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The map label for this gene is bioA [C]

Identifier: 126445683

GI number: 126445683

Start: 795255

End: 796676

Strand: Reverse

Name: bioA [C]

Synonym: BMA10247_A0847

Alternate gene names: 126445683

Gene position: 796676-795255 (Counterclockwise)

Preceding gene: 126447619

Following gene: 126446442

Centisome position: 33.86

GC content: 69.34

Gene sequence:

>1422_bases
ATGGCATACCGAAACGATTCCCTTCTCACGAGCGCGCAGCAGGACACGCGGCATCTGCTGCACCCGTGGGCCGATCTGTC
CGCGCTCGGCCGCGAGACGCCGACCGTCATCGTCGAAGCGCAGGGCACGCGCGTGACCGACGCCGAAGGCCGTACCTATC
TCGACGCGATCGGCGGCATGTGGTGCGTGACGCTCGGCTACGGCCGGCGCGAGATCGCCGACGCGATCCGCGATCAGGCG
CTGCGCATGCCGTTCTACACGCCGTTCGGCGCGATGACGAACGAGCCCGCCGCCGCGCTCGGCGCGCGGCTCGCCGAGCT
CGCGCCCGGCGATCTGAAGCGCGTGCACCTGACCACCTGCGGCTCGACAGCGGTCGAATCGGCGCTGCGTTTCGCGCACT
ACTACTTCGGCGCGACGGGCCGCCCGCGCAAGCGCCACATCGTCACGCGCGGCGACGCGTACCACGGCAGCACGTATCTC
GCCGCATCGATATCCGGCAAGGCGTGGGACCGCACGTGCTTTCACTACGACAGCACGATCGTCCATCACCTGTCGTCGCC
GAACCCGTACCGGCGGCCGGCCGGCATGAGCGTCGACGCGTTCTGCGCGTCGCTCGTCGACGAATTCGACGCGCTGATCG
CGAAGCTCGGCGCGGAGCAGATCGCATGCTTCATCGCCGAGCCGATCCTCGCGTCGGGCGGCGTGATCGTGCCGCCGCCC
GGCTATCTCGCCGCGATGCGCGAGCGCTGCCGCCGGCACGACATCCTGTACATCAGCGACGAAGTCGTCACGGGCTTCGG
CCGCGTCGGCCACTTCTTCGCGTCGCACGCGCACTTCGGCATCGAGCCCGACATGATCGTCGTCGCGAAGGGGCTCACCT
CCGGCTACCAGCCGCTCGGCGCGGTGCTGATCTCGGAGCGGCTCGTCGATGCGGTGTCCGGCGAGCACGCGTACGGCAAC
GGTGTGTTCACGAACGGTTTCACCTACTCGGGCCATCCGGTCGCCTGCGCGGCCGCGCTCGCCAACATCGAGCTGATGGA
GCGCGAGCGGATCTGCGAGCACGTGCGCGACGTCGGCCCGTACTTCATTCGCCGGCTCGATGCGCTGCGGCGCCTGCCGA
TCGTCGGCGACGTGCGCGGCGATCATCTGATGGCGTGCATCGAATGCACGAGCGGCGCGGGCGCGACGGGCGCGTTGCCG
ACGCCTGCGGACATCGCGATCGCGCAGCGCGTCGATCGCCACTGCGAAGAGATGGGCCTGCTCGTGCGGCCCTACGAGAG
CATGTGCATCCTGTCGCCGCCCCTCACCGTGACGCGCGCCGACATCGACGAAATCTGCGCGATTCTCGCGGCCGCGCTCG
AGCGCACGCAGCGCGAGCTCGCGCAACATGCCCCCGTTCGCGAGGAAAACGAAACATGCTGA

Upstream 100 bases:

>100_bases
GCGACGTGCTCGTGCTCGACAACGTCTACGTGCAGCACGGCCGCTTCGCGTTCTCCGGGCCGCGCCTGCATCTCGTCAGC
CTGACCGACTGAGGCAACAT

Downstream 100 bases:

>100_bases
TCAACGGCCTTTGCATCGAAGGGGGCGGCGAGCCGCTGTCGATCGTCGATCCGGCGACGGGCGAGCCGCTCGCGGCGCCC
GCCGCCGCGAGCGCGGCCGA

Product: hypothetical protein

Products: S-Adenosyl-4-methylthio-2-oxobutanoate; 7,8-Diaminononanoate [C]

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MAYRNDSLLTSAQQDTRHLLHPWADLSALGRETPTVIVEAQGTRVTDAEGRTYLDAIGGMWCVTLGYGRREIADAIRDQA
LRMPFYTPFGAMTNEPAAALGARLAELAPGDLKRVHLTTCGSTAVESALRFAHYYFGATGRPRKRHIVTRGDAYHGSTYL
AASISGKAWDRTCFHYDSTIVHHLSSPNPYRRPAGMSVDAFCASLVDEFDALIAKLGAEQIACFIAEPILASGGVIVPPP
GYLAAMRERCRRHDILYISDEVVTGFGRVGHFFASHAHFGIEPDMIVVAKGLTSGYQPLGAVLISERLVDAVSGEHAYGN
GVFTNGFTYSGHPVACAAALANIELMERERICEHVRDVGPYFIRRLDALRRLPIVGDVRGDHLMACIECTSGAGATGALP
TPADIAIAQRVDRHCEEMGLLVRPYESMCILSPPLTVTRADIDEICAILAAALERTQRELAQHAPVREENETC

Sequences:

>Translated_473_residues
MAYRNDSLLTSAQQDTRHLLHPWADLSALGRETPTVIVEAQGTRVTDAEGRTYLDAIGGMWCVTLGYGRREIADAIRDQA
LRMPFYTPFGAMTNEPAAALGARLAELAPGDLKRVHLTTCGSTAVESALRFAHYYFGATGRPRKRHIVTRGDAYHGSTYL
AASISGKAWDRTCFHYDSTIVHHLSSPNPYRRPAGMSVDAFCASLVDEFDALIAKLGAEQIACFIAEPILASGGVIVPPP
GYLAAMRERCRRHDILYISDEVVTGFGRVGHFFASHAHFGIEPDMIVVAKGLTSGYQPLGAVLISERLVDAVSGEHAYGN
GVFTNGFTYSGHPVACAAALANIELMERERICEHVRDVGPYFIRRLDALRRLPIVGDVRGDHLMACIECTSGAGATGALP
TPADIAIAQRVDRHCEEMGLLVRPYESMCILSPPLTVTRADIDEICAILAAALERTQRELAQHAPVREENETC
>Mature_472_residues
AYRNDSLLTSAQQDTRHLLHPWADLSALGRETPTVIVEAQGTRVTDAEGRTYLDAIGGMWCVTLGYGRREIADAIRDQAL
RMPFYTPFGAMTNEPAAALGARLAELAPGDLKRVHLTTCGSTAVESALRFAHYYFGATGRPRKRHIVTRGDAYHGSTYLA
ASISGKAWDRTCFHYDSTIVHHLSSPNPYRRPAGMSVDAFCASLVDEFDALIAKLGAEQIACFIAEPILASGGVIVPPPG
YLAAMRERCRRHDILYISDEVVTGFGRVGHFFASHAHFGIEPDMIVVAKGLTSGYQPLGAVLISERLVDAVSGEHAYGNG
VFTNGFTYSGHPVACAAALANIELMERERICEHVRDVGPYFIRRLDALRRLPIVGDVRGDHLMACIECTSGAGATGALPT
PADIAIAQRVDRHCEEMGLLVRPYESMCILSPPLTVTRADIDEICAILAAALERTQRELAQHAPVREENETC

Specific function: Biotin biosynthesis. [C]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=447, Percent_Identity=26.3982102908277, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI24119277, Length=436, Percent_Identity=27.2935779816514, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI226442705, Length=451, Percent_Identity=26.8292682926829, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI37574042, Length=450, Percent_Identity=27.1111111111111, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI4557809, Length=425, Percent_Identity=27.0588235294118, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI226442709, Length=381, Percent_Identity=27.8215223097113, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI284507298, Length=316, Percent_Identity=29.4303797468354, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1786991, Length=446, Percent_Identity=30.0448430493274, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1788044, Length=428, Percent_Identity=28.7383177570093, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI145693181, Length=349, Percent_Identity=30.3724928366762, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1789016, Length=436, Percent_Identity=29.3577981651376, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1789759, Length=410, Percent_Identity=28.0487804878049, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1787560, Length=425, Percent_Identity=30.1176470588235, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1786349, Length=316, Percent_Identity=28.1645569620253, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI32564660, Length=447, Percent_Identity=28.4116331096197, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25144271, Length=423, Percent_Identity=25.0591016548463, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI25144274, Length=267, Percent_Identity=28.8389513108614, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI71992977, Length=444, Percent_Identity=24.3243243243243, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17541228, Length=459, Percent_Identity=23.7472766884532, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324386, Length=485, Percent_Identity=25.1546391752577, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6323470, Length=418, Percent_Identity=27.2727272727273, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324432, Length=421, Percent_Identity=26.8408551068884, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6321456, Length=359, Percent_Identity=23.6768802228412, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28574759, Length=455, Percent_Identity=28.1318681318681, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI161085790, Length=450, Percent_Identity=27.5555555555556, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI21356575, Length=426, Percent_Identity=28.169014084507, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI21357415, Length=430, Percent_Identity=25.1162790697674, Blast_Score=122, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.62 [C]

Molecular weight: Translated: 51462; Mature: 51331

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYRNDSLLTSAQQDTRHLLHPWADLSALGRETPTVIVEAQGTRVTDAEGRTYLDAIGGM
CCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCEEECCCCCHHHHHHCCE
WCVTLGYGRREIADAIRDQALRMPFYTPFGAMTNEPAAALGARLAELAPGDLKRVHLTTC
EEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEC
GSTAVESALRFAHYYFGATGRPRKRHIVTRGDAYHGSTYLAASISGKAWDRTCFHYDSTI
CHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCHHHHHCHHH
VHHLSSPNPYRRPAGMSVDAFCASLVDEFDALIAKLGAEQIACFIAEPILASGGVIVPPP
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEECCC
GYLAAMRERCRRHDILYISDEVVTGFGRVGHFFASHAHFGIEPDMIVVAKGLTSGYQPLG
HHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHH
AVLISERLVDAVSGEHAYGNGVFTNGFTYSGHPVACAAALANIELMERERICEHVRDVGP
HHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCH
YFIRRLDALRRLPIVGDVRGDHLMACIECTSGAGATGALPTPADIAIAQRVDRHCEEMGL
HHHHHHHHHHHCCCEECCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
LVRPYESMCILSPPLTVTRADIDEICAILAAALERTQRELAQHAPVREENETC
EECCCCCEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AYRNDSLLTSAQQDTRHLLHPWADLSALGRETPTVIVEAQGTRVTDAEGRTYLDAIGGM
CCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCEEECCCCCHHHHHHCCE
WCVTLGYGRREIADAIRDQALRMPFYTPFGAMTNEPAAALGARLAELAPGDLKRVHLTTC
EEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEC
GSTAVESALRFAHYYFGATGRPRKRHIVTRGDAYHGSTYLAASISGKAWDRTCFHYDSTI
CHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCHHHHHCHHH
VHHLSSPNPYRRPAGMSVDAFCASLVDEFDALIAKLGAEQIACFIAEPILASGGVIVPPP
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEECCC
GYLAAMRERCRRHDILYISDEVVTGFGRVGHFFASHAHFGIEPDMIVVAKGLTSGYQPLG
HHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHH
AVLISERLVDAVSGEHAYGNGVFTNGFTYSGHPVACAAALANIELMERERICEHVRDVGP
HHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCH
YFIRRLDALRRLPIVGDVRGDHLMACIECTSGAGATGALPTPADIAIAQRVDRHCEEMGL
HHHHHHHHHHHCCCEECCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
LVRPYESMCILSPPLTVTRADIDEICAILAAALERTQRELAQHAPVREENETC
EECCCCCEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 8-Amino-7-oxononanoate; S-Adenosyl-L-methionine [C]

Specific reaction: 8-Amino-7-oxononanoate + S-Adenosyl-L-methionine <==> S-Adenosyl-4-methylthio-2-oxobutanoate + 7,8-Diaminononanoate [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8796346; 9163424 [H]