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The map label for this gene is nadC [H]

Identifier: 126454043

GI number: 126454043

Start: 962302

End: 963186

Strand: Direct

Name: nadC [H]

Synonym: BURPS1106A_0979

Alternate gene names: 126454043

Gene position: 962302-963186 (Clockwise)

Preceding gene: 126451762

Following gene: 126454503

Centisome position: 24.13

GC content: 70.06

Gene sequence:

>885_bases
ATGACCATCGACGCGGTATCGCCGCTCTTTGCCGACATCTCGCGCGAATACGGCGCCGCGTTCGACGCGGCGATCGCGCG
CAACGTCGCCGATGCGCTCGCGGAGGACGTCGGCAGCGGCGACCAGACCGGGCGCCTCGTGCCGGACGGCGCGCCGCGCC
GCGCGCGCGTGATCGTGCGCGAGGACGCGGTGCTGTGCGGCGTGCCGTGGTTCGACGCGGTGGTGCGCGCGGTCGATCCG
TCGATCGAAGTCGACTGGCGCCATCGCGAAGGCGACCGGATGAGCGCGGATTCGACCGTCTGCGAACTGCGCGGCCCCGC
GCGCGCGCTGCTGACGGCCGAACGCAACGCGCTGAACTTCCTGCAACTGCTGTCGGGCGTCGCGAGCGCGACGCGGCAGT
ATGTCGACCGGATCGCCGATACGCGCGCGCGGATCCTCGATACGCGCAAGACGCTGCCGGGCCTGCGGCTCGCCCAGAAG
TACGCGGTGCGCGTCGGCGGCGGCGCGAACCAGCGGCTGGCGCTCTACGCGGGCATCCTGATCAAGGAAAATCACATCGC
GGCGGCGGGCGGGGTGGGCGAGGCGCTCGACGCGGCGTTCGCGCTGAACGCCGACGTGCCGGTGCAGATCGAGGTCGAAA
CGCTCGACCAGTTGCGCACGGCGCTCGCGCACGGCGCGCGATCGGTGCTGCTCGATAACTTCACGCTCGACATGATGCGC
GATGCGGTGCATGTCACCGAGGGCCGTGCGGTGCTCGAGGTGTCGGGCGGCGTGAATTTCGATACGGTGCGCGCGATCGC
GGAGACGGGCGTCGATCGGATCTCGATCGGTGCGCTGACGAAGGACGTGCGCGCGACCGATTATTCGATGCGTATCGTCG
AATGA

Upstream 100 bases:

>100_bases
TCGACCGAATGCTCGATTTCGCCGCGCGTCACAAGCAGCGCGTGCAGGCGAGCGGCGATCTGCAGCGCGACCAGGCGCTG
TTCGCAAACGTGGGGGCGGC

Downstream 100 bases:

>100_bases
CGTGCGGGCGGCGTGCGCTGGCATCGCGATGCGCGCCGCCCGTAGCCTGCCGGCCGAATCCGCGCCGAAAAGGCATCCGG
ACGGAACGGGCCGAGGCAAG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTIDAVSPLFADISREYGAAFDAAIARNVADALAEDVGSGDQTGRLVPDGAPRRARVIVREDAVLCGVPWFDAVVRAVDP
SIEVDWRHREGDRMSADSTVCELRGPARALLTAERNALNFLQLLSGVASATRQYVDRIADTRARILDTRKTLPGLRLAQK
YAVRVGGGANQRLALYAGILIKENHIAAAGGVGEALDAAFALNADVPVQIEVETLDQLRTALAHGARSVLLDNFTLDMMR
DAVHVTEGRAVLEVSGGVNFDTVRAIAETGVDRISIGALTKDVRATDYSMRIVE

Sequences:

>Translated_294_residues
MTIDAVSPLFADISREYGAAFDAAIARNVADALAEDVGSGDQTGRLVPDGAPRRARVIVREDAVLCGVPWFDAVVRAVDP
SIEVDWRHREGDRMSADSTVCELRGPARALLTAERNALNFLQLLSGVASATRQYVDRIADTRARILDTRKTLPGLRLAQK
YAVRVGGGANQRLALYAGILIKENHIAAAGGVGEALDAAFALNADVPVQIEVETLDQLRTALAHGARSVLLDNFTLDMMR
DAVHVTEGRAVLEVSGGVNFDTVRAIAETGVDRISIGALTKDVRATDYSMRIVE
>Mature_293_residues
TIDAVSPLFADISREYGAAFDAAIARNVADALAEDVGSGDQTGRLVPDGAPRRARVIVREDAVLCGVPWFDAVVRAVDPS
IEVDWRHREGDRMSADSTVCELRGPARALLTAERNALNFLQLLSGVASATRQYVDRIADTRARILDTRKTLPGLRLAQKY
AVRVGGGANQRLALYAGILIKENHIAAAGGVGEALDAAFALNADVPVQIEVETLDQLRTALAHGARSVLLDNFTLDMMRD
AVHVTEGRAVLEVSGGVNFDTVRAIAETGVDRISIGALTKDVRATDYSMRIVE

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=270, Percent_Identity=35.5555555555556, Blast_Score=138, Evalue=8e-33,
Organism=Escherichia coli, GI1786299, Length=270, Percent_Identity=50.7407407407407, Blast_Score=236, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6321162, Length=287, Percent_Identity=31.7073170731707, Blast_Score=138, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31545; Mature: 31414

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDAVSPLFADISREYGAAFDAAIARNVADALAEDVGSGDQTGRLVPDGAPRRARVIVR
CCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEE
EDAVLCGVPWFDAVVRAVDPSIEVDWRHREGDRMSADSTVCELRGPARALLTAERNALNF
CCCEEECCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHEECCCCHHHHHHHHHHHHHH
LQLLSGVASATRQYVDRIADTRARILDTRKTLPGLRLAQKYAVRVGGGANQRLALYAGIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEECCCCCCEEEEEEEEE
IKENHIAAAGGVGEALDAAFALNADVPVQIEVETLDQLRTALAHGARSVLLDNFTLDMMR
EECCCEEECCCCCHHHHHHEEECCCCCEEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
DAVHVTEGRAVLEVSGGVNFDTVRAIAETGVDRISIGALTKDVRATDYSMRIVE
HHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHHHHCCCCEEEEEC
>Mature Secondary Structure 
TIDAVSPLFADISREYGAAFDAAIARNVADALAEDVGSGDQTGRLVPDGAPRRARVIVR
CCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEE
EDAVLCGVPWFDAVVRAVDPSIEVDWRHREGDRMSADSTVCELRGPARALLTAERNALNF
CCCEEECCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHEECCCCHHHHHHHHHHHHHH
LQLLSGVASATRQYVDRIADTRARILDTRKTLPGLRLAQKYAVRVGGGANQRLALYAGIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEECCCCCCEEEEEEEEE
IKENHIAAAGGVGEALDAAFALNADVPVQIEVETLDQLRTALAHGARSVLLDNFTLDMMR
EECCCEEECCCCCHHHHHHEEECCCCCEEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
DAVHVTEGRAVLEVSGGVNFDTVRAIAETGVDRISIGALTKDVRATDYSMRIVE
HHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]