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The map label for this gene is clpC [H]

Identifier: 126697592

GI number: 126697592

Start: 42914

End: 45361

Strand: Direct

Name: clpC [H]

Synonym: CD0026

Alternate gene names: 126697592

Gene position: 42914-45361 (Clockwise)

Preceding gene: 126697591

Following gene: 126697593

Centisome position: 1.0

GC content: 31.25

Gene sequence:

>2448_bases
GTGAACTTCAATAGATTTACACAAAGAGCTAAAAAGGCAATTGATTTAGCGTTTGAATCTGCTAAAAGTCTAGGACACAA
TATTGTCGGAAGTGAACATATACTTTTAGGTCTTTTAAGAGAAGAAGAAGGTATAGCTGCTAAAGTTCTAAGTAAAGTTG
GATTTACAGAAGCTTATTTAGAAGGCAAAATAGTTGATATGGAAGGTAAGGGAGAAGAAATCTCAGAAGATATAGTATTA
AGTCCAAGAAGTAAACAAATACTTGAATTATCAGGAATGTTTGCAAATAAATTAAAAACAAATTATATTGGGACTGAGCA
TATATTATTAGCAATTATTCAAGAAGGTGAAGGAATAGCTAATAAGATTTTAAATTATGCTGGAGTAAATGATAGGACTT
TAGCCCAATTAACAATTGATATGATGGGTATTAGTGATAAAAATCAATACAAAGCAGAAAATAGTTACACGGGCAACCAG
AATCAAGCAGAATCTAAAGTACTTGATAAGTATGGAAGAAATCTTACACTATATGCAAAACAGAATAAAATAGACCCTGT
AATAGGTAGAGAAAAAGAAATACAAAGAGTAATACAAATATTAAGTAGAAGAACTAAAAACAATCCAGTGTTGATAGGAG
ACCCAGGTGTAGGGAAAACAGCCATAGCTGAAGGTCTGGCTACAAATATAGCCTTAGGAAATGTTCCAGAAACACTAAAA
AACAAAACTTTATACTCTTTAGAGATGGGTTCATTATTGGCTGGAGCTAAGTATAGAGGAGAATTTGAAGAAAGAATTAA
AGAAGTTGTAGATGAAGTTGTTAAAAATGGAAACATAATCTTATTTATAGATGAGATGCACACAATAATAGGGGCTGGGT
CTACTGGAGAAGGCTCTATAGATGCTTCAAATATATTAAAGCCAGCCTTAGCAAGAGGAGAAATACAAGTTATAGGTGCA
ACTACAATTGATGAATATAGAAAGCATGTTGAAAAAGATTCTGCTCTAGAAAGAAGATTCCAACCAGTTATGGTAGATGA
ACCAACTAAAGAGGACTCAATAAAAATATTAGAAGGATTAAGAGATAAATATGAAGCTCATCATAAAGTTAAAATAACTG
ATGATGCTATAAAGGCAGCTGTAGAATTATCAACTAGATATATATCAGACAGATATCTGCCAGATAAAGCTATAGACTTG
ATTGATGAAGCTGCATCAAAAGTAAGATTAAAAGAAAATACACCTCCTTCAGAAATAAAAAAATTAGAACTAGAAATAGA
AAATATAGATAAAGAAAAAGAAGAAGCAGTAAGATGTCAAGACTTTGAGAAAGCAGCCAAAATAAGAGATGAACAAGGTC
TACTTAAAAAACAATTAGAAGATGTTAGAGAAAGATGGAACAAGTCATCTAAACATTCAGATTTAGTTGATGGAGAAGTT
ATTGCTGAAGTAGTGGGCTTATGGACAGGAATACCAGTTAATAAAATTCTTGAAGAAGAGGCTGATAGACTTTTGAGACT
TGAGGAAATACTGCACAATAGAGTTATAGGTCAAGAACAAGCAGTAAAATCTATTTCAAAGGCAATCAGAAGGTCAAGAG
CAGGTCTTAAAGACCCTAATAGACCAATTGGTTCATTTTTATTTTTAGGTCCAACAGGAGTAGGTAAAACAGAATTATCT
AAGGCATTAGCAGAAGTGCAATTTGGAGATGAAAATCAAATAATTAGAATAGATATGTCTGAATATATGGAAAAACATGC
TGTGTCAAGAATGATAGGTTCACCTCCAGGTTATGTAGGTCATGATGAAGGTGGTCAATTAACTGAAAAAGTAAGAAGAA
ATCCATATTCAGTTATCTTATTTGATGAGATAGAAAAAGCTCATCCAGATGTATTTAATATTCTGTTACAAATTCTAGAT
GATGGTAGACTAACTGATTCAAAAGGAAGAACTGTAGATTTTAAGAATACTATTGTAATAATGACATCAAATGTTGGAGC
ATCTACAATTGGTAGACAAAAAACTTTAGGATTTAGTATAGCTAAAGGAGACGAAGAAGAAAAATCTCAATATGAAAAAA
TGAAAGAAAATATAATGGGTGAATTAAAACAAAGATTCAGACCAGAGTTTTTAAACAGAATAGATGATATAATTGTTTTC
CACTCACTAAATGAAAATCATATATCAAAAATAGTACTTTTAATGGCAGCGAAACTACAAGAGAGATTAAAAGAAATGGA
TATAAAATTAGAAATGAGTGATGAGGCTGTTAAATTAATTTCTAAATCTGGATTTGACTTAGAATATGGAGCAAGACCTC
TTAAAAGAGCTTTACAAAAAGAGTTGGAAGATGAGCTATCTGAAGCAATCTTAAAAGGTAATGTGAAAAAGGGAAGTAAT
GTAGTAGCAAAAGTCAAAGATGAAAAAATAGTTTTTGAAACTAAATAA

Upstream 100 bases:

>100_bases
CAGTCAATAATGTATAAGAGTGATGATGTTGAGAATAGAGATATAAATAGAGCAACATATATTAGAGAAACTTTGGAAAA
ATTAAGAGGAGGGATGAATT

Downstream 100 bases:

>100_bases
TTTAATAGAGTTGCATTTTAAAATATTGCAAATATAAGTTTTATAATCTAAACAAAATTTTAAGGGCAATGAATCTATAA
TAATTCATTGTCCTTAATTA

Product: ATP-dependent Clp protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 815; Mature: 815

Protein sequence:

>815_residues
MNFNRFTQRAKKAIDLAFESAKSLGHNIVGSEHILLGLLREEEGIAAKVLSKVGFTEAYLEGKIVDMEGKGEEISEDIVL
SPRSKQILELSGMFANKLKTNYIGTEHILLAIIQEGEGIANKILNYAGVNDRTLAQLTIDMMGISDKNQYKAENSYTGNQ
NQAESKVLDKYGRNLTLYAKQNKIDPVIGREKEIQRVIQILSRRTKNNPVLIGDPGVGKTAIAEGLATNIALGNVPETLK
NKTLYSLEMGSLLAGAKYRGEFEERIKEVVDEVVKNGNIILFIDEMHTIIGAGSTGEGSIDASNILKPALARGEIQVIGA
TTIDEYRKHVEKDSALERRFQPVMVDEPTKEDSIKILEGLRDKYEAHHKVKITDDAIKAAVELSTRYISDRYLPDKAIDL
IDEAASKVRLKENTPPSEIKKLELEIENIDKEKEEAVRCQDFEKAAKIRDEQGLLKKQLEDVRERWNKSSKHSDLVDGEV
IAEVVGLWTGIPVNKILEEEADRLLRLEEILHNRVIGQEQAVKSISKAIRRSRAGLKDPNRPIGSFLFLGPTGVGKTELS
KALAEVQFGDENQIIRIDMSEYMEKHAVSRMIGSPPGYVGHDEGGQLTEKVRRNPYSVILFDEIEKAHPDVFNILLQILD
DGRLTDSKGRTVDFKNTIVIMTSNVGASTIGRQKTLGFSIAKGDEEEKSQYEKMKENIMGELKQRFRPEFLNRIDDIIVF
HSLNENHISKIVLLMAAKLQERLKEMDIKLEMSDEAVKLISKSGFDLEYGARPLKRALQKELEDELSEAILKGNVKKGSN
VVAKVKDEKIVFETK

Sequences:

>Translated_815_residues
MNFNRFTQRAKKAIDLAFESAKSLGHNIVGSEHILLGLLREEEGIAAKVLSKVGFTEAYLEGKIVDMEGKGEEISEDIVL
SPRSKQILELSGMFANKLKTNYIGTEHILLAIIQEGEGIANKILNYAGVNDRTLAQLTIDMMGISDKNQYKAENSYTGNQ
NQAESKVLDKYGRNLTLYAKQNKIDPVIGREKEIQRVIQILSRRTKNNPVLIGDPGVGKTAIAEGLATNIALGNVPETLK
NKTLYSLEMGSLLAGAKYRGEFEERIKEVVDEVVKNGNIILFIDEMHTIIGAGSTGEGSIDASNILKPALARGEIQVIGA
TTIDEYRKHVEKDSALERRFQPVMVDEPTKEDSIKILEGLRDKYEAHHKVKITDDAIKAAVELSTRYISDRYLPDKAIDL
IDEAASKVRLKENTPPSEIKKLELEIENIDKEKEEAVRCQDFEKAAKIRDEQGLLKKQLEDVRERWNKSSKHSDLVDGEV
IAEVVGLWTGIPVNKILEEEADRLLRLEEILHNRVIGQEQAVKSISKAIRRSRAGLKDPNRPIGSFLFLGPTGVGKTELS
KALAEVQFGDENQIIRIDMSEYMEKHAVSRMIGSPPGYVGHDEGGQLTEKVRRNPYSVILFDEIEKAHPDVFNILLQILD
DGRLTDSKGRTVDFKNTIVIMTSNVGASTIGRQKTLGFSIAKGDEEEKSQYEKMKENIMGELKQRFRPEFLNRIDDIIVF
HSLNENHISKIVLLMAAKLQERLKEMDIKLEMSDEAVKLISKSGFDLEYGARPLKRALQKELEDELSEAILKGNVKKGSN
VVAKVKDEKIVFETK
>Mature_815_residues
MNFNRFTQRAKKAIDLAFESAKSLGHNIVGSEHILLGLLREEEGIAAKVLSKVGFTEAYLEGKIVDMEGKGEEISEDIVL
SPRSKQILELSGMFANKLKTNYIGTEHILLAIIQEGEGIANKILNYAGVNDRTLAQLTIDMMGISDKNQYKAENSYTGNQ
NQAESKVLDKYGRNLTLYAKQNKIDPVIGREKEIQRVIQILSRRTKNNPVLIGDPGVGKTAIAEGLATNIALGNVPETLK
NKTLYSLEMGSLLAGAKYRGEFEERIKEVVDEVVKNGNIILFIDEMHTIIGAGSTGEGSIDASNILKPALARGEIQVIGA
TTIDEYRKHVEKDSALERRFQPVMVDEPTKEDSIKILEGLRDKYEAHHKVKITDDAIKAAVELSTRYISDRYLPDKAIDL
IDEAASKVRLKENTPPSEIKKLELEIENIDKEKEEAVRCQDFEKAAKIRDEQGLLKKQLEDVRERWNKSSKHSDLVDGEV
IAEVVGLWTGIPVNKILEEEADRLLRLEEILHNRVIGQEQAVKSISKAIRRSRAGLKDPNRPIGSFLFLGPTGVGKTELS
KALAEVQFGDENQIIRIDMSEYMEKHAVSRMIGSPPGYVGHDEGGQLTEKVRRNPYSVILFDEIEKAHPDVFNILLQILD
DGRLTDSKGRTVDFKNTIVIMTSNVGASTIGRQKTLGFSIAKGDEEEKSQYEKMKENIMGELKQRFRPEFLNRIDDIIVF
HSLNENHISKIVLLMAAKLQERLKEMDIKLEMSDEAVKLISKSGFDLEYGARPLKRALQKELEDELSEAILKGNVKKGSN
VVAKVKDEKIVFETK

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=318, Percent_Identity=39.937106918239, Blast_Score=216, Evalue=1e-55,
Organism=Escherichia coli, GI1788943, Length=886, Percent_Identity=47.6297968397291, Blast_Score=753, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=815, Percent_Identity=38.5276073619632, Blast_Score=543, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6320464, Length=765, Percent_Identity=45.6209150326797, Blast_Score=626, Evalue=1e-180,
Organism=Saccharomyces cerevisiae, GI6323002, Length=363, Percent_Identity=44.0771349862259, Blast_Score=297, Evalue=4e-81,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 91293; Mature: 91293

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS50151 UVR ; PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFNRFTQRAKKAIDLAFESAKSLGHNIVGSEHILLGLLREEEGIAAKVLSKVGFTEAYL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCHHHHH
EGKIVDMEGKGEEISEDIVLSPRSKQILELSGMFANKLKTNYIGTEHILLAIIQEGEGIA
CCEEEECCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHH
NKILNYAGVNDRTLAQLTIDMMGISDKNQYKAENSYTGNQNQAESKVLDKYGRNLTLYAK
HHHHHHCCCCCCCHHHEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEE
QNKIDPVIGREKEIQRVIQILSRRTKNNPVLIGDPGVGKTAIAEGLATNIALGNVPETLK
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCHHHH
NKTLYSLEMGSLLAGAKYRGEFEERIKEVVDEVVKNGNIILFIDEMHTIIGAGSTGEGSI
CCEEEEEEHHHHHHCCHHCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHHCCCCCCCCCC
DASNILKPALARGEIQVIGATTIDEYRKHVEKDSALERRFQPVMVDEPTKEDSIKILEGL
CHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
RDKYEAHHKVKITDDAIKAAVELSTRYISDRYLPDKAIDLIDEAASKVRLKENTPPSEIK
HHHHHCCCEEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEECCCCCHHHHH
KLELEIENIDKEKEEAVRCQDFEKAAKIRDEQGLLKKQLEDVRERWNKSSKHSDLVDGEV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
IAEVVGLWTGIPVNKILEEEADRLLRLEEILHNRVIGQEQAVKSISKAIRRSRAGLKDPN
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCC
RPIGSFLFLGPTGVGKTELSKALAEVQFGDENQIIRIDMSEYMEKHAVSRMIGSPPGYVG
CCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCC
HDEGGQLTEKVRRNPYSVILFDEIEKAHPDVFNILLQILDDGRLTDSKGRTVDFKNTIVI
CCCCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCEECCCCCEEEECCEEEE
MTSNVGASTIGRQKTLGFSIAKGDEEEKSQYEKMKENIMGELKQRFRPEFLNRIDDIIVF
EECCCCCHHCCCHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEE
HSLNENHISKIVLLMAAKLQERLKEMDIKLEMSDEAVKLISKSGFDLEYGARPLKRALQK
ECCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHCCCCCCCCCCHHHHHHHHH
ELEDELSEAILKGNVKKGSNVVAKVKDEKIVFETK
HHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECC
>Mature Secondary Structure
MNFNRFTQRAKKAIDLAFESAKSLGHNIVGSEHILLGLLREEEGIAAKVLSKVGFTEAYL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCHHHHH
EGKIVDMEGKGEEISEDIVLSPRSKQILELSGMFANKLKTNYIGTEHILLAIIQEGEGIA
CCEEEECCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHH
NKILNYAGVNDRTLAQLTIDMMGISDKNQYKAENSYTGNQNQAESKVLDKYGRNLTLYAK
HHHHHHCCCCCCCHHHEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEE
QNKIDPVIGREKEIQRVIQILSRRTKNNPVLIGDPGVGKTAIAEGLATNIALGNVPETLK
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCHHHH
NKTLYSLEMGSLLAGAKYRGEFEERIKEVVDEVVKNGNIILFIDEMHTIIGAGSTGEGSI
CCEEEEEEHHHHHHCCHHCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHHCCCCCCCCCC
DASNILKPALARGEIQVIGATTIDEYRKHVEKDSALERRFQPVMVDEPTKEDSIKILEGL
CHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
RDKYEAHHKVKITDDAIKAAVELSTRYISDRYLPDKAIDLIDEAASKVRLKENTPPSEIK
HHHHHCCCEEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEECCCCCHHHHH
KLELEIENIDKEKEEAVRCQDFEKAAKIRDEQGLLKKQLEDVRERWNKSSKHSDLVDGEV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
IAEVVGLWTGIPVNKILEEEADRLLRLEEILHNRVIGQEQAVKSISKAIRRSRAGLKDPN
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCC
RPIGSFLFLGPTGVGKTELSKALAEVQFGDENQIIRIDMSEYMEKHAVSRMIGSPPGYVG
CCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCC
HDEGGQLTEKVRRNPYSVILFDEIEKAHPDVFNILLQILDDGRLTDSKGRTVDFKNTIVI
CCCCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCEECCCCCEEEECCEEEE
MTSNVGASTIGRQKTLGFSIAKGDEEEKSQYEKMKENIMGELKQRFRPEFLNRIDDIIVF
EECCCCCHHCCCHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEE
HSLNENHISKIVLLMAAKLQERLKEMDIKLEMSDEAVKLISKSGFDLEYGARPLKRALQK
ECCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHCCCCCCCCCCHHHHHHHHH
ELEDELSEAILKGNVKKGSNVVAKVKDEKIVFETK
HHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]