Click here to switch to the map view.

The map label for this gene is folE [H]

Identifier: 262192868

GI number: 262192868

Start: 1636699

End: 1637382

Strand: Direct

Name: folE [H]

Synonym: BMA10247_A1698

Alternate gene names: 262192868

Gene position: 1636699-1637382 (Clockwise)

Preceding gene: 126445656

Following gene: 126447942

Centisome position: 69.57

GC content: 55.41

Gene sequence:

>684_bases
ATGGCAAGCGTTCCCGAAAAATGTTGTGGATTCTTTTGGAGATGTGATGTCATGATTGACACCCAATACAATGGCGCATG
CGATGTCCACCACCATTCTCCGGCCGAAATTCGACGCATCCGCCAGTTCGATCCCGCCGCATTCGAAATGGCGGTCGGTA
GCTTGCTCATGGCCTGTGGTATCGAGATAGACGCCGCACATACCAGCCGCACGGCGCAACGTGTGCGGGAACTCTGGCAG
AAGCGCTTGCTTGACGGCTACGATGTTGATCCTGCAGAGGCGCTGGGTGTGGGTTTCGATGATCGAAAGGAAGATATGGT
CATCATCCGCAGTATCGCTGTCCATGGTGTTTGTCCGCATCACTTGTTGCCATTTCGCGGCGTGGCACACGTGGCCTATC
TGCCGGGAGGGCGACTGCATGGCTTCGGGCGCATCGCCCGTATGATCGATGCGATCAGCCATCGATTTACATACCAAGAG
TGGATTACAAACGAGATTGCGACAGCCCTTGTCACTCATGGAAAAGCACGGGGAGCAGCTTGCCTGATCGAAGCCGAACA
ACTGTGCTTGCTCATGGGCGAAAATCGCCGCGGCGACGAGCGCGTAATTACGCAATGCTACGTGGGCGAATTTGACCATA
ACGCCCAGGCGCGCAACGAGTTTCTTCGCGCCATCAATCGATAG

Upstream 100 bases:

>100_bases
AAACACACTTCGAACCACCCCGACCACTCCAGTGCGCCGCCAAATCTCGAGAAATTAGAAAATTATCCCGACCTTTTCGC
GAGAAAAACCATCGAACTCA

Downstream 100 bases:

>100_bases
TAACTTTCTGTGAGCGAGCCTGATTCAATTGTGGTGCGTGCGAAGCTGCGGTCGAGACGCTATTGTGGGCGTGATAGCGG
TTTTCGATCAATTTCGTCGA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MASVPEKCCGFFWRCDVMIDTQYNGACDVHHHSPAEIRRIRQFDPAAFEMAVGSLLMACGIEIDAAHTSRTAQRVRELWQ
KRLLDGYDVDPAEALGVGFDDRKEDMVIIRSIAVHGVCPHHLLPFRGVAHVAYLPGGRLHGFGRIARMIDAISHRFTYQE
WITNEIATALVTHGKARGAACLIEAEQLCLLMGENRRGDERVITQCYVGEFDHNAQARNEFLRAINR

Sequences:

>Translated_227_residues
MASVPEKCCGFFWRCDVMIDTQYNGACDVHHHSPAEIRRIRQFDPAAFEMAVGSLLMACGIEIDAAHTSRTAQRVRELWQ
KRLLDGYDVDPAEALGVGFDDRKEDMVIIRSIAVHGVCPHHLLPFRGVAHVAYLPGGRLHGFGRIARMIDAISHRFTYQE
WITNEIATALVTHGKARGAACLIEAEQLCLLMGENRRGDERVITQCYVGEFDHNAQARNEFLRAINR
>Mature_226_residues
ASVPEKCCGFFWRCDVMIDTQYNGACDVHHHSPAEIRRIRQFDPAAFEMAVGSLLMACGIEIDAAHTSRTAQRVRELWQK
RLLDGYDVDPAEALGVGFDDRKEDMVIIRSIAVHGVCPHHLLPFRGVAHVAYLPGGRLHGFGRIARMIDAISHRFTYQEW
ITNEIATALVTHGKARGAACLIEAEQLCLLMGENRRGDERVITQCYVGEFDHNAQARNEFLRAINR

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=127, Percent_Identity=32.2834645669291, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI4503949, Length=127, Percent_Identity=32.2834645669291, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI66932970, Length=110, Percent_Identity=30, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI66932972, Length=87, Percent_Identity=35.632183908046, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1788476, Length=168, Percent_Identity=27.9761904761905, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560486, Length=178, Percent_Identity=32.0224719101124, Blast_Score=111, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6321706, Length=182, Percent_Identity=28.5714285714286, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24656796, Length=142, Percent_Identity=30.9859154929577, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24656791, Length=142, Percent_Identity=30.9859154929577, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24656782, Length=142, Percent_Identity=30.9859154929577, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 25558; Mature: 25426

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASVPEKCCGFFWRCDVMIDTQYNGACDVHHHSPAEIRRIRQFDPAAFEMAVGSLLMACG
CCCCCHHHCCHHEEEEEEEECCCCCEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHC
IEIDAAHTSRTAQRVRELWQKRLLDGYDVDPAEALGVGFDDRKEDMVIIRSIAVHGVCPH
CEEECHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCCH
HLLPFRGVAHVAYLPGGRLHGFGRIARMIDAISHRFTYQEWITNEIATALVTHGKARGAA
HCCCCCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
CLIEAEQLCLLMGENRRGDERVITQCYVGEFDHNAQARNEFLRAINR
EEEEHHHHHHEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
ASVPEKCCGFFWRCDVMIDTQYNGACDVHHHSPAEIRRIRQFDPAAFEMAVGSLLMACG
CCCCHHHCCHHEEEEEEEECCCCCEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHC
IEIDAAHTSRTAQRVRELWQKRLLDGYDVDPAEALGVGFDDRKEDMVIIRSIAVHGVCPH
CEEECHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCCH
HLLPFRGVAHVAYLPGGRLHGFGRIARMIDAISHRFTYQEWITNEIATALVTHGKARGAA
HCCCCCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
CLIEAEQLCLLMGENRRGDERVITQCYVGEFDHNAQARNEFLRAINR
EEEEHHHHHHEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]