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The map label for this gene is moaA [H]

Identifier: 126454258

GI number: 126454258

Start: 2818913

End: 2820046

Strand: Direct

Name: moaA [H]

Synonym: BURPS1106A_2864

Alternate gene names: 126454258

Gene position: 2818913-2820046 (Clockwise)

Preceding gene: 126454922

Following gene: 126453182

Centisome position: 70.68

GC content: 67.46

Gene sequence:

>1134_bases
TTGGCTCAACTTGCAACGCCCATGTCCCGACGCATCATTCCCGTGACCCCGGTGAGCGCAGCGCCCGATCTGTCCGGCGC
CCCGCTCACGCCGACCGGCACGCTGCGCGACGCCCTCGCGCGCCCGCTGCGCGATCTGCGCATCTCGGTCACGGACCGCT
GCAACTTCCGATGCGTGTACTGCATGCCGCGCACCGTGTTCGGCAAGGATTACCCATTCCTGCCGCACAGCGCGCTGCTC
ACGCTCGAGGAAATCGAGCGCCTGGCGCGGCTTTTCGTCGCACACGGCGTCGAGAAGATCCGCATCACCGGCGGCGAGCC
GCTCTTGCGCAAGAACCTCGAGTTCCTGATCGAGCGCCTCGCGAACATGACGACCGTCGACGGCCGTCCGCTCGACATCA
CGCTGACGACCAACGGCTCTCTGCTCATGCGCAAGGCGAAGAGCCTGCGCGATGCGGGGCTCTCGCGCGTGACGGTCAGC
CTCGACGCGCTCGACGACACGCTCTTCAAACGCATGAACGATGCCGACTTCGCGAGCGCCGACGTGCTCGACGGCATCTT
CGCCGCGCATGCGGCGGGCCTGGCGCCCGTGAAGGTCAACATGGTCGTCAAGCGCGGCACGAACGACGCCGAGATCGTGC
CGATGGCGCGCCGCTTCAAAGGCACGGGCGTCGTACTGCGCTTCATCGAATACATGGACGTCGGTATGTCGAACGGCTGG
AACATGGCGCAAGTGCTGCCGTCCGCCGACGTGATCGCGCGCATCGCCGAGCATTTCCCGCTCGTGCCGCTCGAACGGCA
CACGCCGTCCGAGACCGCTCAACGCTGGGGCTATGCGGACGGCAGCGGCGAAATCGGCGTGATCTCGAGCGTCACGCGCG
CGTTCTGCGGCGATTGCACGCGCGCGCGACTGTCGACCGAAGGACGGCTCTATCTGTGCCTTTTCGCATCGTCCGGCCAC
GATCTGCGCAGCCTCGTGCGCGGCGGCGCGACCGACGAGCAGATCGCCGCGCTGATCGGCCACATCTGGCAGGCGCGCAC
CGACCGCTACTCGCAACTGCGCGGCAGCGCGCAAGCCACCGACGAAGCGGCGGGCGAAGCGAAGCGCGTCGAAATGTCCT
ACATCGGCGGCTAG

Upstream 100 bases:

>100_bases
GAAAAAGCCCGCCCCCGAAAGGCGGGCTTTTTTGTCTGTGCTCCGGTTCTGCGGGTTTCCATGCCCGACCCCGCGCGGCG
CTTCCAGCTAAAATGGAAGC

Downstream 100 bases:

>100_bases
GCCCGCCCGATTCGTATGCGCCCCGCTCCCGCCATGCCGTCGCACGCCGCGCCCGCCTGCCCGATCACCGGCCTCTTGCT
CGCCGGCGGACGCGGCACGC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MAQLATPMSRRIIPVTPVSAAPDLSGAPLTPTGTLRDALARPLRDLRISVTDRCNFRCVYCMPRTVFGKDYPFLPHSALL
TLEEIERLARLFVAHGVEKIRITGGEPLLRKNLEFLIERLANMTTVDGRPLDITLTTNGSLLMRKAKSLRDAGLSRVTVS
LDALDDTLFKRMNDADFASADVLDGIFAAHAAGLAPVKVNMVVKRGTNDAEIVPMARRFKGTGVVLRFIEYMDVGMSNGW
NMAQVLPSADVIARIAEHFPLVPLERHTPSETAQRWGYADGSGEIGVISSVTRAFCGDCTRARLSTEGRLYLCLFASSGH
DLRSLVRGGATDEQIAALIGHIWQARTDRYSQLRGSAQATDEAAGEAKRVEMSYIGG

Sequences:

>Translated_377_residues
MAQLATPMSRRIIPVTPVSAAPDLSGAPLTPTGTLRDALARPLRDLRISVTDRCNFRCVYCMPRTVFGKDYPFLPHSALL
TLEEIERLARLFVAHGVEKIRITGGEPLLRKNLEFLIERLANMTTVDGRPLDITLTTNGSLLMRKAKSLRDAGLSRVTVS
LDALDDTLFKRMNDADFASADVLDGIFAAHAAGLAPVKVNMVVKRGTNDAEIVPMARRFKGTGVVLRFIEYMDVGMSNGW
NMAQVLPSADVIARIAEHFPLVPLERHTPSETAQRWGYADGSGEIGVISSVTRAFCGDCTRARLSTEGRLYLCLFASSGH
DLRSLVRGGATDEQIAALIGHIWQARTDRYSQLRGSAQATDEAAGEAKRVEMSYIGG
>Mature_376_residues
AQLATPMSRRIIPVTPVSAAPDLSGAPLTPTGTLRDALARPLRDLRISVTDRCNFRCVYCMPRTVFGKDYPFLPHSALLT
LEEIERLARLFVAHGVEKIRITGGEPLLRKNLEFLIERLANMTTVDGRPLDITLTTNGSLLMRKAKSLRDAGLSRVTVSL
DALDDTLFKRMNDADFASADVLDGIFAAHAAGLAPVKVNMVVKRGTNDAEIVPMARRFKGTGVVLRFIEYMDVGMSNGWN
MAQVLPSADVIARIAEHFPLVPLERHTPSETAQRWGYADGSGEIGVISSVTRAFCGDCTRARLSTEGRLYLCLFASSGHD
LRSLVRGGATDEQIAALIGHIWQARTDRYSQLRGSAQATDEAAGEAKRVEMSYIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=306, Percent_Identity=36.9281045751634, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI22027536, Length=306, Percent_Identity=36.9281045751634, Blast_Score=195, Evalue=5e-50,
Organism=Escherichia coli, GI1786999, Length=343, Percent_Identity=33.2361516034985, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI32566331, Length=339, Percent_Identity=31.858407079646, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI32566329, Length=320, Percent_Identity=32.8125, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17561210, Length=307, Percent_Identity=33.5504885993485, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI28574488, Length=334, Percent_Identity=33.8323353293413, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI28574490, Length=324, Percent_Identity=34.5679012345679, Blast_Score=180, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 41144; Mature: 41013

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQLATPMSRRIIPVTPVSAAPDLSGAPLTPTGTLRDALARPLRDLRISVTDRCNFRCVY
CCCCCCCHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEECCCCEEEEE
CMPRTVFGKDYPFLPHSALLTLEEIERLARLFVAHGVEKIRITGGEPLLRKNLEFLIERL
ECCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHH
ANMTTVDGRPLDITLTTNGSLLMRKAKSLRDAGLSRVTVSLDALDDTLFKRMNDADFASA
HCCEECCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCCCCHH
DVLDGIFAAHAAGLAPVKVNMVVKRGTNDAEIVPMARRFKGTGVVLRFIEYMDVGMSNGW
HHHHHHHHHHHCCCCEEEEEEEEECCCCCCCEEHHHHHCCCCHHHHHHHHHHHCCCCCCC
NMAQVLPSADVIARIAEHFPLVPLERHTPSETAQRWGYADGSGEIGVISSVTRAFCGDCT
CHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCH
RARLSTEGRLYLCLFASSGHDLRSLVRGGATDEQIAALIGHIWQARTDRYSQLRGSAQAT
HHHCCCCCCEEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DEAAGEAKRVEMSYIGG
HHHCCCHHEEEEEECCC
>Mature Secondary Structure 
AQLATPMSRRIIPVTPVSAAPDLSGAPLTPTGTLRDALARPLRDLRISVTDRCNFRCVY
CCCCCCHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEECCCCEEEEE
CMPRTVFGKDYPFLPHSALLTLEEIERLARLFVAHGVEKIRITGGEPLLRKNLEFLIERL
ECCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHH
ANMTTVDGRPLDITLTTNGSLLMRKAKSLRDAGLSRVTVSLDALDDTLFKRMNDADFASA
HCCEECCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCCCCHH
DVLDGIFAAHAAGLAPVKVNMVVKRGTNDAEIVPMARRFKGTGVVLRFIEYMDVGMSNGW
HHHHHHHHHHHCCCCEEEEEEEEECCCCCCCEEHHHHHCCCCHHHHHHHHHHHCCCCCCC
NMAQVLPSADVIARIAEHFPLVPLERHTPSETAQRWGYADGSGEIGVISSVTRAFCGDCT
CHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCH
RARLSTEGRLYLCLFASSGHDLRSLVRGGATDEQIAALIGHIWQARTDRYSQLRGSAQAT
HHHCCCCCCEEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DEAAGEAKRVEMSYIGG
HHHCCCHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]