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The map label for this gene is ivd [H]

Identifier: 126447430

GI number: 126447430

Start: 1544660

End: 1545841

Strand: Reverse

Name: ivd [H]

Synonym: BMA10247_A1608

Alternate gene names: 126447430

Gene position: 1545841-1544660 (Counterclockwise)

Preceding gene: 126447364

Following gene: 126446921

Centisome position: 65.71

GC content: 67.09

Gene sequence:

>1182_bases
ATGAGCAACCTGCCCGGCGTGAACTTCATGCTCGGTGAAGACATCGAGATGCTGCGCGATTCGATCGCGCATTTCGCCGC
GAAGGAAATCGCGCCGCGCGCGGCCGAGATCGACCGCACCGACCAGTTCCCGATGGACCTCTGGCGCAAGTTCGGCGAGC
TGGGCGTGCTCGGGATGACGGTGGCCGAGGAGTACGGCGGCGCGAATCTCGGCTACACCGCGCACATGGTCGCGATGGAG
GAGATCTCGCGCGCGTCGGCGTCGGTCGGGCTGTCGTACGGCGCGCATTCGAACCTGTGCGTGAACCAGATCCACCGCAA
CGGCACCGATGCCCAGAAGCGCAGGTATCTGCCGAAGCTGATTTCCGGCGAGCACATCGGCGCGCTCGCGATGAGCGAGC
CGAACGCGGGCTCCGACGTCGTCGGCATGAAGCTGCGCGCCGAGCCGCGCGGCGCGCGCTACGTGCTCAACGGCACGAAG
ATGTGGATCACGAACGGCCCGGATTGCGACACGCTCGTCGTCTACGCGAAGACCGAGCCCGAGGCCGGCGCGCGCGGGAT
CACCGCGTTCATCGTCGAGAAGGGGATGAAGGGCTTCTCGGTCGCGCAAAAGCTCGACAAGCTCGGCATGCGCGGCTCGC
ATACGGGCGAGCTGGTGTTCGAGGACGTCGAGGTGCCCGAGGAGAACATCCTCGGCGAGCTGAACGGCGGCGTGAAGGTG
CTGATGAGCGGGCTCGACTACGAGCGCGCGGTGCTCGCGGGCGGCCCGACGGGCATCATGGCCGCGTGTCTCGACGCGGT
CGTGCCGTACGTTCACGATCGCAAGCAGTTCGGCCAGCCGATCGGCGAATTCCAACTGATCCAGGGCAAGATCGCCGACA
TGTACACGACGTTTCAGGCGTGCCGCGCCTACCTTTACGCGGTGGGCCGGCATCTCGACGCGGGCGGCAGCGCCCACCCG
CGCCAGGTGCGCAAGGACTGCGCGGGGGTGATCCTCTACACCGCGGAGAAGGCGACGTGGATGGCGGGCGAGGCGATCCA
GATCCTCGGCGGCAACGGCTACATCAACGAGTATTCGGTCGGCCGTCTCTGGCGTGACGCGAAGCTCTACGAGATCGGCG
CCGGCACGAGCGAGATCCGCCGGATGCTGATCGGCCGCGAGCTGTTCGCGGAAACGGCCTGA

Upstream 100 bases:

>100_bases
GAAAATTTCCGCAGCATATGGCAATGAACCGGCGGACGCACGAAATTGAGCAAGACTCAATAATCGGCGCGTTCAAGGAC
TTCCTGGAGACGGAGGAGAC

Downstream 100 bases:

>100_bases
CCTCGCGCGCAGAGCCCACGCGATGCCGATCATCGAATCCAAGCTGAACCCGCGTTCCGACGAATTCCGCGCGAACGCCG
CGGCGCTCGAGGCGCTCGTT

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSNLPGVNFMLGEDIEMLRDSIAHFAAKEIAPRAAEIDRTDQFPMDLWRKFGELGVLGMTVAEEYGGANLGYTAHMVAME
EISRASASVGLSYGAHSNLCVNQIHRNGTDAQKRRYLPKLISGEHIGALAMSEPNAGSDVVGMKLRAEPRGARYVLNGTK
MWITNGPDCDTLVVYAKTEPEAGARGITAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFEDVEVPEENILGELNGGVKV
LMSGLDYERAVLAGGPTGIMAACLDAVVPYVHDRKQFGQPIGEFQLIQGKIADMYTTFQACRAYLYAVGRHLDAGGSAHP
RQVRKDCAGVILYTAEKATWMAGEAIQILGGNGYINEYSVGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETA

Sequences:

>Translated_393_residues
MSNLPGVNFMLGEDIEMLRDSIAHFAAKEIAPRAAEIDRTDQFPMDLWRKFGELGVLGMTVAEEYGGANLGYTAHMVAME
EISRASASVGLSYGAHSNLCVNQIHRNGTDAQKRRYLPKLISGEHIGALAMSEPNAGSDVVGMKLRAEPRGARYVLNGTK
MWITNGPDCDTLVVYAKTEPEAGARGITAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFEDVEVPEENILGELNGGVKV
LMSGLDYERAVLAGGPTGIMAACLDAVVPYVHDRKQFGQPIGEFQLIQGKIADMYTTFQACRAYLYAVGRHLDAGGSAHP
RQVRKDCAGVILYTAEKATWMAGEAIQILGGNGYINEYSVGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETA
>Mature_392_residues
SNLPGVNFMLGEDIEMLRDSIAHFAAKEIAPRAAEIDRTDQFPMDLWRKFGELGVLGMTVAEEYGGANLGYTAHMVAMEE
ISRASASVGLSYGAHSNLCVNQIHRNGTDAQKRRYLPKLISGEHIGALAMSEPNAGSDVVGMKLRAEPRGARYVLNGTKM
WITNGPDCDTLVVYAKTEPEAGARGITAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFEDVEVPEENILGELNGGVKVL
MSGLDYERAVLAGGPTGIMAACLDAVVPYVHDRKQFGQPIGEFQLIQGKIADMYTTFQACRAYLYAVGRHLDAGGSAHPR
QVRKDCAGVILYTAEKATWMAGEAIQILGGNGYINEYSVGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETA

Specific function: Unknown

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=385, Percent_Identity=62.3376623376623, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI226958414, Length=380, Percent_Identity=61.3157894736842, Blast_Score=463, Evalue=1e-130,
Organism=Homo sapiens, GI4557233, Length=379, Percent_Identity=39.8416886543536, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=33.6, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI4557231, Length=386, Percent_Identity=36.0103626943005, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI187960098, Length=386, Percent_Identity=36.0103626943005, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI21361497, Length=381, Percent_Identity=37.007874015748, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI4501857, Length=388, Percent_Identity=32.4742268041237, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI4557235, Length=344, Percent_Identity=36.3372093023256, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI76496475, Length=344, Percent_Identity=36.3372093023256, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI7656849, Length=385, Percent_Identity=30.3896103896104, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI4503943, Length=387, Percent_Identity=33.8501291989664, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI7669494, Length=361, Percent_Identity=34.9030470914127, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI48976061, Length=288, Percent_Identity=26.7361111111111, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI211971008, Length=288, Percent_Identity=26.7361111111111, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI38505218, Length=286, Percent_Identity=22.3776223776224, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI87081958, Length=388, Percent_Identity=29.1237113402062, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI1786223, Length=386, Percent_Identity=27.4611398963731, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI87081702, Length=269, Percent_Identity=27.1375464684015, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87082384, Length=264, Percent_Identity=26.1363636363636, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=385, Percent_Identity=60.2597402597403, Blast_Score=470, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17570075, Length=393, Percent_Identity=33.587786259542, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17534899, Length=390, Percent_Identity=34.3589743589744, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17569725, Length=392, Percent_Identity=33.4183673469388, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI17506239, Length=382, Percent_Identity=32.9842931937173, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17508101, Length=384, Percent_Identity=30.9895833333333, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17533517, Length=388, Percent_Identity=30.9278350515464, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI71990804, Length=274, Percent_Identity=38.6861313868613, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI71985184, Length=354, Percent_Identity=33.0508474576271, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17534353, Length=382, Percent_Identity=31.6753926701571, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=37.6623376623377, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71985192, Length=285, Percent_Identity=34.7368421052632, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=31.7518248175182, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17551932, Length=381, Percent_Identity=28.3464566929134, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17505929, Length=373, Percent_Identity=29.7587131367292, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=28.2786885245902, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355753, Length=387, Percent_Identity=63.0490956072351, Blast_Score=473, Evalue=1e-134,
Organism=Drosophila melanogaster, GI21356377, Length=383, Percent_Identity=40.9921671018277, Blast_Score=283, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24646207, Length=381, Percent_Identity=37.7952755905512, Blast_Score=258, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24660351, Length=387, Percent_Identity=34.625322997416, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24666513, Length=385, Percent_Identity=33.5064935064935, Blast_Score=224, Evalue=5e-59,
Organism=Drosophila melanogaster, GI281363737, Length=357, Percent_Identity=33.8935574229692, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI19920834, Length=389, Percent_Identity=32.3907455012853, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24652780, Length=363, Percent_Identity=22.8650137741047, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 42673; Mature: 42542

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLPGVNFMLGEDIEMLRDSIAHFAAKEIAPRAAEIDRTDQFPMDLWRKFGELGVLGMT
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHCCCEEHHH
VAEEYGGANLGYTAHMVAMEEISRASASVGLSYGAHSNLCVNQIHRNGTDAQKRRYLPKL
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHH
ISGEHIGALAMSEPNAGSDVVGMKLRAEPRGARYVLNGTKMWITNGPDCDTLVVYAKTEP
HCCCCCCEEEECCCCCCCCEEEEEEECCCCCCEEEEECEEEEEECCCCCCEEEEEEECCC
EAGARGITAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFEDVEVPEENILGELNGGVKV
CCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHCCCCHHH
LMSGLDYERAVLAGGPTGIMAACLDAVVPYVHDRKQFGQPIGEFQLIQGKIADMYTTFQA
HHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHH
CRAYLYAVGRHLDAGGSAHPRQVRKDCAGVILYTAEKATWMAGEAIQILGGNGYINEYSV
HHHHHHHHHHHCCCCCCCCHHHHHHHHCCEEEEECCCCEEECCCEEEEECCCCCCCCCHH
GRLWRDAKLYEIGAGTSEIRRMLIGRELFAETA
HHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNLPGVNFMLGEDIEMLRDSIAHFAAKEIAPRAAEIDRTDQFPMDLWRKFGELGVLGMT
CCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHCCCEEHHH
VAEEYGGANLGYTAHMVAMEEISRASASVGLSYGAHSNLCVNQIHRNGTDAQKRRYLPKL
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHH
ISGEHIGALAMSEPNAGSDVVGMKLRAEPRGARYVLNGTKMWITNGPDCDTLVVYAKTEP
HCCCCCCEEEECCCCCCCCEEEEEEECCCCCCEEEEECEEEEEECCCCCCEEEEEEECCC
EAGARGITAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFEDVEVPEENILGELNGGVKV
CCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHCCCCHHH
LMSGLDYERAVLAGGPTGIMAACLDAVVPYVHDRKQFGQPIGEFQLIQGKIADMYTTFQA
HHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHH
CRAYLYAVGRHLDAGGSAHPRQVRKDCAGVILYTAEKATWMAGEAIQILGGNGYINEYSV
HHHHHHHHHHHCCCCCCCCHHHHHHHHCCEEEEECCCCEEECCCEEEEECCCCCCCCCHH
GRLWRDAKLYEIGAGTSEIRRMLIGRELFAETA
HHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]