: 126697846

Gene position: 335742-336872 (Clockwise)

Preceding gene: 126697845

Following gene: 126697847

Centisome position: 7.83

GC content: 30.77

Gene sequence:

>1131_bases
ATGAATTTTAATTATAATTTGCCAGTAAATATCTTATTTGGGAGAGGCAGAATTAATGATGTGGGAAAAGAAGTATCTAA
ATATGGCAAAAAAGTATTGATAGTAACAGGTAAAAATAGTACAAAGAAAACTGGATTACTTGATAAAACAATAGATTTAC
TAAAAGACTCTAAAATAGAATATGAAGTTTTTGATAGAGTAGAACAAAATCCTCTTATAACTACTATATATTCAGGAGTA
GAAATTATAAAATCAACTGGATGTGATTGTGTTTTAGGGCTTGGTGGTGGAAGCATTATGGATGCTGCCAAGAGTATAGC
TTTTTCTTATAAAAACCCAGGAGATTTAAATGATTATATATTTGGAATTAGACAAGGTGAAGAAGCTTTACCTATAATCT
TAGTTCCAACAACATCAGGTACAGGTAGTGAAGGAAATTGTTTTGCAGTACTTACAAATTCAGAAACTAAAGATAAAAAA
TCTATAAAGAAGAATAGTATGTATGCAAAAGCATCAATAATTGACCCAGAACTTATGGTTACAATGCCAAAACATATAAT
TGCATCAGTTGGATTTGATGCACTTGCCCATAATATGGAAGCATATCTTTCTAATGGAAGAAACCCTCTTGCAGATGTAC
AAGCTATTTATGGGATTGAACTTATATCAGAAAACCTAATAAAGGTATATAATGATGTTAATGATTTAGAAGCATGGGAA
AAAATAACACTTGCAAGTACTATTGGAGGAATGACGATTGGTACAGCGGGTACAGCCTTGCCACATGGAATGGAGCATCC
TGTAAGTGGTCTTAGAGATGTAATGCATGGAAAAGGACTTGCAGCTTTGACTCCTACTATTATAGAAAGTTCATGGGATA
GTGATATTGAAAGATTTGGTAATATTTCAAAGGTATTAGGAGGAACTTGTGCAGAAGATTGTTCAGATGCAATTAGAAAT
TTCCTTAAAAAAATAGATTTAGATATAAAACTAAGTGATTTAGGTATTGAAAAATCAGATATAGATTGGTTAACTGATAA
TTGTATGAAAATATCAGTTGCAAATATTAAGAGACATCCAAAGTATTTTAATAAGGAACAAATAAAGGAAATGTACCATA
AGTCTTTATAA

Upstream 100 bases:

>100_bases
AATTAAGTAAAAGATTGTTTTTTAGTTTATGTTTAAATACATAATTACACTTTGTTAAAAACATAAAATTATTACTAAAG
TAGAAATAGGAGGTTTTAGA

Downstream 100 bases:

>100_bases
TTTGACTTTACATATTTAGTTTTATATAAAAATTATAAATTAATAATAAAAAATTATAAGTAATTAATAGTAAAAAAATT
GTGTATAGAAGTTATATATA

Product: 1,3-propanediol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MNFNYNLPVNILFGRGRINDVGKEVSKYGKKVLIVTGKNSTKKTGLLDKTIDLLKDSKIEYEVFDRVEQNPLITTIYSGV
EIIKSTGCDCVLGLGGGSIMDAAKSIAFSYKNPGDLNDYIFGIRQGEEALPIILVPTTSGTGSEGNCFAVLTNSETKDKK
SIKKNSMYAKASIIDPELMVTMPKHIIASVGFDALAHNMEAYLSNGRNPLADVQAIYGIELISENLIKVYNDVNDLEAWE
KITLASTIGGMTIGTAGTALPHGMEHPVSGLRDVMHGKGLAALTPTIIESSWDSDIERFGNISKVLGGTCAEDCSDAIRN
FLKKIDLDIKLSDLGIEKSDIDWLTDNCMKISVANIKRHPKYFNKEQIKEMYHKSL

Sequences:

>Translated_376_residues
MNFNYNLPVNILFGRGRINDVGKEVSKYGKKVLIVTGKNSTKKTGLLDKTIDLLKDSKIEYEVFDRVEQNPLITTIYSGV
EIIKSTGCDCVLGLGGGSIMDAAKSIAFSYKNPGDLNDYIFGIRQGEEALPIILVPTTSGTGSEGNCFAVLTNSETKDKK
SIKKNSMYAKASIIDPELMVTMPKHIIASVGFDALAHNMEAYLSNGRNPLADVQAIYGIELISENLIKVYNDVNDLEAWE
KITLASTIGGMTIGTAGTALPHGMEHPVSGLRDVMHGKGLAALTPTIIESSWDSDIERFGNISKVLGGTCAEDCSDAIRN
FLKKIDLDIKLSDLGIEKSDIDWLTDNCMKISVANIKRHPKYFNKEQIKEMYHKSL
>Mature_376_residues
MNFNYNLPVNILFGRGRINDVGKEVSKYGKKVLIVTGKNSTKKTGLLDKTIDLLKDSKIEYEVFDRVEQNPLITTIYSGV
EIIKSTGCDCVLGLGGGSIMDAAKSIAFSYKNPGDLNDYIFGIRQGEEALPIILVPTTSGTGSEGNCFAVLTNSETKDKK
SIKKNSMYAKASIIDPELMVTMPKHIIASVGFDALAHNMEAYLSNGRNPLADVQAIYGIELISENLIKVYNDVNDLEAWE
KITLASTIGGMTIGTAGTALPHGMEHPVSGLRDVMHGKGLAALTPTIIESSWDSDIERFGNISKVLGGTCAEDCSDAIRN
FLKKIDLDIKLSDLGIEKSDIDWLTDNCMKISVANIKRHPKYFNKEQIKEMYHKSL

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=382, Percent_Identity=29.0575916230367, Blast_Score=135, Evalue=4e-32,
Organism=Escherichia coli, GI48994951, Length=381, Percent_Identity=29.6587926509186, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI87082107, Length=376, Percent_Identity=28.4574468085106, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789163, Length=374, Percent_Identity=28.8770053475936, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI1787493, Length=363, Percent_Identity=30.5785123966942, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789386, Length=359, Percent_Identity=27.2980501392758, Blast_Score=129, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17537053, Length=414, Percent_Identity=28.5024154589372, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321181, Length=378, Percent_Identity=29.6296296296296, Blast_Score=175, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24657991, Length=424, Percent_Identity=27.5943396226415, Blast_Score=145, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 41167; Mature: 41167

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFNYNLPVNILFGRGRINDVGKEVSKYGKKVLIVTGKNSTKKTGLLDKTIDLLKDSKIE
CCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCC
YEVFDRVEQNPLITTIYSGVEIIKSTGCDCVLGLGGGSIMDAAKSIAFSYKNPGDLNDYI
HHHHHHHCCCCCEEEHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHEECCCCCCCCCHHH
FGIRQGEEALPIILVPTTSGTGSEGNCFAVLTNSETKDKKSIKKNSMYAKASIIDPELMV
EEEECCCCCCCEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHCCEEEEEECCCHHHH
TMPKHIIASVGFDALAHNMEAYLSNGRNPLADVQAIYGIELISENLIKVYNDVNDLEAWE
HHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
KITLASTIGGMTIGTAGTALPHGMEHPVSGLRDVMHGKGLAALTPTIIESSWDSDIERFG
HHHHHHHHCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHC
NISKVLGGTCAEDCSDAIRNFLKKIDLDIKLSDLGIEKSDIDWLTDNCMKISVANIKRHP
CHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHCCCCEEEEEHHHHHCC
KYFNKEQIKEMYHKSL
CCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNFNYNLPVNILFGRGRINDVGKEVSKYGKKVLIVTGKNSTKKTGLLDKTIDLLKDSKIE
CCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCC
YEVFDRVEQNPLITTIYSGVEIIKSTGCDCVLGLGGGSIMDAAKSIAFSYKNPGDLNDYI
HHHHHHHCCCCCEEEHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHEECCCCCCCCCHHH
FGIRQGEEALPIILVPTTSGTGSEGNCFAVLTNSETKDKKSIKKNSMYAKASIIDPELMV
EEEECCCCCCCEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHCCEEEEEECCCHHHH
TMPKHIIASVGFDALAHNMEAYLSNGRNPLADVQAIYGIELISENLIKVYNDVNDLEAWE
HHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
KITLASTIGGMTIGTAGTALPHGMEHPVSGLRDVMHGKGLAALTPTIIESSWDSDIERFG
HHHHHHHHCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHC
NISKVLGGTCAEDCSDAIRNFLKKIDLDIKLSDLGIEKSDIDWLTDNCMKISVANIKRHP
CHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHCCCCEEEEEHHHHHCC
KYFNKEQIKEMYHKSL
CCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]