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The map label for this gene is ytnA [H]

Identifier: 126446625

GI number: 126446625

Start: 1644117

End: 1645460

Strand: Reverse

Name: ytnA [H]

Synonym: BMA10247_A1709

Alternate gene names: 126446625

Gene position: 1645460-1644117 (Counterclockwise)

Preceding gene: 126445619

Following gene: 126446276

Centisome position: 69.94

GC content: 65.48

Gene sequence:

>1344_bases
GTGACTTCACGAGACGAACGGCTGCACCGCGGCCTGGAGGAGCGGCACATCAATCTGATGGCGCTCGGCGCGACGATCGG
CGTCGGCCTCTTTCTCGGCTCCGCCACCGCGATCCGCGCGGCCGGCCCGGCGATCCTGCTCACTTACATACTCGGCGGCG
TCGCGATCTTCCTGATCATGCGCGCGCTCGGCGAGATGGCGATCGACAATCCGGTCGCGGGCGCGTTCAGCCGCTACGCG
CGGGACTACATCGGGCCGCTCGCCGGCTATCTGACGGGCTGGACCTACTGGTTCATGTGGATCGTCACATGCATGGCCGA
AATCACCGCGGTCGGCGTCTACATGCACATGTGGTTCCCCGACGTGCCGAACTGGATCTGGACGTTCGCCGCACTGATCG
TGATGGGCGCGGTGAACTTCATCGCGGTCAAGCTGTACGGCGAATTCGAATTCTGGTTCGCGCTGATCAAGATCGTGACG
ATCGTGCTGATGATCGCCGGCGGCGCGCTGATGATCGTCGCGGGCGTCGGCAACGGCGGCGTGCCGACCGGCGTGTCGAA
CCTGTGGGCGTACGGCGGGTTCCTGCCGAACGGATGGCCGGGCGTCGTCGACGCGTTGCCGATCGTGATGTTCGCGTATC
TCGGCGTCGAGATGCTCGGGTTGACGGCGGGCGAGGCGCGCAATCCCGAAAAATCGCTCGCGAAGGCGGTGAATTCGGTG
TTCTGGCGCGTGGTGATCTTCTACGTCGGCGCGCTGTTCGTGATCATGTCGGTCTACCCGTGGAACCAGATCGGCACGCA
GGGCAGCCCGTTCGTGATGACATTCTCGCGTCTCGGCATCCCGGCCGCCGCCGGCATCATCAATTTCGTCGTGCTGACGG
CCGCGCTCTCGTCGTGCAACAGCGGCATCTTCAGCACCGCGCGGATGCTGTTCAACCTCGCGGAGCAAGGGCAGGCGCCC
GAGCGGCTCGCTTCGGTGAACCGGCGCGGCGTGCCGGTTCACGGCGTGCTCATCTCGGTCGCGCTGCTGTTCGTCGGCGT
CGTGCTCAATTATTTCGCACCGCAGAAAGTGTTCGTGTGGCTCACGTCGGTGTCGACGTTCGGCGCGATCTGGACGTGGT
GCGTGATCCTGATCGCGCAACTGCGCTTTCGCCGCCGCGTGTCGGCCGAGCGTCTCGCGCGGCTGCCGCTGCGCGTGCCG
TGCTATCCGTTGTCGTCGTTCGTCGCGCTCGCGTTTCTCGCGTTCGTCGTCGTGCTGATGGCGTTTTCGCCCGATACGCG
CGTGGCACTCGTGATCGGGCCGCTGTGGATCGCCGCGCTGACCGTGTACTACTACGCGAGCTAG

Upstream 100 bases:

>100_bases
GCGATGAGCATGCAACATTGAGCGCAAGTTGCGCGCGCAACGTTTTTCCCTTTTGATACGACACGAGCGGCACGCGCCCG
CGCGCCGCCAGGAGACATCT

Downstream 100 bases:

