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The map label for this gene is hemB [H]

Identifier: 126455399

GI number: 126455399

Start: 3687318

End: 3688406

Strand: Direct

Name: hemB [H]

Synonym: BURPS1106A_3774

Alternate gene names: 126455399

Gene position: 3687318-3688406 (Clockwise)

Preceding gene: 126454410

Following gene: 126452966

Centisome position: 92.45

GC content: 64.65

Gene sequence:

>1089_bases
TTGCTCGATCGCTATCATATACCATTGTCTCAAAAGTTTACCGAAGGGAACTGTAAGGTTTCGTCGGTTACCTATCCCAG
CCATTCCGCCATGAGCATCCATCCCCTGCACCGCCCGCGCCGCATGCGCCGCGACGATTTCTCGCGACGCCTGATGCGCG
AAAATATCCTCACCACGAACGATCTGATCTACCCGGTGTTCGTCGTCGAAGGCACGAACGTGCGCCAGCCGGTGCCGTCG
ATGCCGGGCGTCGAGCGCGTGTCGATCGATCTGCTGATGGGTGTCGCCGAGCAATGCGTCGAGCTCGGCGTGCCGGTCCT
GTCGCTCTTTCCGGCCATCGAGCCGTCGCTGAAGACGCCCGACGGCCGCGAAGCGGCCAATCCCGAAGGGCTGATCCCGC
GTGCGGTACGCGAGCTGAAGCGCCGCTTCCCCGAACTCGGCGTGCTGACCGACGTCGCGCTCGATCCGTACACGAGCCAC
GGCCAGGACGGCGTGCTCGACGAGGCCGGCTATGTGCTCAACGACGAAACGCTCGAGATTCTCGTCGAGCAGGCGCGCGC
GCAGGCCGAAGCGGGTGTCGACATCGTCGCGCCGTCGGACATGATGGACGGGCGCATCGGCGCGGTGCGCGAGATGCTCG
AGCGTGAAGGCCACATCTACACGCGGATCATGGCCTACTCGGCGAAGTACGCGTCGGCGTTCTACGGCCCGTTCCGCGAC
GCGGTCGGCTCCGCGTCGAATCTCGGCAAGGGCAACAAGATGACCTACCAGATGGACCCCGCGAACAGCGACGAGGCGCT
GCGCGAAGTGCGCCTCGACATCGACGAGGGCGCGGACATGGTCATGGTGAAGCCCGGCATGCCGTATCTCGACATCGTGC
GCCGCGTGAAGGACGAATTCCGCTATCCGACCTACGTCTATCAGGTGAGCGGCGAATACGCGATGCTGAAGGCCGCCGCG
CAGAACGGCTGGCTCGATCACGACAAAGTCGTGCTCGAATCGCTGCTCGCGTTCAAGCGCGCGGGCGCGGACGGCATTCT
CACGTACTTCGCGCTCGACGCGGCGCGGCTGCTGCGCGCGCAGAAGTAA

Upstream 100 bases:

>100_bases
ATAAAAAAACCCGCCGTTCAACGGCGGGTTAAACAGCCTAATCGAAAAACGACAGGCACCCGCTCAGGGAGGAGAAGCGG
GGAGCATCACGCAGTGCGCT

Downstream 100 bases:

>100_bases
GCCGCGCGGCATACGCTCTTCGCCTGCATCGCGGGCGCGGAGCGCGCCGCCATGCGTGAAAACGAAAACGGCGAGGCCTG
AAGCCTCGCCGTTTTTCATT

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MLDRYHIPLSQKFTEGNCKVSSVTYPSHSAMSIHPLHRPRRMRRDDFSRRLMRENILTTNDLIYPVFVVEGTNVRQPVPS
MPGVERVSIDLLMGVAEQCVELGVPVLSLFPAIEPSLKTPDGREAANPEGLIPRAVRELKRRFPELGVLTDVALDPYTSH
GQDGVLDEAGYVLNDETLEILVEQARAQAEAGVDIVAPSDMMDGRIGAVREMLEREGHIYTRIMAYSAKYASAFYGPFRD
AVGSASNLGKGNKMTYQMDPANSDEALREVRLDIDEGADMVMVKPGMPYLDIVRRVKDEFRYPTYVYQVSGEYAMLKAAA
QNGWLDHDKVVLESLLAFKRAGADGILTYFALDAARLLRAQK

Sequences:

>Translated_362_residues
MLDRYHIPLSQKFTEGNCKVSSVTYPSHSAMSIHPLHRPRRMRRDDFSRRLMRENILTTNDLIYPVFVVEGTNVRQPVPS
MPGVERVSIDLLMGVAEQCVELGVPVLSLFPAIEPSLKTPDGREAANPEGLIPRAVRELKRRFPELGVLTDVALDPYTSH
GQDGVLDEAGYVLNDETLEILVEQARAQAEAGVDIVAPSDMMDGRIGAVREMLEREGHIYTRIMAYSAKYASAFYGPFRD
AVGSASNLGKGNKMTYQMDPANSDEALREVRLDIDEGADMVMVKPGMPYLDIVRRVKDEFRYPTYVYQVSGEYAMLKAAA
QNGWLDHDKVVLESLLAFKRAGADGILTYFALDAARLLRAQK
>Mature_362_residues
MLDRYHIPLSQKFTEGNCKVSSVTYPSHSAMSIHPLHRPRRMRRDDFSRRLMRENILTTNDLIYPVFVVEGTNVRQPVPS
MPGVERVSIDLLMGVAEQCVELGVPVLSLFPAIEPSLKTPDGREAANPEGLIPRAVRELKRRFPELGVLTDVALDPYTSH
GQDGVLDEAGYVLNDETLEILVEQARAQAEAGVDIVAPSDMMDGRIGAVREMLEREGHIYTRIMAYSAKYASAFYGPFRD
AVGSASNLGKGNKMTYQMDPANSDEALREVRLDIDEGADMVMVKPGMPYLDIVRRVKDEFRYPTYVYQVSGEYAMLKAAA
QNGWLDHDKVVLESLLAFKRAGADGILTYFALDAARLLRAQK

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=298, Percent_Identity=45.9731543624161, Blast_Score=236, Evalue=2e-62,
Organism=Escherichia coli, GI87081728, Length=326, Percent_Identity=46.319018404908, Blast_Score=253, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6321398, Length=307, Percent_Identity=38.1107491856677, Blast_Score=192, Evalue=6e-50,
Organism=Drosophila melanogaster, GI21358291, Length=295, Percent_Identity=42.7118644067797, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 40413; Mature: 40413

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDRYHIPLSQKFTEGNCKVSSVTYPSHSAMSIHPLHRPRRMRRDDFSRRLMRENILTTN
CCCCCCCCHHCCCCCCCCEEEEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCC
DLIYPVFVVEGTNVRQPVPSMPGVERVSIDLLMGVAEQCVELGVPVLSLFPAIEPSLKTP
CCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCC
DGREAANPEGLIPRAVRELKRRFPELGVLTDVALDPYTSHGQDGVLDEAGYVLNDETLEI
CCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCHHCCCCEECHHHHHH
LVEQARAQAEAGVDIVAPSDMMDGRIGAVREMLEREGHIYTRIMAYSAKYASAFYGPFRD
HHHHHHHHHHCCEEEECCCHHHCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHH
AVGSASNLGKGNKMTYQMDPANSDEALREVRLDIDEGADMVMVKPGMPYLDIVRRVKDEF
HHCCHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHC
RYPTYVYQVSGEYAMLKAAAQNGWLDHDKVVLESLLAFKRAGADGILTYFALDAARLLRA
CCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
QK
CC
>Mature Secondary Structure
MLDRYHIPLSQKFTEGNCKVSSVTYPSHSAMSIHPLHRPRRMRRDDFSRRLMRENILTTN
CCCCCCCCHHCCCCCCCCEEEEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCC
DLIYPVFVVEGTNVRQPVPSMPGVERVSIDLLMGVAEQCVELGVPVLSLFPAIEPSLKTP
CCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCC
DGREAANPEGLIPRAVRELKRRFPELGVLTDVALDPYTSHGQDGVLDEAGYVLNDETLEI
CCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCHHCCCCEECHHHHHH
LVEQARAQAEAGVDIVAPSDMMDGRIGAVREMLEREGHIYTRIMAYSAKYASAFYGPFRD
HHHHHHHHHHCCEEEECCCHHHCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHH
AVGSASNLGKGNKMTYQMDPANSDEALREVRLDIDEGADMVMVKPGMPYLDIVRRVKDEF
HHCCHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHC
RYPTYVYQVSGEYAMLKAAAQNGWLDHDKVVLESLLAFKRAGADGILTYFALDAARLLRA
CCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
QK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9529530; 10984043; 10356331; 12079382 [H]