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The map label for this gene is msrA [H]

Identifier: 126454402

GI number: 126454402

Start: 885280

End: 886179

Strand: Direct

Name: msrA [H]

Synonym: BURPS1106A_0900

Alternate gene names: 126454402

Gene position: 885280-886179 (Clockwise)

Preceding gene: 126452736

Following gene: 126455086

Centisome position: 22.2

GC content: 68.67

Gene sequence:

>900_bases
GTGGCGAGCGGAACGGGCGGCGGTGCCGCGGGCGAAATGGCGGGAAGGGAGCAGGGCGGTCATCGGGAAATTCGTCTGGT
TAGTGACGATTTTAGCGGCAATCGTGTACGACTGCGACGGGCCGCCGCGCCCCGCGCGTGCCGCGAGTGGCCGGCGCCAC
ATTTTGCGCGGCGGGCGGCGCGTTGCGGCGCGGCCGCGCCGCCGGGCGAGGAGGGCGCGCCGCGCCGGCCTGCCGATGCG
GCGCGTGCCCGCGGCGAAGCGGGGCGCGCGGCGCACGACGGCGAGCGTCGCGCGCCGCCGCACGGCGAACGAAACGAACG
AAACGAACGAAAGGAAACCGATATGAGCGAAGCAACGAGCGAAGTCGCGACGCTGGGCGGCGGATGCTTCTGGTGCCAGG
AAGCGGTGTTTCTCGATGTCGACGGCGTGACGGCCGTCGAATCCGGCTACGCGGGCGGCCATACGCGCAACCCCGGCTAC
CGCGACGTGTGCGACGGCGACACGGGCCATGCGGAGGTCGTCAGCGTGAGCTTCGATCCGGCCCGGATCGGCTACCGCGA
GATCCTCGAGATCTTTTTCGCCACGCACGATCCGACGCAGTTGAACCGGCAGGGCAACGACGTCGGCACGCAGTACCGGT
CGGTGATCTTCACGCATTCGGATGCGCAGCGCGACGCGGCGCTCGAGCTGATCCGCACGCTGGAGCGCGATAAGCTGTAC
GACGATCCGATCGTCACGCAGGTCGAGCCGCTGAACGGCAATTACTGGCCCGCGGAGGCATATCACCAGAACTATTACGC
GCGCAATCCCGGGCAGGGCTATTGCGCGGTCGTGATCGGCCCGAAGCTTGCGAAGTTCCGGCAGAAGTTCGCGCATCGGC
TGAAGTCGCGCGGCGCTTGA

Upstream 100 bases:

>100_bases
AACTGGCCGAGCGCTTGACGAAACGCGGCGGTATCGAAATTCGGCGGGCTCGCCTGTAGGTGTTTCATCGCGTGACGGCC
TCGAGCGACGGGCGCGCGCG

Downstream 100 bases:

>100_bases
GGGCCGCGCCGGATGGCCGCGCGCGGCCCGCGCGACGGCCGAACGTCACGGCCGCGCGTGATGCCGGCAGGCAGGGCGTT
GCCGGCGCGCGTCGCGTTGT

Product: methionine-S-sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MASGTGGGAAGEMAGREQGGHREIRLVSDDFSGNRVRLRRAAAPRACREWPAPHFARRAARCGAAAPPGEEGAPRRPADA
ARARGEAGRAAHDGERRAPPHGERNERNERKETDMSEATSEVATLGGGCFWCQEAVFLDVDGVTAVESGYAGGHTRNPGY
RDVCDGDTGHAEVVSVSFDPARIGYREILEIFFATHDPTQLNRQGNDVGTQYRSVIFTHSDAQRDAALELIRTLERDKLY
DDPIVTQVEPLNGNYWPAEAYHQNYYARNPGQGYCAVVIGPKLAKFRQKFAHRLKSRGA

Sequences:

>Translated_299_residues
MASGTGGGAAGEMAGREQGGHREIRLVSDDFSGNRVRLRRAAAPRACREWPAPHFARRAARCGAAAPPGEEGAPRRPADA
ARARGEAGRAAHDGERRAPPHGERNERNERKETDMSEATSEVATLGGGCFWCQEAVFLDVDGVTAVESGYAGGHTRNPGY
RDVCDGDTGHAEVVSVSFDPARIGYREILEIFFATHDPTQLNRQGNDVGTQYRSVIFTHSDAQRDAALELIRTLERDKLY
DDPIVTQVEPLNGNYWPAEAYHQNYYARNPGQGYCAVVIGPKLAKFRQKFAHRLKSRGA
>Mature_298_residues
ASGTGGGAAGEMAGREQGGHREIRLVSDDFSGNRVRLRRAAAPRACREWPAPHFARRAARCGAAAPPGEEGAPRRPADAA
RARGEAGRAAHDGERRAPPHGERNERNERKETDMSEATSEVATLGGGCFWCQEAVFLDVDGVTAVESGYAGGHTRNPGYR
DVCDGDTGHAEVVSVSFDPARIGYREILEIFFATHDPTQLNRQGNDVGTQYRSVIFTHSDAQRDAALELIRTLERDKLYD
DPIVTQVEPLNGNYWPAEAYHQNYYARNPGQGYCAVVIGPKLAKFRQKFAHRLKSRGA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=193, Percent_Identity=38.3419689119171, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI208609995, Length=160, Percent_Identity=43.125, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI208609993, Length=114, Percent_Identity=43.859649122807, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=43.7908496732026, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17533973, Length=151, Percent_Identity=34.4370860927152, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=165, Percent_Identity=40, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24664627, Length=187, Percent_Identity=32.0855614973262, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24664631, Length=187, Percent_Identity=31.5508021390374, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI45553131, Length=161, Percent_Identity=31.055900621118, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 32673; Mature: 32542

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASGTGGGAAGEMAGREQGGHREIRLVSDDFSGNRVRLRRAAAPRACREWPAPHFARRAA
CCCCCCCCCHHHHCCCCCCCCEEEEEEECCCCCCEEEEEHHHCCHHHHHCCCHHHHHHHH
RCGAAAPPGEEGAPRRPADAARARGEAGRAAHDGERRAPPHGERNERNERKETDMSEATS
HCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EVATLGGGCFWCQEAVFLDVDGVTAVESGYAGGHTRNPGYRDVCDGDTGHAEVVSVSFDP
HHHHHCCCHHEECCEEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCH
ARIGYREILEIFFATHDPTQLNRQGNDVGTQYRSVIFTHSDAQRDAALELIRTLERDKLY
HHCCHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHCC
DDPIVTQVEPLNGNYWPAEAYHQNYYARNPGQGYCAVVIGPKLAKFRQKFAHRLKSRGA
CCCCCEEEECCCCCCCCHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASGTGGGAAGEMAGREQGGHREIRLVSDDFSGNRVRLRRAAAPRACREWPAPHFARRAA
CCCCCCCCHHHHCCCCCCCCEEEEEEECCCCCCEEEEEHHHCCHHHHHCCCHHHHHHHH
RCGAAAPPGEEGAPRRPADAARARGEAGRAAHDGERRAPPHGERNERNERKETDMSEATS
HCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EVATLGGGCFWCQEAVFLDVDGVTAVESGYAGGHTRNPGYRDVCDGDTGHAEVVSVSFDP
HHHHHCCCHHEECCEEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCH
ARIGYREILEIFFATHDPTQLNRQGNDVGTQYRSVIFTHSDAQRDAALELIRTLERDKLY
HHCCHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHCC
DDPIVTQVEPLNGNYWPAEAYHQNYYARNPGQGYCAVVIGPKLAKFRQKFAHRLKSRGA
CCCCCEEEECCCCCCCCHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]