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The map label for this gene is thrC [H]

Identifier: 126454084

GI number: 126454084

Start: 2253484

End: 2254935

Strand: Reverse

Name: thrC [H]

Synonym: BURPS1106A_2269

Alternate gene names: 126454084

Gene position: 2254935-2253484 (Counterclockwise)

Preceding gene: 126454983

Following gene: 126454605

Centisome position: 56.54

GC content: 67.01

Gene sequence:

>1452_bases
ATGAATTACATCTCCACGCGCGGCGCCGGCATCGGCGAGCGTCACACGTTCTCCGACATCCTGCTCGGCGGCCTCGCGAA
GGACGGCGGGCTCTACCTGCCGAGCGAGTATCCGCGGGTGAGCGCGGACGAGCTCGCGCGCTGGCGCGCGCTGCCGTACG
CGGATCTCGCGTTCGAGATCCTCGCGAAGTTCTGCGACGACATCCCGGCCGACGACCTGCGCGCGATCACGCGCCGCACG
TATACGGCCGACGTCTATCGTCACACGCGCCACGGCGGCAACGCGGCCGACATCACGCCGCTCACGACGCTCGGCGCCGA
GAACGGCGCGCCGGTCTCGCTGCTCGAACTGTCGAACGGCCCGACGCTCGCGTTCAAGGACATGGCGATGCAGTTGCTCG
GCAACCTGTTCGAGTACACGCTCGCCGCGCACGGCGAAACGCTGAACATCCTCGGCGCGACGTCGGGCGATACGGGCAGC
GCGGCCGAATACGCGATGCGCGGCAAGCGGGGCGTGCGCGTGTTCATGCTGTCGCCGCACCGGAAGATGAGTGCGTTCCA
GACGGCCCAGATGTACAGCCTGCAGGACCCGAACATCTTCAACCTCGCGGTGAAGGGCGTGTTCGACGATTGCCAGGACA
TCGTGAAGGCCGTGTCGAACGATCACGCGTTCAAGGCGCAGCAGAAGATCGGCACGGTCAATTCGATCAACTGGGCGCGT
GTCGTCGCGCAGGTCGTGTACTACTTCAAGGGCTATTTCGCGGCGACGCGCACGAACGACGAGCGCGTGTCGTTTACGGT
GCCGTCGGGCAACTTCGGCAATGTCTGCGCGGGCCACATCGCGCGGATGATGGGGCTGCCGATCGAGAAGCTCGTCGTCG
CGACCAACGAGAACGACGTGCTCGACGAATTCTTCCGCACGGGTGCGTATCGCGTGCGCAGCGCCGAGCACACGTACCAC
ACGAGCAGCCCGAGCATGGACATCTCGAAGGCGTCGAACTTCGAGCGCTTCGTGTTCGACCTGCTCGGCCGCGATCCGGC
GCGCGTCGTTCAGCTGTTTCGCGACGTCGAGCAAAAGGGTGGCTTCGATCTCGCGGCGAGCGGCGATTTCGCGCGCGTCG
CCGAGTTCGGCTTCGTGTCGGGCCGCAGCACGCACGCGGACCGGCTCGCGACGATCCGCGACGTGTTCGAGCGCTATCGC
ACGACGATCGACACGCACACGGCCGACGGCCTGAAAGTGGCGCGCGAGCATCTGCAGCCGGGCGTGCCGATGATCGTGCT
CGAGACCGCGCAGCCGATCAAGTTCGGCGAAACGATTCGCGAGGCGCTCGGGCAGGAGCCGTCGCGGCCCGCCGCGTTCG
ACGGGCTCGAGGCGCTGCCGCAGCGCTTCGAGGTGGTCGACGCGAGCGCGCAGCAGGTGAAGGACTTCATCGCCGCGCAC
ACGGGCGCATGA

Upstream 100 bases:

>100_bases
GAGAAGAACGTCAACGCGGCGATCGCGCGCATCGAATCGCTCGCGACCGTCGTGTCGAAGGTCACGAAGCTGCGCATGGA
AGCGCTCAACTGAGGACGAC

Downstream 100 bases:

>100_bases
TGGCGTGATGTGCCGGCGGCGGGGCGGCGCCGCGCGATATCGTTGTCGCCGTCGCCGTCGCCGTCGCCGTTGCTGTCGCC
GTCGCTGTCGTTCGCCGGGT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MNYISTRGAGIGERHTFSDILLGGLAKDGGLYLPSEYPRVSADELARWRALPYADLAFEILAKFCDDIPADDLRAITRRT
YTADVYRHTRHGGNAADITPLTTLGAENGAPVSLLELSNGPTLAFKDMAMQLLGNLFEYTLAAHGETLNILGATSGDTGS
AAEYAMRGKRGVRVFMLSPHRKMSAFQTAQMYSLQDPNIFNLAVKGVFDDCQDIVKAVSNDHAFKAQQKIGTVNSINWAR
VVAQVVYYFKGYFAATRTNDERVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDVLDEFFRTGAYRVRSAEHTYH
TSSPSMDISKASNFERFVFDLLGRDPARVVQLFRDVEQKGGFDLAASGDFARVAEFGFVSGRSTHADRLATIRDVFERYR
TTIDTHTADGLKVAREHLQPGVPMIVLETAQPIKFGETIREALGQEPSRPAAFDGLEALPQRFEVVDASAQQVKDFIAAH
TGA

Sequences:

>Translated_483_residues
MNYISTRGAGIGERHTFSDILLGGLAKDGGLYLPSEYPRVSADELARWRALPYADLAFEILAKFCDDIPADDLRAITRRT
YTADVYRHTRHGGNAADITPLTTLGAENGAPVSLLELSNGPTLAFKDMAMQLLGNLFEYTLAAHGETLNILGATSGDTGS
AAEYAMRGKRGVRVFMLSPHRKMSAFQTAQMYSLQDPNIFNLAVKGVFDDCQDIVKAVSNDHAFKAQQKIGTVNSINWAR
VVAQVVYYFKGYFAATRTNDERVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDVLDEFFRTGAYRVRSAEHTYH
TSSPSMDISKASNFERFVFDLLGRDPARVVQLFRDVEQKGGFDLAASGDFARVAEFGFVSGRSTHADRLATIRDVFERYR
TTIDTHTADGLKVAREHLQPGVPMIVLETAQPIKFGETIREALGQEPSRPAAFDGLEALPQRFEVVDASAQQVKDFIAAH
TGA
>Mature_483_residues
MNYISTRGAGIGERHTFSDILLGGLAKDGGLYLPSEYPRVSADELARWRALPYADLAFEILAKFCDDIPADDLRAITRRT
YTADVYRHTRHGGNAADITPLTTLGAENGAPVSLLELSNGPTLAFKDMAMQLLGNLFEYTLAAHGETLNILGATSGDTGS
AAEYAMRGKRGVRVFMLSPHRKMSAFQTAQMYSLQDPNIFNLAVKGVFDDCQDIVKAVSNDHAFKAQQKIGTVNSINWAR
VVAQVVYYFKGYFAATRTNDERVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDVLDEFFRTGAYRVRSAEHTYH
TSSPSMDISKASNFERFVFDLLGRDPARVVQLFRDVEQKGGFDLAASGDFARVAEFGFVSGRSTHADRLATIRDVFERYR
TTIDTHTADGLKVAREHLQPGVPMIVLETAQPIKFGETIREALGQEPSRPAAFDGLEALPQRFEVVDASAQQVKDFIAAH
TGA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=451, Percent_Identity=32.8159645232816, Blast_Score=203, Evalue=4e-52,
Organism=Homo sapiens, GI149193323, Length=467, Percent_Identity=30.1927194860814, Blast_Score=196, Evalue=5e-50,
Organism=Escherichia coli, GI1786185, Length=441, Percent_Identity=29.7052154195011, Blast_Score=182, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6319901, Length=472, Percent_Identity=38.771186440678, Blast_Score=308, Evalue=2e-84,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 53027; Mature: 53027

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYISTRGAGIGERHTFSDILLGGLAKDGGLYLPSEYPRVSADELARWRALPYADLAFEI
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHCCCHHHHHHHH
LAKFCDDIPADDLRAITRRTYTADVYRHTRHGGNAADITPLTTLGAENGAPVSLLELSNG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCEEEEEECCC
PTLAFKDMAMQLLGNLFEYTLAAHGETLNILGATSGDTGSAAEYAMRGKRGVRVFMLSPH
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHCCCCCCEEEEECCC
RKMSAFQTAQMYSLQDPNIFNLAVKGVFDDCQDIVKAVSNDHAFKAQQKIGTVNSINWAR
HHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHH
VVAQVVYYFKGYFAATRTNDERVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDV
HHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHH
LDEFFRTGAYRVRSAEHTYHTSSPSMDISKASNFERFVFDLLGRDPARVVQLFRDVEQKG
HHHHHHCCCCEEECCCCCEECCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHC
GFDLAASGDFARVAEFGFVSGRSTHADRLATIRDVFERYRTTIDTHTADGLKVAREHLQP
CEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
GVPMIVLETAQPIKFGETIREALGQEPSRPAAFDGLEALPQRFEVVDASAQQVKDFIAAH
CCCEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHC
TGA
CCC
>Mature Secondary Structure
MNYISTRGAGIGERHTFSDILLGGLAKDGGLYLPSEYPRVSADELARWRALPYADLAFEI
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHCCCHHHHHHHH
LAKFCDDIPADDLRAITRRTYTADVYRHTRHGGNAADITPLTTLGAENGAPVSLLELSNG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCEEEEEECCC
PTLAFKDMAMQLLGNLFEYTLAAHGETLNILGATSGDTGSAAEYAMRGKRGVRVFMLSPH
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHCCCCCCEEEEECCC
RKMSAFQTAQMYSLQDPNIFNLAVKGVFDDCQDIVKAVSNDHAFKAQQKIGTVNSINWAR
HHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHH
VVAQVVYYFKGYFAATRTNDERVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDV
HHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHH
LDEFFRTGAYRVRSAEHTYHTSSPSMDISKASNFERFVFDLLGRDPARVVQLFRDVEQKG
HHHHHHCCCCEEECCCCCEECCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHC
GFDLAASGDFARVAEFGFVSGRSTHADRLATIRDVFERYRTTIDTHTADGLKVAREHLQP
CEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
GVPMIVLETAQPIKFGETIREALGQEPSRPAAFDGLEALPQRFEVVDASAQQVKDFIAAH
CCCEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHC
TGA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8117070 [H]