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The map label for this gene is 126447010

Identifier: 126447010

GI number: 126447010

Start: 164823

End: 166241

Strand: Reverse

Name: 126447010

Synonym: BMA10247_A0195

Alternate gene names: NA

Gene position: 166241-164823 (Counterclockwise)

Preceding gene: 126446569

Following gene: 126447668

Centisome position: 7.07

GC content: 68.57

Gene sequence:

>1419_bases
ATGGGCGCATCGAACACCACACGCATTCCGGGAGGTCTCATGAAACTGACGTTCCTCGGCGCGACGGAAACCGTCACCGG
CTCGAAGTATCTGCTCGAGGACGCCGGGACACGCGTCCTGATCGACTGCGGGCTGTTCCAGGGCACGAAGAAGCTGCGGC
TGCGCAACTGGAGCCCGCTGCCCGTGCCCGCCGATTCGATCGACGCCGTCGTGCTCACGCATGCGCATCTCGATCACAGC
GGCTATCTGCCCGTGCTCGTGCGCGAGGGCTTCCGCGGGCCGATCTATTGCACGCACGGCACCGCGGCGCTCTGCGAGAT
CATGCTGATCGACAGCGCGCGGCTCCTCGAGGAAGAAGCCGATTTCGCGAACCGCCACGGCTACTCGAAACATCATCCGG
CGTTGCCGCTCTACACGACCGACGACGCGAAGCGCACGCTCGAGCGCCTCGCGCCGCGCGATTTCGACGCGCCGAGCGCG
CTCGCGGGCGATCTGCACTTCCGTCTGCTGCCCGCCGGGCACATTCTCGGCGCGGCGAGCGTCGTCGTCTGCTGGCGGCA
TACGCTGCTCGCGTTCTCCGGCGATCTCGGCCGCGCGCACGATCCGATCATGCGCGCGCCCGTGCCGCCCGTTCATGCGG
ACTATCTCGTCGTCGAATCGACGTACGGCGACCGGCTGCACGATGCGAGCGATCCGCAGACCGAGCTCGCCGACGTGTTC
GCGAAGACGTTCGCGCGCGGCGGCGTGGTCGTGATGCCGTGCTTCACGGTCGGGCGCGCGCAGGAGATCCTTTACTACAT
CGCGCAATTGAAGCAGACCGGGCGGATGCCGCACGTCCCCGTCTTTCTCGACAGCCCGATGGCGACGAGCGTCACCGAGA
TCTACCGGCGGCGGCTATCCGACCACCGGCTCACGATGTCCGACGCGGATGCGATCGGTCATGCGGCGGTGATGGTGCGC
ACGGTCGAGCAATCGAAGGCGATCGCCGATCACCATGGGCCGATGGTCGTCATCGCCGGCAGCGGCATGGCGACGGGCGG
CCGCGTGCTGCATCATCTCGCGCGCTACGCGCCCGACAGCCGCAACACGGTCCTGCTCGTCGGCTACCAGGCGGCGGGCA
CGCGCGGGGCGGCGCTCGCCGCGCACGAGCCGACGCTGAAGATTCACGGCGAATACGTGCGCGTGCGCGCGCAGGTCCAG
ATGATCTCGTCGCTGTCCGCGCACGCGGATTACGGCGAGATCCTCGGATGGCTCGGCGCGCAATCGAGCGCGCCCGCGCG
CACGTTCGTCACGCACGGCGAGCCCGCAGCGGCCGACGCGCTGCGGCGGCGAATCGAGGAAACCCTGCATTGGCGTTGCG
ACGTGCCGTCGTACCTCGAATCGGTCGAACTGGAGGACGCGCCCACGCGCGCGGCATGA

Upstream 100 bases:

>100_bases
CCCACGCCTTCATCCGTTCATGCCCCTTTTCGTCGCGCCTGCCGGCGCTTCGCCGCGCGGATTGATCCACGTCAGCAAGG
CGCGCGTCGCGTGTAGTGCA

Downstream 100 bases:

>100_bases
TCCGGGCGAGTGCAGCGAGGCCGCCGGGCGAGCGGCGAGGCCCGCCGTTTTGCCGCATCGAATCGGTGAATCGGTGAATT
GGCGGAATGCGTGGAATGGG

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MGASNTTRIPGGLMKLTFLGATETVTGSKYLLEDAGTRVLIDCGLFQGTKKLRLRNWSPLPVPADSIDAVVLTHAHLDHS
GYLPVLVREGFRGPIYCTHGTAALCEIMLIDSARLLEEEADFANRHGYSKHHPALPLYTTDDAKRTLERLAPRDFDAPSA
LAGDLHFRLLPAGHILGAASVVVCWRHTLLAFSGDLGRAHDPIMRAPVPPVHADYLVVESTYGDRLHDASDPQTELADVF
AKTFARGGVVVMPCFTVGRAQEILYYIAQLKQTGRMPHVPVFLDSPMATSVTEIYRRRLSDHRLTMSDADAIGHAAVMVR
TVEQSKAIADHHGPMVVIAGSGMATGGRVLHHLARYAPDSRNTVLLVGYQAAGTRGAALAAHEPTLKIHGEYVRVRAQVQ
MISSLSAHADYGEILGWLGAQSSAPARTFVTHGEPAAADALRRRIEETLHWRCDVPSYLESVELEDAPTRAA

Sequences:

>Translated_472_residues
MGASNTTRIPGGLMKLTFLGATETVTGSKYLLEDAGTRVLIDCGLFQGTKKLRLRNWSPLPVPADSIDAVVLTHAHLDHS
GYLPVLVREGFRGPIYCTHGTAALCEIMLIDSARLLEEEADFANRHGYSKHHPALPLYTTDDAKRTLERLAPRDFDAPSA
LAGDLHFRLLPAGHILGAASVVVCWRHTLLAFSGDLGRAHDPIMRAPVPPVHADYLVVESTYGDRLHDASDPQTELADVF
AKTFARGGVVVMPCFTVGRAQEILYYIAQLKQTGRMPHVPVFLDSPMATSVTEIYRRRLSDHRLTMSDADAIGHAAVMVR
TVEQSKAIADHHGPMVVIAGSGMATGGRVLHHLARYAPDSRNTVLLVGYQAAGTRGAALAAHEPTLKIHGEYVRVRAQVQ
MISSLSAHADYGEILGWLGAQSSAPARTFVTHGEPAAADALRRRIEETLHWRCDVPSYLESVELEDAPTRAA
>Mature_471_residues
GASNTTRIPGGLMKLTFLGATETVTGSKYLLEDAGTRVLIDCGLFQGTKKLRLRNWSPLPVPADSIDAVVLTHAHLDHSG
YLPVLVREGFRGPIYCTHGTAALCEIMLIDSARLLEEEADFANRHGYSKHHPALPLYTTDDAKRTLERLAPRDFDAPSAL
AGDLHFRLLPAGHILGAASVVVCWRHTLLAFSGDLGRAHDPIMRAPVPPVHADYLVVESTYGDRLHDASDPQTELADVFA
KTFARGGVVVMPCFTVGRAQEILYYIAQLKQTGRMPHVPVFLDSPMATSVTEIYRRRLSDHRLTMSDADAIGHAAVMVRT
VEQSKAIADHHGPMVVIAGSGMATGGRVLHHLARYAPDSRNTVLLVGYQAAGTRGAALAAHEPTLKIHGEYVRVRAQVQM
ISSLSAHADYGEILGWLGAQSSAPARTFVTHGEPAAADALRRRIEETLHWRCDVPSYLESVELEDAPTRAA

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=466, Percent_Identity=27.0386266094421, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI7706427, Length=423, Percent_Identity=28.1323877068558, Blast_Score=161, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI32566029, Length=446, Percent_Identity=28.0269058295964, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI32564696, Length=464, Percent_Identity=25.8620689655172, Blast_Score=154, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6323307, Length=454, Percent_Identity=28.4140969162996, Blast_Score=146, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24648013, Length=451, Percent_Identity=28.159645232816, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21358523, Length=467, Percent_Identity=27.6231263383298, Blast_Score=152, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 51293; Mature: 51162

