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The map label for this gene is purM

Identifier: 126452618

GI number: 126452618

Start: 3218814

End: 3219869

Strand: Reverse

Name: purM

Synonym: BURPS1106A_3300

Alternate gene names: 126452618

Gene position: 3219869-3218814 (Counterclockwise)

Preceding gene: 126453743

Following gene: 126451501

Centisome position: 80.73

GC content: 67.61

Gene sequence:

>1056_bases
ATGAATCCTCCGAAATCCGCTCCCGACGCCCAGGGCCTGTCCTACCGTGACGCGGGCGTCGACATCGACGCGGGCGACGC
GCTCGTCGACAAGATCAAGCCCTTTGCGAAGAAAACGCTGCGCGACGGCGTGCTCGGCGGCATCGGCGGGTTCGGCGCGC
TGTTCGAGGTGCCGAAGAAGTACCGGGAGCCCGTGCTCGTATCGGGCACGGACGGCGTCGGCACGAAGCTCAAGCTCGCG
TTTCATCTGAACAAACACGATACGGTCGGCCAGGATCTCGTCGCGATGAGCGTAAACGACATTCTCGTGCAGGGCGCCGA
GCCGCTGTTCTTCCTCGACTACTTCGCGTGCGGCAAGCTCGACGTCGAGACGGCCGCGACCGTCGTCAAGGGCATCGCGA
CGGGCTGTGAGCTGGCGGGCTGCGCGCTGATCGGCGGCGAGACGGCCGAGATGCCGGGCATGTACCCGGACGGCGAATAC
GATCTGGCGGGCTTCGCGGTCGGCGCGGTCGAGAAGAGCAAGATCATTGACGGCAGCACGATCGCCGAGGGCGACGTCGT
GCTGGGCCTCGCGTCGAGCGGCATCCATTCGAACGGTTTCTCGCTCGTGCGCAAGATCATCGAGCGCGCGAATCCGGACC
TGTCGGCCGATTTCCACGGCCGCTCGCTCGCCGACGCGCTGATGGCGCCGACGCGCATCTACGTGAAGCCGCTCCTCGCG
CTGATGGAGAAGATCGCGGTGAAGGGAATGGCGCACATCACGGGCGGCGGCCTCGTCGAGAACATTCCGCGCGTGCTGCG
CGACGGCCTCACGGCCGAACTCGACCAGCACGCATGGCCGCTGCCGCCGCTGTTCCAGTGGCTGCAGCAGCACGGCGGCG
TCGCCGATGCGGAGATGCACCGCGTGTTCAACTGCGGGATCGGGATGGCCGTGATCGTGTCGGCCGCCGACGCGGACGAC
GCGCTCCGCCAACTGGCCGACGCGGGCGAGCAGGTATGGAAGATCGGCACCGTGCGCGCGAGCCGCGAAGGCGAGGCGCA
GACGGTCGTGGTCTGA

Upstream 100 bases:

>100_bases
CGGGGCAAGTTGCTTTCCCTGAAGTATCGGTGCGGGGAATTCCGGCCGCCCGGCCGGCTTCGGGTAAAATCGCATTTTAC
CGACCTTCTCGCATTCCCCC

Downstream 100 bases:

>100_bases
CGCGCCGCGCCGTCGAGAGGTTCTCGAAAGCCGCCTGGGGGTCGATCCGGGCGGCTTTTTTCTTGGGCGTGCGCGGTGAG
GGGGAGGACATGGGCCAGGG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MNPPKSAPDAQGLSYRDAGVDIDAGDALVDKIKPFAKKTLRDGVLGGIGGFGALFEVPKKYREPVLVSGTDGVGTKLKLA
FHLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVETAATVVKGIATGCELAGCALIGGETAEMPGMYPDGEY
DLAGFAVGAVEKSKIIDGSTIAEGDVVLGLASSGIHSNGFSLVRKIIERANPDLSADFHGRSLADALMAPTRIYVKPLLA
LMEKIAVKGMAHITGGGLVENIPRVLRDGLTAELDQHAWPLPPLFQWLQQHGGVADAEMHRVFNCGIGMAVIVSAADADD
ALRQLADAGEQVWKIGTVRASREGEAQTVVV

Sequences:

>Translated_351_residues
MNPPKSAPDAQGLSYRDAGVDIDAGDALVDKIKPFAKKTLRDGVLGGIGGFGALFEVPKKYREPVLVSGTDGVGTKLKLA
FHLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVETAATVVKGIATGCELAGCALIGGETAEMPGMYPDGEY
DLAGFAVGAVEKSKIIDGSTIAEGDVVLGLASSGIHSNGFSLVRKIIERANPDLSADFHGRSLADALMAPTRIYVKPLLA
LMEKIAVKGMAHITGGGLVENIPRVLRDGLTAELDQHAWPLPPLFQWLQQHGGVADAEMHRVFNCGIGMAVIVSAADADD
ALRQLADAGEQVWKIGTVRASREGEAQTVVV
>Mature_351_residues
MNPPKSAPDAQGLSYRDAGVDIDAGDALVDKIKPFAKKTLRDGVLGGIGGFGALFEVPKKYREPVLVSGTDGVGTKLKLA
FHLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVETAATVVKGIATGCELAGCALIGGETAEMPGMYPDGEY
DLAGFAVGAVEKSKIIDGSTIAEGDVVLGLASSGIHSNGFSLVRKIIERANPDLSADFHGRSLADALMAPTRIYVKPLLA
LMEKIAVKGMAHITGGGLVENIPRVLRDGLTAELDQHAWPLPPLFQWLQQHGGVADAEMHRVFNCGIGMAVIVSAADADD
ALRQLADAGEQVWKIGTVRASREGEAQTVVV

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=349, Percent_Identity=54.7277936962751, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI209869995, Length=349, Percent_Identity=54.7277936962751, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI209869993, Length=349, Percent_Identity=54.7277936962751, Blast_Score=375, Evalue=1e-104,
Organism=Escherichia coli, GI1788845, Length=343, Percent_Identity=60.0583090379009, Blast_Score=416, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17567511, Length=346, Percent_Identity=45.6647398843931, Blast_Score=271, Evalue=4e-73,
Organism=Saccharomyces cerevisiae, GI6321203, Length=335, Percent_Identity=48.6567164179104, Blast_Score=317, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24582400, Length=303, Percent_Identity=43.8943894389439, Blast_Score=253, Evalue=1e-67,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_BURM7 (A3MN88)

Other databases:

- EMBL:   CP000548
- RefSeq:   YP_001081724.1
- ProteinModelPortal:   A3MN88
- SMR:   A3MN88
- GeneID:   4893725
- GenomeReviews:   CP000548_GR
- KEGG:   bmn:BMA10247_2195
- TIGR:   BMA10247_2195
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- ProtClustDB:   PRK05385
- BioCyc:   BMAL320389:BMA10247_2195-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 36914; Mature: 36914

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPPKSAPDAQGLSYRDAGVDIDAGDALVDKIKPFAKKTLRDGVLGGIGGFGALFEVPKK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
YREPVLVSGTDGVGTKLKLAFHLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKL
HCCCEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCCCC
DVETAATVVKGIATGCELAGCALIGGETAEMPGMYPDGEYDLAGFAVGAVEKSKIIDGST
CHHHHHHHHHHHHHCCHHHCEEEECCCCCCCCCCCCCCCCCCHHEEECCCHHHHCCCCCC
IAEGDVVLGLASSGIHSNGFSLVRKIIERANPDLSADFHGRSLADALMAPTRIYVKPLLA
CCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHH
LMEKIAVKGMAHITGGGLVENIPRVLRDGLTAELDQHAWPLPPLFQWLQQHGGVADAEMH
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHCCCCHHHHH
RVFNCGIGMAVIVSAADADDALRQLADAGEQVWKIGTVRASREGEAQTVVV
HHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCEEECCCCCCCEEEC
>Mature Secondary Structure
MNPPKSAPDAQGLSYRDAGVDIDAGDALVDKIKPFAKKTLRDGVLGGIGGFGALFEVPKK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
YREPVLVSGTDGVGTKLKLAFHLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKL
HCCCEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCCCC
DVETAATVVKGIATGCELAGCALIGGETAEMPGMYPDGEYDLAGFAVGAVEKSKIIDGST
CHHHHHHHHHHHHHCCHHHCEEEECCCCCCCCCCCCCCCCCCHHEEECCCHHHHCCCCCC
IAEGDVVLGLASSGIHSNGFSLVRKIIERANPDLSADFHGRSLADALMAPTRIYVKPLLA
CCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHH
LMEKIAVKGMAHITGGGLVENIPRVLRDGLTAELDQHAWPLPPLFQWLQQHGGVADAEMH
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHCCCCHHHHH
RVFNCGIGMAVIVSAADADDALRQLADAGEQVWKIGTVRASREGEAQTVVV
HHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCEEECCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA