Click here to switch to the map view.

The map label for this gene is hsrA [H]

Identifier: 126447216

GI number: 126447216

Start: 1492664

End: 1494124

Strand: Direct

Name: hsrA [H]

Synonym: BMA10247_A1545

Alternate gene names: 126447216

Gene position: 1492664-1494124 (Clockwise)

Preceding gene: 126446517

Following gene: 126446390

Centisome position: 63.44

GC content: 68.51

Gene sequence:

>1461_bases
TTGCGCGCGCAAGCATGCCGCAACAATCGATGCAATAATGGCGTCTTTACGCGCGTCGTTGCCATGCCGTCCGCCCTCTA
CGCTTTCATCGCACCGCTGATCGTCGCTTGCGCGTTGTTCATGGAGAGCGTGGATGCCAACATCATCGTCACGGCATTGC
CCGCGATGGCGCGCGACTTCGGGCAGAACCCCGTCACGCTGAACATCGCGATCACGAGCTACGTCGTCGGCCTCGGCGTG
TTCATCCCGATCTGCGGGTGGCTCGCGGACCGCTTCGGCGCGCGCACCGTGTTCCGCACCGCGATCGGCATCTTCGTCGC
GGGCTCGCTGCTGTGCGCGGCATCGAACAATCTCGAGCTCTTCACGTTCGCGCGCTTCGTGCAAGGCGTCGGCGGCGCGA
TGATGGTGCCCGTCGGGCGCATCATCATCTTCCGCGCGGTGCCGCGCACGGAGCTCGTGCGCGCGATGAACTACCTGAGC
GTGCCCGCGCTCTTCAGGCCGGCGGCCGGGCCGCTCCTCGGCGGCTTCATCACGACGTACCTGCACTGGCGGCTGATCTT
CTTCATCAACGTGCCGATCGGCATCCTCGGCATCTATCTCGCGAACAGGCACATCGCGAACACGCACGAGCTCGATCCCG
GCCCGCTCGACGGGTTCGGCTTCGTGCTGTCCGCCGCCGGCGCGGCGCTCCTGCTGATGGGGCTCACGCTGCTCGACGGC
GCGCTCGTCACGCGCGGCGCGGCGCTCGCGATGGGCGCGACGGGCGCGGCGCTCCTCGGCGGCTACGTGCTGTATGCACG
GCGCGTCGAGCGGCCGGTGCTCGATCTGCGGTTTCTGCGCATTCCGACCTATCACGCAAGCGTCGTCGGCGGCTCGCTGT
TCCGGATCGGCCTCGGCGCGGTGCCGTTTCTGCTGCCGCTCGCGCTGCAGGAAGGGCTCGGCATGAGCGCGTTCCATTCC
GGCGCGATCACGTGCGCGTCGGCCGTCGGCGGCGCGCTCACGCGGATGCTCGCGCCGCGCACGCTCAAGCGCTTCGGCTT
TCGCACGGTGCTGATGTACAACGCGGCGTTCTCCGGGCTCGCGATCGCCGCGTACGGCGTGTTCCATCCCGGCATGTCGA
CGCTCGCGATCTGGCTCATCGTGCTCGTCGGCGGCATCTTTCCGGCGCTGCAGTTCACGAGCCTCAATTCGATGATCTAC
GCGGAAATCGCGGCGCGCGACGCGGGCCGCGCGACGAGCCTCGGCAGCGTCGTCCAGCAGATGTCGCTCGGCCTCGGCGT
GACGGTCGCGGCGCTCGTGCTGCACGTGTCGCATTGGGCGCAGGGACATCCGGCGATGGTCTGGTCGGACTTCTGGCCGG
CGTTCGTCGTGGTCGGCCTATGCTCGTTCGCATCGATTCCGATCACGCGCCGGCTGTCGCCGAACGCGGGCGACGAGGTG
GCGCGCGGCAAGCGCGGCTGA

Upstream 100 bases:

>100_bases
GCGCAGACGCGCGCCGCCCCAACGACACCGCCGCGGCACCGCGCGCCGCGGCCCGATCGCACGCGGCGCGCGAACGGCAA
CGCGTGACGGCAACACGTCG

Downstream 100 bases:

>100_bases
AGCAGGCCGCGCGGCCGAAGCGATCAGGAAAACGAAGCAAGCGAAGCCGCGTGCGGGGCGCGCTGCGCGCCGCCGCCGGG
CATGGTCAGCCGGAATTGAG

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: High-copy suppressor of rspA [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MRAQACRNNRCNNGVFTRVVAMPSALYAFIAPLIVACALFMESVDANIIVTALPAMARDFGQNPVTLNIAITSYVVGLGV
FIPICGWLADRFGARTVFRTAIGIFVAGSLLCAASNNLELFTFARFVQGVGGAMMVPVGRIIIFRAVPRTELVRAMNYLS
VPALFRPAAGPLLGGFITTYLHWRLIFFINVPIGILGIYLANRHIANTHELDPGPLDGFGFVLSAAGAALLLMGLTLLDG
ALVTRGAALAMGATGAALLGGYVLYARRVERPVLDLRFLRIPTYHASVVGGSLFRIGLGAVPFLLPLALQEGLGMSAFHS
GAITCASAVGGALTRMLAPRTLKRFGFRTVLMYNAAFSGLAIAAYGVFHPGMSTLAIWLIVLVGGIFPALQFTSLNSMIY
AEIAARDAGRATSLGSVVQQMSLGLGVTVAALVLHVSHWAQGHPAMVWSDFWPAFVVVGLCSFASIPITRRLSPNAGDEV
ARGKRG

Sequences:

>Translated_486_residues
MRAQACRNNRCNNGVFTRVVAMPSALYAFIAPLIVACALFMESVDANIIVTALPAMARDFGQNPVTLNIAITSYVVGLGV
FIPICGWLADRFGARTVFRTAIGIFVAGSLLCAASNNLELFTFARFVQGVGGAMMVPVGRIIIFRAVPRTELVRAMNYLS
VPALFRPAAGPLLGGFITTYLHWRLIFFINVPIGILGIYLANRHIANTHELDPGPLDGFGFVLSAAGAALLLMGLTLLDG
ALVTRGAALAMGATGAALLGGYVLYARRVERPVLDLRFLRIPTYHASVVGGSLFRIGLGAVPFLLPLALQEGLGMSAFHS
GAITCASAVGGALTRMLAPRTLKRFGFRTVLMYNAAFSGLAIAAYGVFHPGMSTLAIWLIVLVGGIFPALQFTSLNSMIY
AEIAARDAGRATSLGSVVQQMSLGLGVTVAALVLHVSHWAQGHPAMVWSDFWPAFVVVGLCSFASIPITRRLSPNAGDEV
ARGKRG
>Mature_486_residues
MRAQACRNNRCNNGVFTRVVAMPSALYAFIAPLIVACALFMESVDANIIVTALPAMARDFGQNPVTLNIAITSYVVGLGV
FIPICGWLADRFGARTVFRTAIGIFVAGSLLCAASNNLELFTFARFVQGVGGAMMVPVGRIIIFRAVPRTELVRAMNYLS
VPALFRPAAGPLLGGFITTYLHWRLIFFINVPIGILGIYLANRHIANTHELDPGPLDGFGFVLSAAGAALLLMGLTLLDG
ALVTRGAALAMGATGAALLGGYVLYARRVERPVLDLRFLRIPTYHASVVGGSLFRIGLGAVPFLLPLALQEGLGMSAFHS
GAITCASAVGGALTRMLAPRTLKRFGFRTVLMYNAAFSGLAIAAYGVFHPGMSTLAIWLIVLVGGIFPALQFTSLNSMIY
AEIAARDAGRATSLGSVVQQMSLGLGVTVAALVLHVSHWAQGHPAMVWSDFWPAFVVVGLCSFASIPITRRLSPNAGDEV
ARGKRG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=457, Percent_Identity=36.5426695842451, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1788392, Length=406, Percent_Identity=36.4532019704434, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI1789042, Length=416, Percent_Identity=25.9615384615385, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1788710, Length=409, Percent_Identity=24.6943765281174, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI87081983, Length=295, Percent_Identity=28.135593220339, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322958, Length=264, Percent_Identity=29.5454545454545, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325455, Length=231, Percent_Identity=26.4069264069264, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 51485; Mature: 51485

Theoretical pI: Translated: 10.53; Mature: 10.53

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAQACRNNRCNNGVFTRVVAMPSALYAFIAPLIVACALFMESVDANIIVTALPAMARDF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
GQNPVTLNIAITSYVVGLGVFIPICGWLADRFGARTVFRTAIGIFVAGSLLCAASNNLEL
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHH
FTFARFVQGVGGAMMVPVGRIIIFRAVPRTELVRAMNYLSVPALFRPAAGPLLGGFITTY
HHHHHHHHCCCCEEHHHHHHEEEEECCCHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHH
LHWRLIFFINVPIGILGIYLANRHIANTHELDPGPLDGFGFVLSAAGAALLLMGLTLLDG
HHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ALVTRGAALAMGATGAALLGGYVLYARRVERPVLDLRFLRIPTYHASVVGGSLFRIGLGA
HHHHCCHHHHCCCCHHHHHHHHHHHHHHHCCCHHHEEEEECCCHHHHHHCCHHHHHHHHH
VPFLLPLALQEGLGMSAFHSGAITCASAVGGALTRMLAPRTLKRFGFRTVLMYNAAFSGL
HHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
AIAAYGVFHPGMSTLAIWLIVLVGGIFPALQFTSLNSMIYAEIAARDAGRATSLGSVVQQ
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
MSLGLGVTVAALVLHVSHWAQGHPAMVWSDFWPAFVVVGLCSFASIPITRRLSPNAGDEV
HHCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHH
ARGKRG
HCCCCC
>Mature Secondary Structure
MRAQACRNNRCNNGVFTRVVAMPSALYAFIAPLIVACALFMESVDANIIVTALPAMARDF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
GQNPVTLNIAITSYVVGLGVFIPICGWLADRFGARTVFRTAIGIFVAGSLLCAASNNLEL
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHH
FTFARFVQGVGGAMMVPVGRIIIFRAVPRTELVRAMNYLSVPALFRPAAGPLLGGFITTY
HHHHHHHHCCCCEEHHHHHHEEEEECCCHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHH
LHWRLIFFINVPIGILGIYLANRHIANTHELDPGPLDGFGFVLSAAGAALLLMGLTLLDG
HHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ALVTRGAALAMGATGAALLGGYVLYARRVERPVLDLRFLRIPTYHASVVGGSLFRIGLGA
HHHHCCHHHHCCCCHHHHHHHHHHHHHHHCCCHHHEEEEECCCHHHHHHCCHHHHHHHHH
VPFLLPLALQEGLGMSAFHSGAITCASAVGGALTRMLAPRTLKRFGFRTVLMYNAAFSGL
HHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
AIAAYGVFHPGMSTLAIWLIVLVGGIFPALQFTSLNSMIYAEIAARDAGRATSLGSVVQQ
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
MSLGLGVTVAALVLHVSHWAQGHPAMVWSDFWPAFVVVGLCSFASIPITRRLSPNAGDEV
HHCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHH
ARGKRG
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]