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The map label for this gene is pepQ [H]

Identifier: 126454960

GI number: 126454960

Start: 3513572

End: 3515386

Strand: Reverse

Name: pepQ [H]

Synonym: BURPS1106A_3609

Alternate gene names: 126454960

Gene position: 3515386-3513572 (Counterclockwise)

Preceding gene: 126453867

Following gene: 126451568

Centisome position: 88.14

GC content: 71.52

Gene sequence:

>1815_bases
ATGAATGCCCGACTTCCCGATCCGTCGCCCGTGCCGGCGCGTCTTGCCCTGTTGCGCGGCGCGATGACGCGCGAGGATCT
GGCCGCCTACGTGGTGCCGTCCGCCGATCCCCATTTGTCCGAGTATTTGCCCGAGCGCTGGCAGGCGCGCCAATGGCTGT
CGGGCTTCACCGGCTCGGTCGGCACGCTCGTCGTGACCGCCGATTTCGCCGGCCTCTGGGTCGACAGCCGCTATTGGATG
CAGGCCGAGGCGCAACTCGCGGGCACGGGCGTCGCGTTGATGAAGATGGTGGGCGGCCAGCAGACGCAGCCGCACGTCGA
ATGGCTCGCCGAGCACGTGCCCGAGGGCACGACGGTCGGCGTGGACGGCGCGGTGCTCGGCGTCGCGGCGGCGCGCGCGC
TCACGTCGGCGCTTACCCCGCGCGGCATCGTGCTGCGCACCGATCTCGATCTGCTCGATGCGATCTGGCCGCAGCGCCCG
TCGCTGCCGGGCGACGCGGTGTTCGAGCACGCGGCGCCGCAGGCCGACACCGCGCGCGCGGGCAAGCTCGCGCAGGTGCG
CCGCGCGATGCACGAGCAGGGCGCGCAGTGGCACTTCGTGTCGACGCTCGACGATCTCGCGTGGCTCTTCAACCTGCGCG
GCGCCGACGTCAACTACAACCCGGTGTTCGTCGCGCACGCGCTCGTCGGCCTCGAGCGCGCGACGCTGTTCGTCGCCGAC
GGCAAGGTGTCGGCCGAGCTGGCGACGTCGCTCGCGCGGGACGGCGTCGACGTGAAGCCGTACGACGCCGCGGCCGCCGC
GCTCGCCGCGCTGCCCGAGGGCGCGGGGCTGCTGATCGATCCGCGTCGCGTCACGTACGGGCTGCTGCAGGCGGTGCCGC
AGCAGGTGCGCGTGATCGAGGCGGTGAATCCGTCGACGTTCGCGAAATCGCGCAAGACGCCCGCCGAGATCGAGCACGTG
CGCGCGACGATGGAGCACGACGGCGCGGCGCTCGCCGAATTCTTCGCATGGTTCGAGCGCGCGCTCGGCCGCGAGACGAT
CACCGAGCTGACCATCGACGAGCAGCTCACGGCCGCGCGCGCGCGACGGCCGGGCTATGTGTCGCCGAGCTTCGCGACGA
TCGCGGGCTTCAACGCGAACGGCGCGATGCCGCATTACCGCGCGACGCGCGCCGCGCACGCGACGATCGAAGGCGACGGC
CTGCTGCTCGTCGATTCGGGCGGCCAGTATCTGAGCGGGACGACGGACATCACGCGGGTCGTGCCGGTCGGCGCGATCGG
CGACGCGCACCGGCGCGACTTCACGATCGTGCTGAAGGCGATGATGGCGCTGTCGCGTGCGCGCTTTCCGCGCGGCATCC
GCTCGCCGATGCTCGACGCGATCGCGCGCGCGCCGATGTGGGCGGCCGGGCTCGACTACGGGCACGGCACGGGGCACGGC
GTCGGCTATTTCCTGAACGTACACGAAGGGCCGCAGGTGATCTCGCACTACGCGCCCGCCGAGCCGTACACGGCGATGGA
GGAGGGGATGATCACGTCGATCGAGCCCGGCGTGTACCGGCCCGGCAACTGGGGCGTGCGCATCGAGAATCTCGTCGTGA
ACCGCGCGGCGGGCCAGACCGAGTTCGGCGATTTCCTCGAATTCGAGACGCTCACGCTCTGCCCGATCGATACGCGCTGC
GTGCTGCCCGCGCTCCTCGACGACGTCGAGCGCGCGTGGCTGAACGCGTATCACGCGACGGTGCGCGAGCGGGTCGGCAA
GCACGTGTCGGGCGACGCGAGGGCGTGGCTCGACGCGCGCACGCAACCGATCTGA

Upstream 100 bases:

>100_bases
CGAGACGCTCGAATGGCCGGTCTGCACCGCCGCCGCGCTTCTCGCCGTTGCCGTGACGGTGGGCCTGTCGGCCCGCCGCT
GAACGTTTGCAGGTGAACTC

Downstream 100 bases:

>100_bases
CGGGCGCGCGGGCGCCGGCGGCGACGAGCGTCGCCGGTTCGGCGGCGTCGACGCCGACGCCGATGTCGGTGCAGGTGTCG
ATGCCGGCGGCCGGGGGCGA

Product: M24 family metallopeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MNARLPDPSPVPARLALLRGAMTREDLAAYVVPSADPHLSEYLPERWQARQWLSGFTGSVGTLVVTADFAGLWVDSRYWM
QAEAQLAGTGVALMKMVGGQQTQPHVEWLAEHVPEGTTVGVDGAVLGVAAARALTSALTPRGIVLRTDLDLLDAIWPQRP
SLPGDAVFEHAAPQADTARAGKLAQVRRAMHEQGAQWHFVSTLDDLAWLFNLRGADVNYNPVFVAHALVGLERATLFVAD
GKVSAELATSLARDGVDVKPYDAAAAALAALPEGAGLLIDPRRVTYGLLQAVPQQVRVIEAVNPSTFAKSRKTPAEIEHV
RATMEHDGAALAEFFAWFERALGRETITELTIDEQLTAARARRPGYVSPSFATIAGFNANGAMPHYRATRAAHATIEGDG
LLLVDSGGQYLSGTTDITRVVPVGAIGDAHRRDFTIVLKAMMALSRARFPRGIRSPMLDAIARAPMWAAGLDYGHGTGHG
VGYFLNVHEGPQVISHYAPAEPYTAMEEGMITSIEPGVYRPGNWGVRIENLVVNRAAGQTEFGDFLEFETLTLCPIDTRC
VLPALLDDVERAWLNAYHATVRERVGKHVSGDARAWLDARTQPI

Sequences:

>Translated_604_residues
MNARLPDPSPVPARLALLRGAMTREDLAAYVVPSADPHLSEYLPERWQARQWLSGFTGSVGTLVVTADFAGLWVDSRYWM
QAEAQLAGTGVALMKMVGGQQTQPHVEWLAEHVPEGTTVGVDGAVLGVAAARALTSALTPRGIVLRTDLDLLDAIWPQRP
SLPGDAVFEHAAPQADTARAGKLAQVRRAMHEQGAQWHFVSTLDDLAWLFNLRGADVNYNPVFVAHALVGLERATLFVAD
GKVSAELATSLARDGVDVKPYDAAAAALAALPEGAGLLIDPRRVTYGLLQAVPQQVRVIEAVNPSTFAKSRKTPAEIEHV
RATMEHDGAALAEFFAWFERALGRETITELTIDEQLTAARARRPGYVSPSFATIAGFNANGAMPHYRATRAAHATIEGDG
LLLVDSGGQYLSGTTDITRVVPVGAIGDAHRRDFTIVLKAMMALSRARFPRGIRSPMLDAIARAPMWAAGLDYGHGTGHG
VGYFLNVHEGPQVISHYAPAEPYTAMEEGMITSIEPGVYRPGNWGVRIENLVVNRAAGQTEFGDFLEFETLTLCPIDTRC
VLPALLDDVERAWLNAYHATVRERVGKHVSGDARAWLDARTQPI
>Mature_604_residues
MNARLPDPSPVPARLALLRGAMTREDLAAYVVPSADPHLSEYLPERWQARQWLSGFTGSVGTLVVTADFAGLWVDSRYWM
QAEAQLAGTGVALMKMVGGQQTQPHVEWLAEHVPEGTTVGVDGAVLGVAAARALTSALTPRGIVLRTDLDLLDAIWPQRP
SLPGDAVFEHAAPQADTARAGKLAQVRRAMHEQGAQWHFVSTLDDLAWLFNLRGADVNYNPVFVAHALVGLERATLFVAD
GKVSAELATSLARDGVDVKPYDAAAAALAALPEGAGLLIDPRRVTYGLLQAVPQQVRVIEAVNPSTFAKSRKTPAEIEHV
RATMEHDGAALAEFFAWFERALGRETITELTIDEQLTAARARRPGYVSPSFATIAGFNANGAMPHYRATRAAHATIEGDG
LLLVDSGGQYLSGTTDITRVVPVGAIGDAHRRDFTIVLKAMMALSRARFPRGIRSPMLDAIARAPMWAAGLDYGHGTGHG
VGYFLNVHEGPQVISHYAPAEPYTAMEEGMITSIEPGVYRPGNWGVRIENLVVNRAAGQTEFGDFLEFETLTLCPIDTRC
VLPALLDDVERAWLNAYHATVRERVGKHVSGDARAWLDARTQPI

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=631, Percent_Identity=36.1331220285262, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI264681565, Length=631, Percent_Identity=34.86529318542, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI93141226, Length=605, Percent_Identity=33.3884297520661, Blast_Score=333, Evalue=3e-91,
Organism=Escherichia coli, GI1788728, Length=229, Percent_Identity=33.1877729257642, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17509539, Length=596, Percent_Identity=31.7114093959732, Blast_Score=300, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI25149105, Length=629, Percent_Identity=27.9809220985692, Blast_Score=241, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6322999, Length=653, Percent_Identity=29.8621745788668, Blast_Score=284, Evalue=3e-77,
Organism=Drosophila melanogaster, GI17137632, Length=595, Percent_Identity=33.781512605042, Blast_Score=309, Evalue=3e-84,
Organism=Drosophila melanogaster, GI161078230, Length=610, Percent_Identity=26.7213114754098, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI21357287, Length=610, Percent_Identity=26.7213114754098, Blast_Score=233, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 65296; Mature: 65296

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNARLPDPSPVPARLALLRGAMTREDLAAYVVPSADPHLSEYLPERWQARQWLSGFTGSV
CCCCCCCCCCCHHHHHHHHHHCCHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCC
GTLVVTADFAGLWVDSRYWMQAEAQLAGTGVALMKMVGGQQTQPHVEWLAEHVPEGTTVG
EEEEEEECCCEEEECCCHHEEECHHHHCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEC
VDGAVLGVAAARALTSALTPRGIVLRTDLDLLDAIWPQRPSLPGDAVFEHAAPQADTARA
CCHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHCCCCCCCCCHHHHHHCCCCCCHHHH
GKLAQVRRAMHEQGAQWHFVSTLDDLAWLFNLRGADVNYNPVFVAHALVGLERATLFVAD
HHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCEEEEEEEC
GKVSAELATSLARDGVDVKPYDAAAAALAALPEGAGLLIDPRRVTYGLLQAVPQQVRVIE
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHH
AVNPSTFAKSRKTPAEIEHVRATMEHDGAALAEFFAWFERALGRETITELTIDEQLTAAR
HCCCHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
ARRPGYVSPSFATIAGFNANGAMPHYRATRAAHATIEGDGLLLVDSGGQYLSGTTDITRV
HCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHEEEECCCCEEEECCCCCEECCCCCHHHE
VPVGAIGDAHRRDFTIVLKAMMALSRARFPRGIRSPMLDAIARAPMWAAGLDYGHGTGHG
EEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
VGYFLNVHEGPQVISHYAPAEPYTAMEEGMITSIEPGVYRPGNWGVRIENLVVNRAAGQT
EEEEEEECCCHHHHHHCCCCCCCHHHHCCCEEECCCCCCCCCCCCEEEEEEEEECCCCCC
EFGDFLEFETLTLCPIDTRCVLPALLDDVERAWLNAYHATVRERVGKHVSGDARAWLDAR
CCCCHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCC
TQPI
CCCC
>Mature Secondary Structure
MNARLPDPSPVPARLALLRGAMTREDLAAYVVPSADPHLSEYLPERWQARQWLSGFTGSV
CCCCCCCCCCCHHHHHHHHHHCCHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCC
GTLVVTADFAGLWVDSRYWMQAEAQLAGTGVALMKMVGGQQTQPHVEWLAEHVPEGTTVG
EEEEEEECCCEEEECCCHHEEECHHHHCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEC
VDGAVLGVAAARALTSALTPRGIVLRTDLDLLDAIWPQRPSLPGDAVFEHAAPQADTARA
CCHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHCCCCCCCCCHHHHHHCCCCCCHHHH
GKLAQVRRAMHEQGAQWHFVSTLDDLAWLFNLRGADVNYNPVFVAHALVGLERATLFVAD
HHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCEEEEEEEC
GKVSAELATSLARDGVDVKPYDAAAAALAALPEGAGLLIDPRRVTYGLLQAVPQQVRVIE
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHH
AVNPSTFAKSRKTPAEIEHVRATMEHDGAALAEFFAWFERALGRETITELTIDEQLTAAR
HCCCHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
ARRPGYVSPSFATIAGFNANGAMPHYRATRAAHATIEGDGLLLVDSGGQYLSGTTDITRV
HCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHEEEECCCCEEEECCCCCEECCCCCHHHE
VPVGAIGDAHRRDFTIVLKAMMALSRARFPRGIRSPMLDAIARAPMWAAGLDYGHGTGHG
EEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
VGYFLNVHEGPQVISHYAPAEPYTAMEEGMITSIEPGVYRPGNWGVRIENLVVNRAAGQT
EEEEEEECCCHHHHHHCCCCCCCHHHHCCCEEECCCCCCCCCCCCEEEEEEEEECCCCCC
EFGDFLEFETLTLCPIDTRCVLPALLDDVERAWLNAYHATVRERVGKHVSGDARAWLDAR
CCCCHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCC
TQPI
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]