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The map label for this gene is trpA

Identifier: 126445927

GI number: 126445927

Start: 478169

End: 478984

Strand: Direct

Name: trpA

Synonym: BMA10247_A0531

Alternate gene names: 126445927

Gene position: 478169-478984 (Clockwise)

Preceding gene: 126446610

Following gene: 126447194

Centisome position: 20.32

GC content: 70.22

Gene sequence:

>816_bases
ATGTCCCGTATTCAGAACACTTTTGCCGCACTCGCCGCCCAAGGTCGCAAGGGGCTGATTCCGTTCATCACCGCGGGAGA
CCCGGACCCGGCGAAGACCGTCGAGCTGATGCACGCGCTCGCCGAAGGCGGCGCCGACGTGATCGAGCTCGGCGTGCCGT
TCTCCGACCCGATGGCCGACGGCCCCGTGATCCAGCGCTCGTCGGAGCGCGCGCTCGCGAAAGGCGTGACGCTTCACAGC
GTGCTCGACGACGTGAAGCGCTTTCGCGCGCGCGACCAGAAGACGCCCGTCGTGCTGATGGGCTACGCGAATCCGATCGA
GCGCATGGGCGCGGACGCATTCGCCGCGGCCGCGCGCGACGCGGGCGTCGACGGCGTGCTCGTCGTTGACTATCCGCCCG
AGGAATCGCACGATTTCGCCGCGAAGATGCGCGCGGCGGGCATCGATCCGATCTTCCTGCTCGCGCCGACGTCGACCGAC
GACCGGATCGCCGCCGTCGGCCAGGTGGCGAGCGGCTACGTCTACTATGTGTCGCTCAAGGGGGTGACGGGCGCCGCAAA
TCTGGATGTTTCCAGCATTGCGGGTAAAATCCCGGCCATCAAGTCGCGCGTGCCGCTTCCCGTCGGGGTCGGTTTCGGCA
TCCGCGACGCCGCGACGGCGCGCGCGGTGGCCGAGGTGGCGGACGCCGTCGTGATCGGCAGCCGCCTTGTCCAGCTGCTG
GAGCAGGCCGTGCCGGAGCGGGCCGCCGCCGAGCTCGCGGGGTTCGTCGCCGAGCTGCGCGCCGCGATCGACGGCGCGGC
GAAGCCGGCGGCATGA

Upstream 100 bases:

>100_bases
ATCGCGCGCGAACGCGTCGCGTCGCTCGCGGCCGTCTCCGCGCCGGCCGACGCGTAAGCGGCGCGGCGCGCGCGATAGCG
AACGATCTGGAAAAAAAGCC

Downstream 100 bases:

>100_bases
GCCGCGCGACACGTCAACACAAGCTGACCGCGAACCGGGTGCGCCATGCCCGGTTCGCCACCGAACAGGAAACCATACGA
TGAGCTGGCTCGACAAACTG

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MSRIQNTFAALAAQGRKGLIPFITAGDPDPAKTVELMHALAEGGADVIELGVPFSDPMADGPVIQRSSERALAKGVTLHS
VLDDVKRFRARDQKTPVVLMGYANPIERMGADAFAAAARDAGVDGVLVVDYPPEESHDFAAKMRAAGIDPIFLLAPTSTD
DRIAAVGQVASGYVYYVSLKGVTGAANLDVSSIAGKIPAIKSRVPLPVGVGFGIRDAATARAVAEVADAVVIGSRLVQLL
EQAVPERAAAELAGFVAELRAAIDGAAKPAA

Sequences:

>Translated_271_residues
MSRIQNTFAALAAQGRKGLIPFITAGDPDPAKTVELMHALAEGGADVIELGVPFSDPMADGPVIQRSSERALAKGVTLHS
VLDDVKRFRARDQKTPVVLMGYANPIERMGADAFAAAARDAGVDGVLVVDYPPEESHDFAAKMRAAGIDPIFLLAPTSTD
DRIAAVGQVASGYVYYVSLKGVTGAANLDVSSIAGKIPAIKSRVPLPVGVGFGIRDAATARAVAEVADAVVIGSRLVQLL
EQAVPERAAAELAGFVAELRAAIDGAAKPAA
>Mature_270_residues
SRIQNTFAALAAQGRKGLIPFITAGDPDPAKTVELMHALAEGGADVIELGVPFSDPMADGPVIQRSSERALAKGVTLHSV
LDDVKRFRARDQKTPVVLMGYANPIERMGADAFAAAARDAGVDGVLVVDYPPEESHDFAAKMRAAGIDPIFLLAPTSTDD
RIAAVGQVASGYVYYVSLKGVTGAANLDVSSIAGKIPAIKSRVPLPVGVGFGIRDAATARAVAEVADAVVIGSRLVQLLE
QAVPERAAAELAGFVAELRAAIDGAAKPAA

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family

Homologues:

Organism=Escherichia coli, GI1787514, Length=268, Percent_Identity=36.5671641791045, Blast_Score=159, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6321412, Length=249, Percent_Identity=40.5622489959839, Blast_Score=178, Evalue=1e-45,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPA_BURM7 (A3MBU6)

Other databases:

- EMBL:   CP000547
- RefSeq:   YP_001077732.1
- ProteinModelPortal:   A3MBU6
- SMR:   A3MBU6
- GeneID:   4889201
- GenomeReviews:   CP000547_GR
- KEGG:   bmn:BMA10247_A0531
- TIGR:   BMA10247_A0531
- HOGENOM:   HBG391690
- OMA:   NPIYIYG
- ProtClustDB:   PRK13111
- BioCyc:   BMAL320389:BMA10247_A0531-MONOMER
- HAMAP:   MF_00131
- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00262

Pfam domain/function: PF00290 Trp_syntA; SSF51366 RibP_bind_barrel

EC number: =4.2.1.20

Molecular weight: Translated: 27978; Mature: 27847

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA; PS00287 CYSTATIN

Important sites: ACT_SITE 49-49 ACT_SITE 60-60

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIQNTFAALAAQGRKGLIPFITAGDPDPAKTVELMHALAEGGADVIELGVPFSDPMAD
CCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
GPVIQRSSERALAKGVTLHSVLDDVKRFRARDQKTPVVLMGYANPIERMGADAFAAAARD
CCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHCCHHHHHHHHH
AGVDGVLVVDYPPEESHDFAAKMRAAGIDPIFLLAPTSTDDRIAAVGQVASGYVYYVSLK
CCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEEEEC
GVTGAANLDVSSIAGKIPAIKSRVPLPVGVGFGIRDAATARAVAEVADAVVIGSRLVQLL
CCCCCCCCCHHHHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EQAVPERAAAELAGFVAELRAAIDGAAKPAA
HHHCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SRIQNTFAALAAQGRKGLIPFITAGDPDPAKTVELMHALAEGGADVIELGVPFSDPMAD
CHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
GPVIQRSSERALAKGVTLHSVLDDVKRFRARDQKTPVVLMGYANPIERMGADAFAAAARD
CCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHCCHHHHHHHHH
AGVDGVLVVDYPPEESHDFAAKMRAAGIDPIFLLAPTSTDDRIAAVGQVASGYVYYVSLK
CCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEEEEC
GVTGAANLDVSSIAGKIPAIKSRVPLPVGVGFGIRDAATARAVAEVADAVVIGSRLVQLL
CCCCCCCCCHHHHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EQAVPERAAAELAGFVAELRAAIDGAAKPAA
HHHCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA