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The map label for this gene is map [H]

Identifier: 126452369

GI number: 126452369

Start: 2511372

End: 2512190

Strand: Reverse

Name: map [H]

Synonym: BURPS1106A_2557

Alternate gene names: 126452369

Gene position: 2512190-2511372 (Counterclockwise)

Preceding gene: 126452198

Following gene: 126454614

Centisome position: 62.99

GC content: 69.6

Gene sequence:

>819_bases
ATGGCGCGTTCGCGACAGGTTCCGATCCGCTCGAAAGCGGAGATCGCGATGGCGCGCCGCGCCGGCACGATGGCGGCGCA
GGTGCTGAGCATGATCGCGCCGCACGTGAAGGCCGGCGTGACGACCAACGCGCTCGACCGGCTATGCCGCGAGTACATCG
TCGACGTACTGCGCGCGCGGCCCGCGAACATCGGCTATCACGGTTATCCGAAGACGATCTGCGCTTCCGTGAACCATGTG
GTGTGCCACGGCATTCCGTCCGATCACGCGCTGCAGGACGGCGACATCGTCAATATCGACGTCGCGCTCGACCACGACGG
CTGGTATGGCGACACGAGCCGCATGTACTGCGTCGGCGAGCCGGCCGCGCCGGCGCGGCGTCTCGTCGATGCGACCTACG
AAGCGATGATGGCGGGCATCGCGGCGGTGCGCCCGGGCGCGACGCTCGGCGACGTCGGCCATGCGATCCAGAGCGTGGCG
CATCGCGAGGGCTTCAGCATCGTGCGCGAGTATTGCGGCCACGGCATCGGCCGCATCTATCACGACGAGCCGCAGGTGCT
CCATTACGGCCGGCCCGGCGCGGGGCTGCGTCTCGCGCCGGGAATGATCTTCACGATCGAGCCGATGCTCAATGCGGGGC
GCGCCGAAACGCGGCAGCTCGCCGACGGCTGGACGGTCGTGACGCAGGACCGCTCGTGGTCCGCGCAATGGGAGCATATG
GTCGTCGTGACGGAAGACGGCTTCGACATCCTGACGCCATGGCCGGATGGCGAGCCGGCGCGCTCGCCGGCGGCGACGGG
GGCGGCCGGCGCCGCCTAG

Upstream 100 bases:

>100_bases
ATCCGACGCTGAGCTATGCCGAGATTTGCCGCCTGCTGATCGAGACGGAAATCCAGGGCGACGAAGCGGCGCCGTCCGTC
GACGCCGCGAGGAGCGCATG

Downstream 100 bases:

>100_bases
CGGCGCCGAATCGGCCGTGCGCGGGGTTGCCCGGCCGGTTTGCGCGCCGGCGCGCGGCGCGCATGCGCGTGCGTCACTTC
TTTTTCCGTGCGTCGGCGTC

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MARSRQVPIRSKAEIAMARRAGTMAAQVLSMIAPHVKAGVTTNALDRLCREYIVDVLRARPANIGYHGYPKTICASVNHV
VCHGIPSDHALQDGDIVNIDVALDHDGWYGDTSRMYCVGEPAAPARRLVDATYEAMMAGIAAVRPGATLGDVGHAIQSVA
HREGFSIVREYCGHGIGRIYHDEPQVLHYGRPGAGLRLAPGMIFTIEPMLNAGRAETRQLADGWTVVTQDRSWSAQWEHM
VVVTEDGFDILTPWPDGEPARSPAATGAAGAA

Sequences:

>Translated_272_residues
MARSRQVPIRSKAEIAMARRAGTMAAQVLSMIAPHVKAGVTTNALDRLCREYIVDVLRARPANIGYHGYPKTICASVNHV
VCHGIPSDHALQDGDIVNIDVALDHDGWYGDTSRMYCVGEPAAPARRLVDATYEAMMAGIAAVRPGATLGDVGHAIQSVA
HREGFSIVREYCGHGIGRIYHDEPQVLHYGRPGAGLRLAPGMIFTIEPMLNAGRAETRQLADGWTVVTQDRSWSAQWEHM
VVVTEDGFDILTPWPDGEPARSPAATGAAGAA
>Mature_271_residues
ARSRQVPIRSKAEIAMARRAGTMAAQVLSMIAPHVKAGVTTNALDRLCREYIVDVLRARPANIGYHGYPKTICASVNHVV
CHGIPSDHALQDGDIVNIDVALDHDGWYGDTSRMYCVGEPAAPARRLVDATYEAMMAGIAAVRPGATLGDVGHAIQSVAH
REGFSIVREYCGHGIGRIYHDEPQVLHYGRPGAGLRLAPGMIFTIEPMLNAGRAETRQLADGWTVVTQDRSWSAQWEHMV
VVTEDGFDILTPWPDGEPARSPAATGAAGAA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=249, Percent_Identity=41.3654618473896, Blast_Score=204, Evalue=5e-53,
Organism=Homo sapiens, GI40385867, Length=249, Percent_Identity=38.1526104417671, Blast_Score=192, Evalue=4e-49,
Organism=Escherichia coli, GI1786364, Length=251, Percent_Identity=54.1832669322709, Blast_Score=290, Evalue=5e-80,
Organism=Escherichia coli, GI1789275, Length=285, Percent_Identity=25.6140350877193, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71996291, Length=258, Percent_Identity=37.984496124031, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6323273, Length=251, Percent_Identity=38.6454183266932, Blast_Score=203, Evalue=2e-53,
Organism=Drosophila melanogaster, GI21355531, Length=250, Percent_Identity=41.6, Blast_Score=210, Evalue=9e-55,
Organism=Drosophila melanogaster, GI24583427, Length=244, Percent_Identity=38.5245901639344, Blast_Score=187, Evalue=8e-48,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29283; Mature: 29151

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARSRQVPIRSKAEIAMARRAGTMAAQVLSMIAPHVKAGVTTNALDRLCREYIVDVLRAR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
PANIGYHGYPKTICASVNHVVCHGIPSDHALQDGDIVNIDVALDHDGWYGDTSRMYCVGE
CCCCCCCCCCHHHHHCCCEEEEECCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEECC
PAAPARRLVDATYEAMMAGIAAVRPGATLGDVGHAIQSVAHREGFSIVREYCGHGIGRIY
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
HDEPQVLHYGRPGAGLRLAPGMIFTIEPMLNAGRAETRQLADGWTVVTQDRSWSAQWEHM
CCCCCEEECCCCCCCCEECCCEEEEECCHHCCCCHHHHHHCCCCEEEEECCCCCCCCEEE
VVVTEDGFDILTPWPDGEPARSPAATGAAGAA
EEEEECCCEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ARSRQVPIRSKAEIAMARRAGTMAAQVLSMIAPHVKAGVTTNALDRLCREYIVDVLRAR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
PANIGYHGYPKTICASVNHVVCHGIPSDHALQDGDIVNIDVALDHDGWYGDTSRMYCVGE
CCCCCCCCCCHHHHHCCCEEEEECCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEECC
PAAPARRLVDATYEAMMAGIAAVRPGATLGDVGHAIQSVAHREGFSIVREYCGHGIGRIY
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
HDEPQVLHYGRPGAGLRLAPGMIFTIEPMLNAGRAETRQLADGWTVVTQDRSWSAQWEHM
CCCCCEEECCCCCCCCEECCCEEEEECCHHCCCCHHHHHHCCCCEEEEECCCCCCCCEEE
VVVTEDGFDILTPWPDGEPARSPAATGAAGAA
EEEEECCCEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]