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The map label for this gene is serA [H]

Identifier: 126454274

GI number: 126454274

Start: 1316716

End: 1317990

Strand: Direct

Name: serA [H]

Synonym: BURPS1106A_1345

Alternate gene names: 126454274

Gene position: 1316716-1317990 (Clockwise)

Preceding gene: 126455409

Following gene: 126453802

Centisome position: 33.01

GC content: 66.2

Gene sequence:

>1275_bases
ATGGCCGCGTACGCGTACCGCGCCGGAATTTCCGGCCTCCGTTACGATTCGACCACCACGCTGGGTAACATGACTTCCGT
TCTTCTCCTCGAAAACATTCACGACAGCGCGTCGCGGCATTTCGCCGACGCGAACGTCGACATCGAGCGGCGCAAGGGCG
CGCTCGCCGGCGCCGAATTGCGGCGCGCGCTGCAGCAGCATCAACTAATCGGCATTCGCTCGGCGACGCATCTGCTGCGC
GACGAGATCGACGCCGCGCGCCATCTGCTCGCGATCGGGTGCTTCTGCATCGGCACGTCGCAGGTGGATTTGCCGGCCGC
CGCGCATCACGGCATTCCGGTGTTCAACGCGCCGTTCTCGAATACGCGGTCGGTCGCGGAGCTCGTGATCGCCGAGGCCA
TTCTGTTGCTGCGGCGCGTGCCGGAGAAGAGCGTCCTCGCGCATGCGGGCGAATGGGCGAAGGGCGCGGGCGGATCGTTC
GAGGCGCGCGGCAAGACGATCGCGATCGTCGGCTACGGCAACATCGGCGCGCAGGTCGGCGTGCTCGCCGAAGCGCTCGG
CATGAGGGTCGTCTATTACGATGTGCAGGCGAAGCTGTCGCTCGGCTCCGCGCAGCCGGCGCGCTCGCTCGGTGAGGCGA
TCGCGCTCGCGGACGTCGTCACGCTGCACGTGCCCGCACACGCGTCGACGCACAACATGATCGACGCGAGCGTCCTCGCG
CAATTCAAATCGAATGCAATCCTGATCAATGCGTCGCGCGGCACCGTCGTCGATATCGACGCGCTGCGCGACGCGCTCGT
GCAGAAGCGCCTGAGCGGCGCGGCGATCGACGTGTTTCCGCGCGAGCCGAAGACCAATGCGGACCGTTTCGAATCGGTGC
TGCAAGGATTGCCGAACGTGATCCTCACGCCGCATATCGGCGGCAGCACGCAGGAAGCGCAGGAGAACATCGGCGAAGAG
GTGTCGTCGAAGCTCGTCGCATTCCTCACGCGCGGCGATACCGCGGGCGCCGTCAATTTTCCGCAGGTGAGCCCGGGCGA
ATGCACGTCGGCCGCGCGGCTCCTGAACGTGCACGGCAATACGCCGGGCGTGCTCGCGGTGCTCAACACGCTGCTTGCTC
AGGATGGCGCGAACATCGTCGCGCAGCATCTGCAGACGCGCGGCGATATCGGCTATGTCGTGACCGACTTGGACCGCGTG
CCGTCCGATGCGTTTCTCGACACGCTGAGCGGCAATCGCGCATTCACGCGCAGCCGCTTGCTGCGCAGCGCATGA

Upstream 100 bases:

>100_bases
AGGACAGGCCGGCCGGCTTGTGCAGTGCTGGCGCCAGGCATACGCTTTTTGAGCGGCGACGCGACCGACATCGCGGCCGT
GCGATCGACGCGAACGCCGC

Downstream 100 bases:

>100_bases
TGCCCCGCGCGGGCCGCCGGTGCGCGGTTCGCGCGCGATGCACGCCGTGCAGTTGACGCGCCGCCGCACCCTGTCGATTT
TGACAGCGTTGGATTTCTCG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MAAYAYRAGISGLRYDSTTTLGNMTSVLLLENIHDSASRHFADANVDIERRKGALAGAELRRALQQHQLIGIRSATHLLR
DEIDAARHLLAIGCFCIGTSQVDLPAAAHHGIPVFNAPFSNTRSVAELVIAEAILLLRRVPEKSVLAHAGEWAKGAGGSF
EARGKTIAIVGYGNIGAQVGVLAEALGMRVVYYDVQAKLSLGSAQPARSLGEAIALADVVTLHVPAHASTHNMIDASVLA
QFKSNAILINASRGTVVDIDALRDALVQKRLSGAAIDVFPREPKTNADRFESVLQGLPNVILTPHIGGSTQEAQENIGEE
VSSKLVAFLTRGDTAGAVNFPQVSPGECTSAARLLNVHGNTPGVLAVLNTLLAQDGANIVAQHLQTRGDIGYVVTDLDRV
PSDAFLDTLSGNRAFTRSRLLRSA

Sequences:

>Translated_424_residues
MAAYAYRAGISGLRYDSTTTLGNMTSVLLLENIHDSASRHFADANVDIERRKGALAGAELRRALQQHQLIGIRSATHLLR
DEIDAARHLLAIGCFCIGTSQVDLPAAAHHGIPVFNAPFSNTRSVAELVIAEAILLLRRVPEKSVLAHAGEWAKGAGGSF
EARGKTIAIVGYGNIGAQVGVLAEALGMRVVYYDVQAKLSLGSAQPARSLGEAIALADVVTLHVPAHASTHNMIDASVLA
QFKSNAILINASRGTVVDIDALRDALVQKRLSGAAIDVFPREPKTNADRFESVLQGLPNVILTPHIGGSTQEAQENIGEE
VSSKLVAFLTRGDTAGAVNFPQVSPGECTSAARLLNVHGNTPGVLAVLNTLLAQDGANIVAQHLQTRGDIGYVVTDLDRV
PSDAFLDTLSGNRAFTRSRLLRSA
>Mature_423_residues
AAYAYRAGISGLRYDSTTTLGNMTSVLLLENIHDSASRHFADANVDIERRKGALAGAELRRALQQHQLIGIRSATHLLRD
EIDAARHLLAIGCFCIGTSQVDLPAAAHHGIPVFNAPFSNTRSVAELVIAEAILLLRRVPEKSVLAHAGEWAKGAGGSFE
ARGKTIAIVGYGNIGAQVGVLAEALGMRVVYYDVQAKLSLGSAQPARSLGEAIALADVVTLHVPAHASTHNMIDASVLAQ
FKSNAILINASRGTVVDIDALRDALVQKRLSGAAIDVFPREPKTNADRFESVLQGLPNVILTPHIGGSTQEAQENIGEEV
SSKLVAFLTRGDTAGAVNFPQVSPGECTSAARLLNVHGNTPGVLAVLNTLLAQDGANIVAQHLQTRGDIGYVVTDLDRVP
SDAFLDTLSGNRAFTRSRLLRSA

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=319, Percent_Identity=32.9153605015674, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI145580578, Length=259, Percent_Identity=30.1158301158301, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI4557499, Length=259, Percent_Identity=30.1158301158301, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI145580575, Length=264, Percent_Identity=29.9242424242424, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI61743967, Length=306, Percent_Identity=28.1045751633987, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI4557497, Length=306, Percent_Identity=28.1045751633987, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI6912396, Length=301, Percent_Identity=26.9102990033223, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1789279, Length=397, Percent_Identity=54.4080604534005, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI87082289, Length=232, Percent_Identity=31.8965517241379, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1787645, Length=252, Percent_Identity=26.984126984127, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788660, Length=247, Percent_Identity=29.1497975708502, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=288, Percent_Identity=34.7222222222222, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=299, Percent_Identity=26.0869565217391, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322116, Length=398, Percent_Identity=44.9748743718593, Blast_Score=337, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6320925, Length=391, Percent_Identity=44.7570332480818, Blast_Score=333, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6324964, Length=276, Percent_Identity=27.536231884058, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324055, Length=231, Percent_Identity=25.974025974026, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321253, Length=193, Percent_Identity=27.4611398963731, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=172, Percent_Identity=30.8139534883721, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19921140, Length=310, Percent_Identity=30, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646446, Length=309, Percent_Identity=29.7734627831715, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646448, Length=309, Percent_Identity=29.7734627831715, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646452, Length=309, Percent_Identity=29.7734627831715, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646450, Length=309, Percent_Identity=29.7734627831715, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI62472511, Length=309, Percent_Identity=29.4498381877023, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28574286, Length=244, Percent_Identity=26.6393442622951, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI45551003, Length=247, Percent_Identity=25.1012145748988, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI45552429, Length=247, Percent_Identity=25.1012145748988, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24585514, Length=247, Percent_Identity=25.1012145748988, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28574282, Length=247, Percent_Identity=25.1012145748988, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28574284, Length=247, Percent_Identity=25.1012145748988, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28571528, Length=263, Percent_Identity=25.8555133079848, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44841; Mature: 44709

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAYAYRAGISGLRYDSTTTLGNMTSVLLLENIHDSASRHFADANVDIERRKGALAGAEL
CCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHH
RRALQQHQLIGIRSATHLLRDEIDAARHLLAIGCFCIGTSQVDLPAAAHHGIPVFNAPFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCEECCCCC
NTRSVAELVIAEAILLLRRVPEKSVLAHAGEWAKGAGGSFEARGKTIAIVGYGNIGAQVG
CHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCEECCCCEEEEEECCCCCHHHH
VLAEALGMRVVYYDVQAKLSLGSAQPARSLGEAIALADVVTLHVPAHASTHNMIDASVLA
HHHHHHCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHH
QFKSNAILINASRGTVVDIDALRDALVQKRLSGAAIDVFPREPKTNADRFESVLQGLPNV
HHCCCEEEEECCCCCEEEHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCE
ILTPHIGGSTQEAQENIGEEVSSKLVAFLTRGDTAGAVNFPQVSPGECTSAARLLNVHGN
EEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHEEECCCC
TPGVLAVLNTLLAQDGANIVAQHLQTRGDIGYVVTDLDRVPSDAFLDTLSGNRAFTRSRL
CCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEECHHHCCCHHHHHHCCCCHHHHHHHH
LRSA
HHCC
>Mature Secondary Structure 
AAYAYRAGISGLRYDSTTTLGNMTSVLLLENIHDSASRHFADANVDIERRKGALAGAEL
CCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHH
RRALQQHQLIGIRSATHLLRDEIDAARHLLAIGCFCIGTSQVDLPAAAHHGIPVFNAPFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCEECCCCC
NTRSVAELVIAEAILLLRRVPEKSVLAHAGEWAKGAGGSFEARGKTIAIVGYGNIGAQVG
CHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCEECCCCEEEEEECCCCCHHHH
VLAEALGMRVVYYDVQAKLSLGSAQPARSLGEAIALADVVTLHVPAHASTHNMIDASVLA
HHHHHHCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHH
QFKSNAILINASRGTVVDIDALRDALVQKRLSGAAIDVFPREPKTNADRFESVLQGLPNV
HHCCCEEEEECCCCCEEEHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCE
ILTPHIGGSTQEAQENIGEEVSSKLVAFLTRGDTAGAVNFPQVSPGECTSAARLLNVHGN
EEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHEEECCCC
TPGVLAVLNTLLAQDGANIVAQHLQTRGDIGYVVTDLDRVPSDAFLDTLSGNRAFTRSRL
CCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEECHHHCCCHHHHHHCCCCHHHHHHHH
LRSA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]