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The map label for this gene is iscS-2 [H]

Identifier: 126447472

GI number: 126447472

Start: 369293

End: 370414

Strand: Reverse

Name: iscS-2 [H]

Synonym: BMA10247_A0422

Alternate gene names: 126447472

Gene position: 370414-369293 (Counterclockwise)

Preceding gene: 126446939

Following gene: 126446933

Centisome position: 15.74

GC content: 65.86

Gene sequence:

>1122_bases
ATGACGCATATCTACCTCGACTACAACGCAAGCACCCCCATCGACCCGGCGGTCGCGAATGCGATGCGCCCGCTGCTGCC
TGAAGCCTTCGGCAATCCGTCCAGCGGACATTGGGCAAGCGTGCCGGCAAAGGTTGCACTGGATCGGGCGCGCGCCCAGG
TCGCGACGCTGATCGGCGCCGCACCGGACGAAATTGTCTTCACGAGCGGCGGCAGTGAAGCGAACAACCTTGCGCTGAAA
GGAACTGTACTCGCATCGTCGAACGCAGGCGGCCACGTGATCACCCAGTCGACCGAACATCCGGCAATCCTGAAGCCGCT
GCAATTCCTTGAGCGACTGGGCACTAAAGTCACCTGCGTTCCCGTGGACGGCAACGGCCGCGTCGATCCCGACGCCATCC
GTCGCGCAATCACGCCGCGCACCACGCTCATCACGGTCATGCATGCGAACAACGAAACCGGCACCATTCAGCCGATCGAG
GATATCGGCACGATCGCCCGCGAGCACGGCATCCGGTTTCACACGGACGCGGCCCAGTCGATCGGCAAGATCCCGGCCGA
CGTCGATGCGCTCGGCGTCGATCTGCTGTCGATCGCCGGTCACAAGCTCTACGCGCCGAAGGGCATCGGCGCGCTCTACG
TTCGAAAGGGAGTCGGGCTCGAGCCGCTGATTCACGGCGCAGGCCATGAAAATGGCCGGCGTGCGGGGACGGAATCCGCA
CTCCTCGCGGCAGGGTTCGGCGAGGCCTGTGCGCTCGCGCGCGATCTCGCGGCGATGGACGGCATTCGCGCGTTGCGCGA
CCGGCTGTGGCACGCGTTGCAGGATCGCTTCGACGATCGCGTTCGCCTGAACGGACATCTCGAGTACCGCTTGCCGAACA
CGGTGAACGTGTCGTTCGTCGGCCGCGTCGGCACTGACGTGCTTGCCGCACTCGACGGCGTCGCCGCGTCCACCGGTTCG
GCCTGCCACGCCGGACGCATGACGCTGTCGCCGGTGCTGGCCGCGATGGGCATCGCCGAGCAGGTCGGGATGGGGGCCAT
CCGATTCAGCCTCGGCCGGCACACGACAGCCGACGAGATCGATACCGTCATCGCGAAATTGAGCGCGATCGCCCGTGGCT
GA

Upstream 100 bases:

>100_bases
GTCACGTTCCTGTCAGGCGCCGTGGTGGCAATCGTCATGCACGCGCGCCACTGACGTATTCCGAAGCACGAAGCGAACAT
TTCTCACCCAGATCGACGAC

Downstream 100 bases:

>100_bases
AATCGGTGCTATGCGACGATGCCCGTGTAGTCGAATGAAGGGCGAGCAGCGTGATCCGCGGTGGCCTCGCCTGATCGCGT
GGGTGCCCCGACCGTTCGGG

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MTHIYLDYNASTPIDPAVANAMRPLLPEAFGNPSSGHWASVPAKVALDRARAQVATLIGAAPDEIVFTSGGSEANNLALK
GTVLASSNAGGHVITQSTEHPAILKPLQFLERLGTKVTCVPVDGNGRVDPDAIRRAITPRTTLITVMHANNETGTIQPIE
DIGTIAREHGIRFHTDAAQSIGKIPADVDALGVDLLSIAGHKLYAPKGIGALYVRKGVGLEPLIHGAGHENGRRAGTESA
LLAAGFGEACALARDLAAMDGIRALRDRLWHALQDRFDDRVRLNGHLEYRLPNTVNVSFVGRVGTDVLAALDGVAASTGS
ACHAGRMTLSPVLAAMGIAEQVGMGAIRFSLGRHTTADEIDTVIAKLSAIARG

Sequences:

>Translated_373_residues
MTHIYLDYNASTPIDPAVANAMRPLLPEAFGNPSSGHWASVPAKVALDRARAQVATLIGAAPDEIVFTSGGSEANNLALK
GTVLASSNAGGHVITQSTEHPAILKPLQFLERLGTKVTCVPVDGNGRVDPDAIRRAITPRTTLITVMHANNETGTIQPIE
DIGTIAREHGIRFHTDAAQSIGKIPADVDALGVDLLSIAGHKLYAPKGIGALYVRKGVGLEPLIHGAGHENGRRAGTESA
LLAAGFGEACALARDLAAMDGIRALRDRLWHALQDRFDDRVRLNGHLEYRLPNTVNVSFVGRVGTDVLAALDGVAASTGS
ACHAGRMTLSPVLAAMGIAEQVGMGAIRFSLGRHTTADEIDTVIAKLSAIARG
>Mature_372_residues
THIYLDYNASTPIDPAVANAMRPLLPEAFGNPSSGHWASVPAKVALDRARAQVATLIGAAPDEIVFTSGGSEANNLALKG
TVLASSNAGGHVITQSTEHPAILKPLQFLERLGTKVTCVPVDGNGRVDPDAIRRAITPRTTLITVMHANNETGTIQPIED
IGTIAREHGIRFHTDAAQSIGKIPADVDALGVDLLSIAGHKLYAPKGIGALYVRKGVGLEPLIHGAGHENGRRAGTESAL
LAAGFGEACALARDLAAMDGIRALRDRLWHALQDRFDDRVRLNGHLEYRLPNTVNVSFVGRVGTDVLAALDGVAASTGSA
CHAGRMTLSPVLAAMGIAEQVGMGAIRFSLGRHTTADEIDTVIAKLSAIARG

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=368, Percent_Identity=42.9347826086957, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI156713448, Length=406, Percent_Identity=40.1477832512315, Blast_Score=237, Evalue=1e-62,
Organism=Escherichia coli, GI48994898, Length=368, Percent_Identity=45.9239130434783, Blast_Score=310, Evalue=9e-86,
Organism=Escherichia coli, GI1787970, Length=390, Percent_Identity=25.8974358974359, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789175, Length=379, Percent_Identity=27.1767810026385, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25143064, Length=367, Percent_Identity=43.3242506811989, Blast_Score=290, Evalue=6e-79,
Organism=Caenorhabditis elegans, GI17533177, Length=315, Percent_Identity=36.5079365079365, Blast_Score=182, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6319831, Length=370, Percent_Identity=43.5135135135135, Blast_Score=286, Evalue=3e-78,
Organism=Drosophila melanogaster, GI20129463, Length=364, Percent_Identity=44.7802197802198, Blast_Score=293, Evalue=1e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 39053; Mature: 38922

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHIYLDYNASTPIDPAVANAMRPLLPEAFGNPSSGHWASVPAKVALDRARAQVATLIGA
CEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
APDEIVFTSGGSEANNLALKGTVLASSNAGGHVITQSTEHPAILKPLQFLERLGTKVTCV
CCCCEEEECCCCCCCCEEEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHCCEEEEE
PVDGNGRVDPDAIRRAITPRTTLITVMHANNETGTIQPIEDIGTIAREHGIRFHTDAAQS
EECCCCCCCHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEECHHHHH
IGKIPADVDALGVDLLSIAGHKLYAPKGIGALYVRKGVGLEPLIHGAGHENGRRAGTESA
HCCCCCCHHHHHHHHHHHCCCEEECCCCCCEEEEECCCCCCHHEECCCCCCCCCCCCCCC
LLAAGFGEACALARDLAAMDGIRALRDRLWHALQDRFDDRVRLNGHLEYRLPNTVNVSFV
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEECCCEEEEEEE
GRVGTDVLAALDGVAASTGSACHAGRMTLSPVLAAMGIAEQVGMGAIRFSLGRHTTADEI
CCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHH
DTVIAKLSAIARG
HHHHHHHHHHHCC
>Mature Secondary Structure 
THIYLDYNASTPIDPAVANAMRPLLPEAFGNPSSGHWASVPAKVALDRARAQVATLIGA
EEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
APDEIVFTSGGSEANNLALKGTVLASSNAGGHVITQSTEHPAILKPLQFLERLGTKVTCV
CCCCEEEECCCCCCCCEEEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHCCEEEEE
PVDGNGRVDPDAIRRAITPRTTLITVMHANNETGTIQPIEDIGTIAREHGIRFHTDAAQS
EECCCCCCCHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEECHHHHH
IGKIPADVDALGVDLLSIAGHKLYAPKGIGALYVRKGVGLEPLIHGAGHENGRRAGTESA
HCCCCCCHHHHHHHHHHHCCCEEECCCCCCEEEEECCCCCCHHEECCCCCCCCCCCCCCC
LLAAGFGEACALARDLAAMDGIRALRDRLWHALQDRFDDRVRLNGHLEYRLPNTVNVSFV
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEECCCEEEEEEE
GRVGTDVLAALDGVAASTGSACHAGRMTLSPVLAAMGIAEQVGMGAIRFSLGRHTTADEI
CCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHH
DTVIAKLSAIARG
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA