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The map label for this gene is slt [H]

Identifier: 126453322

GI number: 126453322

Start: 252099

End: 254054

Strand: Direct

Name: slt [H]

Synonym: BURPS1106A_0269

Alternate gene names: 126453322

Gene position: 252099-254054 (Clockwise)

Preceding gene: 126454754

Following gene: 126453488

Centisome position: 6.32

GC content: 68.51

Gene sequence:

>1956_bases
ATGTCAACCAGCCTTTTTCGAGTATATCGCGCGGTCGCGGCGCCCCTCGTCGCGATCGCGCTGGCCGCCGTGGCGGCCGC
CTGCGCCGCGCAGACCGCCGACGAAGCGTCGTCGAACGACGATCGGGTGTTCGTCCAGCTGCGCGAGGCCGCGCGCAGGA
ACGATCCGGTGCGCGCCGCGCAGCTCGCCGCGCTGATCCCGAATTATCCGGCGCCGTCATATCTCGAGTACTTCCAGATC
AAGCCGCAGTTGTTCGATTCGGCGGGCCATGCGCGCCTTGACGCGCCGGACGCGCCGGTGCTGTCGTTCCTGTCGCGCTA
CGACGGCCAGGCGATCGCCGACCGCATGCGCAACGATTACCTGCTCGTGCTCGGCGCGCGCCATGACTGGCGCGCCTTCG
ACGAGCAGTACAAGCGCTTCGTGCTCGACGACGACACGCAGGTCAAGTGCTATGCGCTCGAATCGCGCGCATCGCGTGGC
GAGAACGTCGCGGACATGGCGCGCGAGCTGCTCGTCGAGCCGAAGTATTACGGCGACGCGTGCGTCGACCTCATCACGGC
GCTCGCGACGAACAAGCAGTTCTCGAGCGACGACGTGTGGGCGCAGGTGCGCCTCGCGTACGAGCAGAACTACACGACGC
TCGGCGGCAAGATTGCCGACGCGCTCGGCCCGCGCCCGGTCGGCTTCGATCAGGTGACGAGCGCGCCGCCGCTGTTCCTC
GCGCGCGGCGTGGGCTCCGACGCGACGTCGCGGCAACTCGCGCTCGTCGCGATCACGCGCATGGCGCGCAACGATCCGGA
AGCGGCGGCGGGGCAGCTCGCGTCGCTCGCGTCGACGCTGTCGGCGGCCGAGCAGGCGATCGGCTGGGGCGAGATCGGCT
ATCAGGCGACGGTCAAGCGGCTGCCGCAGGCCGCGTCGTGGTACCGGAAATCGATGGACGCGCCGCTGTCGAATCCGGCG
TACGAATGGCGTGTGCGCGCGGCGCTGCTCGCCGGCGACTGGCCGATGGTGCGCCGCTCGATCGAGCAGATGCCCGAGCG
GCTGCGCGACGACACGGCATGGATCTACTGGCGCGGCCGCGCGCTGAAGGAGAGCGGCGACACGCTCAAGGCGAACCAGG
AGTTCGAGCGCATCGCCGGGCAGTTCAACTTCTACGGGCAGCTCGCGGGCGAGGAGCTCGGCCAGAAGACGACGATCCCG
CCGCGCACGAAGGTGACGGACGCCGAGATCGACGCGATGAGCAAGGTGCCGGGCTTCGCGCTCGCGCAGCGCTTCTACGC
GCTGAACCTGCGGCTCGAAGGCAACCGCGAATGGAACTGGCCGCTGCGCGGGATGACCGATCGGCAACTGCTCGCGGCGG
CCGAGTACGGCAAGCGCGTCGACCTGCTCGACCGCACGGTCAACACCGCCGATCGCACGACGGCCGAGCACGATTTCTCG
CTGCGCTATCCGTCGCCGTATCGCGACATCGTCGAGCGCTACGCGCGGACCAACGGGCTCGACGTCGAATGGGCGTACGG
GCTGATCCGCCAGGAATCGCGCTTCATCACGAACGCGCGCTCGACGGTGGGCGCAGGCGGCCTGATGCAACTGATGCCGG
CGACCGCGCAACTCGTCGCGAAGAAGCTCGGCCTCGGCACGGTCTCGCGCGCGCAGATGCACGACATCGATACGAACGTG
CAGCTCGGCACCTGGTATCTGTCCGACATCTACCAGAAGTTCGACGATTCGGCCGTGCTCGCGACGGCCGGCTACAACGC
CGGCCCGGGCCGGCCGGCCCAATGGCGGCAGGTGCTCACGCGCCCCGTCGAAGGCGCGATCTTCGCGGAGACGATCCCGT
TCAACGAGACGCGCGAATACGTGAAGAACGTGCTGTCCAACGAGACGTACTACGCGGCGCTCTTCGAGAAGAAGCCGCAA
TCGCTGAAGGCTCGCCTCGGCTTCATCGCGCCGTAA

Upstream 100 bases:

>100_bases
CGAGGCGGCGCCGAGCAAGCGTTTCGCGCAGCGTGCGCTTCGGATTCGGCGCCGGGGCGCGTGCTATGCTTTCGCTCACT
AGAGTGCTCCGTTCACAACG

Downstream 100 bases:

>100_bases
CGCGCGCCGCGCAACGCAGCGGCGTGCCGCGCACGCGCTGTCCGGGCGCAGCCGGCCGGCGCTTCGTATCACATTCGCCG
CCCGCGCGTCGCGTGGGCGG

Product: Slt family transglycosylase

Products: 1,6-Anhydrobond [C]

Alternate protein names: Exomuramidase; Peptidoglycan lytic exotransglycosylase; Slt70 [H]

Number of amino acids: Translated: 651; Mature: 650

Protein sequence:

>651_residues
MSTSLFRVYRAVAAPLVAIALAAVAAACAAQTADEASSNDDRVFVQLREAARRNDPVRAAQLAALIPNYPAPSYLEYFQI
KPQLFDSAGHARLDAPDAPVLSFLSRYDGQAIADRMRNDYLLVLGARHDWRAFDEQYKRFVLDDDTQVKCYALESRASRG
ENVADMARELLVEPKYYGDACVDLITALATNKQFSSDDVWAQVRLAYEQNYTTLGGKIADALGPRPVGFDQVTSAPPLFL
ARGVGSDATSRQLALVAITRMARNDPEAAAGQLASLASTLSAAEQAIGWGEIGYQATVKRLPQAASWYRKSMDAPLSNPA
YEWRVRAALLAGDWPMVRRSIEQMPERLRDDTAWIYWRGRALKESGDTLKANQEFERIAGQFNFYGQLAGEELGQKTTIP
PRTKVTDAEIDAMSKVPGFALAQRFYALNLRLEGNREWNWPLRGMTDRQLLAAAEYGKRVDLLDRTVNTADRTTAEHDFS
LRYPSPYRDIVERYARTNGLDVEWAYGLIRQESRFITNARSTVGAGGLMQLMPATAQLVAKKLGLGTVSRAQMHDIDTNV
QLGTWYLSDIYQKFDDSAVLATAGYNAGPGRPAQWRQVLTRPVEGAIFAETIPFNETREYVKNVLSNETYYAALFEKKPQ
SLKARLGFIAP

Sequences:

>Translated_651_residues
MSTSLFRVYRAVAAPLVAIALAAVAAACAAQTADEASSNDDRVFVQLREAARRNDPVRAAQLAALIPNYPAPSYLEYFQI
KPQLFDSAGHARLDAPDAPVLSFLSRYDGQAIADRMRNDYLLVLGARHDWRAFDEQYKRFVLDDDTQVKCYALESRASRG
ENVADMARELLVEPKYYGDACVDLITALATNKQFSSDDVWAQVRLAYEQNYTTLGGKIADALGPRPVGFDQVTSAPPLFL
ARGVGSDATSRQLALVAITRMARNDPEAAAGQLASLASTLSAAEQAIGWGEIGYQATVKRLPQAASWYRKSMDAPLSNPA
YEWRVRAALLAGDWPMVRRSIEQMPERLRDDTAWIYWRGRALKESGDTLKANQEFERIAGQFNFYGQLAGEELGQKTTIP
PRTKVTDAEIDAMSKVPGFALAQRFYALNLRLEGNREWNWPLRGMTDRQLLAAAEYGKRVDLLDRTVNTADRTTAEHDFS
LRYPSPYRDIVERYARTNGLDVEWAYGLIRQESRFITNARSTVGAGGLMQLMPATAQLVAKKLGLGTVSRAQMHDIDTNV
QLGTWYLSDIYQKFDDSAVLATAGYNAGPGRPAQWRQVLTRPVEGAIFAETIPFNETREYVKNVLSNETYYAALFEKKPQ
SLKARLGFIAP
>Mature_650_residues
STSLFRVYRAVAAPLVAIALAAVAAACAAQTADEASSNDDRVFVQLREAARRNDPVRAAQLAALIPNYPAPSYLEYFQIK
PQLFDSAGHARLDAPDAPVLSFLSRYDGQAIADRMRNDYLLVLGARHDWRAFDEQYKRFVLDDDTQVKCYALESRASRGE
NVADMARELLVEPKYYGDACVDLITALATNKQFSSDDVWAQVRLAYEQNYTTLGGKIADALGPRPVGFDQVTSAPPLFLA
RGVGSDATSRQLALVAITRMARNDPEAAAGQLASLASTLSAAEQAIGWGEIGYQATVKRLPQAASWYRKSMDAPLSNPAY
EWRVRAALLAGDWPMVRRSIEQMPERLRDDTAWIYWRGRALKESGDTLKANQEFERIAGQFNFYGQLAGEELGQKTTIPP
RTKVTDAEIDAMSKVPGFALAQRFYALNLRLEGNREWNWPLRGMTDRQLLAAAEYGKRVDLLDRTVNTADRTTAEHDFSL
RYPSPYRDIVERYARTNGLDVEWAYGLIRQESRFITNARSTVGAGGLMQLMPATAQLVAKKLGLGTVSRAQMHDIDTNVQ
LGTWYLSDIYQKFDDSAVLATAGYNAGPGRPAQWRQVLTRPVEGAIFAETIPFNETREYVKNVLSNETYYAALFEKKPQS
LKARLGFIAP

Specific function: Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Periplasm. Note=Tightly associated with the murein sacculus (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transglycosylase slt family [H]

Homologues:

Organism=Escherichia coli, GI87082441, Length=656, Percent_Identity=26.6768292682927, Blast_Score=195, Evalue=7e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016026
- InterPro:   IPR008258
- InterPro:   IPR012289
- InterPro:   IPR008939
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 72424; Mature: 72293

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSLFRVYRAVAAPLVAIALAAVAAACAAQTADEASSNDDRVFVQLREAARRNDPVRAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCHHHH
QLAALIPNYPAPSYLEYFQIKPQLFDSAGHARLDAPDAPVLSFLSRYDGQAIADRMRNDY
HHHHHCCCCCCCCHHHHHHCCHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCE
LLVLGARHDWRAFDEQYKRFVLDDDTQVKCYALESRASRGENVADMARELLVEPKYYGDA
EEEEECCCHHHHHHHHHHHEECCCCCCEEEEEEHHHHCCCCCHHHHHHHHHCCCCCCCHH
CVDLITALATNKQFSSDDVWAQVRLAYEQNYTTLGGKIADALGPRPVGFDQVTSAPPLFL
HHHHHHHHHCCCCCCCCCHHHHEEEHHHCCCHHCCCHHHHHCCCCCCCCHHHCCCCCHHE
ARGVGSDATSRQLALVAITRMARNDPEAAAGQLASLASTLSAAEQAIGWGEIGYQATVKR
ECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHH
LPQAASWYRKSMDAPLSNPAYEWRVRAALLAGDWPMVRRSIEQMPERLRDDTAWIYWRGR
CHHHHHHHHHHCCCCCCCCCHHHEEEEHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECC
ALKESGDTLKANQEFERIAGQFNFYGQLAGEELGQKTTIPPRTKVTDAEIDAMSKVPGFA
CCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCHHH
LAQRFYALNLRLEGNREWNWPLRGMTDRQLLAAAEYGKRVDLLDRTVNTADRTTAEHDFS
HHHHHEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCHHCCCCCCCCE
LRYPSPYRDIVERYARTNGLDVEWAYGLIRQESRFITNARSTVGAGGLMQLMPATAQLVA
ECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
KKLGLGTVSRAQMHDIDTNVQLGTWYLSDIYQKFDDSAVLATAGYNAGPGRPAQWRQVLT
HHHCCCCCCHHHHHCCCCCCEEHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHH
RPVEGAIFAETIPFNETREYVKNVLSNETYYAALFEKKPQSLKARLGFIAP
CCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEEHHHCCCHHHHHHCCCCCC
>Mature Secondary Structure 
STSLFRVYRAVAAPLVAIALAAVAAACAAQTADEASSNDDRVFVQLREAARRNDPVRAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCHHHH
QLAALIPNYPAPSYLEYFQIKPQLFDSAGHARLDAPDAPVLSFLSRYDGQAIADRMRNDY
HHHHHCCCCCCCCHHHHHHCCHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCE
LLVLGARHDWRAFDEQYKRFVLDDDTQVKCYALESRASRGENVADMARELLVEPKYYGDA
EEEEECCCHHHHHHHHHHHEECCCCCCEEEEEEHHHHCCCCCHHHHHHHHHCCCCCCCHH
CVDLITALATNKQFSSDDVWAQVRLAYEQNYTTLGGKIADALGPRPVGFDQVTSAPPLFL
HHHHHHHHHCCCCCCCCCHHHHEEEHHHCCCHHCCCHHHHHCCCCCCCCHHHCCCCCHHE
ARGVGSDATSRQLALVAITRMARNDPEAAAGQLASLASTLSAAEQAIGWGEIGYQATVKR
ECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHH
LPQAASWYRKSMDAPLSNPAYEWRVRAALLAGDWPMVRRSIEQMPERLRDDTAWIYWRGR
CHHHHHHHHHHCCCCCCCCCHHHEEEEHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECC
ALKESGDTLKANQEFERIAGQFNFYGQLAGEELGQKTTIPPRTKVTDAEIDAMSKVPGFA
CCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCHHH
LAQRFYALNLRLEGNREWNWPLRGMTDRQLLAAAEYGKRVDLLDRTVNTADRTTAEHDFS
HHHHHEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCHHCCCCCCCCE
LRYPSPYRDIVERYARTNGLDVEWAYGLIRQESRFITNARSTVGAGGLMQLMPATAQLVA
ECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
KKLGLGTVSRAQMHDIDTNVQLGTWYLSDIYQKFDDSAVLATAGYNAGPGRPAQWRQVLT
HHHCCCCCCHHHHHCCCCCCEEHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHH
RPVEGAIFAETIPFNETREYVKNVLSNETYYAALFEKKPQSLKARLGFIAP
CCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEEHHHCCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]