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The map label for this gene is poxB [H]

Identifier: 126447349

GI number: 126447349

Start: 555046

End: 556776

Strand: Direct

Name: poxB [H]

Synonym: BMA10247_A0611

Alternate gene names: 126447349

Gene position: 555046-556776 (Clockwise)

Preceding gene: 126447579

Following gene: 126447854

Centisome position: 23.59

GC content: 68.28

Gene sequence:

>1731_bases
ATGGAGGATCGCATGGCGAGCACGATTGCCGACTACCTCGCGCGGACGCTGGCCGCCGCCGGCGTCACGAAGATCTGGGG
CGTGACGGGCGACAGCCTGAACGGATTGTCCGACAGCCTGCGCCGCGACGGCGGCATTCGCTGGATGCATACCCGGCATG
AAGAGGTGGCGGCGTTCGCCGCGGGCGCCGAAGCGGCGCAGACCGGCCGGCTGGCCGTATGCGCGGGCAGTTGCGGGCCG
GGCAATCTGCATCTGATCAACGGCTTGTTCGATTGCCATCGCAATCATGTGCCGGTGCTTGCGATCGCCGCGCAGATTTC
GTCGACCGAAATCGGGCTCGGCTATTTTCAGGAAACGCATCCGCAGGAACTGTTCCGCGAATGCAGCCATTACGTCGAGT
TCGTGACGAACGCATCGCAATTTCCGCGCGTGCTCGAGCGCGCGATGCGCGCCGCGATCGGCGAGCACGGCGTCGCGGTG
ATCGTGCTCCCGGGCGATGTCGCGCTGAGCGCGGCGCCCGCGCGGACACCGTCGTGGTTCGATTTCGCCTCGCCGGTGAC
GACGCCCGCCGACGCCGATCTGGAGCGGCTCGCGGCGTTGCTCGACGGCTCCGATGCAGTCACGCTGCTGTGCGGCAGCG
GTTGCGCGGGCGCGCACGACGAAGTCGTCGCGTTGGCCGATGCGCTCGCGGCACCCGTCGTGCATGCGCTGCGCGGCAAG
CAGCACATTGAATACGACAATCCGAACAGCGTCGGCATGACGGGGCTGATCGGCTTCAGCTCCGGCTATCACGCGATGCA
ATCGTGCGACACGCTGCTGATGCTCGGCACCGATTTCCCCTATCGCAATTTCTATCCGACGCGCGCCCGGATCGCGCAGA
TCGACCGCCGCGCGTCGGCGCTCGGCCGTCGCGCGCCGCTCGACGTCGGCCTCGTCGGCGACGTGCGCGCCACGCTGTCC
GCGCTGTTGCCGCGCATCCGGCGCAAGACGCGGCGCGGTTTCGTCGAGCGTGCGCTTGCGCATTATGCCGCCGCGCGCAA
GGGGCTCGACGAACTGGCGAGACCGTCGCCGGCCGGGCGGCCGATTCATCCGCAGTACTTGACGCGCGTCGTCGACGAGC
TCGCCGCCGCCGATGCGATCTTCGCCGCGGACGTCGGCACGCCGACGCTGTGGGCGGCGCGCTATCTGACGATGAACGGC
CGCAGGCGGCTGCACGGATCGTTCAATCACGGCTCGATGGCGAACGCGTTGCCGCAGGCGCTGGGCGCGCAGGCCGCGCA
TCCCGGGCGGCAAGTCGTGTCGCTGTCGGGCGACGGCGGGCTGTCGATGCTCCTCGGCGATCTGCTGAGCGCGCGGCAAC
TCGATTTGCCGATCAAGGTGATCGTCTACAACAACAGCTCGCTGGGCTTCGTCGCGATGGAGATGAAGGCGGGCGGTTAT
CTGGATACGGGCACCGATCTGCACGAGACCGATTTCGCGGCGATCGCGAAGGGGGCGGGCCTCTACAGCCTGCGCGTGAC
CGAATCGGAAGCGTTGCCCGATGCGCTCGGCAAGCTGCTCGCGCACCCGGGGCCCGCGCTGCTCGACGTCGTCACCGACA
AGCACGAGCTCGCGATGCCGCCGAAGATCGAATGGGCGCAGGCGAAGGGATTCAGCCTCTACATGTTGCGCGCGGTGCTG
AGCGGGCGCGGCGACGAAGTGCTCGAGCTCGCGCAGACGAATCTGCGGTGA

Upstream 100 bases:

>100_bases
CCTGTCGTCGACCGAACGGGCGCGCGCGCTGATCCGGCTCGCGCACCCCGATTTTCGCGACGCGCTGAGCGTACACGCAC
GCCGGCTGCACTTGATCTGA

Downstream 100 bases:

>100_bases
AGGCAGGGGGGTGGCTGCGCGATGCGCCGCCCCATTGAACGTGGGCATCGCGAATGGCTACCGGCGTGCGCCGCGCCTCG
TCGACCCAGCCCGCCCGCGT

Product: pyruvate dehydrogenase

Products: NA

Alternate protein names: Pyruvate oxidase; POX [H]

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MEDRMASTIADYLARTLAAAGVTKIWGVTGDSLNGLSDSLRRDGGIRWMHTRHEEVAAFAAGAEAAQTGRLAVCAGSCGP
GNLHLINGLFDCHRNHVPVLAIAAQISSTEIGLGYFQETHPQELFRECSHYVEFVTNASQFPRVLERAMRAAIGEHGVAV
IVLPGDVALSAAPARTPSWFDFASPVTTPADADLERLAALLDGSDAVTLLCGSGCAGAHDEVVALADALAAPVVHALRGK
QHIEYDNPNSVGMTGLIGFSSGYHAMQSCDTLLMLGTDFPYRNFYPTRARIAQIDRRASALGRRAPLDVGLVGDVRATLS
ALLPRIRRKTRRGFVERALAHYAAARKGLDELARPSPAGRPIHPQYLTRVVDELAAADAIFAADVGTPTLWAARYLTMNG
RRRLHGSFNHGSMANALPQALGAQAAHPGRQVVSLSGDGGLSMLLGDLLSARQLDLPIKVIVYNNSSLGFVAMEMKAGGY
LDTGTDLHETDFAAIAKGAGLYSLRVTESEALPDALGKLLAHPGPALLDVVTDKHELAMPPKIEWAQAKGFSLYMLRAVL
SGRGDEVLELAQTNLR

Sequences:

>Translated_576_residues
MEDRMASTIADYLARTLAAAGVTKIWGVTGDSLNGLSDSLRRDGGIRWMHTRHEEVAAFAAGAEAAQTGRLAVCAGSCGP
GNLHLINGLFDCHRNHVPVLAIAAQISSTEIGLGYFQETHPQELFRECSHYVEFVTNASQFPRVLERAMRAAIGEHGVAV
IVLPGDVALSAAPARTPSWFDFASPVTTPADADLERLAALLDGSDAVTLLCGSGCAGAHDEVVALADALAAPVVHALRGK
QHIEYDNPNSVGMTGLIGFSSGYHAMQSCDTLLMLGTDFPYRNFYPTRARIAQIDRRASALGRRAPLDVGLVGDVRATLS
ALLPRIRRKTRRGFVERALAHYAAARKGLDELARPSPAGRPIHPQYLTRVVDELAAADAIFAADVGTPTLWAARYLTMNG
RRRLHGSFNHGSMANALPQALGAQAAHPGRQVVSLSGDGGLSMLLGDLLSARQLDLPIKVIVYNNSSLGFVAMEMKAGGY
LDTGTDLHETDFAAIAKGAGLYSLRVTESEALPDALGKLLAHPGPALLDVVTDKHELAMPPKIEWAQAKGFSLYMLRAVL
SGRGDEVLELAQTNLR
>Mature_576_residues
MEDRMASTIADYLARTLAAAGVTKIWGVTGDSLNGLSDSLRRDGGIRWMHTRHEEVAAFAAGAEAAQTGRLAVCAGSCGP
GNLHLINGLFDCHRNHVPVLAIAAQISSTEIGLGYFQETHPQELFRECSHYVEFVTNASQFPRVLERAMRAAIGEHGVAV
IVLPGDVALSAAPARTPSWFDFASPVTTPADADLERLAALLDGSDAVTLLCGSGCAGAHDEVVALADALAAPVVHALRGK
QHIEYDNPNSVGMTGLIGFSSGYHAMQSCDTLLMLGTDFPYRNFYPTRARIAQIDRRASALGRRAPLDVGLVGDVRATLS
ALLPRIRRKTRRGFVERALAHYAAARKGLDELARPSPAGRPIHPQYLTRVVDELAAADAIFAADVGTPTLWAARYLTMNG
RRRLHGSFNHGSMANALPQALGAQAAHPGRQVVSLSGDGGLSMLLGDLLSARQLDLPIKVIVYNNSSLGFVAMEMKAGGY
LDTGTDLHETDFAAIAKGAGLYSLRVTESEALPDALGKLLAHPGPALLDVVTDKHELAMPPKIEWAQAKGFSLYMLRAVL
SGRGDEVLELAQTNLR

Specific function: Unknown

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=491, Percent_Identity=24.2362525458248, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1787096, Length=571, Percent_Identity=64.0980735551664, Blast_Score=743, Evalue=0.0,
Organism=Escherichia coli, GI1790104, Length=554, Percent_Identity=27.7978339350181, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI87081685, Length=553, Percent_Identity=26.0397830018083, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1786717, Length=550, Percent_Identity=25.0909090909091, Blast_Score=147, Evalue=3e-36,
Organism=Escherichia coli, GI1788716, Length=542, Percent_Identity=20.479704797048, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17531299, Length=483, Percent_Identity=24.4306418219462, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17531301, Length=483, Percent_Identity=24.6376811594203, Blast_Score=98, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323755, Length=562, Percent_Identity=24.0213523131673, Blast_Score=153, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6320816, Length=505, Percent_Identity=22.1782178217822, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323073, Length=494, Percent_Identity=22.6720647773279, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922626, Length=477, Percent_Identity=24.9475890985325, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =1.2.5.1 [H]

Molecular weight: Translated: 61395; Mature: 61395

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDRMASTIADYLARTLAAAGVTKIWGVTGDSLNGLSDSLRRDGGIRWMHTRHEEVAAFA
CCHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHCCCEEEEECCHHHHHHHH
AGAEAAQTGRLAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAQISSTEIGLGYFQETH
HCCHHHCCCCEEEEECCCCCCCEEHHHHHHHHCCCCCCEEEEEEHHCCCCCCCCHHHCCC
PQELFRECSHYVEFVTNASQFPRVLERAMRAAIGEHGVAVIVLPGDVALSAAPARTPSWF
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCCC
DFASPVTTPADADLERLAALLDGSDAVTLLCGSGCAGAHDEVVALADALAAPVVHALRGK
CCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCC
QHIEYDNPNSVGMTGLIGFSSGYHAMQSCDTLLMLGTDFPYRNFYPTRARIAQIDRRASA
CCCCCCCCCCCCCEEEEECCCCHHHHHHCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
LGRRAPLDVGLVGDVRATLSALLPRIRRKTRRGFVERALAHYAAARKGLDELARPSPAGR
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCC
PIHPQYLTRVVDELAAADAIFAADVGTPTLWAARYLTMNGRRRLHGSFNHGSMANALPQA
CCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHH
LGAQAAHPGRQVVSLSGDGGLSMLLGDLLSARQLDLPIKVIVYNNSSLGFVAMEMKAGGY
HCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCC
LDTGTDLHETDFAAIAKGAGLYSLRVTESEALPDALGKLLAHPGPALLDVVTDKHELAMP
CCCCCCCCHHHHHHHHCCCCEEEEEECCHHCCHHHHHHHHHCCCCHHHHHHCCCHHCCCC
PKIEWAQAKGFSLYMLRAVLSGRGDEVLELAQTNLR
CCCCHHHCCCCHHHHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MEDRMASTIADYLARTLAAAGVTKIWGVTGDSLNGLSDSLRRDGGIRWMHTRHEEVAAFA
CCHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHCCCEEEEECCHHHHHHHH
AGAEAAQTGRLAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAQISSTEIGLGYFQETH
HCCHHHCCCCEEEEECCCCCCCEEHHHHHHHHCCCCCCEEEEEEHHCCCCCCCCHHHCCC
PQELFRECSHYVEFVTNASQFPRVLERAMRAAIGEHGVAVIVLPGDVALSAAPARTPSWF
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCCC
DFASPVTTPADADLERLAALLDGSDAVTLLCGSGCAGAHDEVVALADALAAPVVHALRGK
CCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCC
QHIEYDNPNSVGMTGLIGFSSGYHAMQSCDTLLMLGTDFPYRNFYPTRARIAQIDRRASA
CCCCCCCCCCCCCEEEEECCCCHHHHHHCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
LGRRAPLDVGLVGDVRATLSALLPRIRRKTRRGFVERALAHYAAARKGLDELARPSPAGR
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCC
PIHPQYLTRVVDELAAADAIFAADVGTPTLWAARYLTMNGRRRLHGSFNHGSMANALPQA
CCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHH
LGAQAAHPGRQVVSLSGDGGLSMLLGDLLSARQLDLPIKVIVYNNSSLGFVAMEMKAGGY
HCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCC
LDTGTDLHETDFAAIAKGAGLYSLRVTESEALPDALGKLLAHPGPALLDVVTDKHELAMP
CCCCCCCCHHHHHHHHCCCCEEEEEECCHHCCHHHHHHHHHCCCCHHHHHHCCCHHCCCC
PKIEWAQAKGFSLYMLRAVLSGRGDEVLELAQTNLR
CCCCHHHCCCCHHHHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3016647; 8905232; 9278503; 2663858; 3902830; 8022274 [H]