Click here to switch to the map view.

The map label for this gene is ttuC [H]

Identifier: 126446469

GI number: 126446469

Start: 10921

End: 12111

Strand: Reverse

Name: ttuC [H]

Synonym: BMA10247_A0014

Alternate gene names: 126446469

Gene position: 12111-10921 (Counterclockwise)

Preceding gene: 126446619

Following gene: 126447705

Centisome position: 0.51

GC content: 67.76

Gene sequence:

>1191_bases
ATGAATCGGCGATCGCGCAAGCTCCGCGCGATCGCTTTCCCGACGCCGCCCGCGCCTGGCGCGACGACGCGCGCGCGGCA
GGATACGAAGGACGAGGACCTCAGCATGAGCGAGAAGGTGTACAGGATCGCCGTCATCCCCGGCGACGGGATCGGCGTGG
AAGTGATGCCCGAAGGGCTGCGCGCGCTCGACGCGGTGAGCCGCCGCTTCGGCTTGCGCTTCGCATACGAGCCGATCGAA
TGGGCAAGCTGCGACTATTACGCGAAGCACGGGCAGATGATGCCCGACGACTGGAAGACGCAACTGTCCGGCATGGACGC
GCTGCTGTTCGGCGCGGTGGGCTGGCCCGAGACGGTGCCCGATCACATATCGCTGTGGGGCTCGCTGATCAAATTCCGCC
GCGAGTTCGATCAATACGTGAACCTGCGTCCCGCGCGCCTGTTCGACGGCGTGCCGTGCCCGCTCGCCGGCCGCAAGGCG
GGCGACATCGATTTCATGATCGTGCGCGAGAACACCGAGGGCGAATACTCGGCCGTCGGCGGCACGATGTTCGAGGGCAC
CGAGCGCGAGTTCGTCGTCCAGCAGGCGGTGTTCACGCGGCACGGCACCGAGCGCGTGCTGAAGTTCGCGTTCGAGCTCG
CGCAGCGCCGCGCAAAGCGGCTCACCGTCGCGACGAAGAGCAACGGCATCGCGATCAGCATGCCGTGGTGGGACGCGCGC
GCCGCCGAGATGGCCGCACGCTATCCGGACGTCACCTGGGACAAGCAGCATATCGACATCCTGTGCGCACGCTTCGTGAT
GCAGCCGGACCGCTTCGACGTCGTCGTCGCGTCGAACCTGTTCGGCGATATCCTGTCCGATCTCGGCCCCGCCTGCACCG
GCACGATCGGCATCGCGCCGTCGGCGAACCTGAATCCGGAGCGCAACTTTCCGTCGCTGTTCGAGCCGGTGCACGGGTCC
GCGCCGGATATCGCCGGCAAGCACATTGCCAACCCGATCGCGATGATCTGGTCGGCCGCGATGATGGTCGATTTCCTCGG
CGCCGGCACGGGCCGCGCGCGCGAAGCGCACGATGCGATCGTCGCCGCGATCGAGCACGTGCTGAAGCACGGCCCGCGCA
CGCGCGACATGGGCGGCCGAGCATCGACGCGCGAAGTGGGCGACGCAATCGTCGCGCACCTGCTCGGCTGA

Upstream 100 bases:

>100_bases
ACACGCGCAGATCGTCGAGGTTCGGCGAATTGTTCACGATGCGTGGAAAGTCGATTAACCGAATGGCCGATTTTAATCCC
GCCAGGAATAAATAGAATGC

Downstream 100 bases:

>100_bases
ACGCCGAACGCACGCGCGTGTCGCGCGCCGCTTCGACGCCACTTTCCGTCGGGATCGCGCCACGGGCTCGACGGCTATCG
CACAAGCGAGTCTCTATGCG

Product: tartrate dehydrogenase

Products: NA

Alternate protein names: D-malate degradation protein A; D-malate oxidase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MNRRSRKLRAIAFPTPPAPGATTRARQDTKDEDLSMSEKVYRIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIE
WASCDYYAKHGQMMPDDWKTQLSGMDALLFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPLAGRKA
GDIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQQAVFTRHGTERVLKFAFELAQRRAKRLTVATKSNGIAISMPWWDAR
AAEMAARYPDVTWDKQHIDILCARFVMQPDRFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERNFPSLFEPVHGS
APDIAGKHIANPIAMIWSAAMMVDFLGAGTGRAREAHDAIVAAIEHVLKHGPRTRDMGGRASTREVGDAIVAHLLG

Sequences:

>Translated_396_residues
MNRRSRKLRAIAFPTPPAPGATTRARQDTKDEDLSMSEKVYRIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIE
WASCDYYAKHGQMMPDDWKTQLSGMDALLFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPLAGRKA
GDIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQQAVFTRHGTERVLKFAFELAQRRAKRLTVATKSNGIAISMPWWDAR
AAEMAARYPDVTWDKQHIDILCARFVMQPDRFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERNFPSLFEPVHGS
APDIAGKHIANPIAMIWSAAMMVDFLGAGTGRAREAHDAIVAAIEHVLKHGPRTRDMGGRASTREVGDAIVAHLLG
>Mature_396_residues
MNRRSRKLRAIAFPTPPAPGATTRARQDTKDEDLSMSEKVYRIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIE
WASCDYYAKHGQMMPDDWKTQLSGMDALLFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPLAGRKA
GDIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQQAVFTRHGTERVLKFAFELAQRRAKRLTVATKSNGIAISMPWWDAR
AAEMAARYPDVTWDKQHIDILCARFVMQPDRFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERNFPSLFEPVHGS
APDIAGKHIANPIAMIWSAAMMVDFLGAGTGRAREAHDAIVAAIEHVLKHGPRTRDMGGRASTREVGDAIVAHLLG

Specific function: Catalyzes the NAD(+)-dependent oxidative decarboxylation of D-malate into pyruvate. Is essential for aerobic growth on D- malate as the sole carbon source. But is not required for anaerobic D-malate utilization, although DmlA is expressed and active in th

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=359, Percent_Identity=33.1476323119777, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI28178821, Length=365, Percent_Identity=27.3972602739726, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI4758582, Length=360, Percent_Identity=27.7777777777778, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI28178816, Length=365, Percent_Identity=27.3972602739726, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI28178838, Length=312, Percent_Identity=28.525641025641, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI28178819, Length=203, Percent_Identity=30.0492610837438, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1788101, Length=358, Percent_Identity=71.2290502793296, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI87081683, Length=367, Percent_Identity=40.0544959128065, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1787381, Length=403, Percent_Identity=28.7841191066998, Blast_Score=112, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71986051, Length=356, Percent_Identity=32.5842696629214, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17550882, Length=394, Percent_Identity=27.6649746192893, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI25144293, Length=354, Percent_Identity=26.8361581920904, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17505779, Length=356, Percent_Identity=25.8426966292135, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322097, Length=371, Percent_Identity=35.8490566037736, Blast_Score=199, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6324709, Length=364, Percent_Identity=33.2417582417582, Blast_Score=169, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6319830, Length=368, Percent_Identity=33.4239130434783, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6324291, Length=363, Percent_Identity=28.9256198347107, Blast_Score=128, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24643270, Length=402, Percent_Identity=33.5820895522388, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24643268, Length=371, Percent_Identity=33.9622641509434, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24661184, Length=362, Percent_Identity=31.4917127071823, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI161078635, Length=358, Percent_Identity=27.9329608938547, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI161078637, Length=358, Percent_Identity=27.9329608938547, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI161078633, Length=358, Percent_Identity=27.9329608938547, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24650122, Length=358, Percent_Identity=27.9329608938547, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI161078639, Length=354, Percent_Identity=28.2485875706215, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI281362242, Length=359, Percent_Identity=27.0194986072423, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24648872, Length=359, Percent_Identity=27.0194986072423, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI20130355, Length=361, Percent_Identity=26.0387811634349, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.83 [H]

Molecular weight: Translated: 43695; Mature: 43695

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRSRKLRAIAFPTPPAPGATTRARQDTKDEDLSMSEKVYRIAVIPGDGIGVEVMPEGL
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEECHHHH
RALDAVSRRFGLRFAYEPIEWASCDYYAKHGQMMPDDWKTQLSGMDALLFGAVGWPETVP
HHHHHHHHHHCCEEEECCCCCCCCHHHHHCCCCCCHHHHHHHCCCHHHHHCCCCCCCCCH
DHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPLAGRKAGDIDFMIVRENTEGEYSAVG
HHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCHHHCC
GTMFEGTEREFVVQQAVFTRHGTERVLKFAFELAQRRAKRLTVATKSNGIAISMPWWDAR
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEECCCCHH
AAEMAARYPDVTWDKQHIDILCARFVMQPDRFDVVVASNLFGDILSDLGPACTGTIGIAP
HHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHCCCHHCCCEECCC
SANLNPERNFPSLFEPVHGSAPDIAGKHIANPIAMIWSAAMMVDFLGAGTGRAREAHDAI
CCCCCCCCCCCHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
VAAIEHVLKHGPRTRDMGGRASTREVGDAIVAHLLG
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNRRSRKLRAIAFPTPPAPGATTRARQDTKDEDLSMSEKVYRIAVIPGDGIGVEVMPEGL
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEECHHHH
RALDAVSRRFGLRFAYEPIEWASCDYYAKHGQMMPDDWKTQLSGMDALLFGAVGWPETVP
HHHHHHHHHHCCEEEECCCCCCCCHHHHHCCCCCCHHHHHHHCCCHHHHHCCCCCCCCCH
DHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPLAGRKAGDIDFMIVRENTEGEYSAVG
HHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCHHHCC
GTMFEGTEREFVVQQAVFTRHGTERVLKFAFELAQRRAKRLTVATKSNGIAISMPWWDAR
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEECCCCHH
AAEMAARYPDVTWDKQHIDILCARFVMQPDRFDVVVASNLFGDILSDLGPACTGTIGIAP
HHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHCCCHHCCCEECCC
SANLNPERNFPSLFEPVHGSAPDIAGKHIANPIAMIWSAAMMVDFLGAGTGRAREAHDAI
CCCCCCCCCCCHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
VAAIEHVLKHGPRTRDMGGRASTREVGDAIVAHLLG
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]