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGASNTTRIPGGLMKLTFLGATETVTGSKYLLEDAGTRVLIDCGLFQGTKKLRLRNWSPL
CCCCCCCCCCCCEEEEEEECCCCCCCCCHHEECCCCCEEEEEECCCCCCHHHEECCCCCC
PVPADSIDAVVLTHAHLDHSGYLPVLVREGFRGPIYCTHGTAALCEIMLIDSARLLEEEA
CCCCCCCCEEEEEEEECCCCCCCCHHEECCCCCCEEEECCHHHHHHHHHHCCHHHHHHHH
DFANRHGYSKHHPALPLYTTDDAKRTLERLAPRDFDAPSALAGDLHFRLLPAGHILGAAS
HHHHHCCCCCCCCCCCEEECCHHHHHHHHHCCCCCCCCCHHCCCEEEEEECCCHHHHHHH
VVVCWRHTLLAFSGDLGRAHDPIMRAPVPPVHADYLVVESTYGDRLHDASDPQTELADVF
HHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHH
AKTFARGGVVVMPCFTVGRAQEILYYIAQLKQTGRMPHVPVFLDSPMATSVTEIYRRRLS
HHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHC
DHRLTMSDADAIGHAAVMVRTVEQSKAIADHHGPMVVIAGSGMATGGRVLHHLARYAPDS
CCEEECCCHHHHHHHHHHEEHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCC
RNTVLLVGYQAAGTRGAALAAHEPTLKIHGEYVRVRAQVQMISSLSAHADYGEILGWLGA
CCEEEEEEEECCCCCCCEEEECCCCEEECCCEEEHHHHHHHHHHHHCCCCHHHHHHHHCC
QSSAPARTFVTHGEPAAADALRRRIEETLHWRCDVPSYLESVELEDAPTRAA
CCCCCCEEEEECCCCHHHHHHHHHHHHHHEEECCCHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
GASNTTRIPGGLMKLTFLGATETVTGSKYLLEDAGTRVLIDCGLFQGTKKLRLRNWSPL
CCCCCCCCCCCEEEEEEECCCCCCCCCHHEECCCCCEEEEEECCCCCCHHHEECCCCCC
PVPADSIDAVVLTHAHLDHSGYLPVLVREGFRGPIYCTHGTAALCEIMLIDSARLLEEEA
CCCCCCCCEEEEEEEECCCCCCCCHHEECCCCCCEEEECCHHHHHHHHHHCCHHHHHHHH
DFANRHGYSKHHPALPLYTTDDAKRTLERLAPRDFDAPSALAGDLHFRLLPAGHILGAAS
HHHHHCCCCCCCCCCCEEECCHHHHHHHHHCCCCCCCCCHHCCCEEEEEECCCHHHHHHH
VVVCWRHTLLAFSGDLGRAHDPIMRAPVPPVHADYLVVESTYGDRLHDASDPQTELADVF
HHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHH
AKTFARGGVVVMPCFTVGRAQEILYYIAQLKQTGRMPHVPVFLDSPMATSVTEIYRRRLS
HHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHC
DHRLTMSDADAIGHAAVMVRTVEQSKAIADHHGPMVVIAGSGMATGGRVLHHLARYAPDS
CCEEECCCHHHHHHHHHHEEHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCC
RNTVLLVGYQAAGTRGAALAAHEPTLKIHGEYVRVRAQVQMISSLSAHADYGEILGWLGA
CCEEEEEEEECCCCCCCEEEECCCCEEECCCEEEHHHHHHHHHHHHCCCCHHHHHHHHCC
QSSAPARTFVTHGEPAAADALRRRIEETLHWRCDVPSYLESVELEDAPTRAA
CCCCCCEEEEECCCCHHHHHHHHHHHHHHEEECCCHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA