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The map label for this gene is iorA [H]

Identifier: 126447776

GI number: 126447776

Start: 1479806

End: 1480267

Strand: Direct

Name: iorA [H]

Synonym: BMA10247_A1530

Alternate gene names: 126447776

Gene position: 1479806-1480267 (Clockwise)

Preceding gene: 126447532

Following gene: 126446323

Centisome position: 62.9

GC content: 69.91

Gene sequence:

>462_bases
ATGTCTACCTCGTTTGTGCTGAACGGCAAGAACCTCACGCTGGACGCCGATCCCGCGATGCCGCTCCTCTGGGCGATCCG
CGAGGACGCGGGCCTGCACGGCACGAAGTTCGGCTGCGGCGCCGCGCAGTGCGGCGCGTGCACCGTGCATCTCGAAGGCC
AGGCGGTGCGCTCGTGCGTGCTGCCGCTCGCGGCCGTCGCCGGCAAGCGCGTGACGACCATCGAAGGACTCGCGAGCCGG
CCCGCGAAGGCCGTCCAGGCTGCGTGGGTCAAGCTGCAGGTGCCGCAGTGCGGCTACTGCCAGTCCGGCCAGATCATGTC
GGCGACCGCGCTCCTCGAACAGAACCCGGCGCCGACCGACGCCGACATCGACGCCGCGATGAACGACAACATCTGCCGTT
GCGCGACCTACACCCGCATCCGCGCCGCGATTCACGAAGCGGCCGCCACCCTGAAGGCCTGA

Upstream 100 bases:

>100_bases
ATATTTTTGCAGGATTGTGTAAACGCAACGGCGGTCCGTCCCTCACACTGCCGGCTATCACCCGGCGCCAAGTCCGGGCA
TTCCCCCACGGAGATTGTCC

Downstream 100 bases:

>100_bases
CGATGACGACCGACCTCGATCTCCCGGACGCCGTGCGCGCGTCCCGCCGCACGTTCCTGAAAGCCGCCGGCGCCGCCGCG
GCCGTCGGCCTCACGATCGG

Product: isoquinoline 1-oxidoreductase, alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MSTSFVLNGKNLTLDADPAMPLLWAIREDAGLHGTKFGCGAAQCGACTVHLEGQAVRSCVLPLAAVAGKRVTTIEGLASR
PAKAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPAPTDADIDAAMNDNICRCATYTRIRAAIHEAAATLKA

Sequences:

>Translated_153_residues
MSTSFVLNGKNLTLDADPAMPLLWAIREDAGLHGTKFGCGAAQCGACTVHLEGQAVRSCVLPLAAVAGKRVTTIEGLASR
PAKAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPAPTDADIDAAMNDNICRCATYTRIRAAIHEAAATLKA
>Mature_152_residues
STSFVLNGKNLTLDADPAMPLLWAIREDAGLHGTKFGCGAAQCGACTVHLEGQAVRSCVLPLAAVAGKRVTTIEGLASRP
AKAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPAPTDADIDAAMNDNICRCATYTRIRAAIHEAAATLKA

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=149, Percent_Identity=36.9127516778523, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI71773480, Length=95, Percent_Identity=33.6842105263158, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1786480, Length=169, Percent_Identity=39.0532544378698, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1789232, Length=138, Percent_Identity=39.1304347826087, Blast_Score=84, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17540638, Length=156, Percent_Identity=39.1025641025641, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17539860, Length=153, Percent_Identity=37.9084967320261, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI32566215, Length=153, Percent_Identity=37.2549019607843, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17737937, Length=156, Percent_Identity=37.8205128205128, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24647199, Length=159, Percent_Identity=36.4779874213836, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24647201, Length=159, Percent_Identity=35.2201257861635, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24647193, Length=164, Percent_Identity=35.3658536585366, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24647197, Length=164, Percent_Identity=28.6585365853659, Blast_Score=63, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24647195, Length=164, Percent_Identity=28.6585365853659, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 15954; Mature: 15822

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
5.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSFVLNGKNLTLDADPAMPLLWAIREDAGLHGTKFGCGAAQCGACTVHLEGQAVRSCV
CCCEEEECCCEEEEECCCCCHHHEEECCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHH
LPLAAVAGKRVTTIEGLASRPAKAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPAPTD
HHHHHHCCCCEEEHHHHHCCCHHHHHEEEEEEECCCCCCCCCCCEEEHHHHHHCCCCCCC
ADIDAAMNDNICRCATYTRIRAAIHEAAATLKA
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STSFVLNGKNLTLDADPAMPLLWAIREDAGLHGTKFGCGAAQCGACTVHLEGQAVRSCV
CCEEEECCCEEEEECCCCCHHHEEECCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHH
LPLAAVAGKRVTTIEGLASRPAKAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPAPTD
HHHHHHCCCCEEEHHHHHCCCHHHHHEEEEEEECCCCCCCCCCCEEEHHHHHHCCCCCCC
ADIDAAMNDNICRCATYTRIRAAIHEAAATLKA
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]