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The map label for this gene is basR [H]

Identifier: 126447427

GI number: 126447427

Start: 1512798

End: 1513460

Strand: Direct

Name: basR [H]

Synonym: BMA10247_A1570

Alternate gene names: 126447427

Gene position: 1512798-1513460 (Clockwise)

Preceding gene: 126445730

Following gene: 126445924

Centisome position: 64.3

GC content: 70.44

Gene sequence:

>663_bases
ATGCGCGTATTGCTTGTCGAAGACGATCCGCTCATCGGCAGCGGGCTCGAACAGGGGCTGAAACAGGAAGGCTTCGCGGT
GGACTGGGCGCAGAACGCCGACGCGGCGACGCTCGCGCTGCGCACGACGTCGTACGGCCTGCTGCTGCTCGACCTCGGCC
TGCCGGACAAGGACGGCCTCGCGGTGCTCGCCGCGCTGCGCCGCCGCGACGACGCGCTGCCCGTGATCGTCGTCACCGCG
CGCGACGCGCTGCCCGACCGGATCGCGGGCCTCGATTGCGGCGCGGACGATTACCTCGTCAAGCCGTTCGCGCTCGAGGA
ACTGCTCGCGCGCATCCGCGCGGTGAACCGCCGCCAGGCCGGCCGCGCGCAGACGGTGCTCGCGGTCGGCGCGCTGCGGC
TCGATCCGGCGCGCCATCAGGTGTGGCGCGGCGACGAGGAAGTCGCGCTGTCGCCGAAGGAATTCGTGCTGCTGCACGAG
CTGATGCGCGAGCCGGGCGCGGTGATCTCGCGCGAGCAGTTCGAGGAGCGGCTGTACAGCTGGGGCGAGGAAATCGAGAG
CAACGCGGTGCAGGTGCATATCCACAACCTGCGCAAGAAGCTCGGCCACGACACGATCCTCACGGTGCGCGGCGTCGGCT
ACCGGATCGGAGACGGCGCATGA

Upstream 100 bases:

>100_bases
CCGACGCCGCGCCGCTTTAAGCCGCCGCTAAGCATCCACCGCTTATCATTGCCGCCAGCGGCCCGCATGCGCGCGCCGCA
TTCAGACGGAATCACCGAAC

Downstream 100 bases:

>100_bases
CGGGCGCGCGCGGATTCGCGCGGCGCCTGAACGCGTCGCTGCGCGGGCGGCTGCTGATGTGGCTGCTGCCCGCCGCGTGC
GTCGTCGGCGTGCTCGCGAG

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MRVLLVEDDPLIGSGLEQGLKQEGFAVDWAQNADAATLALRTTSYGLLLLDLGLPDKDGLAVLAALRRRDDALPVIVVTA
RDALPDRIAGLDCGADDYLVKPFALEELLARIRAVNRRQAGRAQTVLAVGALRLDPARHQVWRGDEEVALSPKEFVLLHE
LMREPGAVISREQFEERLYSWGEEIESNAVQVHIHNLRKKLGHDTILTVRGVGYRIGDGA

Sequences:

>Translated_220_residues
MRVLLVEDDPLIGSGLEQGLKQEGFAVDWAQNADAATLALRTTSYGLLLLDLGLPDKDGLAVLAALRRRDDALPVIVVTA
RDALPDRIAGLDCGADDYLVKPFALEELLARIRAVNRRQAGRAQTVLAVGALRLDPARHQVWRGDEEVALSPKEFVLLHE
LMREPGAVISREQFEERLYSWGEEIESNAVQVHIHNLRKKLGHDTILTVRGVGYRIGDGA
>Mature_220_residues
MRVLLVEDDPLIGSGLEQGLKQEGFAVDWAQNADAATLALRTTSYGLLLLDLGLPDKDGLAVLAALRRRDDALPVIVVTA
RDALPDRIAGLDCGADDYLVKPFALEELLARIRAVNRRQAGRAQTVLAVGALRLDPARHQVWRGDEEVALSPKEFVLLHE
LMREPGAVISREQFEERLYSWGEEIESNAVQVHIHNLRKKLGHDTILTVRGVGYRIGDGA

Specific function: Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790552, Length=216, Percent_Identity=50.9259259259259, Blast_Score=215, Evalue=2e-57,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=49.0825688073394, Blast_Score=208, Evalue=3e-55,
Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=37.1559633027523, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=40.8071748878924, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=37.10407239819, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=38.8127853881278, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789809, Length=236, Percent_Identity=37.2881355932203, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=38.7387387387387, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=36.6515837104072, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=35.7466063348416, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=38.4955752212389, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787229, Length=220, Percent_Identity=32.2727272727273, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=27.1929824561404, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=30.1310043668122, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=31.7757009345794, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790299, Length=118, Percent_Identity=35.5932203389831, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788521, Length=209, Percent_Identity=32.5358851674641, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24226; Mature: 24226

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLLVEDDPLIGSGLEQGLKQEGFAVDWAQNADAATLALRTTSYGLLLLDLGLPDKDGL
CEEEEECCCCCCCCHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCEEEEECCCCCCCHH
AVLAALRRRDDALPVIVVTARDALPDRIAGLDCGADDYLVKPFALEELLARIRAVNRRQA
HHHHHHHHCCCCCCEEEEECCCCCCHHHCCCCCCCCCCEECHHHHHHHHHHHHHHHHHCC
GRAQTVLAVGALRLDPARHQVWRGDEEVALSPKEFVLLHELMREPGAVISREQFEERLYS
CCHHHHHHHHHHHCCHHHHHHHCCCCCEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
WGEEIESNAVQVHIHNLRKKLGHDTILTVRGVGYRIGDGA
HHHHHHCCEEEEEHHHHHHHHCCCEEEEEECCCEECCCCC
>Mature Secondary Structure
MRVLLVEDDPLIGSGLEQGLKQEGFAVDWAQNADAATLALRTTSYGLLLLDLGLPDKDGL
CEEEEECCCCCCCCHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCEEEEECCCCCCCHH
AVLAALRRRDDALPVIVVTARDALPDRIAGLDCGADDYLVKPFALEELLARIRAVNRRQA
HHHHHHHHCCCCCCEEEEECCCCCCHHHCCCCCCCCCCEECHHHHHHHHHHHHHHHHHCC
GRAQTVLAVGALRLDPARHQVWRGDEEVALSPKEFVLLHELMREPGAVISREQFEERLYS
CCHHHHHHHHHHHCCHHHHHHHCCCCCEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
WGEEIESNAVQVHIHNLRKKLGHDTILTVRGVGYRIGDGA
HHHHHHCCEEEEEHHHHHHHHCCCEEEEEECCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8282725; 7610040; 9278503 [H]