>100_bases
GCGGGGCGGCGCTCGCCGCTGGGCGCGCCGACGGACGGCTGAGCGGGCGGCGCGTCGCGCCCGGCCGTGAAGATGCGACG
GCGGCGCGCGAGGGGGGGCG

Product: amino acid permease

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MTSRDERLHRGLEERHINLMALGATIGVGLFLGSATAIRAAGPAILLTYILGGVAIFLIMRALGEMAIDNPVAGAFSRYA
RDYIGPLAGYLTGWTYWFMWIVTCMAEITAVGVYMHMWFPDVPNWIWTFAALIVMGAVNFIAVKLYGEFEFWFALIKIVT
IVLMIAGGALMIVAGVGNGGVPTGVSNLWAYGGFLPNGWPGVVDALPIVMFAYLGVEMLGLTAGEARNPEKSLAKAVNSV
FWRVVIFYVGALFVIMSVYPWNQIGTQGSPFVMTFSRLGIPAAAGIINFVVLTAALSSCNSGIFSTARMLFNLAEQGQAP
ERLASVNRRGVPVHGVLISVALLFVGVVLNYFAPQKVFVWLTSVSTFGAIWTWCVILIAQLRFRRRVSAERLARLPLRVP
CYPLSSFVALAFLAFVVVLMAFSPDTRVALVIGPLWIAALTVYYYAS

Sequences:

>Translated_447_residues
MTSRDERLHRGLEERHINLMALGATIGVGLFLGSATAIRAAGPAILLTYILGGVAIFLIMRALGEMAIDNPVAGAFSRYA
RDYIGPLAGYLTGWTYWFMWIVTCMAEITAVGVYMHMWFPDVPNWIWTFAALIVMGAVNFIAVKLYGEFEFWFALIKIVT
IVLMIAGGALMIVAGVGNGGVPTGVSNLWAYGGFLPNGWPGVVDALPIVMFAYLGVEMLGLTAGEARNPEKSLAKAVNSV
FWRVVIFYVGALFVIMSVYPWNQIGTQGSPFVMTFSRLGIPAAAGIINFVVLTAALSSCNSGIFSTARMLFNLAEQGQAP
ERLASVNRRGVPVHGVLISVALLFVGVVLNYFAPQKVFVWLTSVSTFGAIWTWCVILIAQLRFRRRVSAERLARLPLRVP
CYPLSSFVALAFLAFVVVLMAFSPDTRVALVIGPLWIAALTVYYYAS
>Mature_446_residues
TSRDERLHRGLEERHINLMALGATIGVGLFLGSATAIRAAGPAILLTYILGGVAIFLIMRALGEMAIDNPVAGAFSRYAR
DYIGPLAGYLTGWTYWFMWIVTCMAEITAVGVYMHMWFPDVPNWIWTFAALIVMGAVNFIAVKLYGEFEFWFALIKIVTI
VLMIAGGALMIVAGVGNGGVPTGVSNLWAYGGFLPNGWPGVVDALPIVMFAYLGVEMLGLTAGEARNPEKSLAKAVNSVF
WRVVIFYVGALFVIMSVYPWNQIGTQGSPFVMTFSRLGIPAAAGIINFVVLTAALSSCNSGIFSTARMLFNLAEQGQAPE
RLASVNRRGVPVHGVLISVALLFVGVVLNYFAPQKVFVWLTSVSTFGAIWTWCVILIAQLRFRRRVSAERLARLPLRVPC
YPLSSFVALAFLAFVVVLMAFSPDTRVALVIGPLWIAALTVYYYAS

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Proline. [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=435, Percent_Identity=20.9195402298851, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI258614003, Length=436, Percent_Identity=21.1009174311927, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI258614005, Length=436, Percent_Identity=21.1009174311927, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI181337167, Length=341, Percent_Identity=22.5806451612903, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1786602, Length=442, Percent_Identity=51.8099547511312, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI48994972, Length=446, Percent_Identity=51.5695067264574, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1786789, Length=442, Percent_Identity=45.9276018099548, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1786302, Length=445, Percent_Identity=44.4943820224719, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1790653, Length=443, Percent_Identity=43.7923250564334, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI87081915, Length=425, Percent_Identity=39.7647058823529, Blast_Score=325, Evalue=5e-90,
Organism=Escherichia coli, GI1789017, Length=431, Percent_Identity=37.5870069605568, Blast_Score=315, Evalue=5e-87,
Organism=Escherichia coli, GI87081708, Length=441, Percent_Identity=36.9614512471655, Blast_Score=294, Evalue=8e-81,
Organism=Escherichia coli, GI1788480, Length=441, Percent_Identity=36.0544217687075, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI87081869, Length=327, Percent_Identity=21.4067278287462, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI2367353, Length=384, Percent_Identity=26.0416666666667, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=357, Percent_Identity=24.0896358543417, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17531343, Length=358, Percent_Identity=22.6256983240223, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=443, Percent_Identity=32.9571106094808, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6320772, Length=442, Percent_Identity=31.9004524886878, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6324924, Length=455, Percent_Identity=31.2087912087912, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6322892, Length=431, Percent_Identity=32.7146171693735, Blast_Score=199, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6324059, Length=448, Percent_Identity=31.4732142857143, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6324990, Length=450, Percent_Identity=29.5555555555556, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319824, Length=412, Percent_Identity=28.1553398058252, Blast_Score=179, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6319542, Length=411, Percent_Identity=28.7104622871046, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324553, Length=395, Percent_Identity=29.873417721519, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6320717, Length=409, Percent_Identity=27.8728606356968, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6322967, Length=402, Percent_Identity=27.1144278606965, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6321629, Length=412, Percent_Identity=26.2135922330097, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321053, Length=425, Percent_Identity=26.8235294117647, Blast_Score=163, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6319608, Length=446, Percent_Identity=27.3542600896861, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6320251, Length=403, Percent_Identity=26.302729528536, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6319543, Length=401, Percent_Identity=26.4339152119701, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6324981, Length=393, Percent_Identity=25.6997455470738, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320364, Length=505, Percent_Identity=25.3465346534653, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24666159, Length=421, Percent_Identity=19.0023752969121, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI221512776, Length=423, Percent_Identity=19.6217494089835, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24668806, Length=415, Percent_Identity=21.2048192771084, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356285, Length=415, Percent_Identity=21.2048192771084, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24668802, Length=415, Percent_Identity=21.2048192771084, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI161077963, Length=350, Percent_Identity=22, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48683; Mature: 48552

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRDERLHRGLEERHINLMALGATIGVGLFLGSATAIRAAGPAILLTYILGGVAIFLIM
CCCCHHHHHCCHHHHCCHHEEEHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHH
RALGEMAIDNPVAGAFSRYARDYIGPLAGYLTGWTYWFMWIVTCMAEITAVGVYMHMWFP
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DVPNWIWTFAALIVMGAVNFIAVKLYGEFEFWFALIKIVTIVLMIAGGALMIVAGVGNGG
CCCHHHHHHHHHHHHHHHHHHEEHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
VPTGVSNLWAYGGFLPNGWPGVVDALPIVMFAYLGVEMLGLTAGEARNPEKSLAKAVNSV
CCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
FWRVVIFYVGALFVIMSVYPWNQIGTQGSPFVMTFSRLGIPAAAGIINFVVLTAALSSCN
HHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCEEEHHHCCCHHHHHHHHHHHHHHHHHHHC
SGIFSTARMLFNLAEQGQAPERLASVNRRGVPVHGVLISVALLFVGVVLNYFAPQKVFVW
CHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LTSVSTFGAIWTWCVILIAQLRFRRRVSAERLARLPLRVPCYPLSSFVALAFLAFVVVLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
AFSPDTRVALVIGPLWIAALTVYYYAS
HCCCCCCEEEEEHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSRDERLHRGLEERHINLMALGATIGVGLFLGSATAIRAAGPAILLTYILGGVAIFLIM
CCCHHHHHCCHHHHCCHHEEEHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHH
RALGEMAIDNPVAGAFSRYARDYIGPLAGYLTGWTYWFMWIVTCMAEITAVGVYMHMWFP
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DVPNWIWTFAALIVMGAVNFIAVKLYGEFEFWFALIKIVTIVLMIAGGALMIVAGVGNGG
CCCHHHHHHHHHHHHHHHHHHEEHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
VPTGVSNLWAYGGFLPNGWPGVVDALPIVMFAYLGVEMLGLTAGEARNPEKSLAKAVNSV
CCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
FWRVVIFYVGALFVIMSVYPWNQIGTQGSPFVMTFSRLGIPAAAGIINFVVLTAALSSCN
HHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCEEEHHHCCCHHHHHHHHHHHHHHHHHHHC
SGIFSTARMLFNLAEQGQAPERLASVNRRGVPVHGVLISVALLFVGVVLNYFAPQKVFVW
CHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LTSVSTFGAIWTWCVILIAQLRFRRRVSAERLARLPLRVPCYPLSSFVALAFLAFVVVLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
AFSPDTRVALVIGPLWIAALTVYYYAS
HCCCCCCEEEEEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]