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The map label for this gene is envZ [H]

Identifier: 126453072

GI number: 126453072

Start: 1081288

End: 1082601

Strand: Direct

Name: envZ [H]

Synonym: BURPS1106A_1100

Alternate gene names: 126453072

Gene position: 1081288-1082601 (Clockwise)

Preceding gene: 126452418

Following gene: 126453617

Centisome position: 27.11

GC content: 72.83

Gene sequence:

>1314_bases
ATGCGCAAACCCATTGATTCGCTGTTCGGGCGGCTCGCGCTCCTTGTCGTCTGCGTGCTGCTGCTGTCGCACTTCGCGTG
GTACTTCGCGATCCGGCTCGAGCGCAATCAGTTCCAGACGCGCTATGCGGTCGAGGAGGCGGCGTTCCTCGTCGACGCGG
TGCGCCAGCACGCGGAGCGCTCGCCCGACCAGCCGCTGCCGTCGCGGGTGCGGCTCGTCGCGCCGGGCAGCGGCGACGTG
CCCGAGGCGAAGCAGGATCTGCCGCCCCCGCTCAAGCGCTTCGCGGACGATCTGCGCGAGCGCCTGCCGGCCGGCACGCA
GGTGCGCATCGGCCGGCCGGGCCATCCGCCCGTGCTGTGGGTCAAGCAGCCGAGCGATCGCGACTGGATCGTCGTGCCGG
TTCAGCCGCTGCGGCCGCCGCGCTCGCTCGACCGGATGGTGCTCTGGCTGGTGATGATCTTCTCGGCCGCGGTGATGGCG
GCGCTCTTCGCCGCCTGGCAACTGCAGCAGCCGCTCAGTTCGCTCGCGCGCGCGGTCGCGCGCTTCGGCCGCGGGATGGC
GGTGCCGCCGCTGCCCGAGCGCGGGCCGCGCGAGCTGCGCCAGCTCACGCACGGCTTCAATCAGATGGTTCAGCAGGTGT
CGCGCGCGGAGAACGACCGCGCGGTGATGCTCGCGGGCGTCGCGCACGATCTGCGCACGCCGCTCGCGCGGATGCGGCTG
CGCGCGGAGATGATGGACGACGCGCGGCTGCGCGACGGCGTCGTGCGCGACGTCGATTCGATGACGCACATCGTCGACCA
GTTCCTCGTGTTCGCGCACGGCGACGCCGACCGCAGCGAGGCCGTGCCGGTCGACCAGGCGTGCGAGCGGATCGCGCGCA
CTTACCGCGCGGTGTCCCCGAACGCGCCCACCGTGCGCACCGAGCTCGCGGCCGGGCCGGGCTTTCGCCTGCCGGCGGCG
ACGCTCGACCGGGTGCTGTCGAACCTGCTCGACAATGCGCATGCCTATGGCGCGCCGCCCGTCGTGATCGCGACCGCGCG
CACCGCGACGGGCTACACGCTCACCGTCAGCGACCACGGCAAGGGCATCGCGCCGCGCGATCTCGCGGACGCGACGCGCC
CGTTCGTGCGGCTCGATCCGGCGCGCGGCGGCAATGGGCACAGCGGTCTCGGGCTTGCGATCGTCGAGCGGCTCGTGCAG
CGTACGGGGGGCGCGTGCGAGATCGGCAACCGGGAAGAAGGAGGCCTGCGGGTCGCGATGACGTTCGCGTTCGACGTCGT
GCCGAAGGCGGAGCCGCAGACGGAGGCGCCCTGA

Upstream 100 bases:

>100_bases
TGGCGTCTGCGCCGGATCCTCGAAACCGATCCGTCGACGCCGCGCTTCATCCAGACGGTGCGCGGGCGCGGCTACGTGTT
CGTGCCGAACGGCGAGGCTC

Downstream 100 bases:

>100_bases
CGCCCGGCCGCCCGGCCGGCGCGGGGGCCGCGGCGCCCGGCGCCGCTGCGCCGCCACGCCGCGCGGCGGCGGGTCACTCG
CCGAAGAGCGTGCTGAGCGT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MRKPIDSLFGRLALLVVCVLLLSHFAWYFAIRLERNQFQTRYAVEEAAFLVDAVRQHAERSPDQPLPSRVRLVAPGSGDV
PEAKQDLPPPLKRFADDLRERLPAGTQVRIGRPGHPPVLWVKQPSDRDWIVVPVQPLRPPRSLDRMVLWLVMIFSAAVMA
ALFAAWQLQQPLSSLARAVARFGRGMAVPPLPERGPRELRQLTHGFNQMVQQVSRAENDRAVMLAGVAHDLRTPLARMRL
RAEMMDDARLRDGVVRDVDSMTHIVDQFLVFAHGDADRSEAVPVDQACERIARTYRAVSPNAPTVRTELAAGPGFRLPAA
TLDRVLSNLLDNAHAYGAPPVVIATARTATGYTLTVSDHGKGIAPRDLADATRPFVRLDPARGGNGHSGLGLAIVERLVQ
RTGGACEIGNREEGGLRVAMTFAFDVVPKAEPQTEAP

Sequences:

>Translated_437_residues
MRKPIDSLFGRLALLVVCVLLLSHFAWYFAIRLERNQFQTRYAVEEAAFLVDAVRQHAERSPDQPLPSRVRLVAPGSGDV
PEAKQDLPPPLKRFADDLRERLPAGTQVRIGRPGHPPVLWVKQPSDRDWIVVPVQPLRPPRSLDRMVLWLVMIFSAAVMA
ALFAAWQLQQPLSSLARAVARFGRGMAVPPLPERGPRELRQLTHGFNQMVQQVSRAENDRAVMLAGVAHDLRTPLARMRL
RAEMMDDARLRDGVVRDVDSMTHIVDQFLVFAHGDADRSEAVPVDQACERIARTYRAVSPNAPTVRTELAAGPGFRLPAA
TLDRVLSNLLDNAHAYGAPPVVIATARTATGYTLTVSDHGKGIAPRDLADATRPFVRLDPARGGNGHSGLGLAIVERLVQ
RTGGACEIGNREEGGLRVAMTFAFDVVPKAEPQTEAP
>Mature_437_residues
MRKPIDSLFGRLALLVVCVLLLSHFAWYFAIRLERNQFQTRYAVEEAAFLVDAVRQHAERSPDQPLPSRVRLVAPGSGDV
PEAKQDLPPPLKRFADDLRERLPAGTQVRIGRPGHPPVLWVKQPSDRDWIVVPVQPLRPPRSLDRMVLWLVMIFSAAVMA
ALFAAWQLQQPLSSLARAVARFGRGMAVPPLPERGPRELRQLTHGFNQMVQQVSRAENDRAVMLAGVAHDLRTPLARMRL
RAEMMDDARLRDGVVRDVDSMTHIVDQFLVFAHGDADRSEAVPVDQACERIARTYRAVSPNAPTVRTELAAGPGFRLPAA
TLDRVLSNLLDNAHAYGAPPVVIATARTATGYTLTVSDHGKGIAPRDLADATRPFVRLDPARGGNGHSGLGLAIVERLVQ
RTGGACEIGNREEGGLRVAMTFAFDVVPKAEPQTEAP

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=439, Percent_Identity=29.1571753986333, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1787894, Length=260, Percent_Identity=31.1538461538462, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1790346, Length=250, Percent_Identity=28.4, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1790551, Length=319, Percent_Identity=26.3322884012539, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786600, Length=236, Percent_Identity=30.0847457627119, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1790861, Length=297, Percent_Identity=26.2626262626263, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87081816, Length=260, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789403, Length=293, Percent_Identity=27.6450511945392, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48062; Mature: 48062

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKPIDSLFGRLALLVVCVLLLSHFAWYFAIRLERNQFQTRYAVEEAAFLVDAVRQHAER
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
SPDQPLPSRVRLVAPGSGDVPEAKQDLPPPLKRFADDLRERLPAGTQVRIGRPGHPPVLW
CCCCCCCCCEEEECCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEE
VKQPSDRDWIVVPVQPLRPPRSLDRMVLWLVMIFSAAVMAALFAAWQLQQPLSSLARAVA
EECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFGRGMAVPPLPERGPRELRQLTHGFNQMVQQVSRAENDRAVMLAGVAHDLRTPLARMRL
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHH
RAEMMDDARLRDGVVRDVDSMTHIVDQFLVFAHGDADRSEAVPVDQACERIARTYRAVSP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
NAPTVRTELAAGPGFRLPAATLDRVLSNLLDNAHAYGAPPVVIATARTATGYTLTVSDHG
CCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEECCCC
KGIAPRDLADATRPFVRLDPARGGNGHSGLGLAIVERLVQRTGGACEIGNREEGGLRVAM
CCCCCHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCEEEEE
TFAFDVVPKAEPQTEAP
EEHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRKPIDSLFGRLALLVVCVLLLSHFAWYFAIRLERNQFQTRYAVEEAAFLVDAVRQHAER
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
SPDQPLPSRVRLVAPGSGDVPEAKQDLPPPLKRFADDLRERLPAGTQVRIGRPGHPPVLW
CCCCCCCCCEEEECCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEE
VKQPSDRDWIVVPVQPLRPPRSLDRMVLWLVMIFSAAVMAALFAAWQLQQPLSSLARAVA
EECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFGRGMAVPPLPERGPRELRQLTHGFNQMVQQVSRAENDRAVMLAGVAHDLRTPLARMRL
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHH
RAEMMDDARLRDGVVRDVDSMTHIVDQFLVFAHGDADRSEAVPVDQACERIARTYRAVSP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
NAPTVRTELAAGPGFRLPAATLDRVLSNLLDNAHAYGAPPVVIATARTATGYTLTVSDHG
CCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEECCCC
KGIAPRDLADATRPFVRLDPARGGNGHSGLGLAIVERLVQRTGGACEIGNREEGGLRVAM
CCCCCHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCEEEEE
TFAFDVVPKAEPQTEAP
EEHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]