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The map label for this gene is aqpZ [H]

Identifier: 126455312

GI number: 126455312

Start: 3851469

End: 3852173

Strand: Direct

Name: aqpZ [H]

Synonym: BURPS1106A_3945

Alternate gene names: 126455312

Gene position: 3851469-3852173 (Clockwise)

Preceding gene: 126454592

Following gene: 126453188

Centisome position: 96.57

GC content: 68.79

Gene sequence:

>705_bases
ATGAAATTACCTCAGCGTCTCGCAGCGGAAGTGTTCGGCACGTTCTGGCTCGTCCTCGGCGGCTGTGGCAGCGCCGTCCT
GGCGGCCGCCTTTCCGGGCCTGGGCATCGGCTTTGCCGGCGTCGCATTGGCGTTCGGCCTGACCGTTCTGACGATGGCGT
TCGCCATCGGCCATGTCTCCGGATGCCACCTGAACCCGGCCGTGAGCGTCGGCCTGACGGTGGCGGGACGTTTCCCGGCC
CGCGATCTCGTGCCGTACGTCATCGCGCAGGTCATCGGCGCCACGCTCGGCGCGTTCGTGCTCTATCTGATCGCGACCGG
CAAGCCGGGCTTCGACGTCGCCGGCAGCGGCTTCGCGACGAACGGCTATGACGCGCGCTCGCCCGGCCATTACTCGCTCG
CCGCCGCATTCATCTGCGAAGTCGTGCTGACGGGCTTCTTCCTGTTCGTGATCCTCGGCTCGACCGACAAGCGCGCGCCG
GCCGGCTTCGCGCCGATCGCGATCGGCCTGTGCCTCACGCTGATCCACCTGATCTCGATCCCGGTGACGAACACGTCGGT
GAACCCGGCGCGCTCGACGGGCCCGGCGCTGTTCGTCGGGAGCGAGGCGATCGGCCAGCTGTGGCTGTTCTGGGTGGCGC
CCATCATCGGCGCGGCGATCGCGGGGGTCGTCTACCCGCTCGTCGCGGGACGCGACGAAAGCTGA

Upstream 100 bases:

>100_bases
AACCCGTAGGATTTCCTATAATCCAGGCGGCACGCGTGGATGCGTCCCTGCTTTTTACGGCGCCATCCGTTTTCAATTTT
CACGACCAGGAACTACTCCA

Downstream 100 bases:

>100_bases
CGAGGATGTGGCCGGACGCGCGCCGTCCGGCCCGCCCTCGCCACACCGGGCAACACGATAGAGGAACACGAAAGACCATC
CCGCGCCGGCCGACGGCAGC

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MKLPQRLAAEVFGTFWLVLGGCGSAVLAAAFPGLGIGFAGVALAFGLTVLTMAFAIGHVSGCHLNPAVSVGLTVAGRFPA
RDLVPYVIAQVIGATLGAFVLYLIATGKPGFDVAGSGFATNGYDARSPGHYSLAAAFICEVVLTGFFLFVILGSTDKRAP
AGFAPIAIGLCLTLIHLISIPVTNTSVNPARSTGPALFVGSEAIGQLWLFWVAPIIGAAIAGVVYPLVAGRDES

Sequences:

>Translated_234_residues
MKLPQRLAAEVFGTFWLVLGGCGSAVLAAAFPGLGIGFAGVALAFGLTVLTMAFAIGHVSGCHLNPAVSVGLTVAGRFPA
RDLVPYVIAQVIGATLGAFVLYLIATGKPGFDVAGSGFATNGYDARSPGHYSLAAAFICEVVLTGFFLFVILGSTDKRAP
AGFAPIAIGLCLTLIHLISIPVTNTSVNPARSTGPALFVGSEAIGQLWLFWVAPIIGAAIAGVVYPLVAGRDES
>Mature_234_residues
MKLPQRLAAEVFGTFWLVLGGCGSAVLAAAFPGLGIGFAGVALAFGLTVLTMAFAIGHVSGCHLNPAVSVGLTVAGRFPA
RDLVPYVIAQVIGATLGAFVLYLIATGKPGFDVAGSGFATNGYDARSPGHYSLAAAFICEVVLTGFFLFVILGSTDKRAP
AGFAPIAIGLCLTLIHLISIPVTNTSVNPARSTGPALFVGSEAIGQLWLFWVAPIIGAAIAGVVYPLVAGRDES

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502183, Length=219, Percent_Identity=36.5296803652968, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI37694062, Length=190, Percent_Identity=34.7368421052632, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4755125, Length=190, Percent_Identity=36.8421052631579, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI4502181, Length=190, Percent_Identity=36.8421052631579, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI4502179, Length=222, Percent_Identity=32.8828828828829, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI6912506, Length=224, Percent_Identity=33.0357142857143, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI86792455, Length=188, Percent_Identity=34.0425531914894, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI157266307, Length=246, Percent_Identity=33.739837398374, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI4826645, Length=249, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI45446752, Length=211, Percent_Identity=28.436018957346, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI22538420, Length=247, Percent_Identity=29.9595141700405, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4502187, Length=242, Percent_Identity=28.5123966942149, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI297307120, Length=91, Percent_Identity=38.4615384615385, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI1787101, Length=207, Percent_Identity=71.4975845410628, Blast_Score=288, Evalue=2e-79,
Organism=Escherichia coli, GI1790362, Length=260, Percent_Identity=28.0769230769231, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71993722, Length=204, Percent_Identity=31.8627450980392, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71992966, Length=238, Percent_Identity=30.2521008403361, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17558372, Length=204, Percent_Identity=31.3725490196078, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71992961, Length=236, Percent_Identity=29.2372881355932, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17531431, Length=235, Percent_Identity=31.063829787234, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17531429, Length=235, Percent_Identity=31.063829787234, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994009, Length=238, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24652747, Length=239, Percent_Identity=34.7280334728033, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45551084, Length=239, Percent_Identity=34.7280334728033, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19922038, Length=232, Percent_Identity=30.6034482758621, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24652751, Length=232, Percent_Identity=30.6034482758621, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24762344, Length=225, Percent_Identity=30.6666666666667, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24762346, Length=225, Percent_Identity=30.6666666666667, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24762348, Length=225, Percent_Identity=30.6666666666667, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI20130305, Length=225, Percent_Identity=30.6666666666667, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24762342, Length=202, Percent_Identity=28.7128712871287, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45550503, Length=227, Percent_Identity=27.3127753303965, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 23820; Mature: 23820

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLPQRLAAEVFGTFWLVLGGCGSAVLAAAFPGLGIGFAGVALAFGLTVLTMAFAIGHVS
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
GCHLNPAVSVGLTVAGRFPARDLVPYVIAQVIGATLGAFVLYLIATGKPGFDVAGSGFAT
CCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
NGYDARSPGHYSLAAAFICEVVLTGFFLFVILGSTDKRAPAGFAPIAIGLCLTLIHLISI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHC
PVTNTSVNPARSTGPALFVGSEAIGQLWLFWVAPIIGAAIAGVVYPLVAGRDES
CCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKLPQRLAAEVFGTFWLVLGGCGSAVLAAAFPGLGIGFAGVALAFGLTVLTMAFAIGHVS
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
GCHLNPAVSVGLTVAGRFPARDLVPYVIAQVIGATLGAFVLYLIATGKPGFDVAGSGFAT
CCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
NGYDARSPGHYSLAAAFICEVVLTGFFLFVILGSTDKRAPAGFAPIAIGLCLTLIHLISI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHC
PVTNTSVNPARSTGPALFVGSEAIGQLWLFWVAPIIGAAIAGVVYPLVAGRDES
CCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]