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The map label for this gene is prlC [H]

Identifier: 126454502

GI number: 126454502

Start: 2636114

End: 2638213

Strand: Direct

Name: prlC [H]

Synonym: BURPS1106A_2674

Alternate gene names: 126454502

Gene position: 2636114-2638213 (Clockwise)

Preceding gene: 126454518

Following gene: 126452085

Centisome position: 66.09

GC content: 68.24

Gene sequence:

>2100_bases
ATGTCCGTCAGCGCAAACGCCAACCCGCTTCTCGATTTTTCAGGCCTGCCCCGCTTCGGCGAAATTCGCCCCGAACACGT
GACGCCCGCGCTCGATACGCTGCTCGCGAACGCAAACGACGCAGTCGAGCAAGCCGCGCGGCCCGACACGCCCGCGACCT
GGGCCGATGTCGTCGAGACCATCGAGCAGGCGACCGAGCCGCTCGGCCGCGCGTGGGGCGTCGTGGGCCATCTGAACGCG
GTCGCCGACACGCCCGAGCTGCGCGCCGTCTACGGCGAGAACCTGCCGCGCGTGACCGAGTTCTGGTCGAGCGTCGGCCA
GAATCTCGCGCTCTACGAAAAGTACAAGGCGATCGCCGCGAGCCCCGAATACGCCGCGCTGTCCGCCGAGCGCAAGAAGA
TCCTCGACAACGCGCTGCGCGACTTCCGCCTGTCGGGCGCCGAGCTGCCGGAGGACCGCAAGCCGCGCTTCGCTCAGTTG
CAGGAGCAGCAGGCGGCGCTGTCGAAGTCGTTCTCCGATCACGTGCTCGACGCGACGAACGGCTACGCGTACTACGCGCG
CAGCGAGGACGAACTGGCCGGCCTGCCCGACGACGCGATCGCGGCCGCGCGCGAGGCCGCGCGAAAGGAAGACAAGGCCG
GCTGGAAGTTCACGCTGCACTTCCCGTCGTATTTCCCGGTGCTGCAATACGCGCGGAACCGCGCGATGCGCGAGGCGATG
TATCGCGCGTACGTGACGCGCGCGTCCGAGCTCGGCCCGCAGTACGGCGACGGCAAGGCCGACTGGGACAACACGACGAT
CATCGCGGATCAGCTCGCGCTGCGCCGCGAAGAGGCGACGATGCTCGGCTATCACGACTTCGCCGAAGTGTCGCTCGCGC
CGAAGATGGCGGAATCGCCGCAGCAGGTGATCGCGTTCCTCGAGGATCTCGCGAAGCGCGCGCGCCCGTTCGCGGAAAAA
GACTGGGACGAGCTGCGCGCGTTCGCGTCGAGCGAGCTCGGCCTCGCCGCGCTCGAGCCGTGGGACGTCGCGTACGCGGC
CGAGAAGCTGCGCGAGCGGCGCTACGCGTTCTCCGAGAACGAGGTGAAGCAGTATTTCCCCGAGCCGGCGGTGCTCAAGG
GGCTTTTCACGGTCGCCGAGACGCTGTTCGGCGTGCGGATCACGCGCGACGACGCGCCCGTCTGGCATGAGGACGTGCGC
TTCTTCCGCGTCGAGAACCGCGACGGCTCGCTCGTCGCGCAGTTCTATCTCGACCTGTACGCACGCGAAGGCAAGCGCGG
CGGCGCGTGGATGGACGACGCGCGCTCGCGCGCGAAGCGCGGCGACGGCCGCGTGCAGACGCCCGTCGCGTACCTGACCT
GCAACTTCTCCGCGCCGATCGGCGGCAAGCCCGCGTGCTTCACGCACGACGAAGTAATCACGCTGTTCCACGAGTTCGGC
CACGGGCTGCATCACATGCTCACGCGCGTCGACGAGATCGGCGTGTCCGGCATCAACGGCGTCGAATGGGACGCGGTCGA
GCTGCCGTCGCAGTTCATGGAGAACTTCTGCTGGGAGTGGGACGTGCTGAAGTCGATGTCGTCGCACGTCGACACGGGCG
ACGCGCTGCCGCGCGTGCTCTTCGACAAGATGCTCGCCGCGAAGAACTTCCAGAGCGGCCTCGGCACGCTGCGCCAGATC
GTGTTCTCGATGTTCGACATGCTGCTGCACGTCGATTTCGATCCGGCCGGCAAGACGAGCGTCAACGAGTTCGCGCGCGA
GATCAACGAGCGCTTCCACGTGATTGCGCAGGCGCCGTTCTCGCGCTGGCCGAACACGTTCAGCCACATCTTCGCGGGCG
GCTACGCGGCCGGCTACTACAGCTACAAGTGGGCCGAAGTGCTGTCCGCCGACGCATACGCGGCGTTCGAGGAAGCGGCC
GGCTCGGCGGGCAGCGTGCTCGATGCGACGACGGGCGCGCGCTATCGGCGCGAGATCCTCGAGGTCGGCGGCAGCCGCCC
GGCGATGGACTCGTTCAAGGCGTTCCGCGGCCGCGAGCCGAACATCGACGCGCTGCTGCGCCACAGCGGGATGGCCGACG
ACGCACAGGCGCGCGCGTAA

Upstream 100 bases:

>100_bases
AGCGCACGATGCGCCCCAATAATGTCGACATGACGAGACGGCCGCCGCCGTGCGCCGCCGTCTTCCGCCCAACCCGAAAC
CAAAACCGCCAGGGAGCACT

Downstream 100 bases:

>100_bases
TGCGCGCGGCGGCGAGCACGCCCCGCCGAACGAACGGCCCGATGATCGGCTGACGGCGCGCGCGGCCGATCGCCGGCCCG
GCGACGAGCGGCGGCAAGCG

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 699; Mature: 698

Protein sequence:

>699_residues
MSVSANANPLLDFSGLPRFGEIRPEHVTPALDTLLANANDAVEQAARPDTPATWADVVETIEQATEPLGRAWGVVGHLNA
VADTPELRAVYGENLPRVTEFWSSVGQNLALYEKYKAIAASPEYAALSAERKKILDNALRDFRLSGAELPEDRKPRFAQL
QEQQAALSKSFSDHVLDATNGYAYYARSEDELAGLPDDAIAAAREAARKEDKAGWKFTLHFPSYFPVLQYARNRAMREAM
YRAYVTRASELGPQYGDGKADWDNTTIIADQLALRREEATMLGYHDFAEVSLAPKMAESPQQVIAFLEDLAKRARPFAEK
DWDELRAFASSELGLAALEPWDVAYAAEKLRERRYAFSENEVKQYFPEPAVLKGLFTVAETLFGVRITRDDAPVWHEDVR
FFRVENRDGSLVAQFYLDLYAREGKRGGAWMDDARSRAKRGDGRVQTPVAYLTCNFSAPIGGKPACFTHDEVITLFHEFG
HGLHHMLTRVDEIGVSGINGVEWDAVELPSQFMENFCWEWDVLKSMSSHVDTGDALPRVLFDKMLAAKNFQSGLGTLRQI
VFSMFDMLLHVDFDPAGKTSVNEFAREINERFHVIAQAPFSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAA
GSAGSVLDATTGARYRREILEVGGSRPAMDSFKAFRGREPNIDALLRHSGMADDAQARA

Sequences:

>Translated_699_residues
MSVSANANPLLDFSGLPRFGEIRPEHVTPALDTLLANANDAVEQAARPDTPATWADVVETIEQATEPLGRAWGVVGHLNA
VADTPELRAVYGENLPRVTEFWSSVGQNLALYEKYKAIAASPEYAALSAERKKILDNALRDFRLSGAELPEDRKPRFAQL
QEQQAALSKSFSDHVLDATNGYAYYARSEDELAGLPDDAIAAAREAARKEDKAGWKFTLHFPSYFPVLQYARNRAMREAM
YRAYVTRASELGPQYGDGKADWDNTTIIADQLALRREEATMLGYHDFAEVSLAPKMAESPQQVIAFLEDLAKRARPFAEK
DWDELRAFASSELGLAALEPWDVAYAAEKLRERRYAFSENEVKQYFPEPAVLKGLFTVAETLFGVRITRDDAPVWHEDVR
FFRVENRDGSLVAQFYLDLYAREGKRGGAWMDDARSRAKRGDGRVQTPVAYLTCNFSAPIGGKPACFTHDEVITLFHEFG
HGLHHMLTRVDEIGVSGINGVEWDAVELPSQFMENFCWEWDVLKSMSSHVDTGDALPRVLFDKMLAAKNFQSGLGTLRQI
VFSMFDMLLHVDFDPAGKTSVNEFAREINERFHVIAQAPFSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAA
GSAGSVLDATTGARYRREILEVGGSRPAMDSFKAFRGREPNIDALLRHSGMADDAQARA
>Mature_698_residues
SVSANANPLLDFSGLPRFGEIRPEHVTPALDTLLANANDAVEQAARPDTPATWADVVETIEQATEPLGRAWGVVGHLNAV
ADTPELRAVYGENLPRVTEFWSSVGQNLALYEKYKAIAASPEYAALSAERKKILDNALRDFRLSGAELPEDRKPRFAQLQ
EQQAALSKSFSDHVLDATNGYAYYARSEDELAGLPDDAIAAAREAARKEDKAGWKFTLHFPSYFPVLQYARNRAMREAMY
RAYVTRASELGPQYGDGKADWDNTTIIADQLALRREEATMLGYHDFAEVSLAPKMAESPQQVIAFLEDLAKRARPFAEKD
WDELRAFASSELGLAALEPWDVAYAAEKLRERRYAFSENEVKQYFPEPAVLKGLFTVAETLFGVRITRDDAPVWHEDVRF
FRVENRDGSLVAQFYLDLYAREGKRGGAWMDDARSRAKRGDGRVQTPVAYLTCNFSAPIGGKPACFTHDEVITLFHEFGH
GLHHMLTRVDEIGVSGINGVEWDAVELPSQFMENFCWEWDVLKSMSSHVDTGDALPRVLFDKMLAAKNFQSGLGTLRQIV
FSMFDMLLHVDFDPAGKTSVNEFAREINERFHVIAQAPFSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAG
SAGSVLDATTGARYRREILEVGGSRPAMDSFKAFRGREPNIDALLRHSGMADDAQARA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=621, Percent_Identity=32.0450885668277, Blast_Score=308, Evalue=8e-84,
Organism=Homo sapiens, GI14149738, Length=620, Percent_Identity=31.7741935483871, Blast_Score=292, Evalue=9e-79,
Organism=Homo sapiens, GI156105687, Length=647, Percent_Identity=24.5749613601236, Blast_Score=168, Evalue=1e-41,
Organism=Escherichia coli, GI1789913, Length=686, Percent_Identity=49.4169096209913, Blast_Score=680, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=695, Percent_Identity=30.9352517985612, Blast_Score=276, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI71999758, Length=486, Percent_Identity=26.1316872427983, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI32565901, Length=591, Percent_Identity=20.9813874788494, Blast_Score=95, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319793, Length=689, Percent_Identity=27.7213352685051, Blast_Score=285, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6322715, Length=606, Percent_Identity=24.9174917491749, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21356111, Length=704, Percent_Identity=26.4204545454545, Blast_Score=239, Evalue=6e-63,
Organism=Drosophila melanogaster, GI20129717, Length=556, Percent_Identity=24.8201438848921, Blast_Score=159, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 77977; Mature: 77846

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSANANPLLDFSGLPRFGEIRPEHVTPALDTLLANANDAVEQAARPDTPATWADVVET
CCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHH
IEQATEPLGRAWGVVGHLNAVADTPELRAVYGENLPRVTEFWSSVGQNLALYEKYKAIAA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHC
SPEYAALSAERKKILDNALRDFRLSGAELPEDRKPRFAQLQEQQAALSKSFSDHVLDATN
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GYAYYARSEDELAGLPDDAIAAAREAARKEDKAGWKFTLHFPSYFPVLQYARNRAMREAM
CEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
YRAYVTRASELGPQYGDGKADWDNTTIIADQLALRREEATMLGYHDFAEVSLAPKMAESP
HHHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHCCCHHHCCH
QQVIAFLEDLAKRARPFAEKDWDELRAFASSELGLAALEPWDVAYAAEKLRERRYAFSEN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHCCCHH
EVKQYFPEPAVLKGLFTVAETLFGVRITRDDAPVWHEDVRFFRVENRDGSLVAQFYLDLY
HHHHHCCCHHHHHHHHHHHHHHHCCEEECCCCCCHHHCCEEEEEECCCCHHHHHHHHHHH
AREGKRGGAWMDDARSRAKRGDGRVQTPVAYLTCNFSAPIGGKPACFTHDEVITLFHEFG
HHCCCCCCCCHHHHHHHHHCCCCCEECCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHH
HGLHHMLTRVDEIGVSGINGVEWDAVELPSQFMENFCWEWDVLKSMSSHVDTGDALPRVL
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHH
FDKMLAAKNFQSGLGTLRQIVFSMFDMLLHVDFDPAGKTSVNEFAREINERFHVIAQAPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCH
SRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAGSAGSVLDATTGARYRREIL
HHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHH
EVGGSRPAMDSFKAFRGREPNIDALLRHSGMADDAQARA
HCCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCHHHCCC
>Mature Secondary Structure 
SVSANANPLLDFSGLPRFGEIRPEHVTPALDTLLANANDAVEQAARPDTPATWADVVET
CCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHH
IEQATEPLGRAWGVVGHLNAVADTPELRAVYGENLPRVTEFWSSVGQNLALYEKYKAIAA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHC
SPEYAALSAERKKILDNALRDFRLSGAELPEDRKPRFAQLQEQQAALSKSFSDHVLDATN
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GYAYYARSEDELAGLPDDAIAAAREAARKEDKAGWKFTLHFPSYFPVLQYARNRAMREAM
CEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
YRAYVTRASELGPQYGDGKADWDNTTIIADQLALRREEATMLGYHDFAEVSLAPKMAESP
HHHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHCCCHHHCCH
QQVIAFLEDLAKRARPFAEKDWDELRAFASSELGLAALEPWDVAYAAEKLRERRYAFSEN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHCCCHH
EVKQYFPEPAVLKGLFTVAETLFGVRITRDDAPVWHEDVRFFRVENRDGSLVAQFYLDLY
HHHHHCCCHHHHHHHHHHHHHHHCCEEECCCCCCHHHCCEEEEEECCCCHHHHHHHHHHH
AREGKRGGAWMDDARSRAKRGDGRVQTPVAYLTCNFSAPIGGKPACFTHDEVITLFHEFG
HHCCCCCCCCHHHHHHHHHCCCCCEECCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHH
HGLHHMLTRVDEIGVSGINGVEWDAVELPSQFMENFCWEWDVLKSMSSHVDTGDALPRVL
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHH
FDKMLAAKNFQSGLGTLRQIVFSMFDMLLHVDFDPAGKTSVNEFAREINERFHVIAQAPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCH
SRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAGSAGSVLDATTGARYRREIL
HHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHH
EVGGSRPAMDSFKAFRGREPNIDALLRHSGMADDAQARA
HCCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]