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The map label for this gene is dctA [H]

Identifier: 126452996

GI number: 126452996

Start: 442062

End: 443348

Strand: Direct

Name: dctA [H]

Synonym: BURPS1106A_0476

Alternate gene names: 126452996

Gene position: 442062-443348 (Clockwise)

Preceding gene: 126454006

Following gene: 126451792

Centisome position: 11.08

GC content: 65.58

Gene sequence:

>1287_bases
GTGAAGAAACCGTTCTATAAAGTCCTCTACGTGCAGGTGATCTTCGCCATCGTCGTCGGCGTGATCCTGGGTCACTACTA
TCCGTCGCTCGCCGTCGACATGAAGCCGCTCGGCGACGGCTTCATCAAGCTGATCAAGATGGTGATCGGCCCGATCATCT
TCTGCACCGTCGTGACCGGCATCGCCGGCATGCAGGACATGAAGAAGGTGGGGCGCGTCGGCGGCAAGGCGCTCCTGTAT
TTCGAGATCGTGTCGACGTGCGCGCTCGTGCTCGGCCTCGCGGCGACGCACATCCTGCGCCCCGGCGTCGGCTTCAACAT
CGATCCGGCGACGCTGAACGGCAAGGAAGTCGCGTCGTACGCGGCGAAGGCGCACGGCCAGTCGAGCGTCGACTTCCTGA
TGCACATCATCCCGAACACGATGATCGACGCGTTCGCGCAGGGGGAGATCCTGCAGATCCTGCTGATCGCGCTGCTGTTC
GGCTCGGTGCTCGCGCACCTCGGCGAGCGCGGCCGCGTCGTCACCGATTTCATCGACGGCATCACGCGCGTGCTGTTCGG
CATCGTGCACATCGTCACGAAGCTCGCGCCGATCGGCGCGTTCGGCGCGATGGCGTTCACGATCGGCAAGTACGGCGTCG
GCTCGCTCGTGCCGCTGCTCAAGCTGATCGGCACGTTCTACCTGACCTCGGTCGTGTTCGTGCTCGTCGTGCTCGGCGCG
ATCGCGCGCTTCACCGGCTTCTCGATCATCCGCTTCGTCGGCTACATCAAGGAAGAGCTCCTGATCGTGCTCGGCACGAG
CTCGTCGGAGGCGGCGCTGCCGCAACTGATGGAGAAGCTCGAGAAGGCGGGCTGCTCGCGCTCGGTCGTCGGCCTCGTCG
TGCCGACCGGCTACTCGTTCAACCTCGACGGCACGAACATCTACATGACGATGGCCGTGCTGTTCATCGCGCAGGCCACC
AACATCGAGCTCACGTGGATGCAGCAGCTCACGCTGCTCGCGGTCGCGATGCTGACGTCGAAGGGCGCGAGCGGCGTCAC
GGGCGCGGGCTTCATCACGCTCGCCGCGACGCTCGCCGTCGTGCCGACCATTCCGCTGTCCGGCATGGTGCTGATTCTCG
GCATCGACCGCTTCATGAGCGAATGCCGCGCGCTGACCAACATCGTCGGCAACGGCGTTGCGACGGTCGTCGTGTCCGCG
TGGGAGAAGGAGCTCGACCGCGCGAAGCTGCGCGCGGCGCTGTCGGGCAACGGCGAGGCAGCCGCGGGCGAAGCCGCGCG
GGTCTGA

Upstream 100 bases:

>100_bases
GGCACGGCGGCCGCGCGGGCGAATGGCGTTCCCCTGACATTCGCCCGCGCGCGTGACGCCGACCTGCTTCGACTCACCTT
CTCTCTTCTCTGGAACCACC

Downstream 100 bases:

>100_bases
CGATGAACGCGGAAACGGCGGGGCGCGCAGCGGCGCCCGCGCCGGGCGGGGCCGGGCCGGACGCGACGAGACGCGCCTGG
CCCGGCCCCGCGGCCTTTTC

Product: C4-dicarboxylate transporter DctA

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MKKPFYKVLYVQVIFAIVVGVILGHYYPSLAVDMKPLGDGFIKLIKMVIGPIIFCTVVTGIAGMQDMKKVGRVGGKALLY
FEIVSTCALVLGLAATHILRPGVGFNIDPATLNGKEVASYAAKAHGQSSVDFLMHIIPNTMIDAFAQGEILQILLIALLF
GSVLAHLGERGRVVTDFIDGITRVLFGIVHIVTKLAPIGAFGAMAFTIGKYGVGSLVPLLKLIGTFYLTSVVFVLVVLGA
IARFTGFSIIRFVGYIKEELLIVLGTSSSEAALPQLMEKLEKAGCSRSVVGLVVPTGYSFNLDGTNIYMTMAVLFIAQAT
NIELTWMQQLTLLAVAMLTSKGASGVTGAGFITLAATLAVVPTIPLSGMVLILGIDRFMSECRALTNIVGNGVATVVVSA
WEKELDRAKLRAALSGNGEAAAGEAARV

Sequences:

>Translated_428_residues
MKKPFYKVLYVQVIFAIVVGVILGHYYPSLAVDMKPLGDGFIKLIKMVIGPIIFCTVVTGIAGMQDMKKVGRVGGKALLY
FEIVSTCALVLGLAATHILRPGVGFNIDPATLNGKEVASYAAKAHGQSSVDFLMHIIPNTMIDAFAQGEILQILLIALLF
GSVLAHLGERGRVVTDFIDGITRVLFGIVHIVTKLAPIGAFGAMAFTIGKYGVGSLVPLLKLIGTFYLTSVVFVLVVLGA
IARFTGFSIIRFVGYIKEELLIVLGTSSSEAALPQLMEKLEKAGCSRSVVGLVVPTGYSFNLDGTNIYMTMAVLFIAQAT
NIELTWMQQLTLLAVAMLTSKGASGVTGAGFITLAATLAVVPTIPLSGMVLILGIDRFMSECRALTNIVGNGVATVVVSA
WEKELDRAKLRAALSGNGEAAAGEAARV
>Mature_428_residues
MKKPFYKVLYVQVIFAIVVGVILGHYYPSLAVDMKPLGDGFIKLIKMVIGPIIFCTVVTGIAGMQDMKKVGRVGGKALLY
FEIVSTCALVLGLAATHILRPGVGFNIDPATLNGKEVASYAAKAHGQSSVDFLMHIIPNTMIDAFAQGEILQILLIALLF
GSVLAHLGERGRVVTDFIDGITRVLFGIVHIVTKLAPIGAFGAMAFTIGKYGVGSLVPLLKLIGTFYLTSVVFVLVVLGA
IARFTGFSIIRFVGYIKEELLIVLGTSSSEAALPQLMEKLEKAGCSRSVVGLVVPTGYSFNLDGTNIYMTMAVLFIAQAT
NIELTWMQQLTLLAVAMLTSKGASGVTGAGFITLAATLAVVPTIPLSGMVLILGIDRFMSECRALTNIVGNGVATVVVSA
WEKELDRAKLRAALSGNGEAAAGEAARV

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=477, Percent_Identity=24.5283018867925, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI4827012, Length=274, Percent_Identity=30.6569343065693, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI21314632, Length=434, Percent_Identity=24.8847926267281, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI40254478, Length=468, Percent_Identity=23.5042735042735, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI66773030, Length=418, Percent_Identity=23.444976076555, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI5032093, Length=396, Percent_Identity=26.7676767676768, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI194239697, Length=460, Percent_Identity=23.9130434782609, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI223468564, Length=268, Percent_Identity=29.1044776119403, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI223468566, Length=268, Percent_Identity=29.1044776119403, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI262359914, Length=418, Percent_Identity=23.444976076555, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI301601644, Length=166, Percent_Identity=30.1204819277108, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1789947, Length=424, Percent_Identity=61.3207547169811, Blast_Score=532, Evalue=1e-152,
Organism=Escherichia coli, GI1790514, Length=413, Percent_Identity=39.4673123486683, Blast_Score=299, Evalue=3e-82,
Organism=Escherichia coli, GI1788024, Length=400, Percent_Identity=21.5, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789473, Length=250, Percent_Identity=26.4, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17537407, Length=401, Percent_Identity=27.930174563591, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI193206505, Length=458, Percent_Identity=25.9825327510917, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71983106, Length=449, Percent_Identity=24.9443207126949, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI71983099, Length=449, Percent_Identity=24.9443207126949, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI71996953, Length=463, Percent_Identity=24.1900647948164, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI193206654, Length=413, Percent_Identity=22.5181598062954, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17541374, Length=400, Percent_Identity=22.5, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24583025, Length=408, Percent_Identity=22.7941176470588, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17137668, Length=408, Percent_Identity=22.7941176470588, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24583023, Length=408, Percent_Identity=22.7941176470588, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI281360481, Length=468, Percent_Identity=24.1452991452991, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI281360483, Length=434, Percent_Identity=24.4239631336406, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI17137666, Length=434, Percent_Identity=24.4239631336406, Blast_Score=85, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45262; Mature: 45262

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKPFYKVLYVQVIFAIVVGVILGHYYPSLAVDMKPLGDGFIKLIKMVIGPIIFCTVVTG
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
IAGMQDMKKVGRVGGKALLYFEIVSTCALVLGLAATHILRPGVGFNIDPATLNGKEVASY
HCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
AAKAHGQSSVDFLMHIIPNTMIDAFAQGEILQILLIALLFGSVLAHLGERGRVVTDFIDG
HHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ITRVLFGIVHIVTKLAPIGAFGAMAFTIGKYGVGSLVPLLKLIGTFYLTSVVFVLVVLGA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IARFTGFSIIRFVGYIKEELLIVLGTSSSEAALPQLMEKLEKAGCSRSVVGLVVPTGYSF
HHHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCEEE
NLDGTNIYMTMAVLFIAQATNIELTWMQQLTLLAVAMLTSKGASGVTGAGFITLAATLAV
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
VPTIPLSGMVLILGIDRFMSECRALTNIVGNGVATVVVSAWEKELDRAKLRAALSGNGEA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AAGEAARV
CCCCCCCC
>Mature Secondary Structure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CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA