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The map label for this gene is nadB [H]

Identifier: 126454473

GI number: 126454473

Start: 963378

End: 965090

Strand: Reverse

Name: nadB [H]

Synonym: BURPS1106A_0980

Alternate gene names: 126454473

Gene position: 965090-963378 (Counterclockwise)

Preceding gene: 126453616

Following gene: 126451803

Centisome position: 24.2

GC content: 67.54

Gene sequence:

>1713_bases
TTGCGTTGGCGCGCGCGCAAGCGCTTCTGCGACGCGGTATGCTCTGCCCTTTCCGCCGCATTGCGCATGGCGGGAAAGAT
AAGACAAAACGCGCAAGAAACGGAGATGCAGATGAATTTCGATGTGGCGATCGTGGGCAGCGGCCTCGCCGGCCTGTCGG
TCGCGCTCAATCTCGCGCAAACACGGCGCGTCGCGCTGATCGCGAAGCGCTCGATGATGGAAGGCGCGAGCGACTACGCT
CAGGGCGGCATCGCCGCGGTGCTCGATTCGGCGGACAGCGTCGAGAATCACGTGAACGACACGCTGATCGCGGGCGGCGG
CCTGTGTGACGAAGCGGCGACGCGCTACATCGTCGAGCACGGCCGCGAGGCAATCGAGTGGCTGATCTCGCAGGGCGTGC
CGTTCACGAAGGACGATGCCGCCGAACTCGGCTTTCATCTGACGCGCGAAGGCGGCCACAGCCATCGCCGCATCATCCAC
GCGGCCGACGCGACAGGCCATGCGGTGCTCGCGACGCTGTCCGAGCGCGCCCGCGCGCACCCGAACATCACGTTCTTCGA
AGATCACCACGCGATCGACCTGATCACCTCCGATCGCCTCGGGCTGCCTGGCCTGCCGGGCCGGCACTGCGTCGGCCTCT
ATGCGCTCGACGTGCAGACGGGCCGGACGATGACGATCGAGGCGCCGCACACGGTGCTCGCGACGGGCGGCGCGGGCAAG
GTCTATCTGTACACGACGAACCCGGACACCGCGACGGGCGACGGCATCGCGATGGCGTGGCGCGCGGGCGCCCGCGTCGC
GAACATGGAGTTCATCCAGTTCCATCCGACCTGCCTCTTCCATCCGTATGCGAAATCGTTCCTGATTTCCGAGGCGGTGC
GCGGCGAAGGCGGCCTCCTCAAGCTGCCGGACGGCACCCGCTTCATGCCCGCGCACGATCCGCGCGCGGAGCTCGCGCCG
CGCGACATCGTCGCGCGCGCGATCGATTTCGAGATCAAGAAGCGCGGGATCGACTGCGTGTATCTCGACATCAGCCACCA
GCCCGAAGCGTTCCTGCGCGAGCATTTCCCGACGATCTACGCACGCTGCGCCGAGTTCGGCATCGACATCTCGAAACAGC
CGATCCCGGTCGTGCCGGCCGCGCATTACACGTGCGGCGGCGTCGTCACCGATCTGGCCGGGCGCACCGACATCACGGGC
CTATACGCGGTCGGCGAAACGTCGTACACGGGCCTGCACGGCGCGAACCGCCTCGCGAGCAATTCGCTGCTCGAATGCCT
CGTGATCGGCCGCGCGACGGCCGAGGCCATCGAAGCCGCCGGCTATGATTCGGCGACGCACGGCCCGTTGCCCGCGTGGG
ACGAGAGCCGCGTGGCGGACGCCGACGAGGAAGTGGTCGTCGCGCACAACTGGGACGAACTGCGCCGCCTGATGTGGAAC
TACGTCGGCATCGTGCGCACCGACAAGCGCCTCGAGCGCGCGCAACATCGGCTCAAGCTGCTGCGCGACGAGATTCACGA
GTACTACGCGAACTTCCGCGTGAGTCGCGACCTGCTCGAGCTGCGCAATCTCGTCGATGTCGCGTCGCTGATCGTCGACA
GCGCGCGGGCTCGCCACGAAAGCCGCGGGCTGCACTACAGCCGCGACTGGCCGCACGCGTTGCCGAAGGCGCTGCCGACC
GTGCTCACGCCGCCGCGGCGCGCATCGAAGTAA

Upstream 100 bases:

>100_bases
TCGCCCGCAAGCACGTGGCGTACAAGGAAACCAAGATCAAGTAATTCTCCGGTTTCGACGAGCCTGACGATGACGAAAAG
CCCCGCAAACGCGGGGCTTT

Downstream 100 bases:

>100_bases
CGCGAAGCGACGATCGCCGGCCACGCGCCACGCGCGCCGGCAAGCGGCTCACGAGGCAAAAAAGGCCGCCCGCGCGCCAC
GCGCCGGCGGCCTTGCCTCG

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO 1; Quinolinate synthase B 1 [H]

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MRWRARKRFCDAVCSALSAALRMAGKIRQNAQETEMQMNFDVAIVGSGLAGLSVALNLAQTRRVALIAKRSMMEGASDYA
QGGIAAVLDSADSVENHVNDTLIAGGGLCDEAATRYIVEHGREAIEWLISQGVPFTKDDAAELGFHLTREGGHSHRRIIH
AADATGHAVLATLSERARAHPNITFFEDHHAIDLITSDRLGLPGLPGRHCVGLYALDVQTGRTMTIEAPHTVLATGGAGK
VYLYTTNPDTATGDGIAMAWRAGARVANMEFIQFHPTCLFHPYAKSFLISEAVRGEGGLLKLPDGTRFMPAHDPRAELAP
RDIVARAIDFEIKKRGIDCVYLDISHQPEAFLREHFPTIYARCAEFGIDISKQPIPVVPAAHYTCGGVVTDLAGRTDITG
LYAVGETSYTGLHGANRLASNSLLECLVIGRATAEAIEAAGYDSATHGPLPAWDESRVADADEEVVVAHNWDELRRLMWN
YVGIVRTDKRLERAQHRLKLLRDEIHEYYANFRVSRDLLELRNLVDVASLIVDSARARHESRGLHYSRDWPHALPKALPT
VLTPPRRASK

Sequences:

>Translated_570_residues
MRWRARKRFCDAVCSALSAALRMAGKIRQNAQETEMQMNFDVAIVGSGLAGLSVALNLAQTRRVALIAKRSMMEGASDYA
QGGIAAVLDSADSVENHVNDTLIAGGGLCDEAATRYIVEHGREAIEWLISQGVPFTKDDAAELGFHLTREGGHSHRRIIH
AADATGHAVLATLSERARAHPNITFFEDHHAIDLITSDRLGLPGLPGRHCVGLYALDVQTGRTMTIEAPHTVLATGGAGK
VYLYTTNPDTATGDGIAMAWRAGARVANMEFIQFHPTCLFHPYAKSFLISEAVRGEGGLLKLPDGTRFMPAHDPRAELAP
RDIVARAIDFEIKKRGIDCVYLDISHQPEAFLREHFPTIYARCAEFGIDISKQPIPVVPAAHYTCGGVVTDLAGRTDITG
LYAVGETSYTGLHGANRLASNSLLECLVIGRATAEAIEAAGYDSATHGPLPAWDESRVADADEEVVVAHNWDELRRLMWN
YVGIVRTDKRLERAQHRLKLLRDEIHEYYANFRVSRDLLELRNLVDVASLIVDSARARHESRGLHYSRDWPHALPKALPT
VLTPPRRASK
>Mature_570_residues
MRWRARKRFCDAVCSALSAALRMAGKIRQNAQETEMQMNFDVAIVGSGLAGLSVALNLAQTRRVALIAKRSMMEGASDYA
QGGIAAVLDSADSVENHVNDTLIAGGGLCDEAATRYIVEHGREAIEWLISQGVPFTKDDAAELGFHLTREGGHSHRRIIH
AADATGHAVLATLSERARAHPNITFFEDHHAIDLITSDRLGLPGLPGRHCVGLYALDVQTGRTMTIEAPHTVLATGGAGK
VYLYTTNPDTATGDGIAMAWRAGARVANMEFIQFHPTCLFHPYAKSFLISEAVRGEGGLLKLPDGTRFMPAHDPRAELAP
RDIVARAIDFEIKKRGIDCVYLDISHQPEAFLREHFPTIYARCAEFGIDISKQPIPVVPAAHYTCGGVVTDLAGRTDITG
LYAVGETSYTGLHGANRLASNSLLECLVIGRATAEAIEAAGYDSATHGPLPAWDESRVADADEEVVVAHNWDELRRLMWN
YVGIVRTDKRLERAQHRLKLLRDEIHEYYANFRVSRDLLELRNLVDVASLIVDSARARHESRGLHYSRDWPHALPKALPT
VLTPPRRASK

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=509, Percent_Identity=34.7740667976424, Blast_Score=236, Evalue=6e-62,
Organism=Escherichia coli, GI1788928, Length=526, Percent_Identity=59.1254752851711, Blast_Score=630, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=526, Percent_Identity=36.5019011406844, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1786942, Length=553, Percent_Identity=33.996383363472, Blast_Score=226, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17550100, Length=533, Percent_Identity=34.5215759849906, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17505833, Length=528, Percent_Identity=32.9545454545455, Blast_Score=234, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI71986328, Length=462, Percent_Identity=29.4372294372294, Blast_Score=104, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322701, Length=529, Percent_Identity=33.648393194707, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6322416, Length=583, Percent_Identity=32.2469982847341, Blast_Score=232, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6322511, Length=481, Percent_Identity=26.4033264033264, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320788, Length=479, Percent_Identity=26.5135699373695, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI17137288, Length=539, Percent_Identity=33.5807050092764, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24655642, Length=539, Percent_Identity=33.5807050092764, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24655647, Length=539, Percent_Identity=33.5807050092764, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24663005, Length=555, Percent_Identity=32.4324324324324, Blast_Score=225, Evalue=5e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 62501; Mature: 62501

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWRARKRFCDAVCSALSAALRMAGKIRQNAQETEMQMNFDVAIVGSGLAGLSVALNLAQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEECCEEEEEECCHHHHHHHHHHHH
TRRVALIAKRSMMEGASDYAQGGIAAVLDSADSVENHVNDTLIAGGGLCDEAATRYIVEH
HHHHHHHHHHHHHHCCHHHHCCCHHEECCCHHHHHHHCCCEEEECCCCCHHHHHHHHHHH
GREAIEWLISQGVPFTKDDAAELGFHLTREGGHSHRRIIHAADATGHAVLATLSERARAH
HHHHHHHHHHCCCCCCCCCHHHHCEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHCC
PNITFFEDHHAIDLITSDRLGLPGLPGRHCVGLYALDVQTGRTMTIEAPHTVLATGGAGK
CCEEEEECCCEEEEEECCCCCCCCCCCCCEEEEEEEEECCCCEEEEECCCEEEEECCCCE
VYLYTTNPDTATGDGIAMAWRAGARVANMEFIQFHPTCLFHPYAKSFLISEAVRGEGGLL
EEEEECCCCCCCCCCEEEEECCCCEEECEEEEEECCCEEECHHHHHHHHHHHHCCCCCEE
KLPDGTRFMPAHDPRAELAPRDIVARAIDFEIKKRGIDCVYLDISHQPEAFLREHFPTIY
ECCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHH
ARCAEFGIDISKQPIPVVPAAHYTCGGVVTDLAGRTDITGLYAVGETSYTGLHGANRLAS
HHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHH
NSLLECLVIGRATAEAIEAAGYDSATHGPLPAWDESRVADADEEVVVAHNWDELRRLMWN
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHH
YVGIVRTDKRLERAQHRLKLLRDEIHEYYANFRVSRDLLELRNLVDVASLIVDSARARHE
HHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRGLHYSRDWPHALPKALPTVLTPPRRASK
HCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRWRARKRFCDAVCSALSAALRMAGKIRQNAQETEMQMNFDVAIVGSGLAGLSVALNLAQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEECCEEEEEECCHHHHHHHHHHHH
TRRVALIAKRSMMEGASDYAQGGIAAVLDSADSVENHVNDTLIAGGGLCDEAATRYIVEH
HHHHHHHHHHHHHHCCHHHHCCCHHEECCCHHHHHHHCCCEEEECCCCCHHHHHHHHHHH
GREAIEWLISQGVPFTKDDAAELGFHLTREGGHSHRRIIHAADATGHAVLATLSERARAH
HHHHHHHHHHCCCCCCCCCHHHHCEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHCC
PNITFFEDHHAIDLITSDRLGLPGLPGRHCVGLYALDVQTGRTMTIEAPHTVLATGGAGK
CCEEEEECCCEEEEEECCCCCCCCCCCCCEEEEEEEEECCCCEEEEECCCEEEEECCCCE
VYLYTTNPDTATGDGIAMAWRAGARVANMEFIQFHPTCLFHPYAKSFLISEAVRGEGGLL
EEEEECCCCCCCCCCEEEEECCCCEEECEEEEEECCCEEECHHHHHHHHHHHHCCCCCEE
KLPDGTRFMPAHDPRAELAPRDIVARAIDFEIKKRGIDCVYLDISHQPEAFLREHFPTIY
ECCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHH
ARCAEFGIDISKQPIPVVPAAHYTCGGVVTDLAGRTDITGLYAVGETSYTGLHGANRLAS
HHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHH
NSLLECLVIGRATAEAIEAAGYDSATHGPLPAWDESRVADADEEVVVAHNWDELRRLMWN
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHH
YVGIVRTDKRLERAQHRLKLLRDEIHEYYANFRVSRDLLELRNLVDVASLIVDSARARHE
HHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRGLHYSRDWPHALPKALPTVLTPPRRASK
HCCCCCCCCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]