Click here to switch to the map view.

The map label for this gene is rsbW [H]

Identifier: 126697576

GI number: 126697576

Start: 9450

End: 9857

Strand: Direct

Name: rsbW [H]

Synonym: CD0010

Alternate gene names: 126697576

Gene position: 9450-9857 (Clockwise)

Preceding gene: 126697575

Following gene: 126697577

Centisome position: 0.22

GC content: 27.45

Gene sequence:

>408_bases
TTGGCTTGTGAGACTATAAAGATGGAAATTACTACAAATCCAGATTATGTTAGTATAATAAGATTAACAGCATCTGGAAT
TGCCAATAAGATGGGTTTTCCAATAGATGATATAGAAGATATAAAGGTAGCAGTATCTGAAGCATGTACAAATGCAATAA
AACACAGTAAAGATGATGTGTTTAATATAGTATTTAATATTTTAGATAATGCAATTAATATAGAAATTCAAGATAATGGA
AAAGGATATGATGTTAGCTCAATAAGTACACCAGATTTAGAGAATCCAAAAGAGAGTGGTCTTGGATTGTTTATAATTAA
AACTTTAATGGATGATGTAGATATTGAATCAGAACATAATCAAGGGACAAAAATAAAAATGACTAAATATTTAGGAGTTG
ATATTTAA

Upstream 100 bases:

>100_bases
AAATGAAAAAGAGATATACATAGTAAATCCTAAGAGTAACGTAAGAAAGATTTTTACTATAACAGGTCTAGATAAAATAT
TTAAAGTGGAGGGATAAACT

Downstream 100 bases:

>100_bases
TGAAAAATGTAGCTAATGCTACACATTACCTAAATATGGATACAAAAGAGCTATTTAATTTATATAATAAAAATAAAAAT
GTAGACATTAGAAATATTCT

Product: serine-protein kinase

Products: NA

Alternate protein names: Anti-sigma-B factor; Sigma-B negative effector rsbW [H]

Number of amino acids: Translated: 135; Mature: 134

Protein sequence:

>135_residues
MACETIKMEITTNPDYVSIIRLTASGIANKMGFPIDDIEDIKVAVSEACTNAIKHSKDDVFNIVFNILDNAINIEIQDNG
KGYDVSSISTPDLENPKESGLGLFIIKTLMDDVDIESEHNQGTKIKMTKYLGVDI

Sequences:

>Translated_135_residues
MACETIKMEITTNPDYVSIIRLTASGIANKMGFPIDDIEDIKVAVSEACTNAIKHSKDDVFNIVFNILDNAINIEIQDNG
KGYDVSSISTPDLENPKESGLGLFIIKTLMDDVDIESEHNQGTKIKMTKYLGVDI
>Mature_134_residues
ACETIKMEITTNPDYVSIIRLTASGIANKMGFPIDDIEDIKVAVSEACTNAIKHSKDDVFNIVFNILDNAINIEIQDNGK
GYDVSSISTPDLENPKESGLGLFIIKTLMDDVDIESEHNQGTKIKMTKYLGVDI

Specific function: Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, rsbV. Upon phosphorylation of rsbV, rsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B

COG id: COG2172

COG function: function code T; Anti-sigma regulatory factor (Ser/Thr protein kinase)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anti-sigma-factor family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010193
- InterPro:   IPR003594 [H]

Pfam domain/function: PF02518 HATPase_c [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 14854; Mature: 14723

Theoretical pI: Translated: 4.19; Mature: 4.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACETIKMEITTNPDYVSIIRLTASGIANKMGFPIDDIEDIKVAVSEACTNAIKHSKDDV
CCCCEEEEEEECCCCEEEEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
FNIVFNILDNAINIEIQDNGKGYDVSSISTPDLENPKESGLGLFIIKTLMDDVDIESEHN
HHHHHHHHCCEEEEEECCCCCCEECCCCCCCCCCCCCCCCCEEEEHHHHHHCCCCCCCCC
QGTKIKMTKYLGVDI
CCCEEEEEEECCCCC
>Mature Secondary Structure 
ACETIKMEITTNPDYVSIIRLTASGIANKMGFPIDDIEDIKVAVSEACTNAIKHSKDDV
CCCEEEEEEECCCCEEEEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
FNIVFNILDNAINIEIQDNGKGYDVSSISTPDLENPKESGLGLFIIKTLMDDVDIESEHN
HHHHHHHHCCEEEEEECCCCCCEECCCCCCCCCCCCCCCCCEEEEHHHHHHCCCCCCCCC
QGTKIKMTKYLGVDI
CCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA