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The map label for this gene is hemN [H]

Identifier: 126454666

GI number: 126454666

Start: 2718797

End: 2720248

Strand: Reverse

Name: hemN [H]

Synonym: BURPS1106A_2754

Alternate gene names: 126454666

Gene position: 2720248-2718797 (Counterclockwise)

Preceding gene: 126455311

Following gene: 126452853

Centisome position: 68.2

GC content: 66.18

Gene sequence:

>1452_bases
ATGGACATGACAACGCATTCGAACGACGGCGCGGATACGACCGCGCCCGCTCCCCAACACGACGTGTCCGCGTTCGCGGA
CGTTCAGATCTCCGAAGCGCTGATTCGGCGCTTCGACCGGCAAGGGCCGCGCTATACGTCCTATCCGACGGCCGACCGGT
TCTCCGACGCATTCGACGAGCGCGCGTACCGCGAACATCTGTCGCGCCGCGCGTCAGCCGAGCGTAATCCGCCGCTGTCG
GTCTATCTGCATCTGCCGTTTTGCGAGTCGCTCTGCTACTTCTGCGCGTGCAACAAGATCATCACGCAGGATCACACCCG
CACGAGCGCGTACGTCGACTATCTGATCCGCGAAATGGAGCTCGTCGCGCCGGATCTCGGCCGCGATCGGCGGACGACGC
AACTGCATCTGGGCGGCGGCTCGCCGACGTTCTTCGCGATCGACGAGCTCGCGCGCCTGATGCGCGCGCTGCGCGAGCAC
TTCGACTTCGCGCCGCACGCGGAGCTCGGCGTCGAGATCGATCCGCGCACGGTCAACGAGCGCACCCTGCAGTCGCTCGC
GGCGCTCGGCTTCAACCGGACGAGCTTCGGCGTGCAGGACTTCGATCCGTCGGTGCAGGAGGCGGTGCATCGGATCCAGC
CGCTGCCGATGGTCGAGCGCGCGCTCGAGGCGAGCCGCGCGGCCGGTTTCGAATCGGTCAACATCGATCTGATCTACGGG
TTGCCGCGGCAGACGCCCGCGAGCTTTTCGCGCACGCTCGACGAGGTGATCCGGCTGTCGCCCGAGCGCATCGCGGTCTA
CAACTACGCGCATTTGCCGAGCCGCTTCAAGGCGCAGCGCCTGATCGTCGAAGCGCAGCTGCCGCCCGCGGAAGACCGGC
TGCGGATCTTCATCGAATCGACGCGGCGGCTGCTCGACGCGGGCTACGTGTACATCGGGCTCGATCACTTCGCGAAGCCG
AACGACGAGCTCGGCAACGCGCTGCGCGAGCGCAGCCTGCACCGCAATTTCCAGGGCTATACGACGCAGGCCGAATGCGA
TCTCGTCGGCTTCGGCGTATCGGCGATCGGCAAGGTCGGCACCTCGTACAGCCAATCGACGCGCTCGCTGAAGACCTATT
ACCGCCAGCTCGACGCGGGGCGCCTGCCGATCGAGCGGGGCTTCGCGCTGACAGCCGACGATTTGCTGCGCCGCGAAGTC
ATCATGACGGTGATGTGCAGCACACCCGTCGATTTCGCGGAGATCGGCCACAGGCACGGCATCGATTTCGCCCGGTATTT
CGCGCCCGAGCTCGCGCAGCTCGAGCCGTATCGCGACGCGGGGCTGCTCACGATCGATGCGCAGCGCATCGCCGTCACGC
CGAAGGGGCGCATGTTCGTGCGCGCGATCGGCATGGTGTTCGACGCGTATCTCGGCCGCAGCGCCGCGGCGTCTTATTCG
AAATTGATCTAG

Upstream 100 bases:

>100_bases
AGCGCGCGGCGTCGGAGGTTGATTTGCATCAAGTCCGTCCGGGCCGCGCGCCCGACAATGGAACGCCGGCGTTTCGCGCG
GCATGCCAGGGTACAAGCAG

Downstream 100 bases:

>100_bases
AAGGTGGCGTGATGAAGGAAAGCAAGATTCCCGTGCAGGATTTTCTTGCGCGGCTGCCGCTTTTCAGCGTGCTGTCGCGC
GGCGAGCTCGACAATCTCGC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MDMTTHSNDGADTTAPAPQHDVSAFADVQISEALIRRFDRQGPRYTSYPTADRFSDAFDERAYREHLSRRASAERNPPLS
VYLHLPFCESLCYFCACNKIITQDHTRTSAYVDYLIREMELVAPDLGRDRRTTQLHLGGGSPTFFAIDELARLMRALREH
FDFAPHAELGVEIDPRTVNERTLQSLAALGFNRTSFGVQDFDPSVQEAVHRIQPLPMVERALEASRAAGFESVNIDLIYG
LPRQTPASFSRTLDEVIRLSPERIAVYNYAHLPSRFKAQRLIVEAQLPPAEDRLRIFIESTRRLLDAGYVYIGLDHFAKP
NDELGNALRERSLHRNFQGYTTQAECDLVGFGVSAIGKVGTSYSQSTRSLKTYYRQLDAGRLPIERGFALTADDLLRREV
IMTVMCSTPVDFAEIGHRHGIDFARYFAPELAQLEPYRDAGLLTIDAQRIAVTPKGRMFVRAIGMVFDAYLGRSAAASYS
KLI

Sequences:

>Translated_483_residues
MDMTTHSNDGADTTAPAPQHDVSAFADVQISEALIRRFDRQGPRYTSYPTADRFSDAFDERAYREHLSRRASAERNPPLS
VYLHLPFCESLCYFCACNKIITQDHTRTSAYVDYLIREMELVAPDLGRDRRTTQLHLGGGSPTFFAIDELARLMRALREH
FDFAPHAELGVEIDPRTVNERTLQSLAALGFNRTSFGVQDFDPSVQEAVHRIQPLPMVERALEASRAAGFESVNIDLIYG
LPRQTPASFSRTLDEVIRLSPERIAVYNYAHLPSRFKAQRLIVEAQLPPAEDRLRIFIESTRRLLDAGYVYIGLDHFAKP
NDELGNALRERSLHRNFQGYTTQAECDLVGFGVSAIGKVGTSYSQSTRSLKTYYRQLDAGRLPIERGFALTADDLLRREV
IMTVMCSTPVDFAEIGHRHGIDFARYFAPELAQLEPYRDAGLLTIDAQRIAVTPKGRMFVRAIGMVFDAYLGRSAAASYS
KLI
>Mature_483_residues
MDMTTHSNDGADTTAPAPQHDVSAFADVQISEALIRRFDRQGPRYTSYPTADRFSDAFDERAYREHLSRRASAERNPPLS
VYLHLPFCESLCYFCACNKIITQDHTRTSAYVDYLIREMELVAPDLGRDRRTTQLHLGGGSPTFFAIDELARLMRALREH
FDFAPHAELGVEIDPRTVNERTLQSLAALGFNRTSFGVQDFDPSVQEAVHRIQPLPMVERALEASRAAGFESVNIDLIYG
LPRQTPASFSRTLDEVIRLSPERIAVYNYAHLPSRFKAQRLIVEAQLPPAEDRLRIFIESTRRLLDAGYVYIGLDHFAKP
NDELGNALRERSLHRNFQGYTTQAECDLVGFGVSAIGKVGTSYSQSTRSLKTYYRQLDAGRLPIERGFALTADDLLRREV
IMTVMCSTPVDFAEIGHRHGIDFARYFAPELAQLEPYRDAGLLTIDAQRIAVTPKGRMFVRAIGMVFDAYLGRSAAASYS
KLI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=191, Percent_Identity=24.6073298429319, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI87082341, Length=452, Percent_Identity=47.787610619469, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI1789325, Length=297, Percent_Identity=28.2828282828283, Blast_Score=112, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 54442; Mature: 54442

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMTTHSNDGADTTAPAPQHDVSAFADVQISEALIRRFDRQGPRYTSYPTADRFSDAFDE
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
RAYREHLSRRASAERNPPLSVYLHLPFCESLCYFCACNKIITQDHTRTSAYVDYLIREME
HHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LVAPDLGRDRRTTQLHLGGGSPTFFAIDELARLMRALREHFDFAPHAELGVEIDPRTVNE
HHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCH
RTLQSLAALGFNRTSFGVQDFDPSVQEAVHRIQPLPMVERALEASRAAGFESVNIDLIYG
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEC
LPRQTPASFSRTLDEVIRLSPERIAVYNYAHLPSRFKAQRLIVEAQLPPAEDRLRIFIES
CCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHEEEEECCCCCHHHHHHHHHH
TRRLLDAGYVYIGLDHFAKPNDELGNALRERSLHRNFQGYTTQAECDLVGFGVSAIGKVG
HHHHHHCCEEEEEHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHC
TSYSQSTRSLKTYYRQLDAGRLPIERGFALTADDLLRREVIMTVMCSTPVDFAEIGHRHG
CCHHHHHHHHHHHHHHHCCCCCCHHCCCEECHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
IDFARYFAPELAQLEPYRDAGLLTIDAQRIAVTPKGRMFVRAIGMVFDAYLGRSAAASYS
CCHHHHHCCHHHHCCCCCCCCEEEEECCEEEECCCCHHHHHHHHHHHHHHHCHHHHHHHH
KLI
HCC
>Mature Secondary Structure
MDMTTHSNDGADTTAPAPQHDVSAFADVQISEALIRRFDRQGPRYTSYPTADRFSDAFDE
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
RAYREHLSRRASAERNPPLSVYLHLPFCESLCYFCACNKIITQDHTRTSAYVDYLIREME
HHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LVAPDLGRDRRTTQLHLGGGSPTFFAIDELARLMRALREHFDFAPHAELGVEIDPRTVNE
HHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCH
RTLQSLAALGFNRTSFGVQDFDPSVQEAVHRIQPLPMVERALEASRAAGFESVNIDLIYG
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEC
LPRQTPASFSRTLDEVIRLSPERIAVYNYAHLPSRFKAQRLIVEAQLPPAEDRLRIFIES
CCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHEEEEECCCCCHHHHHHHHHH
TRRLLDAGYVYIGLDHFAKPNDELGNALRERSLHRNFQGYTTQAECDLVGFGVSAIGKVG
HHHHHHCCEEEEEHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHC
TSYSQSTRSLKTYYRQLDAGRLPIERGFALTADDLLRREVIMTVMCSTPVDFAEIGHRHG
CCHHHHHHHHHHHHHHHCCCCCCHHCCCEECHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
IDFARYFAPELAQLEPYRDAGLLTIDAQRIAVTPKGRMFVRAIGMVFDAYLGRSAAASYS
CCHHHHHCCHHHHCCCCCCCCEEEEECCEEEECCCCHHHHHHHHHHHHHHHCHHHHHHHH
KLI
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9396835 [H]