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The map label for this gene is tyrS [H]

Identifier: 126453181

GI number: 126453181

Start: 3323928

End: 3325169

Strand: Reverse

Name: tyrS [H]

Synonym: BURPS1106A_3406

Alternate gene names: 126453181

Gene position: 3325169-3323928 (Counterclockwise)

Preceding gene: 126454313

Following gene: 126455206

Centisome position: 83.37

GC content: 64.81

Gene sequence:

>1242_bases
ATGAGCACCGATCCCACTTCCAAGCCCGCCTTCCCGATCACCGATGAAGTCCGCCATGCGCTCGCCGTCACGAAGCGCGG
TGTTGACGAGCTGCTGATCGAGGAAGAGTTCGCGCAGAAGCTCGCGAAAAGCGCGGCGACGGACAAGCCGCTGCGCATCA
AGCTGGGCCTCGATCCGACGGCGCCCGACATCCACCTCGGCCACACGGTCGTGCTGAACAAGATGCGCCAGTTGCAGGAT
CTCGGCCATACGGTGATTTTCCTGATCGGCGATTTCACGTCGCTGATCGGCGATCCGTCGGGCCGCAACGCGACCCGCCC
GCCGCTCACGCGCGAGCAGATCGAATCGAACGCGAAGACCTACTTCGAGCAGGCCGCGCTCGTGCTCGATCGGGAGAAGA
CCGAGATCCGCTACAACAGCGAGTGGTCGATGCCGCTCGGCGCGGATGGGATGATCAAGCTCGCGTCGCGCTACACGGTC
GCGCGCATGCTCGAGCGCGAGGATTTCACGAAACGCTTCCAAGGCGGCATCCCGATCTCGATCCATGAATTCCTGTACCC
GCTGATGCAGGGTTACGATTCGGTCGCGCTGAACGCCGATCTCGAGCTCGGCGGCACCGACCAGAAATTCAACCTGCTCG
TCGGCCGCGAGCTGCAGAAGCAATACGGCCAGGAGCAGCAGTGCATCCTGACGATGCCGCTGCTCGAAGGCCTCGACGGC
GTCGAGAAGATGTCGAAATCGAAGGGCAACTACGTCGGCATCAGCGAGAAGCCGACCGACATGTTCGGCAAGCTGATGAG
CATCTCGGACGTGCTGATGTGGCGCTACTTCGAGCTGCTGTCGTTCCGCAGCCTCGACGAGATCGCGCGGTTCCGCGGCG
AGGCCGAAGGCGGGCGCAACCCGCGCGACTTCAAGGTGATGCTCGCGCAGGAGATCGTCGCGCGTTTCCATTCGCAGGCC
GACGCCGAACGCGCGCTCGAGGACTTCAACCATCGCGCGAAGGGCGGCGTGCCCGACGATATCCCGGCCGTGACGCTCGC
CGGCGCGCCGCTCGCGATCGGCCAGTTGCTGAAGCAGGCGGGGCTCGTGCCTTCGACGAGCGAGGCGCTGCGCAACATCG
AGCAGGGCGGTGTGAAGATCGACGGCGCGACGGTGTCCGACAAGGCGCTGAAAGTCGACGCGGGCGAGTTCGTCGTGCAG
GTCGGCAAGCGCCGCTTCGCGCGCGTGACGCTTACCGCATGA

Upstream 100 bases:

>100_bases
TTATCCGCGCAAATCCGCGCGAACGCGCGCGCCGTTGAGCGGCCCGCGTGCAACTTATGGGAAAATCGCTCTTTTTGCGA
CATTCCTTCCTCTTGCACCG

Downstream 100 bases:

>100_bases
GCGCGCGCATCGCCGCTTGGCCGGGCATGCCGCGCGCGGTGCGCGGCGCCGCGCGTGGCCGCCGCGCCGCGTGCGTGACG
CGGACGCGCGCATGATCGCC

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MSTDPTSKPAFPITDEVRHALAVTKRGVDELLIEEEFAQKLAKSAATDKPLRIKLGLDPTAPDIHLGHTVVLNKMRQLQD
LGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKTYFEQAALVLDREKTEIRYNSEWSMPLGADGMIKLASRYTV
ARMLEREDFTKRFQGGIPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEGLDG
VEKMSKSKGNYVGISEKPTDMFGKLMSISDVLMWRYFELLSFRSLDEIARFRGEAEGGRNPRDFKVMLAQEIVARFHSQA
DAERALEDFNHRAKGGVPDDIPAVTLAGAPLAIGQLLKQAGLVPSTSEALRNIEQGGVKIDGATVSDKALKVDAGEFVVQ
VGKRRFARVTLTA

Sequences:

>Translated_413_residues
MSTDPTSKPAFPITDEVRHALAVTKRGVDELLIEEEFAQKLAKSAATDKPLRIKLGLDPTAPDIHLGHTVVLNKMRQLQD
LGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKTYFEQAALVLDREKTEIRYNSEWSMPLGADGMIKLASRYTV
ARMLEREDFTKRFQGGIPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEGLDG
VEKMSKSKGNYVGISEKPTDMFGKLMSISDVLMWRYFELLSFRSLDEIARFRGEAEGGRNPRDFKVMLAQEIVARFHSQA
DAERALEDFNHRAKGGVPDDIPAVTLAGAPLAIGQLLKQAGLVPSTSEALRNIEQGGVKIDGATVSDKALKVDAGEFVVQ
VGKRRFARVTLTA
>Mature_412_residues
STDPTSKPAFPITDEVRHALAVTKRGVDELLIEEEFAQKLAKSAATDKPLRIKLGLDPTAPDIHLGHTVVLNKMRQLQDL
GHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKTYFEQAALVLDREKTEIRYNSEWSMPLGADGMIKLASRYTVA
RMLEREDFTKRFQGGIPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEGLDGV
EKMSKSKGNYVGISEKPTDMFGKLMSISDVLMWRYFELLSFRSLDEIARFRGEAEGGRNPRDFKVMLAQEIVARFHSQAD
AERALEDFNHRAKGGVPDDIPAVTLAGAPLAIGQLLKQAGLVPSTSEALRNIEQGGVKIDGATVSDKALKVDAGEFVVQV
GKRRFARVTLTA

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=401, Percent_Identity=25.9351620947631, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1787925, Length=424, Percent_Identity=29.7169811320755, Blast_Score=138, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI25145802, Length=210, Percent_Identity=29.5238095238095, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325160, Length=402, Percent_Identity=24.6268656716418, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI20130383, Length=450, Percent_Identity=25.5555555555556, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 45719; Mature: 45588

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS50889 S4 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTDPTSKPAFPITDEVRHALAVTKRGVDELLIEEEFAQKLAKSAATDKPLRIKLGLDPT
CCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
APDIHLGHTVVLNKMRQLQDLGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKT
CCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
YFEQAALVLDREKTEIRYNSEWSMPLGADGMIKLASRYTVARMLEREDFTKRFQGGIPIS
HHHHHHHHHCCCHHCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
IHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEGLDG
HHHHHHHHHCCCCCEEEECCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHHCCHH
VEKMSKSKGNYVGISEKPTDMFGKLMSISDVLMWRYFELLSFRSLDEIARFRGEAEGGRN
HHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCC
PRDFKVMLAQEIVARFHSQADAERALEDFNHRAKGGVPDDIPAVTLAGAPLAIGQLLKQA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHC
GLVPSTSEALRNIEQGGVKIDGATVSDKALKVDAGEFVVQVGKRRFARVTLTA
CCCCCHHHHHHHHHHCCEEECCCEECCCEEEECHHHHHHHHHHHHHEEEEECC
>Mature Secondary Structure 
STDPTSKPAFPITDEVRHALAVTKRGVDELLIEEEFAQKLAKSAATDKPLRIKLGLDPT
CCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
APDIHLGHTVVLNKMRQLQDLGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKT
CCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
YFEQAALVLDREKTEIRYNSEWSMPLGADGMIKLASRYTVARMLEREDFTKRFQGGIPIS
HHHHHHHHHCCCHHCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
IHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEGLDG
HHHHHHHHHCCCCCEEEECCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHHCCHH
VEKMSKSKGNYVGISEKPTDMFGKLMSISDVLMWRYFELLSFRSLDEIARFRGEAEGGRN
HHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCC
PRDFKVMLAQEIVARFHSQADAERALEDFNHRAKGGVPDDIPAVTLAGAPLAIGQLLKQA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHC
GLVPSTSEALRNIEQGGVKIDGATVSDKALKVDAGEFVVQVGKRRFARVTLTA
CCCCCHHHHHHHHHHCCEEECCCEECCCEEEECHHHHHHHHHHHHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA