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The map label for this gene is maeB [H]

Identifier: 126455382

GI number: 126455382

Start: 3750582

End: 3752852

Strand: Reverse

Name: maeB [H]

Synonym: BURPS1106A_3849

Alternate gene names: 126455382

Gene position: 3752852-3750582 (Counterclockwise)

Preceding gene: 126452171

Following gene: 126452222

Centisome position: 94.09

GC content: 67.06

Gene sequence:

>2271_bases
ATGGACGAACAACTGAAGCAAAGCGCTCTCGCTTATCACCAGAACCCGAAACCCGGCAAGATTTCGGTCACGCCCACGAA
GCCGCTGTCGAACCAGCTCGACCTGTCGCTCGCGTATTCGCCCGGCGTCGCGGCCGCGTGCGAGGCGATCCACGCGGATC
CGCTCGACGCGCAGAAGTACACGTCGCGCGGCAACCTCGTCGGCGTCGTGACGAACGGCACCGCGGTGCTCGGCCTCGGC
AACATCGGCCCGCTCGCCGCGAAGCCCGTGATGGAAGGCAAGGGGTGCCTGTTCAAGAAGTTCGCCGGCATCGACGTGTT
CGACATCGAGCTCGCCGAGTCCGATCCGGACAAGCTCGTCGAGGCGATCGCGATGCTCGAGCCGACGCTCGGCGGCATCA
ACCTCGAGGACATCAAGGCGCCCGAGTGCTTCTACATCGAGCAGAAGCTGCGCGAGCGGATGAAGATTCCCGTGTTCCAC
GACGACCAGCACGGCACCGCGATCATCGCGTCGGCGGCGATCCTCAACGGCCTGAAAGTGGTCGGCAAGGATCTGTCGAG
CGTGAAGCTCGTCTGCTCGGGGGCGGGCGCGGCGGCGATCGCGTGTCTGGACCTGCTCGTGAAGCTCGGTCTGTCCAAGT
CGAACGTGCTCGTCGCCGATTCGAAGGGCGTGATCTACGAAGGGCGCGGCAACCTCGATCCGTCGAAGCAGCGCTATGCG
GCGACGACCGGCGCGCGCACGCTCGCCGACGCCATCGCCGGCGCGGACGTGTTCCTCGGCTGCTCGAGCGCGGGCGTGCT
GAAGCAGGACATGGTGAAGACGATGGCGGACCGGCCGCTCATCCTCGCGCTCGCGAACCCGGAGCCGGAAATCCGCCCGG
AAGACGCGAAGGCGGTGCGCCCGGACGCGATCGTCGCGACGGGCCGCTCCGACTATCCGAACCAGGTCAACAACGTCCTG
TGCTTCCCGTTCATCTTCCGCGGCGCGCTCGACGTCGGCGCGACGACGATCACCGAAGAGATGAAGCTCGCGTGCGTGCG
CGCGATCGCCGAGCTCGCGCAGGAAACCGACCAGAGCGAGGAAGTCGCGAAGGCGTATGAGGGCCATTCGCTCGAATTCG
GTCCGGAATACCTGATTCCGAAGCCGTTCGATCCGCGCCTCATCATCAAGATCGCGCCCGCCGTCGCGCAGGCCGCGATG
GATTCGGGCGTGGCCACCCGCCCGATCGCCGATATGGATGCGTACCGCGAGCAGCTCGGCACGACCGTCTATCGCACCGG
CATGGTGATGCGCCCCGTGTTCGCGACCGCGAAGACGAAGGCCGCGCGCATCGTGTTCGCCGAGGGCGAGGACGAGCGCG
TGCTGCGCGCCGCGCAATTCGTGCTGCAGGAGCGGATCGCGAAGCCGATCATCGTCGGCCGGCCGTCGGTCGTCGAGATG
CGGCTCAAGAAGATCGGCTCGAAGCTCGTCGGCGGCGTCGATTTCGAGATCGTCAATCCGGAAGACGATCCGCGCTACCA
GCAGTGCTGGCAGGCGTATCACGAGATCGGCGCGCGCGACGGCGTGACGCCGGAGGTCGCGAAGGCCGCGCTGCGCAAGT
TCAACACGCTGATCGGCGCGATGCTCGTGCACCTCGGCGATGCGCACGGCATGATCTGCGGGATGATCGACACGTACCAC
AGCCACCTGAAGTTCATCGAGCAGGTGCTGGGCCGCGCGAAGGGCGCCGAGCACTTCGCCGCGATGAACCTGCTGATGCT
GCCGGGCCGCAACCTGTTCATGTGCGACACGTACGTGAACGAGCAGCCGAGCGCCGAGCAGCTCGCCGACATGACGATCC
AGGCCGCGGCCGAGATCGAACGCTTCGGCATCACGCCGAAGGCGGCGCTGCTGTCGAACTCGAACTTCGGCAGCGCGCCG
TCGGCATCGTCGCGCCGGATGGCGGAAGCGCGCAAGCTGATCGTCGAGCGCGCGCCCGAGCTCGAGGTCGACGGCGAAAT
GCACGGCGACGCCGCGCTGTCCGAAGTGGTGCGCAAGGCCGCGTTCCCGGGCACGACGCTCACCGGCGAGGCGAACTTGC
TGATCATGCCGAACGTCGAGGCGGCGAACATCGCGTACAACCTGCTGAAGATGGTCGGCGGCGAGGGCGTCACGGTGGGC
CCGTTCCTGCTCGGCGCGGCGAAGCCCGTGCACATCCTGACGCCGGCCGCGACCGTGCGCCGGATCATCAACATGACGGC
CGTCGCCGCGGCGAACGTTCAGGTGAAGTAA

Upstream 100 bases:

>100_bases
CGGACGCCGCAGTCGACCATCCCTTCGATTCCCGCATTCGCGGCTCCCGGTGCTCGGTACTGAGTCTTCAAAAATTACGC
ATGTCTCTCGCAGGTCAACC

Downstream 100 bases:

>100_bases
CGCCCGGAAGCCGCGCGTCGCGCGCCGTTCGGGCGGGCGTCGCGCGGCAGCCAAACGAAAGGAAAGGCGGCCGCTCGGCC
GAACCGGATCTCGGCAACTG

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 756; Mature: 756

Protein sequence:

>756_residues
MDEQLKQSALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKYTSRGNLVGVVTNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFAGIDVFDIELAESDPDKLVEAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIIASAAILNGLKVVGKDLSSVKLVCSGAGAAAIACLDLLVKLGLSKSNVLVADSKGVIYEGRGNLDPSKQRYA
ATTGARTLADAIAGADVFLGCSSAGVLKQDMVKTMADRPLILALANPEPEIRPEDAKAVRPDAIVATGRSDYPNQVNNVL
CFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSEEVAKAYEGHSLEFGPEYLIPKPFDPRLIIKIAPAVAQAAM
DSGVATRPIADMDAYREQLGTTVYRTGMVMRPVFATAKTKAARIVFAEGEDERVLRAAQFVLQERIAKPIIVGRPSVVEM
RLKKIGSKLVGGVDFEIVNPEDDPRYQQCWQAYHEIGARDGVTPEVAKAALRKFNTLIGAMLVHLGDAHGMICGMIDTYH
SHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFMCDTYVNEQPSAEQLADMTIQAAAEIERFGITPKAALLSNSNFGSAP
SASSRRMAEARKLIVERAPELEVDGEMHGDAALSEVVRKAAFPGTTLTGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
PFLLGAAKPVHILTPAATVRRIINMTAVAAANVQVK

Sequences:

>Translated_756_residues
MDEQLKQSALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKYTSRGNLVGVVTNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFAGIDVFDIELAESDPDKLVEAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIIASAAILNGLKVVGKDLSSVKLVCSGAGAAAIACLDLLVKLGLSKSNVLVADSKGVIYEGRGNLDPSKQRYA
ATTGARTLADAIAGADVFLGCSSAGVLKQDMVKTMADRPLILALANPEPEIRPEDAKAVRPDAIVATGRSDYPNQVNNVL
CFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSEEVAKAYEGHSLEFGPEYLIPKPFDPRLIIKIAPAVAQAAM
DSGVATRPIADMDAYREQLGTTVYRTGMVMRPVFATAKTKAARIVFAEGEDERVLRAAQFVLQERIAKPIIVGRPSVVEM
RLKKIGSKLVGGVDFEIVNPEDDPRYQQCWQAYHEIGARDGVTPEVAKAALRKFNTLIGAMLVHLGDAHGMICGMIDTYH
SHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFMCDTYVNEQPSAEQLADMTIQAAAEIERFGITPKAALLSNSNFGSAP
SASSRRMAEARKLIVERAPELEVDGEMHGDAALSEVVRKAAFPGTTLTGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
PFLLGAAKPVHILTPAATVRRIINMTAVAAANVQVK
>Mature_756_residues
MDEQLKQSALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKYTSRGNLVGVVTNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFAGIDVFDIELAESDPDKLVEAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIIASAAILNGLKVVGKDLSSVKLVCSGAGAAAIACLDLLVKLGLSKSNVLVADSKGVIYEGRGNLDPSKQRYA
ATTGARTLADAIAGADVFLGCSSAGVLKQDMVKTMADRPLILALANPEPEIRPEDAKAVRPDAIVATGRSDYPNQVNNVL
CFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSEEVAKAYEGHSLEFGPEYLIPKPFDPRLIIKIAPAVAQAAM
DSGVATRPIADMDAYREQLGTTVYRTGMVMRPVFATAKTKAARIVFAEGEDERVLRAAQFVLQERIAKPIIVGRPSVVEM
RLKKIGSKLVGGVDFEIVNPEDDPRYQQCWQAYHEIGARDGVTPEVAKAALRKFNTLIGAMLVHLGDAHGMICGMIDTYH
SHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFMCDTYVNEQPSAEQLADMTIQAAAEIERFGITPKAALLSNSNFGSAP
SASSRRMAEARKLIVERAPELEVDGEMHGDAALSEVVRKAAFPGTTLTGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
PFLLGAAKPVHILTPAATVRRIINMTAVAAANVQVK

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=356, Percent_Identity=27.8089887640449, Blast_Score=91, Evalue=6e-18,
Organism=Homo sapiens, GI62420882, Length=352, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI62420880, Length=352, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI239049447, Length=352, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI4505145, Length=359, Percent_Identity=26.7409470752089, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI270265879, Length=317, Percent_Identity=27.4447949526814, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1788806, Length=758, Percent_Identity=63.7203166226913, Blast_Score=988, Evalue=0.0,
Organism=Escherichia coli, GI1788800, Length=322, Percent_Identity=33.5403726708075, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1788635, Length=352, Percent_Identity=28.6931818181818, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87081919, Length=411, Percent_Identity=23.8442822384428, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322823, Length=268, Percent_Identity=29.4776119402985, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356279, Length=402, Percent_Identity=27.8606965174129, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI281362672, Length=402, Percent_Identity=27.8606965174129, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI281362674, Length=402, Percent_Identity=27.8606965174129, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24646388, Length=350, Percent_Identity=29.4285714285714, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24646386, Length=350, Percent_Identity=29.4285714285714, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI78707242, Length=409, Percent_Identity=23.7163814180929, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI78707238, Length=409, Percent_Identity=23.7163814180929, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI78707240, Length=355, Percent_Identity=24.2253521126761, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 80792; Mature: 80792

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEQLKQSALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKY
CCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCHHHH
TSRGNLVGVVTNGTAVLGLGNIGPLAAKPVMEGKGCLFKKFAGIDVFDIELAESDPDKLV
CCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCCHHHHH
EAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFHDDQHGTAIIASAAILNGLKV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHH
VGKDLSSVKLVCSGAGAAAIACLDLLVKLGLSKSNVLVADSKGVIYEGRGNLDPSKQRYA
HCCCCHHEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEECCCCEEECCCCCCCCCHHHHH
ATTGARTLADAIAGADVFLGCSSAGVLKQDMVKTMADRPLILALANPEPEIRPEDAKAVR
HHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCC
PDAIVATGRSDYPNQVNNVLCFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSE
CCEEEECCCCCCCHHHHCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
EVAKAYEGHSLEFGPEYLIPKPFDPRLIIKIAPAVAQAAMDSGVATRPIADMDAYREQLG
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCCHHHHHHHHHHC
TTVYRTGMVMRPVFATAKTKAARIVFAEGEDERVLRAAQFVLQERIAKPIIVGRPSVVEM
CHHHHCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCEEECCCHHHHH
RLKKIGSKLVGGVDFEIVNPEDDPRYQQCWQAYHEIGARDGVTPEVAKAALRKFNTLIGA
HHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
MLVHLGDAHGMICGMIDTYHSHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFMCDTYVN
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEECCCCEEEEECCCC
EQPSAEQLADMTIQAAAEIERFGITPKAALLSNSNFGSAPSASSRRMAEARKLIVERAPE
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
LEVDGEMHGDAALSEVVRKAAFPGTTLTGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
CCCCCCCCCHHHHHHHHHHHCCCCCEECCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEH
PFLLGAAKPVHILTPAATVRRIINMTAVAAANVQVK
HHHHCCCCCEEEECCHHHHHHHHHHHHHEEECCEEC
>Mature Secondary Structure
MDEQLKQSALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKY
CCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCHHHH
TSRGNLVGVVTNGTAVLGLGNIGPLAAKPVMEGKGCLFKKFAGIDVFDIELAESDPDKLV
CCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCCHHHHH
EAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFHDDQHGTAIIASAAILNGLKV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHH
VGKDLSSVKLVCSGAGAAAIACLDLLVKLGLSKSNVLVADSKGVIYEGRGNLDPSKQRYA
HCCCCHHEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEECCCCEEECCCCCCCCCHHHHH
ATTGARTLADAIAGADVFLGCSSAGVLKQDMVKTMADRPLILALANPEPEIRPEDAKAVR
HHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCC
PDAIVATGRSDYPNQVNNVLCFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSE
CCEEEECCCCCCCHHHHCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
EVAKAYEGHSLEFGPEYLIPKPFDPRLIIKIAPAVAQAAMDSGVATRPIADMDAYREQLG
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCCHHHHHHHHHHC
TTVYRTGMVMRPVFATAKTKAARIVFAEGEDERVLRAAQFVLQERIAKPIIVGRPSVVEM
CHHHHCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCEEECCCHHHHH
RLKKIGSKLVGGVDFEIVNPEDDPRYQQCWQAYHEIGARDGVTPEVAKAALRKFNTLIGA
HHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
MLVHLGDAHGMICGMIDTYHSHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFMCDTYVN
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEECCCCEEEEECCCC
EQPSAEQLADMTIQAAAEIERFGITPKAALLSNSNFGSAPSASSRRMAEARKLIVERAPE
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
LEVDGEMHGDAALSEVVRKAAFPGTTLTGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
CCCCCCCCCHHHHHHHHHHHCCCCCEECCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEH
PFLLGAAKPVHILTPAATVRRIINMTAVAAANVQVK
HHHHCCCCCEEEECCHHHHHHHHHHHHHEEECCEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]