Click here to switch to the map view.

The map label for this gene is uppS [H]

Identifier: 126455056

GI number: 126455056

Start: 2441975

End: 2442757

Strand: Reverse

Name: uppS [H]

Synonym: BURPS1106A_2489

Alternate gene names: 126455056

Gene position: 2442757-2441975 (Counterclockwise)

Preceding gene: 126454912

Following gene: 126454204

Centisome position: 61.25

GC content: 68.07

Gene sequence:

>783_bases
ATGACCTATACCAGCTCTACCGTTCGCGTGCCTGACGTCGCCGCCGTGCCGCGTCACATCGCGATCATCATGGACGGCAA
CGGCCGTTGGGCGACCGAGCGCCGCCTGCCGCGCGTCGCGGGGCACACGCGCGGCGTCGACGCGGTGCGCTCGGTCGTCG
AGGGATGCGCACGCGCGGGCGTCGAATATCTGACGCTCTTCGCGTTCAGCTCCGAGAACTGGCGCCGGCCGAACGACGAA
GTGTCGTTCCTGATGCGACTGTTCATCACCGCGCTCGAGCGCGAGGTCGGCAAGCTGCACGCGAACGGCATCCGGCTGCG
CGTCGTCGGCGATCTGACGAAGTTCGAGCCGCGCATCCAGGCGCTGATTCGTCGCGGCGAGACGAAGACGGCGCGCAATA
CGCGCCTCACGCTCACGATCGCCGCGAACTACGGCGGCCGTTGGGACATCCTGCAGGCGACGCGCAAGCTCGTCGAAGAG
GCGGCGCGCGAAGGGCGCGCGCCCGAAATCGACGAGGACGCGTTCGCCCGCCATCTGGCGATGGCCTATGCGCCCGAGCC
GGATCTCTTCATCCGCACGGGCGGCGAGCAGCGCATCAGCAATTTCCTGCTCTGGCAGCTCGCCTATACCGAGTTCTACT
TCACCGACACGTTCTGGCCGGATTTCGACGCCGGCGCGCTCGCCGAAGCGCTCGCGTCGTACACGCACCGCGAACGCCGC
TTCGGCCGCACGAGCGCGCAGCTCGAACCCCAGGCCCAGGACGCCGATTCCCTTTCATGCTGA

Upstream 100 bases:

>100_bases
CGGAGATCGACAAGCTCGTCCAGGCCAAGGACGCGGAGATCATGACGGTCTGAAGCCGCCTTGCGTCGCACTTTTTCCTG
CAGCTACAGTCTCAGCGGCC

Downstream 100 bases:

>100_bases
AGACCCGTGTCATCACGGCGGTCGTGCTGCTGGCGGTGCTGCTGCCCGTGACGCTGTTCGCGCCGCTTGCCGCGTTCGGC
GCGCTGATCGCGCTCGCGCT

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTYTSSTVRVPDVAAVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRSVVEGCARAGVEYLTLFAFSSENWRRPNDE
VSFLMRLFITALEREVGKLHANGIRLRVVGDLTKFEPRIQALIRRGETKTARNTRLTLTIAANYGGRWDILQATRKLVEE
AAREGRAPEIDEDAFARHLAMAYAPEPDLFIRTGGEQRISNFLLWQLAYTEFYFTDTFWPDFDAGALAEALASYTHRERR
FGRTSAQLEPQAQDADSLSC

Sequences:

>Translated_260_residues
MTYTSSTVRVPDVAAVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRSVVEGCARAGVEYLTLFAFSSENWRRPNDE
VSFLMRLFITALEREVGKLHANGIRLRVVGDLTKFEPRIQALIRRGETKTARNTRLTLTIAANYGGRWDILQATRKLVEE
AAREGRAPEIDEDAFARHLAMAYAPEPDLFIRTGGEQRISNFLLWQLAYTEFYFTDTFWPDFDAGALAEALASYTHRERR
FGRTSAQLEPQAQDADSLSC
>Mature_259_residues
TYTSSTVRVPDVAAVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRSVVEGCARAGVEYLTLFAFSSENWRRPNDEV
SFLMRLFITALEREVGKLHANGIRLRVVGDLTKFEPRIQALIRRGETKTARNTRLTLTIAANYGGRWDILQATRKLVEEA
AREGRAPEIDEDAFARHLAMAYAPEPDLFIRTGGEQRISNFLLWQLAYTEFYFTDTFWPDFDAGALAEALASYTHRERRF
GRTSAQLEPQAQDADSLSC

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=225, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI45580738, Length=225, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=2e-31,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=54.8245614035088, Blast_Score=255, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI71993029, Length=228, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=225, Percent_Identity=36, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319474, Length=239, Percent_Identity=35.5648535564854, Blast_Score=126, Evalue=4e-30,
Organism=Drosophila melanogaster, GI18857969, Length=223, Percent_Identity=33.6322869955157, Blast_Score=148, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29380; Mature: 29248

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYTSSTVRVPDVAAVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRSVVEGCARAG
CCCCCCCEECCCHHHCCCEEEEEECCCCCCCHHHCCHHHHCCCCCHHHHHHHHHHHHHCC
VEYLTLFAFSSENWRRPNDEVSFLMRLFITALEREVGKLHANGIRLRVVGDLTKFEPRIQ
HHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHH
ALIRRGETKTARNTRLTLTIAANYGGRWDILQATRKLVEEAAREGRAPEIDEDAFARHLA
HHHHCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
MAYAPEPDLFIRTGGEQRISNFLLWQLAYTEFYFTDTFWPDFDAGALAEALASYTHRERR
HHCCCCCCEEEECCCHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHH
FGRTSAQLEPQAQDADSLSC
CCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TYTSSTVRVPDVAAVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRSVVEGCARAG
CCCCCCEECCCHHHCCCEEEEEECCCCCCCHHHCCHHHHCCCCCHHHHHHHHHHHHHCC
VEYLTLFAFSSENWRRPNDEVSFLMRLFITALEREVGKLHANGIRLRVVGDLTKFEPRIQ
HHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHH
ALIRRGETKTARNTRLTLTIAANYGGRWDILQATRKLVEEAAREGRAPEIDEDAFARHLA
HHHHCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
MAYAPEPDLFIRTGGEQRISNFLLWQLAYTEFYFTDTFWPDFDAGALAEALASYTHRERR
HHCCCCCCEEEECCCHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHH
FGRTSAQLEPQAQDADSLSC
CCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]