Click here to switch to the map view.

The map label for this gene is lysP [H]

Identifier: 126447680

GI number: 126447680

Start: 170041

End: 171603

Strand: Direct

Name: lysP [H]

Synonym: BMA10247_A0199

Alternate gene names: 126447680

Gene position: 170041-171603 (Clockwise)

Preceding gene: 126446306

Following gene: 126445959

Centisome position: 7.23

GC content: 66.22

Gene sequence:

>1563_bases
ATGTCACCACACCCGAATTCCGACAACTCAACCGCACAATCGAATCCTCCTCAGCTGCGCCGCAGCCTGAAAGCCCGTCA
CCTGACGATGATCGCGATCGGCGGCTCGATCGGCACGGGCCTGTTCGTCGCGTCCGGCGCGTCCATCTCGCAGGCGGGCC
CCGGCGGCGCGATGCTCGCCTATCTGTTGATCGGCCTGATGGTCTATTGCCTGATGATGAGCTTGGGCGAGATGGCCGCG
TTCATGCCGGTGTCGGGCTCGTTCGCGACGTACGGCGCGAAATACGTCGAGGAAGGCTTCGGCTTCGCGCTCGGCTGGAA
CTACTGGTACAACTGGGCGGTGACGATCGCCGTCGAGCTCGTCGCCGCGCAGCTCGTCATGCATTACTGGTTTCCGGACG
TGCCGGGCGTCTGGTGGAGCGCGGCGTTCCTCGGCGTGATGTTCCTGCTCAACGTGCTGACCGTGCGCGGCTTCGGCGAG
GCCGAATACTGGTTCGCGCTCATCAAGGTCGTCACCGTGATCGCGTTCATCGGCGTCGGCCTGCTGATGATCTTCGGCAT
CCTGAAGGGCGGCCCGAGCAACGGCTGGAGCAACTTCACGATCGGCGACGCGCCGTTCGCGGGCGGCCTGCCCGCGATGA
TGGGCGTCGCGATGATCGCCGGCTTCTCGTTCCAGGGCACCGAGCTGATCGGCGTCGCGGCCGGCGAATCGGAAAACCCG
CGCACGACGATCCCGCGCGCGGTGCGCCAGGTGTTCTGGCGCATCCTGCTGTTCTACGTGCTCGCGATCTTCGTGATCGG
CGTGCTGATTCCGTACACCGATCCGAATCTGCTGAAGAGCGACGTGACCGACGTCGGCGTGAGCCCGTTTACGCTCGTGT
TCCGTCACGCGGGCCTCGCGTTCGCCGCGGGCGTGATGAACGCGGTGATCCTGACCGCCGTGCTCTCGGCGGGCAACTCG
GGGATGTACGCGTCGACGCGGATGCTCCACAACCTCGCGACCGAAGGCCGCGCGCCGAAGCTGTTCGCGAAGCTGTCGGC
GGGCGGCGTGCCGCGCAACGCGCTGTATGCGACGACCGCGGTCGGCGCGCTGTGCTTCCTGTCGTCGCTGTACGGCGACA
AGACCGTGTATCTGTGGCTGCTGAACACGTCGGGAATGACGGGCTTCATCGCGTGGCTCGGCATCGCGCTCAGCCACTAT
CGCTTCCGCAAGGGCTACGTGCGCCAGGGCTTCTCGGTCGACCAACTGCCGTATCAGTCGAGCCTGTATCCGTACGGCCC
GATCTTCGCGTTCGCGCTGTGCATCGTGATCGCGCTCGGCCAGGATTATCAGGCGTTCCTCGCGAACCGGATCGACTGGA
TCGGCGTGCTCGCCACCTACGTCGGCATTCCGCTCTTCCTCGTCGTGTGGCTCGGCTATCGGCTCGTCCACAAGACGCGC
GTCGTCCGCTATGAGGACATGGACATCGCATCGTGGGTGGCCGAGCACGAGCGCGCGGCGGCGCACGAGGCGCGCGAGGC
GGCGGCCGTGCGCGTGCCGTCGAGTCCCGAGGCGGCTTCGTAA

Upstream 100 bases:

>100_bases
CACCGGGCGGCGCGCCGCGGATCGTTCCGGGGACGCGCCGAATCCGGCGTCCTGCCCGGCGCGGCGTCGAACCGTCGCCC
GCCGCTTTTGCCAGCCCGTT

Downstream 100 bases:

