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The map label for this gene is ilvD [H]

Identifier: 126452792

GI number: 126452792

Start: 1002479

End: 1004152

Strand: Reverse

Name: ilvD [H]

Synonym: BURPS1106A_1027

Alternate gene names: 126452792

Gene position: 1004152-1002479 (Counterclockwise)

Preceding gene: 126453210

Following gene: 126453159

Centisome position: 25.18

GC content: 67.44

Gene sequence:

>1674_bases
ATGTCGTACAACCGCCGCTCGAAGAACATCACGCAAGGCGTGGCCCGTTCGCCGAACCGCTCGATGTATTACGCGCTCGG
CTATCAGAAGGAAGATTTCGACAAGCCGATGATCGGCATCGCGAACGGCCACTCGACGATCACGCCGTGCAACGCGGGCC
TGCAGCGTCTGTCGGACGCCGCCGTCGCGGCCGTCAAGGACGCCGGCGCGAATCCGCAGATCTTCGGCACGCCGACGATC
TCGGACGGCATGTCGATGGGCACCGAAGGGATGAAGTACTCGCTCGTGTCGCGCGAGGTGATCGCCGATTGCATCGAGAC
CTGCGTGCAGGGCCAATGGATGGACGGCGTCGTCGTCGTGGGCGGCTGCGACAAGAACATGCCGGGCGGCATGATCGCGC
TCGCGCGGATCAACGTGCCGGGCATCTACGTGTACGGCGGCACGATCCGCCCCGGCCACTGGAAAGGCCACGACCTGACG
ATCGTGTCGTCGTTCGAGGCGGTCGGCGAGTTCACCGCCGGACGCATGTCGCAGGAGGATTTCGAAGGGGTCGAAAAGAA
CGCGTGCCCGACGACGGGCTCGTGCGGCGGCATGTATACCGCGAACACGATGAGCTCGTCGTTCGAGGCGCTCGGCATGT
CGCTGCTGTACTCGTCGACGATGGCCAATCCCGATCAGGAGAAGGCCGATTCGGCGGCGGAATCGGCGCGCGTGCTGGTC
GAGGCGGTGAAGAAGGACCTGAAGCCGCGCGACATCATCACGAAGCAGTCGATCGAGAACGCGGTGTCGGTGATCATGGC
CACGGGCGGCTCGACCAACGCGGTGCTCCACTATCTGGCGATCGCGCACGCGGCCGAGATCGACTGGTCGATCGAGGATT
TCGAGCGCATCAGGAAGCGCGTGCCGGTGATTTGCGACCTGAAGCCGTCGGGCCAGTACGTCGCGACCGATCTGCACGCG
GCGGGCGGCATTCCGCAGGTGATGAAGCTGCTGCTCGACGCGGGCCTGCTGCACGGCGGCTGCATGACGATCACGGGCCG
CACGCTCGCCGAGGAGCTGAAGGACGTGCCGAGCGTGCCGCGCGCCGATCAGAAGGTGATCCATCCGATCGACCAGGCGC
TGTACAAGGAAGGCCACCTCGCGATCCTGAAGGGCAACCTCGCCGAGGACGGCGCGGTCGCGAAGATCACCGGCCTGAAG
AACCCGGTCATCACCGGCCCGGCGCGCGTGTTCGACGACGAGCAGAGCGCGCTCGCCGCGATCCTCGACGACAGGATCCG
CGCGGGCGATGTCGTCGTGCTGCGCTACCTCGGCCCGCAAGGCGGCCCGGGGATGCCCGAGATGCTCGCGCCGACGTCGG
CGATCATCGGCAAGGGCCTCGGCGAATCGGTCGGCCTGATCACCGACGGCCGCTTCTCCGGCGGCACGTGGGGGATGGTG
GTCGGCCACGTCGCGCCGGAAGCGTTCGTCGGCGGCACGATCGCGCTCGTGCAGGAAGGCGATTCGATCACGATCGACGC
GCACAAGCTGCTGCTGCAATTGAACGTCGACGACGCCGAACTCGCGCGCCGCCGCGCCGCATGGAAGCAGCCGGCGCCGC
GCTACACGCGCGGCGTGCTCGCGAAGTACGCGGCGCTCGCCCGCCCGGCGAACCAGGGCGCCGTCACGGGCTGA

