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The map label for this gene is pyrG [H]

Identifier: 229335613

GI number: 229335613

Start: 2593473

End: 2595134

Strand: Reverse

Name: pyrG [H]

Synonym: BURPS1106A_2633

Alternate gene names: 229335613

Gene position: 2595134-2593473 (Counterclockwise)

Preceding gene: 126453364

Following gene: 126453670

Centisome position: 65.07

GC content: 64.62

Gene sequence:

>1662_bases
ATGACCAAATATGTTTTCGTCACCGGCGGCGTAGTTTCCTCCCTCGGCAAGGGCATTGCCGCCGCCTCTCTCGCCGCGAT
CCTCGAATCGCGCGGTCTCAAAGTCACCCTCCTCAAACTCGATCCTTACATCAACGTCGACCCCGGCACGATGAGCCCGT
TTCAGCACGGCGAAGTGTTCGTGACGGAAGACGGCGCGGAGACGGATCTCGACCTCGGCCATTATGAGCGCTTCATCAGC
ACGAAGATGCGCAAGGCCAACAATTTCACGACCGGTCAGATCTACGAATCGGTGATCCGCAAGGAGCGCCGCGGCGACTA
CCTCGGCAAGACGGTCCAGGTGATTCCGCACATCACGAACGAGATCCAGGCGTTCATCGAGCGCGGCGCGGCGTCGGCCA
CTTGCGGCGAGCCGGACGTGGCGATCGTCGAGATCGGCGGCACGGTGGGCGACATCGAGTCGCTGCCGTTCCTCGAGGCG
GCGCGCCAGATGAGCCTGCGCCTCGGCCGCAACAGCGCATGCTTCGTTCACCTGACGCTCGTGCCGTTCATCGCGACGGC
GGGCGAGCTGAAGACGAAGCCGACCCAGCACAGCGTGCAGAAGCTGCGCGAGATCGGCATTTCGCCGCACGTGCTGCTCT
GCCGCGCCGATCGCCCGATCCCCGACGACGAATCGAAGAAGATCTCGCTCTTCTCGAACGTGCCGGAAGACGCGGTGATC
TCGGTGTGGGACGTCGACAGCATCTACAAGATTCCGCAGATGCTGCACGATCAGGGGCTCGACCGCCTCATCTGCGAGGA
ACTGCGCCTCGATCCGCAGCCGGCCGACCTGCGCATGTGGGCGGCGCTCGTCGAGAAGCTGCAGAATCCGAAGCACGAGG
TGACGATCGGGATGGTCGGCAAGTACGTGGACCTCACGGAATCGTACAAGTCGCTGATCGAGGCGCTGCGCCATGCGTCG
ATCCACACGTCGACGAAGGTCAACATCGAGTACATCGATTCGGAAGAGCTCGAGACGAACGGCACCGCGAGCCTCGCGCA
TCTCGACGCCGTGCTCGTGCCGGGCGGCTTCGGCCGGCGCGGCACCGAGGGTAAGATCGCGGCCGTGCGCTACGCGCGCG
AAGCGAAGGTGCCGTATCTCGGCATCTGCCTCGGCATGCAGCTCGCCGTCATCGAATTCGCGCGCGACGTCGTCGGCCTC
AAGCAGGCGAACAGCACCGAATTCGATCCGAACACGCCGGAGCGCGTCGTCGCGCTGATCACCGAGTGGTACGACCGCGA
AGGCAAGGTCGAGAAGCGCACCGAGGATTCCGATCTCGGCGGCACGATGCGGCTCGGTTCGCAGCGCTGCCCGATCAAGC
CGGGCACGCTCGCCGAGGCGATCTACGGCAAGGACGTGAACGAGCGCCACCGTCACCGCTATGAAGTCAACAACCGTTTC
GTGCCGCAACTCGAAGCGGGCGGCCTCGTGATCAGCGCGCGCACGCCGAGCGAGGATCTGCCGGAAATGATGGAACTGCC
GAGCACGATGCACCCGTGGTTCGTCGGCGTTCAGTTCCACCCGGAATTCACGTCGACGCCGCGCGACGGCCATCCGCTGT
TCAAGTCGTTCGTGCAGGCCGCGCTCGCGTGCCAGCAGACGCGCGCCGGAGCGAAGGCATGA

Upstream 100 bases:

>100_bases
CGAGCGCGGACGGCGAAGGGAAGGGGGGCGATCGCGCGTCGATTGCTGAGTGACGCGCGGCCTTTACGGTATAATCCGTT
TTTCCCGCGAGCATCCAGCG

Downstream 100 bases:

>100_bases
ATCTCGCCGGGTTCGAAGTCGGGCTCGACAAGCCGTTCTTCCTGATCGCCGGCACCTGCGTCGTCGAATCGGAGCAGATG
ACGATCGACACCGCGGGCCG

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 553; Mature: 552

Protein sequence:

>553_residues
MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIS
TKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITNEIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEA
ARQMSLRLGRNSACFVHLTLVPFIATAGELKTKPTQHSVQKLREIGISPHVLLCRADRPIPDDESKKISLFSNVPEDAVI
SVWDVDSIYKIPQMLHDQGLDRLICEELRLDPQPADLRMWAALVEKLQNPKHEVTIGMVGKYVDLTESYKSLIEALRHAS
IHTSTKVNIEYIDSEELETNGTASLAHLDAVLVPGGFGRRGTEGKIAAVRYAREAKVPYLGICLGMQLAVIEFARDVVGL
KQANSTEFDPNTPERVVALITEWYDREGKVEKRTEDSDLGGTMRLGSQRCPIKPGTLAEAIYGKDVNERHRHRYEVNNRF
VPQLEAGGLVISARTPSEDLPEMMELPSTMHPWFVGVQFHPEFTSTPRDGHPLFKSFVQAALACQQTRAGAKA

Sequences:

>Translated_553_residues
MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIS
TKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITNEIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEA
ARQMSLRLGRNSACFVHLTLVPFIATAGELKTKPTQHSVQKLREIGISPHVLLCRADRPIPDDESKKISLFSNVPEDAVI
SVWDVDSIYKIPQMLHDQGLDRLICEELRLDPQPADLRMWAALVEKLQNPKHEVTIGMVGKYVDLTESYKSLIEALRHAS
IHTSTKVNIEYIDSEELETNGTASLAHLDAVLVPGGFGRRGTEGKIAAVRYAREAKVPYLGICLGMQLAVIEFARDVVGL
KQANSTEFDPNTPERVVALITEWYDREGKVEKRTEDSDLGGTMRLGSQRCPIKPGTLAEAIYGKDVNERHRHRYEVNNRF
VPQLEAGGLVISARTPSEDLPEMMELPSTMHPWFVGVQFHPEFTSTPRDGHPLFKSFVQAALACQQTRAGAKA
>Mature_552_residues
TKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIST
KMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITNEIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEAA
RQMSLRLGRNSACFVHLTLVPFIATAGELKTKPTQHSVQKLREIGISPHVLLCRADRPIPDDESKKISLFSNVPEDAVIS
VWDVDSIYKIPQMLHDQGLDRLICEELRLDPQPADLRMWAALVEKLQNPKHEVTIGMVGKYVDLTESYKSLIEALRHASI
HTSTKVNIEYIDSEELETNGTASLAHLDAVLVPGGFGRRGTEGKIAAVRYAREAKVPYLGICLGMQLAVIEFARDVVGLK
QANSTEFDPNTPERVVALITEWYDREGKVEKRTEDSDLGGTMRLGSQRCPIKPGTLAEAIYGKDVNERHRHRYEVNNRFV
PQLEAGGLVISARTPSEDLPEMMELPSTMHPWFVGVQFHPEFTSTPRDGHPLFKSFVQAALACQQTRAGAKA

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI28559085, Length=559, Percent_Identity=45.0805008944544, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI28559083, Length=559, Percent_Identity=45.0805008944544, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI221316689, Length=559, Percent_Identity=45.0805008944544, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI148491070, Length=561, Percent_Identity=45.632798573975, Blast_Score=485, Evalue=1e-137,
Organism=Escherichia coli, GI1789142, Length=549, Percent_Identity=62.1129326047359, Blast_Score=680, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=609, Percent_Identity=40.0656814449918, Blast_Score=424, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319432, Length=575, Percent_Identity=41.9130434782609, Blast_Score=452, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6322563, Length=573, Percent_Identity=41.8848167539267, Blast_Score=445, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24664469, Length=560, Percent_Identity=45.1785714285714, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI21357815, Length=505, Percent_Identity=43.7623762376238, Blast_Score=407, Evalue=1e-114,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 61042; Mature: 60911

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVF
CCEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFISTKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITN
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHH
EIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEAARQMSLRLGRNSACFVHLTL
HHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEH
VPFIATAGELKTKPTQHSVQKLREIGISPHVLLCRADRPIPDDESKKISLFSNVPEDAVI
HHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCEE
SVWDVDSIYKIPQMLHDQGLDRLICEELRLDPQPADLRMWAALVEKLQNPKHEVTIGMVG
EEECCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECC
KYVDLTESYKSLIEALRHASIHTSTKVNIEYIDSEELETNGTASLAHLDAVLVPGGFGRR
CHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCHHHHEEEEECCCCCCC
GTEGKIAAVRYAREAKVPYLGICLGMQLAVIEFARDVVGLKQANSTEFDPNTPERVVALI
CCCCCEEEEEHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
TEWYDREGKVEKRTEDSDLGGTMRLGSQRCPIKPGTLAEAIYGKDVNERHRHRYEVNNRF
HHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHCCCCC
VPQLEAGGLVISARTPSEDLPEMMELPSTMHPWFVGVQFHPEFTSTPRDGHPLFKSFVQA
CCEECCCCEEEECCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
ALACQQTRAGAKA
HHHHHHHHCCCCC
>Mature Secondary Structure 
TKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVF
CEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFISTKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITN
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHH
EIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEAARQMSLRLGRNSACFVHLTL
HHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEH
VPFIATAGELKTKPTQHSVQKLREIGISPHVLLCRADRPIPDDESKKISLFSNVPEDAVI
HHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCEE
SVWDVDSIYKIPQMLHDQGLDRLICEELRLDPQPADLRMWAALVEKLQNPKHEVTIGMVG
EEECCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECC
KYVDLTESYKSLIEALRHASIHTSTKVNIEYIDSEELETNGTASLAHLDAVLVPGGFGRR
CHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCHHHHEEEEECCCCCCC
GTEGKIAAVRYAREAKVPYLGICLGMQLAVIEFARDVVGLKQANSTEFDPNTPERVVALI
CCCCCEEEEEHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
TEWYDREGKVEKRTEDSDLGGTMRLGSQRCPIKPGTLAEAIYGKDVNERHRHRYEVNNRF
HHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHCCCCC
VPQLEAGGLVISARTPSEDLPEMMELPSTMHPWFVGVQFHPEFTSTPRDGHPLFKSFVQA
CCEECCCCEEEECCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
ALACQQTRAGAKA
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA