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The map label for this gene is cobB [H]

Identifier: 126453621

GI number: 126453621

Start: 3013312

End: 3014562

Strand: Reverse

Name: cobB [H]

Synonym: BURPS1106A_3089

Alternate gene names: 126453621

Gene position: 3014562-3013312 (Counterclockwise)

Preceding gene: 126453672

Following gene: 126455092

Centisome position: 75.58

GC content: 69.54

Gene sequence:

>1251_bases
GTGGCTGAAGAATGTCGAGCTCGACGTGTCGATGCCGAATCGTTCGCGCGTGACATCTGGCTCGGCGTGCACCGGCAATT
GAAGGCGTCGCCGCCGATTCGCGCGGGGATGGATTTCATCGTCGAACGGGTGCAGAGCGCGCCCGCGTTGCAACGGGCGG
GGCGGCGGCGCGTTGATCGCGCGCCGGGCGCGCCGGTGGATGCGCGCAGACCGTTGGGACGTGCGTCGCTCGTCGCCCGT
CGCCCGCCGCCCGTCGCTCGCGATTCGTCGTTCGTCGTTTCACGTTCGAAGCGCTTCCGGCCGTGCGCCGCGCGAGCGTA
TGATCGTTCCCACTTCGAACGCAATCCGGAACGAAAAAGCCGCGCCATGTCCGACTCACGCCGCCCGCCTTCGAACCCGT
CGCCCGCGATGCGCGATGGCGCGCCGCCCGTCGACGCCGAGCGCATCGACGCCGCCGTTCGCGCGCTGTCGCGCGCCGAT
GCGCTGCTCGTCACGGCGGGCGCGGGCATCGGCATCGATTCCGGATTGCCGGATTTTCGCGGCGCCGAAGGGTTGTGGCG
CGCGTACCCGGGGCTCGGCCATGTCGGCTATGCATTCCACGAGATCGCTTCGCCGCGCGCGTTTCGCGAGCGTCCGCGCC
TCGCGTGGGGCTTTTACGGCCATCGGCTCGCGATGTACCGTGCAACCGTGCCGCACGAAGGGTTCGGCATCCTGCGGCGC
TGGATCGGCGCGATGCGCCACGGCGGCTTCGTGTTCACGAGCAATGTCGACGGTCAGTTTCAGAAGGCGGGCTTCGATCC
CGAGCGAATCGTCGAGGTTCACGGCTCGATTCACGCGATGCAGTGCATGAGTTCTTGCTCGGCGTACACGTGGGATGCGG
AATCGTTCGCGCCCGTCGTCGACGAGCCGGCGTGCAGCCTCGTTGGCGCGCTCCCCCGCTGTCCGCGGTGCGGCGGCCTC
GCACGGCCGAACATCCTGATGTTCGACGATGCGGACTGGCTCGGCGCGCGTTACGACGCGCAGCACGAAGCGCTGCGCGC
TTGGCTCGCGCGCGCGGGGCGCGTGGCGGTGGTCGAAGTGGGCGCCGGCACCGCAGTGCCGACGGTGCGTGCCTTCAGCG
AACGCACCGGTGACGACGTGATTCGAATCAACGTCCGCAAAGCGCATGCGCGGCGCGACGATGTGATCGGCCTGCCCGGC
GGCGCGCTCGAGACATTGCGCGCGCTCGATGCCGCGTGGCGGCGGGGTTGA

Upstream 100 bases:

>100_bases
GAGCCGGCCTCACGACACGGCGCCGGCCATTTCCGCAGGAGCCGGCGCGCCGGGAATTCATCGATTATGGCGATGGGATC
AACGACATGCCGCGGCAGCG

Downstream 100 bases:

>100_bases
CGCCCGTCTGCGCATGACGGCCGCCGCCGTGAGGGCGGGCCGCATGGTTGCGGGCGATTTCGGCAGCGCGCGGCGATACC
CGGAATTCCGGGGCGGCCGC

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MAEECRARRVDAESFARDIWLGVHRQLKASPPIRAGMDFIVERVQSAPALQRAGRRRVDRAPGAPVDARRPLGRASLVAR
RPPPVARDSSFVVSRSKRFRPCAARAYDRSHFERNPERKSRAMSDSRRPPSNPSPAMRDGAPPVDAERIDAAVRALSRAD
ALLVTAGAGIGIDSGLPDFRGAEGLWRAYPGLGHVGYAFHEIASPRAFRERPRLAWGFYGHRLAMYRATVPHEGFGILRR
WIGAMRHGGFVFTSNVDGQFQKAGFDPERIVEVHGSIHAMQCMSSCSAYTWDAESFAPVVDEPACSLVGALPRCPRCGGL
ARPNILMFDDADWLGARYDAQHEALRAWLARAGRVAVVEVGAGTAVPTVRAFSERTGDDVIRINVRKAHARRDDVIGLPG
GALETLRALDAAWRRG

Sequences:

>Translated_416_residues
MAEECRARRVDAESFARDIWLGVHRQLKASPPIRAGMDFIVERVQSAPALQRAGRRRVDRAPGAPVDARRPLGRASLVAR
RPPPVARDSSFVVSRSKRFRPCAARAYDRSHFERNPERKSRAMSDSRRPPSNPSPAMRDGAPPVDAERIDAAVRALSRAD
ALLVTAGAGIGIDSGLPDFRGAEGLWRAYPGLGHVGYAFHEIASPRAFRERPRLAWGFYGHRLAMYRATVPHEGFGILRR
WIGAMRHGGFVFTSNVDGQFQKAGFDPERIVEVHGSIHAMQCMSSCSAYTWDAESFAPVVDEPACSLVGALPRCPRCGGL
ARPNILMFDDADWLGARYDAQHEALRAWLARAGRVAVVEVGAGTAVPTVRAFSERTGDDVIRINVRKAHARRDDVIGLPG
GALETLRALDAAWRRG
>Mature_415_residues
AEECRARRVDAESFARDIWLGVHRQLKASPPIRAGMDFIVERVQSAPALQRAGRRRVDRAPGAPVDARRPLGRASLVARR
PPPVARDSSFVVSRSKRFRPCAARAYDRSHFERNPERKSRAMSDSRRPPSNPSPAMRDGAPPVDAERIDAAVRALSRADA
LLVTAGAGIGIDSGLPDFRGAEGLWRAYPGLGHVGYAFHEIASPRAFRERPRLAWGFYGHRLAMYRATVPHEGFGILRRW
IGAMRHGGFVFTSNVDGQFQKAGFDPERIVEVHGSIHAMQCMSSCSAYTWDAESFAPVVDEPACSLVGALPRCPRCGGLA
RPNILMFDDADWLGARYDAQHEALRAWLARAGRVAVVEVGAGTAVPTVRAFSERTGDDVIRINVRKAHARRDDVIGLPGG
ALETLRALDAAWRRG

Specific function: Modulates the activity of chromatin proteins, thereby having an effect on transcription per subunit [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI13787215, Length=192, Percent_Identity=29.6875, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI6912664, Length=192, Percent_Identity=29.6875, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI300795542, Length=181, Percent_Identity=28.1767955801105, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 45691; Mature: 45560

Theoretical pI: Translated: 10.99; Mature: 10.99

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEECRARRVDAESFARDIWLGVHRQLKASPPIRAGMDFIVERVQSAPALQRAGRRRVDR
CCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHC
APGAPVDARRPLGRASLVARRPPPVARDSSFVVSRSKRFRPCAARAYDRSHFERNPERKS
CCCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCHHHHH
RAMSDSRRPPSNPSPAMRDGAPPVDAERIDAAVRALSRADALLVTAGAGIGIDSGLPDFR
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCC
GAEGLWRAYPGLGHVGYAFHEIASPRAFRERPRLAWGFYGHRLAMYRATVPHEGFGILRR
CCCCHHHHCCCCCHHHHHHHHHCCCHHHHHCCCEEEEHHHHEEEEEEECCCCCHHHHHHH
WIGAMRHGGFVFTSNVDGQFQKAGFDPERIVEVHGSIHAMQCMSSCSAYTWDAESFAPVV
HHHHHHCCCEEEECCCCCCHHHCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCC
DEPACSLVGALPRCPRCGGLARPNILMFDDADWLGARYDAQHEALRAWLARAGRVAVVEV
CCHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEE
GAGTAVPTVRAFSERTGDDVIRINVRKAHARRDDVIGLPGGALETLRALDAAWRRG
CCCCCCHHHHHHHHCCCCCEEEEEEHHHHCCCCCEEECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AEECRARRVDAESFARDIWLGVHRQLKASPPIRAGMDFIVERVQSAPALQRAGRRRVDR
CCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHC
APGAPVDARRPLGRASLVARRPPPVARDSSFVVSRSKRFRPCAARAYDRSHFERNPERKS
CCCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCHHHHH
RAMSDSRRPPSNPSPAMRDGAPPVDAERIDAAVRALSRADALLVTAGAGIGIDSGLPDFR
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCC
GAEGLWRAYPGLGHVGYAFHEIASPRAFRERPRLAWGFYGHRLAMYRATVPHEGFGILRR
CCCCHHHHCCCCCHHHHHHHHHCCCHHHHHCCCEEEEHHHHEEEEEEECCCCCHHHHHHH
WIGAMRHGGFVFTSNVDGQFQKAGFDPERIVEVHGSIHAMQCMSSCSAYTWDAESFAPVV
HHHHHHCCCEEEECCCCCCHHHCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCC
DEPACSLVGALPRCPRCGGLARPNILMFDDADWLGARYDAQHEALRAWLARAGRVAVVEV
CCHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEE
GAGTAVPTVRAFSERTGDDVIRINVRKAHARRDDVIGLPGGALETLRALDAAWRRG
CCCCCCHHHHHHHHCCCCCEEEEEEHHHHCCCCCEEECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA