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The map label for this gene is pepA [H]

Identifier: 126452701

GI number: 126452701

Start: 999071

End: 1000582

Strand: Direct

Name: pepA [H]

Synonym: BURPS1106A_1022

Alternate gene names: 126452701

Gene position: 999071-1000582 (Clockwise)

Preceding gene: 126451772

Following gene: 126454054

Centisome position: 25.05

GC content: 67.46

Gene sequence:

>1512_bases
ATGGACTTTAGCATAAAAGGCTGTGATTGGAGCAAAGGCACGGCGAACGGGTTCCTGACGGGGAAATCCGACTGCATCGT
GCTGGGCGTGTTCGAGGCGCAAACCTTGTCCGGCGCGGCGCTCGACATCGACGAAGCCACGAAGGGGCTCGTCTCGCGCG
TGATCAAGGCGGGCGACATCGACGGCAAGCTCGGCAAGACCTTGTTTTTGCACGAGGTTTCGGGCATCGGCGCATCGCGC
GTGCTGCTCGTCGGCCTGGGCAGGCAGGATGCTTTCAGCCAGAAAGCCTACGGCGACGCGGCAAAGGCCGCATGGCGCGC
GCTGCTCGGCACGAAAGTGGTTCAGGTCACGTTCACGCTCGCGCAGTTGCCCGTGCCCGAGCGCGCGTCCGACTGGGGCG
TGCGCGCGGCGATTCTCGCGCTGCGCAATGAAACGTACAAGTTCACGCAGATGAAGAGCAAGCCTGACGCGGGCGCGCCG
GCGCTCAAGCGCGTCGTGTTCAGCGTCGATCCGGCCGACGACAAGGCGGCGAAGGTCGCCGCGAAGCAGGCGGTCGCGCT
CGCGAACGGGATGGACCTCACGCGCGACCTCGGCAATCTGCCCGGCAACGTCTGCACGCCGACCTACCTCGCGAACACCG
CGAAGAAGATCGCGAAGGACTGGGGCCTGAAAGTCGACGTGCTGGGCCTGAAGCAGATCCAGGCGCTCAAGATGGGCTCG
TTCCTGTCGGTCGCGAAGGGCTCGGTCGAGCCGCCGCAGTTCATCGTGCTGCAGTACCGGGGCGCGGCCGCGAAGGCGGC
GCCCGTCGTGCTCGTCGGCAAGGGCATCACGTTCGACTCCGGCGGCATTTCGCTGAAGCCGGGCGAGGGAATGGACGAGA
TGAAGTACGACATGTGCGGCGCGGGCTCGGTGCTCGGCACGATGCGCGCGGTCGCCGAAATGGGCCTGAAGGTCAACGTC
GTCGCGATCGTGCCGACCTGCGAGAACATGCCGGCCGGCAACGCGAACAAGCCGGGCGACATCGTCACGAGCATGAAGGG
CCTGACGATCGAGGTGCTCAACACCGACGCGGAAGGCCGCCTCATCCTGTGCGACGCGCTCACGTACGCGGAGCGCTTCA
AGCCGGCCGCCGTGATCGACGTCGCGACGCTGACGGGCGCGTGCATCATCGCGCTCGGCCACCACAACACCGGCCTTTTC
TCGAAGGACGACGCGCTCGCGGGCGAGCTGCTCGACGCGTCGCGCGAAGCGGGCGATCCGGCGTGGCGCCTGCCGCTCGA
CGACGAGTATCAGGATCAGCTGAAGTCGAACTTCGCGGATCTCGCAAACATCGGCGGGCGCCCGGCCGGCAGCGTGACGG
CCGCGTGCTTCCTGTCGCGCTTCGCGGAAAACTATCCGTGGGCGCACCTCGACATCGCGGGCACCGCCTGGAAGAGCGGC
GCGGCGAAGGGGGCGACGGGCCGCCCCGTGCCGCTCCTCGCGCAATTCCTGATCGACCGCGCCGGCGCGTGA

Upstream 100 bases:

>100_bases
GAAACAGCGCACGAGTGGGGGGCGCTCACGCCGCACGGGAAAAATAGCGGATAATTGCGGCTTTCATCCTTAGCCCAGAT
TTTATCCGAGGACAAGCGCG

Downstream 100 bases:

>100_bases
TGGCGCAAGGTTCGGCAAACGGCGCGGTAGGGCGCGGCGAGCGATGACGCGGATCGATTTCCATACGAATGTCGGCGATT
CGCTCGCGTACGCGTGCCGG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MDFSIKGCDWSKGTANGFLTGKSDCIVLGVFEAQTLSGAALDIDEATKGLVSRVIKAGDIDGKLGKTLFLHEVSGIGASR
VLLVGLGRQDAFSQKAYGDAAKAAWRALLGTKVVQVTFTLAQLPVPERASDWGVRAAILALRNETYKFTQMKSKPDAGAP
ALKRVVFSVDPADDKAAKVAAKQAVALANGMDLTRDLGNLPGNVCTPTYLANTAKKIAKDWGLKVDVLGLKQIQALKMGS
FLSVAKGSVEPPQFIVLQYRGAAAKAAPVVLVGKGITFDSGGISLKPGEGMDEMKYDMCGAGSVLGTMRAVAEMGLKVNV
VAIVPTCENMPAGNANKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDVATLTGACIIALGHHNTGLF
SKDDALAGELLDASREAGDPAWRLPLDDEYQDQLKSNFADLANIGGRPAGSVTAACFLSRFAENYPWAHLDIAGTAWKSG
AAKGATGRPVPLLAQFLIDRAGA

Sequences:

>Translated_503_residues
MDFSIKGCDWSKGTANGFLTGKSDCIVLGVFEAQTLSGAALDIDEATKGLVSRVIKAGDIDGKLGKTLFLHEVSGIGASR
VLLVGLGRQDAFSQKAYGDAAKAAWRALLGTKVVQVTFTLAQLPVPERASDWGVRAAILALRNETYKFTQMKSKPDAGAP
ALKRVVFSVDPADDKAAKVAAKQAVALANGMDLTRDLGNLPGNVCTPTYLANTAKKIAKDWGLKVDVLGLKQIQALKMGS
FLSVAKGSVEPPQFIVLQYRGAAAKAAPVVLVGKGITFDSGGISLKPGEGMDEMKYDMCGAGSVLGTMRAVAEMGLKVNV
VAIVPTCENMPAGNANKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDVATLTGACIIALGHHNTGLF
SKDDALAGELLDASREAGDPAWRLPLDDEYQDQLKSNFADLANIGGRPAGSVTAACFLSRFAENYPWAHLDIAGTAWKSG
AAKGATGRPVPLLAQFLIDRAGA
>Mature_503_residues
MDFSIKGCDWSKGTANGFLTGKSDCIVLGVFEAQTLSGAALDIDEATKGLVSRVIKAGDIDGKLGKTLFLHEVSGIGASR
VLLVGLGRQDAFSQKAYGDAAKAAWRALLGTKVVQVTFTLAQLPVPERASDWGVRAAILALRNETYKFTQMKSKPDAGAP
ALKRVVFSVDPADDKAAKVAAKQAVALANGMDLTRDLGNLPGNVCTPTYLANTAKKIAKDWGLKVDVLGLKQIQALKMGS
FLSVAKGSVEPPQFIVLQYRGAAAKAAPVVLVGKGITFDSGGISLKPGEGMDEMKYDMCGAGSVLGTMRAVAEMGLKVNV
VAIVPTCENMPAGNANKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDVATLTGACIIALGHHNTGLF
SKDDALAGELLDASREAGDPAWRLPLDDEYQDQLKSNFADLANIGGRPAGSVTAACFLSRFAENYPWAHLDIAGTAWKSG
AAKGATGRPVPLLAQFLIDRAGA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=491, Percent_Identity=38.0855397148676, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI47155554, Length=329, Percent_Identity=32.8267477203647, Blast_Score=132, Evalue=7e-31,
Organism=Escherichia coli, GI1790710, Length=506, Percent_Identity=50, Blast_Score=511, Evalue=1e-146,
Organism=Escherichia coli, GI87082123, Length=319, Percent_Identity=42.3197492163009, Blast_Score=211, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI17556903, Length=327, Percent_Identity=33.0275229357798, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17565172, Length=250, Percent_Identity=30.4, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI20129969, Length=497, Percent_Identity=31.58953722334, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24662227, Length=509, Percent_Identity=31.434184675835, Blast_Score=213, Evalue=4e-55,
Organism=Drosophila melanogaster, GI21355725, Length=317, Percent_Identity=37.8548895899054, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24661038, Length=317, Percent_Identity=37.5394321766561, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI161077148, Length=497, Percent_Identity=30.5835010060362, Blast_Score=205, Evalue=7e-53,
Organism=Drosophila melanogaster, GI20130057, Length=497, Percent_Identity=30.5835010060362, Blast_Score=205, Evalue=7e-53,
Organism=Drosophila melanogaster, GI21355645, Length=499, Percent_Identity=30.4609218436874, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24662223, Length=499, Percent_Identity=30.4609218436874, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI20129963, Length=499, Percent_Identity=30.4609218436874, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI19922386, Length=482, Percent_Identity=30.0829875518672, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI21357381, Length=312, Percent_Identity=32.0512820512821, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI221379063, Length=310, Percent_Identity=32.258064516129, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI221379062, Length=310, Percent_Identity=32.258064516129, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24646701, Length=311, Percent_Identity=27.9742765273312, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24646703, Length=311, Percent_Identity=27.9742765273312, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21358201, Length=311, Percent_Identity=27.9742765273312, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52653; Mature: 52653

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSIKGCDWSKGTANGFLTGKSDCIVLGVFEAQTLSGAALDIDEATKGLVSRVIKAGDI
CCCCCCCCCCCCCCCCCEEECCCCEEEEEEEECCCCCCCEEEHHHHHHHHHHHHHHCCCC
DGKLGKTLFLHEVSGIGASRVLLVGLGRQDAFSQKAYGDAAKAAWRALLGTKVVQVTFTL
CCCCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHCCHHHHHHHHHHHCCCEEEEEEEH
AQLPVPERASDWGVRAAILALRNETYKFTQMKSKPDAGAPALKRVVFSVDPADDKAAKVA
HHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHEEECCCCCCHHHHHH
AKQAVALANGMDLTRDLGNLPGNVCTPTYLANTAKKIAKDWGLKVDVLGLKQIQALKMGS
HHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECHHHHHHHHCCC
FLSVAKGSVEPPQFIVLQYRGAAAKAAPVVLVGKGITFDSGGISLKPGEGMDEMKYDMCG
HHHHHCCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHCC
AGSVLGTMRAVAEMGLKVNVVAIVPTCENMPAGNANKPGDIVTSMKGLTIEVLNTDAEGR
CCHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCC
LILCDALTYAERFKPAAVIDVATLTGACIIALGHHNTGLFSKDDALAGELLDASREAGDP
EEEEEHHHHHHHCCCCCEEEHHHHCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCC
AWRLPLDDEYQDQLKSNFADLANIGGRPAGSVTAACFLSRFAENYPWAHLDIAGTAWKSG
EEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
AAKGATGRPVPLLAQFLIDRAGA
CCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFSIKGCDWSKGTANGFLTGKSDCIVLGVFEAQTLSGAALDIDEATKGLVSRVIKAGDI
CCCCCCCCCCCCCCCCCEEECCCCEEEEEEEECCCCCCCEEEHHHHHHHHHHHHHHCCCC
DGKLGKTLFLHEVSGIGASRVLLVGLGRQDAFSQKAYGDAAKAAWRALLGTKVVQVTFTL
CCCCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHCCHHHHHHHHHHHCCCEEEEEEEH
AQLPVPERASDWGVRAAILALRNETYKFTQMKSKPDAGAPALKRVVFSVDPADDKAAKVA
HHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHEEECCCCCCHHHHHH
AKQAVALANGMDLTRDLGNLPGNVCTPTYLANTAKKIAKDWGLKVDVLGLKQIQALKMGS
HHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECHHHHHHHHCCC
FLSVAKGSVEPPQFIVLQYRGAAAKAAPVVLVGKGITFDSGGISLKPGEGMDEMKYDMCG
HHHHHCCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHCC
AGSVLGTMRAVAEMGLKVNVVAIVPTCENMPAGNANKPGDIVTSMKGLTIEVLNTDAEGR
CCHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCC
LILCDALTYAERFKPAAVIDVATLTGACIIALGHHNTGLFSKDDALAGELLDASREAGDP
EEEEEHHHHHHHCCCCCEEEHHHHCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCC
AWRLPLDDEYQDQLKSNFADLANIGGRPAGSVTAACFLSRFAENYPWAHLDIAGTAWKSG
EEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
AAKGATGRPVPLLAQFLIDRAGA
CCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA