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The map label for this gene is dxs [C]

Identifier: 126452363

GI number: 126452363

Start: 2523275

End: 2524186

Strand: Reverse

Name: dxs [C]

Synonym: BURPS1106A_2568

Alternate gene names: 126452363

Gene position: 2524186-2523275 (Counterclockwise)

Preceding gene: 126454534

Following gene: 126453216

Centisome position: 63.29

GC content: 71.93

Gene sequence:

>912_bases
ATGAGGCCCGCCGCGCATTGCGTGCAGGCGCTCGTCGAGCGCGCCGCGCACGATCGCCGGATCTGGCTGCTGGACGGCGA
TCTCGCCGATTCGTACGGCGCGGACCGGTTCGCCGCCGCGTACCCGCAGCGGTTCCTGATGGCCGGGATCGCCGAGCAGT
CGATGGTGTCGACCGCGGCGGGCATGGCCGCTTGCGGCCTGCGGCCGTGGGTGTTCTCGTTCGCGGCGTTCCTGTGCTAT
CGCGCCTATGATCAGATTCGCGTCGGTCTCGCGCAGACCGGCATGCCCGTCACGCTCGTCGGCTCGCACAGCGGCGGCTG
CGGCGGCCCGAACGGCAAGAGTCATCTGGCGCTGAACGATATCGCGGTGATGGCGTCGCTGCCGAACGTCGACGTCTGGG
CGCCCGCGTGCGATCGCGATACGCGCTTCGTCGTCGAGGCGGTGATGCTAACGGATCGGCCGGCGTATGTGCGCTATCCG
CGCGAGCCGTGGGGCGAGCTGCCCGGCGAGCCGGCCGAATGCCGCTGGATCGGCGCGCGGCGCCGGATCGCGCTCGTGAG
CTGTGGGCTGTTTTCGCACGTCGCGCATGATGCGGCCGAGCAGTTGCGCGCGCTCGGCGTCGACGCGGGCGCGCTTCACC
TCGCGCGGCTCGCGCCGTTTCCCGTCGAGGCGTTCGGCGCGCTCGTCGACGGCGTCGACGGGATCTGGGTCGTCGATGAC
CATACGCGCTTCGGCGGCCTGGCCGATCTGCTGCGCGCGAACGGATACGCGGTTCGCGAGCCGGTGTTCAGCTGGCCCGC
GAACTGGAGCGGCGACGTGGGCCCGACGGCCGAGTTGCTGCGGCGTTACGGCCTTTGCGCCGCCGACGTCGCCGCGCGGA
TCGCGGCCGAGCTCGAGCGGCGGGGGCGTTGA

Upstream 100 bases:

>100_bases
GCGGCATCCCCGCGTTCGAATTCGACCCCGGGCTGTCGCACTGCACGTCGCTCACCGACGATCAGTTCAGGCACGCGGTG
GCCGTCGCGGAGGGCGTCGC

Downstream 100 bases:

>100_bases
CGATGCCGGTCGATCTGCTCGTGACGGGTTCCGGCTCGCTCGCCGAGGCGGTGCTGTTCGATCTGGTGGCGATGCCCACG
CTCGCGGCGCCGATGACGAT

Product: transketolase domain-containing protein

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MRPAAHCVQALVERAAHDRRIWLLDGDLADSYGADRFAAAYPQRFLMAGIAEQSMVSTAAGMAACGLRPWVFSFAAFLCY
RAYDQIRVGLAQTGMPVTLVGSHSGGCGGPNGKSHLALNDIAVMASLPNVDVWAPACDRDTRFVVEAVMLTDRPAYVRYP
REPWGELPGEPAECRWIGARRRIALVSCGLFSHVAHDAAEQLRALGVDAGALHLARLAPFPVEAFGALVDGVDGIWVVDD
HTRFGGLADLLRANGYAVREPVFSWPANWSGDVGPTAELLRRYGLCAADVAARIAAELERRGR

Sequences:

>Translated_303_residues
MRPAAHCVQALVERAAHDRRIWLLDGDLADSYGADRFAAAYPQRFLMAGIAEQSMVSTAAGMAACGLRPWVFSFAAFLCY
RAYDQIRVGLAQTGMPVTLVGSHSGGCGGPNGKSHLALNDIAVMASLPNVDVWAPACDRDTRFVVEAVMLTDRPAYVRYP
REPWGELPGEPAECRWIGARRRIALVSCGLFSHVAHDAAEQLRALGVDAGALHLARLAPFPVEAFGALVDGVDGIWVVDD
HTRFGGLADLLRANGYAVREPVFSWPANWSGDVGPTAELLRRYGLCAADVAARIAAELERRGR
>Mature_303_residues
MRPAAHCVQALVERAAHDRRIWLLDGDLADSYGADRFAAAYPQRFLMAGIAEQSMVSTAAGMAACGLRPWVFSFAAFLCY
RAYDQIRVGLAQTGMPVTLVGSHSGGCGGPNGKSHLALNDIAVMASLPNVDVWAPACDRDTRFVVEAVMLTDRPAYVRYP
REPWGELPGEPAECRWIGARRRIALVSCGLFSHVAHDAAEQLRALGVDAGALHLARLAPFPVEAFGALVDGVDGIWVVDD
HTRFGGLADLLRANGYAVREPVFSWPANWSGDVGPTAELLRRYGLCAADVAARIAAELERRGR

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI225637463, Length=307, Percent_Identity=28.9902280130293, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI225637459, Length=296, Percent_Identity=29.7297297297297, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI225637461, Length=296, Percent_Identity=29.7297297297297, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI205277463, Length=293, Percent_Identity=30.3754266211604, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4507521, Length=293, Percent_Identity=30.3754266211604, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI133778974, Length=303, Percent_Identity=27.3927392739274, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786622, Length=297, Percent_Identity=26.9360269360269, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17539652, Length=292, Percent_Identity=29.1095890410959, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45551847, Length=257, Percent_Identity=30.7392996108949, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI45550715, Length=257, Percent_Identity=30.7392996108949, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24645119, Length=259, Percent_Identity=30.1158301158301, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24666278, Length=306, Percent_Identity=29.4117647058824, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 32698; Mature: 32698

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPAAHCVQALVERAAHDRRIWLLDGDLADSYGADRFAAAYPQRFLMAGIAEQSMVSTAA
CCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GMAACGLRPWVFSFAAFLCYRAYDQIRVGLAQTGMPVTLVGSHSGGCGGPNGKSHLALND
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEHH
IAVMASLPNVDVWAPACDRDTRFVVEAVMLTDRPAYVRYPREPWGELPGEPAECRWIGAR
HEEEECCCCCCEECCCCCCCHHHHHHHHHHCCCCCEEECCCCCHHCCCCCCCCEEEECCC
RRIALVSCGLFSHVAHDAAEQLRALGVDAGALHLARLAPFPVEAFGALVDGVDGIWVVDD
CEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEC
HTRFGGLADLLRANGYAVREPVFSWPANWSGDVGPTAELLRRYGLCAADVAARIAAELER
CCCHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
RGR
CCC
>Mature Secondary Structure
MRPAAHCVQALVERAAHDRRIWLLDGDLADSYGADRFAAAYPQRFLMAGIAEQSMVSTAA
CCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GMAACGLRPWVFSFAAFLCYRAYDQIRVGLAQTGMPVTLVGSHSGGCGGPNGKSHLALND
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEHH
IAVMASLPNVDVWAPACDRDTRFVVEAVMLTDRPAYVRYPREPWGELPGEPAECRWIGAR
HEEEECCCCCCEECCCCCCCHHHHHHHHHHCCCCCEEECCCCCHHCCCCCCCCEEEECCC
RRIALVSCGLFSHVAHDAAEQLRALGVDAGALHLARLAPFPVEAFGALVDGVDGIWVVDD
CEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEC
HTRFGGLADLLRANGYAVREPVFSWPANWSGDVGPTAELLRRYGLCAADVAARIAAELER
CCCHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
RGR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]