>100_bases
CGCATCGCGTCCCGCAGCGGGCGGACGCTTCGCTGCGAATTCGACAGGCGGCCTGCCCGGCTTCGGGCGCGGCCGCCTTT
TTTTAGGTTCATCGCGGAAT

Product: lysine-specific permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MSPHPNSDNSTAQSNPPQLRRSLKARHLTMIAIGGSIGTGLFVASGASISQAGPGGAMLAYLLIGLMVYCLMMSLGEMAA
FMPVSGSFATYGAKYVEEGFGFALGWNYWYNWAVTIAVELVAAQLVMHYWFPDVPGVWWSAAFLGVMFLLNVLTVRGFGE
AEYWFALIKVVTVIAFIGVGLLMIFGILKGGPSNGWSNFTIGDAPFAGGLPAMMGVAMIAGFSFQGTELIGVAAGESENP
RTTIPRAVRQVFWRILLFYVLAIFVIGVLIPYTDPNLLKSDVTDVGVSPFTLVFRHAGLAFAAGVMNAVILTAVLSAGNS
GMYASTRMLHNLATEGRAPKLFAKLSAGGVPRNALYATTAVGALCFLSSLYGDKTVYLWLLNTSGMTGFIAWLGIALSHY
RFRKGYVRQGFSVDQLPYQSSLYPYGPIFAFALCIVIALGQDYQAFLANRIDWIGVLATYVGIPLFLVVWLGYRLVHKTR
VVRYEDMDIASWVAEHERAAAHEAREAAAVRVPSSPEAAS

Sequences:

>Translated_520_residues
MSPHPNSDNSTAQSNPPQLRRSLKARHLTMIAIGGSIGTGLFVASGASISQAGPGGAMLAYLLIGLMVYCLMMSLGEMAA
FMPVSGSFATYGAKYVEEGFGFALGWNYWYNWAVTIAVELVAAQLVMHYWFPDVPGVWWSAAFLGVMFLLNVLTVRGFGE
AEYWFALIKVVTVIAFIGVGLLMIFGILKGGPSNGWSNFTIGDAPFAGGLPAMMGVAMIAGFSFQGTELIGVAAGESENP
RTTIPRAVRQVFWRILLFYVLAIFVIGVLIPYTDPNLLKSDVTDVGVSPFTLVFRHAGLAFAAGVMNAVILTAVLSAGNS
GMYASTRMLHNLATEGRAPKLFAKLSAGGVPRNALYATTAVGALCFLSSLYGDKTVYLWLLNTSGMTGFIAWLGIALSHY
RFRKGYVRQGFSVDQLPYQSSLYPYGPIFAFALCIVIALGQDYQAFLANRIDWIGVLATYVGIPLFLVVWLGYRLVHKTR
VVRYEDMDIASWVAEHERAAAHEAREAAAVRVPSSPEAAS
>Mature_519_residues
SPHPNSDNSTAQSNPPQLRRSLKARHLTMIAIGGSIGTGLFVASGASISQAGPGGAMLAYLLIGLMVYCLMMSLGEMAAF
MPVSGSFATYGAKYVEEGFGFALGWNYWYNWAVTIAVELVAAQLVMHYWFPDVPGVWWSAAFLGVMFLLNVLTVRGFGEA
EYWFALIKVVTVIAFIGVGLLMIFGILKGGPSNGWSNFTIGDAPFAGGLPAMMGVAMIAGFSFQGTELIGVAAGESENPR
TTIPRAVRQVFWRILLFYVLAIFVIGVLIPYTDPNLLKSDVTDVGVSPFTLVFRHAGLAFAAGVMNAVILTAVLSAGNSG
MYASTRMLHNLATEGRAPKLFAKLSAGGVPRNALYATTAVGALCFLSSLYGDKTVYLWLLNTSGMTGFIAWLGIALSHYR
FRKGYVRQGFSVDQLPYQSSLYPYGPIFAFALCIVIALGQDYQAFLANRIDWIGVLATYVGIPLFLVVWLGYRLVHKTRV
VRYEDMDIASWVAEHERAAAHEAREAAAVRVPSSPEAAS

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=359, Percent_Identity=23.1197771587744, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788480, Length=480, Percent_Identity=74.5833333333333, Blast_Score=743, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=486, Percent_Identity=40.7407407407407, Blast_Score=347, Evalue=1e-96,
Organism=Escherichia coli, GI1786789, Length=439, Percent_Identity=38.496583143508, Blast_Score=279, Evalue=4e-76,
Organism=Escherichia coli, GI48994972, Length=433, Percent_Identity=37.8752886836028, Blast_Score=274, Evalue=8e-75,
Organism=Escherichia coli, GI1786302, Length=419, Percent_Identity=39.618138424821, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI1789017, Length=413, Percent_Identity=34.6246973365617, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI87081915, Length=520, Percent_Identity=32.6923076923077, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1790653, Length=406, Percent_Identity=35.4679802955665, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1786602, Length=393, Percent_Identity=35.3689567430025, Blast_Score=205, Evalue=7e-54,
Organism=Escherichia coli, GI87081869, Length=245, Percent_Identity=26.1224489795918, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320772, Length=493, Percent_Identity=36.9168356997972, Blast_Score=349, Evalue=7e-97,
Organism=Saccharomyces cerevisiae, GI6324061, Length=501, Percent_Identity=37.3253493013972, Blast_Score=344, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6324990, Length=522, Percent_Identity=33.1417624521073, Blast_Score=321, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6324059, Length=503, Percent_Identity=36.3817097415507, Blast_Score=310, Evalue=4e-85,
Organism=Saccharomyces cerevisiae, GI6322892, Length=497, Percent_Identity=34.8088531187123, Blast_Score=298, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6324924, Length=534, Percent_Identity=31.8352059925094, Blast_Score=288, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6321629, Length=500, Percent_Identity=31.8, Blast_Score=280, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6324553, Length=438, Percent_Identity=36.7579908675799, Blast_Score=275, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6322967, Length=516, Percent_Identity=32.9457364341085, Blast_Score=265, Evalue=9e-72,
Organism=Saccharomyces cerevisiae, GI6319824, Length=531, Percent_Identity=28.6252354048964, Blast_Score=255, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6320717, Length=518, Percent_Identity=27.2200772200772, Blast_Score=244, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6321053, Length=502, Percent_Identity=30.8764940239044, Blast_Score=243, Evalue=6e-65,
Organism=Saccharomyces cerevisiae, GI6324981, Length=517, Percent_Identity=33.8491295938104, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6319542, Length=518, Percent_Identity=27.4131274131274, Blast_Score=233, Evalue=8e-62,
Organism=Saccharomyces cerevisiae, GI6320251, Length=519, Percent_Identity=28.131021194605, Blast_Score=230, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6319543, Length=488, Percent_Identity=29.7131147540984, Blast_Score=229, Evalue=7e-61,
Organism=Saccharomyces cerevisiae, GI6319608, Length=522, Percent_Identity=27.2030651340996, Blast_Score=227, Evalue=4e-60,
Organism=Saccharomyces cerevisiae, GI6320364, Length=572, Percent_Identity=25.3496503496504, Blast_Score=190, Evalue=6e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 56145; Mature: 56014

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPHPNSDNSTAQSNPPQLRRSLKARHLTMIAIGGSIGTGLFVASGASISQAGPGGAMLA
CCCCCCCCCCCCCCCCHHHHHHHHHHHEEEEEECCCCCCCCEEECCCCCCCCCCCHHHHH
YLLIGLMVYCLMMSLGEMAAFMPVSGSFATYGAKYVEEGFGFALGWNYWYNWAVTIAVEL
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHH
VAAQLVMHYWFPDVPGVWWSAAFLGVMFLLNVLTVRGFGEAEYWFALIKVVTVIAFIGVG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LLMIFGILKGGPSNGWSNFTIGDAPFAGGLPAMMGVAMIAGFSFQGTELIGVAAGESENP
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCC
RTTIPRAVRQVFWRILLFYVLAIFVIGVLIPYTDPNLLKSDVTDVGVSPFTLVFRHAGLA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
FAAGVMNAVILTAVLSAGNSGMYASTRMLHNLATEGRAPKLFAKLSAGGVPRNALYATTA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHH
VGALCFLSSLYGDKTVYLWLLNTSGMTGFIAWLGIALSHYRFRKGYVRQGFSVDQLPYQS
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SLYPYGPIFAFALCIVIALGQDYQAFLANRIDWIGVLATYVGIPLFLVVWLGYRLVHKTR
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVRYEDMDIASWVAEHERAAAHEAREAAAVRVPSSPEAAS
HEEECCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCC
>Mature Secondary Structure 
SPHPNSDNSTAQSNPPQLRRSLKARHLTMIAIGGSIGTGLFVASGASISQAGPGGAMLA
CCCCCCCCCCCCCCCHHHHHHHHHHHEEEEEECCCCCCCCEEECCCCCCCCCCCHHHHH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HEEECCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]