Upstream 100 bases:

>100_bases
TTCTCTAACAGAAACTGCATTCTTGCCCACCTGAGCCGGATCGCGCCGATGCAGCGCGCCGAGCAACCCCACAGTCAACC
AGTCGATGACGGAGTTCCCC

Downstream 100 bases:

>100_bases
CGCACCGCGGCGGCACGGCGGTTGCGCGAGCAGAAAGCGCAGGCCGCTTGCTCGCACGCGCCCGCCTCGCGCCACTGCGG
CCGCGCCGCGATGGCGCTGA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD 2 [H]

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MSYNRRSKNITQGVARSPNRSMYYALGYQKEDFDKPMIGIANGHSTITPCNAGLQRLSDAAVAAVKDAGANPQIFGTPTI
SDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVVGGCDKNMPGGMIALARINVPGIYVYGGTIRPGHWKGHDLT
IVSSFEAVGEFTAGRMSQEDFEGVEKNACPTTGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKADSAAESARVLV
EAVKKDLKPRDIITKQSIENAVSVIMATGGSTNAVLHYLAIAHAAEIDWSIEDFERIRKRVPVICDLKPSGQYVATDLHA
AGGIPQVMKLLLDAGLLHGGCMTITGRTLAEELKDVPSVPRADQKVIHPIDQALYKEGHLAILKGNLAEDGAVAKITGLK
NPVITGPARVFDDEQSALAAILDDRIRAGDVVVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGLITDGRFSGGTWGMV
VGHVAPEAFVGGTIALVQEGDSITIDAHKLLLQLNVDDAELARRRAAWKQPAPRYTRGVLAKYAALARPANQGAVTG

Sequences:

>Translated_557_residues
MSYNRRSKNITQGVARSPNRSMYYALGYQKEDFDKPMIGIANGHSTITPCNAGLQRLSDAAVAAVKDAGANPQIFGTPTI
SDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVVGGCDKNMPGGMIALARINVPGIYVYGGTIRPGHWKGHDLT
IVSSFEAVGEFTAGRMSQEDFEGVEKNACPTTGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKADSAAESARVLV
EAVKKDLKPRDIITKQSIENAVSVIMATGGSTNAVLHYLAIAHAAEIDWSIEDFERIRKRVPVICDLKPSGQYVATDLHA
AGGIPQVMKLLLDAGLLHGGCMTITGRTLAEELKDVPSVPRADQKVIHPIDQALYKEGHLAILKGNLAEDGAVAKITGLK
NPVITGPARVFDDEQSALAAILDDRIRAGDVVVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGLITDGRFSGGTWGMV
VGHVAPEAFVGGTIALVQEGDSITIDAHKLLLQLNVDDAELARRRAAWKQPAPRYTRGVLAKYAALARPANQGAVTG
>Mature_556_residues
SYNRRSKNITQGVARSPNRSMYYALGYQKEDFDKPMIGIANGHSTITPCNAGLQRLSDAAVAAVKDAGANPQIFGTPTIS
DGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVVGGCDKNMPGGMIALARINVPGIYVYGGTIRPGHWKGHDLTI
VSSFEAVGEFTAGRMSQEDFEGVEKNACPTTGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKADSAAESARVLVE
AVKKDLKPRDIITKQSIENAVSVIMATGGSTNAVLHYLAIAHAAEIDWSIEDFERIRKRVPVICDLKPSGQYVATDLHAA
GGIPQVMKLLLDAGLLHGGCMTITGRTLAEELKDVPSVPRADQKVIHPIDQALYKEGHLAILKGNLAEDGAVAKITGLKN
PVITGPARVFDDEQSALAAILDDRIRAGDVVVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGLITDGRFSGGTWGMVV
GHVAPEAFVGGTIALVQEGDSITIDAHKLLLQLNVDDAELARRRAAWKQPAPRYTRGVLAKYAALARPANQGAVTG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=604, Percent_Identity=37.0860927152318, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI2367371, Length=493, Percent_Identity=34.0770791075051, Blast_Score=198, Evalue=1e-51,
Organism=Escherichia coli, GI1786464, Length=466, Percent_Identity=34.7639484978541, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1788157, Length=482, Percent_Identity=31.3278008298755, Blast_Score=188, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6322476, Length=560, Percent_Identity=46.0714285714286, Blast_Score=505, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 58953; Mature: 58822

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYNRRSKNITQGVARSPNRSMYYALGYQKEDFDKPMIGIANGHSTITPCNAGLQRLSDA
CCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHH
AVAAVKDAGANPQIFGTPTISDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVV
HHHHHHCCCCCCCEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEE
GGCDKNMPGGMIALARINVPGIYVYGGTIRPGHWKGHDLTIVSSFEAVGEFTAGRMSQED
ECCCCCCCCCEEEEEEECCCEEEEECCEECCCCCCCCCEEEEECHHHHHHHHHCCCCHHH
FEGVEKNACPTTGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKADSAAESARVLV
HHCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
EAVKKDLKPRDIITKQSIENAVSVIMATGGSTNAVLHYLAIAHAAEIDWSIEDFERIRKR
HHHHHCCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VPVICDLKPSGQYVATDLHAAGGIPQVMKLLLDAGLLHGGCMTITGRTLAEELKDVPSVP
CCEEEEECCCCCEEEEEHHHCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCC
RADQKVIHPIDQALYKEGHLAILKGNLAEDGAVAKITGLKNPVITGPARVFDDEQSALAA
CCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCCEECCHHHCCCHHHHHHH
ILDDRIRAGDVVVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGLITDGRFSGGTWGMV
HHHHCCCCCCEEEEEEECCCCCCCCCHHHCCHHHHHHCCCCCCCCEEECCCCCCCCHHEE
VGHVAPEAFVGGTIALVQEGDSITIDAHKLLLQLNVDDAELARRRAAWKQPAPRYTRGVL
EECCCCHHHCCCEEEEEECCCEEEEEEEEEEEEECCCHHHHHHHHHHHCCCCCHHHHHHH
AKYAALARPANQGAVTG
HHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SYNRRSKNITQGVARSPNRSMYYALGYQKEDFDKPMIGIANGHSTITPCNAGLQRLSDA
CCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHH
AVAAVKDAGANPQIFGTPTISDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVV
HHHHHHCCCCCCCEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEE
GGCDKNMPGGMIALARINVPGIYVYGGTIRPGHWKGHDLTIVSSFEAVGEFTAGRMSQED
ECCCCCCCCCEEEEEEECCCEEEEECCEECCCCCCCCCEEEEECHHHHHHHHHCCCCHHH
FEGVEKNACPTTGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKADSAAESARVLV
HHCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
EAVKKDLKPRDIITKQSIENAVSVIMATGGSTNAVLHYLAIAHAAEIDWSIEDFERIRKR
HHHHHCCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VPVICDLKPSGQYVATDLHAAGGIPQVMKLLLDAGLLHGGCMTITGRTLAEELKDVPSVP
CCEEEEECCCCCEEEEEHHHCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCC
RADQKVIHPIDQALYKEGHLAILKGNLAEDGAVAKITGLKNPVITGPARVFDDEQSALAA
CCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCCEECCHHHCCCHHHHHHH
ILDDRIRAGDVVVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGLITDGRFSGGTWGMV
HHHHCCCCCCEEEEEEECCCCCCCCCHHHCCHHHHHHCCCCCCCCEEECCCCCCCCHHEE
VGHVAPEAFVGGTIALVQEGDSITIDAHKLLLQLNVDDAELARRRAAWKQPAPRYTRGVL
EECCCCHHHCCCEEEEEECCCEEEEEEEEEEEEECCCHHHHHHHHHHHCCCCCHHHHHHH
AKYAALARPANQGAVTG
HHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA