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The map label for this gene is pntA [H]

Identifier: 126453411

GI number: 126453411

Start: 3303873

End: 3305012

Strand: Reverse

Name: pntA [H]

Synonym: BURPS1106A_3387

Alternate gene names: 126453411

Gene position: 3305012-3303873 (Counterclockwise)

Preceding gene: 126453474

Following gene: 126452789

Centisome position: 82.86

GC content: 71.23

Gene sequence:

>1140_bases
ATGCATATCGGAGTGCCTGCCGAAACGCGGGCGAACGAGGCGCGCGTGGCGGCGACGCCGGAGACGGTCAGGAAATACGC
GGCGGCCGGCCACCGCGTGACGGTCGAGCGCGGCGCGGGCGCGGGCGCGAGCTTTCCGGACGACGCGTACGCGGCGGCCG
GCGCGGAGCTGGCCGACGCGGCCGCCGCGTTCGGCGCGGACATCGTGCTGAAGGTGCAGGCGCCGACCGACGCGGAATGC
GGGCAACTGAAGCGAGGCTCGGTTCTGATCGGCATGCTCGAGCCGTTCAACGCCGAGCAGGCGGCGCGGCTGGCGGCCGC
GGGCGTGACGGGCTTCGCGCTCGAGGCCGCGCCGCGCACGACGCGCGCGCAGAGCCTCGACGTGCTGTCCTCGCAGGCCA
ACATCGCCGGCTACAAGGCGGTGCTCGTCGCCGCGGCGCTGTATCCGCGCTTCTTTCCGATGCTGATGACGGCCGCGGGC
ACGGTGAAGGCCGCGCGCGTGCTCGTGCTCGGCGCGGGCGTCGCGGGCCTGCAGGCGATCGCGACCGCGAAGCGCCTGGG
CGCGGTGATCGAGGCGTCCGACGTGCGTCCGGCGGTCAAGGAGCAGATCGAATCGCTCGGCGCGAAATTCCTCGACGTAC
CTTACGAAACGCAAGACGAGCGCGACGCGGCGCAAGGCGTCGGCGGCTACGCGCGGCCGATGCCGGCATCGTGGCTCGGG
CGGCAGGCGGCGCTCGTGCACGAGCGCGCGAAGCAGGCCGACATCGTGATCACCACCGCGCTGATTCCCGGCCGCCCCGC
GCCGACGCTGATCTCGGTCGAAACCGTGCAGTCGATGAAGCCGGGCTCGGTGCTCGTCGATCTCGCGGCGGGGCGCGGCC
CCGAATTCGACGGCAGGAAGAGCGGCAACTGCCCGCTCACCGTCGCCGATCAGGTGATCGTGCATCACGGCGTGACGATC
GCCGGCCACACGAACCTGGCCGCGATGGTGCCCGCCGACGCGTCGTCGCTCTACGCGCGCAACCTGTTCGACTTCCTGAA
GCTGATCGTCACGAAGGAAGGCGCGCTCAACATCGATCTTTCGGACGACATCGTCGCCGCGACGCTCTTGTGCCGCGACG
GCGAAGTCGTGCGCAAATAA

Upstream 100 bases:

>100_bases
TCGGTTAAAGTGGCGCCTGAAACAGCCGTTGCCTTCGAGCCGGTATGTCAGTCGTCCGGCTCGCCGTCGCAGTAGAACAA
ACGAAGAGGAGGGATCGACG

Downstream 100 bases:

>100_bases
CGGGAGGAGGCCATGGAGATCATCAATCACACGGTCATCAACGTGATCATTTTCGTGCTGGCGGTGTACGTGGGCTACCA
CGTCGTGTGGAACGTCACGC

Product: NAD(P) transhydrogenase, alpha-1 subunit

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MHIGVPAETRANEARVAATPETVRKYAAAGHRVTVERGAGAGASFPDDAYAAAGAELADAAAAFGADIVLKVQAPTDAEC
GQLKRGSVLIGMLEPFNAEQAARLAAAGVTGFALEAAPRTTRAQSLDVLSSQANIAGYKAVLVAAALYPRFFPMLMTAAG
TVKAARVLVLGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETQDERDAAQGVGGYARPMPASWLG
RQAALVHERAKQADIVITTALIPGRPAPTLISVETVQSMKPGSVLVDLAAGRGPEFDGRKSGNCPLTVADQVIVHHGVTI
AGHTNLAAMVPADASSLYARNLFDFLKLIVTKEGALNIDLSDDIVAATLLCRDGEVVRK

Sequences:

>Translated_379_residues
MHIGVPAETRANEARVAATPETVRKYAAAGHRVTVERGAGAGASFPDDAYAAAGAELADAAAAFGADIVLKVQAPTDAEC
GQLKRGSVLIGMLEPFNAEQAARLAAAGVTGFALEAAPRTTRAQSLDVLSSQANIAGYKAVLVAAALYPRFFPMLMTAAG
TVKAARVLVLGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETQDERDAAQGVGGYARPMPASWLG
RQAALVHERAKQADIVITTALIPGRPAPTLISVETVQSMKPGSVLVDLAAGRGPEFDGRKSGNCPLTVADQVIVHHGVTI
AGHTNLAAMVPADASSLYARNLFDFLKLIVTKEGALNIDLSDDIVAATLLCRDGEVVRK
>Mature_379_residues
MHIGVPAETRANEARVAATPETVRKYAAAGHRVTVERGAGAGASFPDDAYAAAGAELADAAAAFGADIVLKVQAPTDAEC
GQLKRGSVLIGMLEPFNAEQAARLAAAGVTGFALEAAPRTTRAQSLDVLSSQANIAGYKAVLVAAALYPRFFPMLMTAAG
TVKAARVLVLGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETQDERDAAQGVGGYARPMPASWLG
RQAALVHERAKQADIVITTALIPGRPAPTLISVETVQSMKPGSVLVDLAAGRGPEFDGRKSGNCPLTVADQVIVHHGVTI
AGHTNLAAMVPADASSLYARNLFDFLKLIVTKEGALNIDLSDDIVAATLLCRDGEVVRK

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=392, Percent_Identity=38.7755102040816, Blast_Score=255, Evalue=4e-68,
Organism=Homo sapiens, GI122939153, Length=392, Percent_Identity=38.7755102040816, Blast_Score=255, Evalue=4e-68,
Organism=Escherichia coli, GI1787887, Length=379, Percent_Identity=44.8548812664908, Blast_Score=305, Evalue=5e-84,
Organism=Caenorhabditis elegans, GI17550456, Length=377, Percent_Identity=41.3793103448276, Blast_Score=270, Evalue=7e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 39190; Mature: 39190

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIGVPAETRANEARVAATPETVRKYAAAGHRVTVERGAGAGASFPDDAYAAAGAELADA
CCCCCCCCCCCCCCEEECCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHCCCHHHHH
AAAFGADIVLKVQAPTDAECGQLKRGSVLIGMLEPFNAEQAARLAAAGVTGFALEAAPRT
HHHCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEECCCCC
TRAQSLDVLSSQANIAGYKAVLVAAALYPRFFPMLMTAAGTVKAARVLVLGAGVAGLQAI
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETQDERDAAQGVGGYARPMPASWLG
HHHHHHHHEEECCCCCHHHHHHHHHHCHHEECCCCCCCCHHHHHHCCCCCCCCCCHHHHH
RQAALVHERAKQADIVITTALIPGRPAPTLISVETVQSMKPGSVLVDLAAGRGPEFDGRK
HHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEHHHHHCCCCCCEEEEECCCCCCCCCCCC
SGNCPLTVADQVIVHHGVTIAGHTNLAAMVPADASSLYARNLFDFLKLIVTKEGALNIDL
CCCCCEEHHHHHHHHCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEECC
SDDIVAATLLCRDGEVVRK
CCHHHHHHHEECCCHHHCC
>Mature Secondary Structure
MHIGVPAETRANEARVAATPETVRKYAAAGHRVTVERGAGAGASFPDDAYAAAGAELADA
CCCCCCCCCCCCCCEEECCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHCCCHHHHH
AAAFGADIVLKVQAPTDAECGQLKRGSVLIGMLEPFNAEQAARLAAAGVTGFALEAAPRT
HHHCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEECCCCC
TRAQSLDVLSSQANIAGYKAVLVAAALYPRFFPMLMTAAGTVKAARVLVLGAGVAGLQAI
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETQDERDAAQGVGGYARPMPASWLG
HHHHHHHHEEECCCCCHHHHHHHHHHCHHEECCCCCCCCHHHHHHCCCCCCCCCCHHHHH
RQAALVHERAKQADIVITTALIPGRPAPTLISVETVQSMKPGSVLVDLAAGRGPEFDGRK
HHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEHHHHHCCCCCCEEEEECCCCCCCCCCCC
SGNCPLTVADQVIVHHGVTIAGHTNLAAMVPADASSLYARNLFDFLKLIVTKEGALNIDL
CCCCCEEHHHHHHHHCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEECC
SDDIVAATLLCRDGEVVRK
CCHHHHHHHEECCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]