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The map label for this gene is selB [H]

Identifier: 126447545

GI number: 126447545

Start: 525769

End: 527724

Strand: Direct

Name: selB [H]

Synonym: BMA10247_A0576

Alternate gene names: 126447545

Gene position: 525769-527724 (Clockwise)

Preceding gene: 126445653

Following gene: 126447914

Centisome position: 22.35

GC content: 72.96

Gene sequence:

>1956_bases
ATGCGCGCAGGCGCCGACGGGCCCGCGCGCATGATCGTCGGGACCGCAGGCCACATCGATCACGGCAAGACGACGCTTGT
GCGCGCGCTGACGGGCGTCGACACCGATCGGCTGAAGGAAGAGAAGGCGCGCGGAATCTCGATCGAGCTCGGCTACGCGT
ACACGCCGCTGCCGAACGGCGACGTGCTCGGCTTCATCGACGTGCCCGGCCATGAAAAGCTCGTCCACACGATGGCCGCG
GGCGCGTGCGGGATCGACTTCGCGCTCGTCGTGATCGCGGCCGACGACGGCGTGATGCCGCAGACCCGCGAACATCTGTC
GATTCTGCAACTGCTGGGCGTCGCGCATGGCGCGCTCGCGCTGACGAAATGCGATCGCGTCGACGCGGCGCGCGTCGCGC
GGGTGCGCGACGAGATCCGCGCGTGGCTCGCGGCCTCGCCGCTCGCCGATGCGCCGGTTTTCGAGACGCGCGCGAGCGAG
CCGGACGACGCGGGCGTTGCCGCATTGAACGCGCACCTGCGCGACACGGCGCTCGCCTGGCGCGCGCGGCGCGACGACGG
CCTGTTCCGGCTCGCGGTCGATCGCGTGTTCACGCTCGCGGGGCAAGGCACCGTCGTGACGGGCACCGCGGTCGCGGGGC
GCGTGCGCACGGGCGACTCGCTCGCCGTCGCGCGCACGGGCGAAACGGTGCGCGTGCGCAGCATCCATGCGCAGAACCGC
GCGACCGACGTCGGCCATGCGGGCGAGCGCTGCGCGCTGAATCTCGCGGGCATCGACAAGGCGGCGCTCGCGCGCGGCGA
TGCGATCGTCGACGCGCGGCTCGCGACGCTTTCGCCACGCATCGACGTCGAATTGACGTTGACGGCGGACGCCGACCTGA
CGATCTCGCACTGGACGCCGCTGCACGTGCATCTCGGCACGCTGCACCGGGTCGCGCACGTTGCGCTGCTCGAAGGCGAG
ACGCTCGGGCCCGGCCGGCGCGCCCGCGCGCAGTTGAATTTCACGGAGCCGGTGTTCGCCGCGCCGGGCGATCGCTTCAT
CGTGCGCGACGCGCAGGCGACGCGCACCGTGGGCGGCGGGCGCGTGCTCGATCCGTTCGGCCCCGCGCGCAAGCGGCGCA
CGCGCGCGCGACGCGCGTGGCTCGACGCGCTCGCGGCGTGGCTCGACGAAGGCCGTCTCGACGCGTTGCTCGACGAGGCG
CCGCTCGGCATCGCGCGCGCGACGCTGATGCATCTGACCGGCTTGCCGGCGCAGGCGTGGGCGTTGCCGGCCGATGCGGT
GAGCGTCGCCGCGCCGGGCAAGCACGCGGACGAAGCGCGCGTGCTTGCGCGCGGGCATTGGGACGCGCTGCGCACGCGCG
TGCTCGATGCGCTCGCGGCATTCCATCAGCGCTCGCCGGACGAGCAGGGGCCGGATGTCGCGCGGCTGCGCCGGATCGCC
GCGCCGCTCGCGGACGACGCGTTGTGGCGCGCGCTGACCGATGCGCTGATCGCCGAGGGCGCGATCGTGCGCAGCGGCCC
GTGGCTGCATTTGCCGTCGCATGCGGTGAGCTTCGACGCGGCCGAAGAGGCGTTGGCCGGGCGCTTGCTGCCGCTCGTCG
CGGCGGGCCGCTACGATCCGCCGTGGGTGCGCGATCACGCGGCGGCGACGCTCATGGCGGAGGACGCGGTGCGCGCGCTG
CTGCGCAAGCTCGCGCGGCGCGGCGACGTGCATCAGGTCGTGCGGGATCTGTTCTATCACCGCGACGTGATCGCGGAGCT
TGCGCGACTGATCGCGCGACTCGCGGGCGAGCACGGCGGCGGGCTCGATGCGGCGACGTTTCGCGACGCGACCGGGCTCG
GCCGCAAGCGGGCGATTCAAATTCTCGAGTTCTTCGATCGCGTTGGGTATACTCGCTTCCACCGCGACCTGCACTGGTTG
CGGGCTGATAGCCGGTTGCTGGCCGGCTCGCGGTAG

Upstream 100 bases:

>100_bases
GCGGCTGGCCGCGCCCGGTGCTCGGGCGCATCGCCGACGACGCGCTGCGGCTCGACCTGCGCTGCCTCGAAGCGGGCGAC
GAAGCCGCGTTCATCGCGCA

Downstream 100 bases:

>100_bases
TCCGGTTTTTCGGGCTCGTGGGGGTTGCCGCGGTATTCGACGGTTCTCGACGGTTTTTTGACGGGGCGGGGTGCGCTTGA
TGTCGGCTTCCGTTTCCCGT

Product: translation elongation factor, selenocysteine-specific

Products: NA

Alternate protein names: SelB translation factor [H]

Number of amino acids: Translated: 651; Mature: 651

Protein sequence:

>651_residues
MRAGADGPARMIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLPNGDVLGFIDVPGHEKLVHTMAA
GACGIDFALVVIAADDGVMPQTREHLSILQLLGVAHGALALTKCDRVDAARVARVRDEIRAWLAASPLADAPVFETRASE
PDDAGVAALNAHLRDTALAWRARRDDGLFRLAVDRVFTLAGQGTVVTGTAVAGRVRTGDSLAVARTGETVRVRSIHAQNR
ATDVGHAGERCALNLAGIDKAALARGDAIVDARLATLSPRIDVELTLTADADLTISHWTPLHVHLGTLHRVAHVALLEGE
TLGPGRRARAQLNFTEPVFAAPGDRFIVRDAQATRTVGGGRVLDPFGPARKRRTRARRAWLDALAAWLDEGRLDALLDEA
PLGIARATLMHLTGLPAQAWALPADAVSVAAPGKHADEARVLARGHWDALRTRVLDALAAFHQRSPDEQGPDVARLRRIA
APLADDALWRALTDALIAEGAIVRSGPWLHLPSHAVSFDAAEEALAGRLLPLVAAGRYDPPWVRDHAAATLMAEDAVRAL
LRKLARRGDVHQVVRDLFYHRDVIAELARLIARLAGEHGGGLDAATFRDATGLGRKRAIQILEFFDRVGYTRFHRDLHWL
RADSRLLAGSR

Sequences:

>Translated_651_residues
MRAGADGPARMIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLPNGDVLGFIDVPGHEKLVHTMAA
GACGIDFALVVIAADDGVMPQTREHLSILQLLGVAHGALALTKCDRVDAARVARVRDEIRAWLAASPLADAPVFETRASE
PDDAGVAALNAHLRDTALAWRARRDDGLFRLAVDRVFTLAGQGTVVTGTAVAGRVRTGDSLAVARTGETVRVRSIHAQNR
ATDVGHAGERCALNLAGIDKAALARGDAIVDARLATLSPRIDVELTLTADADLTISHWTPLHVHLGTLHRVAHVALLEGE
TLGPGRRARAQLNFTEPVFAAPGDRFIVRDAQATRTVGGGRVLDPFGPARKRRTRARRAWLDALAAWLDEGRLDALLDEA
PLGIARATLMHLTGLPAQAWALPADAVSVAAPGKHADEARVLARGHWDALRTRVLDALAAFHQRSPDEQGPDVARLRRIA
APLADDALWRALTDALIAEGAIVRSGPWLHLPSHAVSFDAAEEALAGRLLPLVAAGRYDPPWVRDHAAATLMAEDAVRAL
LRKLARRGDVHQVVRDLFYHRDVIAELARLIARLAGEHGGGLDAATFRDATGLGRKRAIQILEFFDRVGYTRFHRDLHWL
RADSRLLAGSR
>Mature_651_residues
MRAGADGPARMIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLPNGDVLGFIDVPGHEKLVHTMAA
GACGIDFALVVIAADDGVMPQTREHLSILQLLGVAHGALALTKCDRVDAARVARVRDEIRAWLAASPLADAPVFETRASE
PDDAGVAALNAHLRDTALAWRARRDDGLFRLAVDRVFTLAGQGTVVTGTAVAGRVRTGDSLAVARTGETVRVRSIHAQNR
ATDVGHAGERCALNLAGIDKAALARGDAIVDARLATLSPRIDVELTLTADADLTISHWTPLHVHLGTLHRVAHVALLEGE
TLGPGRRARAQLNFTEPVFAAPGDRFIVRDAQATRTVGGGRVLDPFGPARKRRTRARRAWLDALAAWLDEGRLDALLDEA
PLGIARATLMHLTGLPAQAWALPADAVSVAAPGKHADEARVLARGHWDALRTRVLDALAAFHQRSPDEQGPDVARLRRIA
APLADDALWRALTDALIAEGAIVRSGPWLHLPSHAVSFDAAEEALAGRLLPLVAAGRYDPPWVRDHAAATLMAEDAVRAL
LRKLARRGDVHQVVRDLFYHRDVIAELARLIARLAGEHGGGLDAATFRDATGLGRKRAIQILEFFDRVGYTRFHRDLHWL
RADSRLLAGSR

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP [H]

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147630, Length=403, Percent_Identity=28.0397022332506, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI54607086, Length=340, Percent_Identity=26.1764705882353, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI4503475, Length=324, Percent_Identity=24.3827160493827, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI53729339, Length=226, Percent_Identity=29.646017699115, Blast_Score=74, Evalue=6e-13,
Organism=Homo sapiens, GI53729337, Length=226, Percent_Identity=29.646017699115, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI2367247, Length=639, Percent_Identity=42.2535211267606, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1790412, Length=381, Percent_Identity=30.7086614173228, Blast_Score=135, Evalue=1e-32,
Organism=Escherichia coli, GI1789737, Length=386, Percent_Identity=30.5699481865285, Blast_Score=135, Evalue=1e-32,
Organism=Escherichia coli, GI1789108, Length=265, Percent_Identity=28.3018867924528, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789559, Length=96, Percent_Identity=38.5416666666667, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17556456, Length=395, Percent_Identity=27.5949367088608, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25141371, Length=378, Percent_Identity=28.8359788359788, Blast_Score=120, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17506081, Length=265, Percent_Identity=27.1698113207547, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17565438, Length=325, Percent_Identity=23.6923076923077, Blast_Score=86, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI115532065, Length=329, Percent_Identity=24.6200607902736, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115532067, Length=329, Percent_Identity=24.6200607902736, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324761, Length=398, Percent_Identity=26.3819095477387, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19921738, Length=380, Percent_Identity=28.6842105263158, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI281363316, Length=406, Percent_Identity=26.1083743842365, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17864358, Length=406, Percent_Identity=26.1083743842365, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19922690, Length=276, Percent_Identity=30.4347826086957, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28572034, Length=124, Percent_Identity=39.5161290322581, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17137380, Length=351, Percent_Identity=24.2165242165242, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45550900, Length=327, Percent_Identity=24.4648318042813, Blast_Score=71, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09106 SelB-wing_2; PF09107 SelB-wing_3 [H]

EC number: NA

Molecular weight: Translated: 70001; Mature: 70001

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAGADGPARMIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLPNG
CCCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCEEEECEEECCCCCC
DVLGFIDVPGHEKLVHTMAAGACGIDFALVVIAADDGVMPQTREHLSILQLLGVAHGALA
CEEEEEECCCHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LTKCDRVDAARVARVRDEIRAWLAASPLADAPVFETRASEPDDAGVAALNAHLRDTALAW
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RARRDDGLFRLAVDRVFTLAGQGTVVTGTAVAGRVRTGDSLAVARTGETVRVRSIHAQNR
HHCCCCCEEEHHHHHHHHHCCCCEEEECCCEECEEECCCCEEEEECCCEEEEEEECCCCC
ATDVGHAGERCALNLAGIDKAALARGDAIVDARLATLSPRIDVELTLTADADLTISHWTP
CCCCCCCCCCEEEEECCCCHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCCCEEEECCCE
LHVHLGTLHRVAHVALLEGETLGPGRRARAQLNFTEPVFAAPGDRFIVRDAQATRTVGGG
EEEEHHHHHHHHHHHEECCCCCCCCCHHEEEECCCCCEEECCCCEEEEECCHHHHCCCCC
RVLDPFGPARKRRTRARRAWLDALAAWLDEGRLDALLDEAPLGIARATLMHLTGLPAQAW
EEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCCHHHH
ALPADAVSVAAPGKHADEARVLARGHWDALRTRVLDALAAFHQRSPDEQGPDVARLRRIA
CCCCCCEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
APLADDALWRALTDALIAEGAIVRSGPWLHLPSHAVSFDAAEEALAGRLLPLVAAGRYDP
CCHHHHHHHHHHHHHHHHCCCEEECCCEEECCCCHHCHHHHHHHHHHHHHHHHHCCCCCC
PWVRDHAAATLMAEDAVRALLRKLARRGDVHQVVRDLFYHRDVIAELARLIARLAGEHGG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GLDAATFRDATGLGRKRAIQILEFFDRVGYTRFHRDLHWLRADSRLLAGSR
CCCHHHHCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHCCCC
>Mature Secondary Structure
MRAGADGPARMIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLPNG
CCCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCEEEECEEECCCCCC
DVLGFIDVPGHEKLVHTMAAGACGIDFALVVIAADDGVMPQTREHLSILQLLGVAHGALA
CEEEEEECCCHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LTKCDRVDAARVARVRDEIRAWLAASPLADAPVFETRASEPDDAGVAALNAHLRDTALAW
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RARRDDGLFRLAVDRVFTLAGQGTVVTGTAVAGRVRTGDSLAVARTGETVRVRSIHAQNR
HHCCCCCEEEHHHHHHHHHCCCCEEEECCCEECEEECCCCEEEEECCCEEEEEEECCCCC
ATDVGHAGERCALNLAGIDKAALARGDAIVDARLATLSPRIDVELTLTADADLTISHWTP
CCCCCCCCCCEEEEECCCCHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCCCEEEECCCE
LHVHLGTLHRVAHVALLEGETLGPGRRARAQLNFTEPVFAAPGDRFIVRDAQATRTVGGG
EEEEHHHHHHHHHHHEECCCCCCCCCHHEEEECCCCCEEECCCCEEEEECCHHHHCCCCC
RVLDPFGPARKRRTRARRAWLDALAAWLDEGRLDALLDEAPLGIARATLMHLTGLPAQAW
EEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCCHHHH
ALPADAVSVAAPGKHADEARVLARGHWDALRTRVLDALAAFHQRSPDEQGPDVARLRRIA
CCCCCCEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
APLADDALWRALTDALIAEGAIVRSGPWLHLPSHAVSFDAAEEALAGRLLPLVAAGRYDP
CCHHHHHHHHHHHHHHHHCCCEEECCCEEECCCCHHCHHHHHHHHHHHHHHHHHCCCCCC
PWVRDHAAATLMAEDAVRALLRKLARRGDVHQVVRDLFYHRDVIAELARLIARLAGEHGG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GLDAATFRDATGLGRKRAIQILEFFDRVGYTRFHRDLHWLRADSRLLAGSR
CCCHHHHCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2531290; 8041620; 9278503; 2140572 [H]