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The map label for this gene is ilvY [H]

Identifier: 126452150

GI number: 126452150

Start: 3907551

End: 3909254

Strand: Direct

Name: ilvY [H]

Synonym: BURPS1106A_4004

Alternate gene names: 126452150

Gene position: 3907551-3909254 (Clockwise)

Preceding gene: 126453584

Following gene: 126455275

Centisome position: 97.97

GC content: 71.83

Gene sequence:

>1704_bases
ATGTCGATTTCCCCGGACCGCGAGCAGCGCGCCACCACCGGCGCGCGCCTGCTCGTCGACGCCCTGCTCGCGAATCACGT
CGAGCGCGTGTTCTGCGTGCCCGGCGAGAGCTTCCTCGCCGTGCTCGATTCCCTCGCCGACGAAACCGAACGCATCCGCA
CCATCGTCTGCCGGCACGAAGCCGCGGCCGCGAACATGGCGGAAGCCGTCGGCAAGCTGACCGGCCGGCCAGGCATCGCG
TTCGCCACGCGCGGGCCCGGCGCGACGCACGCGTCGATCGGCGTGCACACCGCGTTTCAGGATTCGACGCCGATGATCCT
CTTCATCGGCCAGTGCGCGCGCGAGCATCTCGATCGGGAAGCGTTCCAGGAGATCGACTATCGGCGCATGTTCGGCCAGC
TCGCGAAATGGGTTGCGCAGATCGACGATCCGCGCCGCATTCCCGAATACCTGAGCCATGCGTTCCATGTCGCGATGTCG
GGCCGGCCGGGCCCCGTCGTGCTCGCGCTGCCCGAGGACGTGCTGTCCGAGCCGTGCGCGGCGCAGCCCGTCGCGCCCGC
GGCCAGGCGCGTCGCCGCCGCGCCGTCCGCCGCGCAGATGAGCGAGCTGCGCGAGCGGCTCGCGCGTGCGCAGCGCCCGC
TCGTGCTCGCGGGCGGCAGCGGCTGGACGCCCGGCGCGTGCGCGGATCTGCGCACGTTCGTCGAACGCTGGCAGTTGCCG
ATCGCGTGCGCATTCCGCTATCAGGACACGTTCGACAACGCGCATCCGCAGTACGCGGGCGACGTCGGCCTCGGTGTGAA
CCCCGAGCTCGCGCGCCGCATCCGCGAAGCGGACCTGCTGTTCGCGCTCGGCCCGCGCCTCGGCGAAGCGACGACGGGCG
GCTATACGCTGATCGACATTCCGAGGCCGAAGCAGGTGCTCATTCATGTGCATCAAGGCGCGGACGAGCTGGGGCGCGTC
TACGCGGCCGATCTGCCGATCGCCTCCGGCATGCCCGAGATCGCCGCGCAGCTCGCCGCGCTCGAACCGCCCGCGTCGCT
CGCGTGGGCGGGCAGCGCCGCCGACGCGCATCGCGCCTACCTCGACTGGCACGCGCCCCGGCCGATGCCGGGCGAGGTGC
AGCTCGGCGACGTGATGCGGCAATTGCGCGAGCGGCTGCCGCACGACGCGATCGTGACGAACGGCGCCGGCAACTACGCG
GCGTGGCTGCACCGCCATTTCGCTTATCGGCACTTCCGCTCGCAGCTCGCGCCGACGAGCGGCGCGATGGGCTACGGCGT
GCCGGCCGCGCTCGCCGCGAAGTCGCTGTATCCGCAGCGCACGGTGGTCGCGCTCGCGGGCGACGGCTGCTTCATGATGG
CCGGCAACGAACTCGCGACGGCGATCCAGTACGGGCTCGCGATCATCGTGCTCGTCGTGAACAACGGCCACTTCGGCACG
ATCCGCATGCATCAGGAACGCCATTACCCCGGCCGCGTGCACGGCACCGGGCTCACGAACCCGGATTTCGCCGCCTATGC
GCGCGCGTTCGGCGCGCACGGCGAGACGGTCGAGCGCACCGCCGATTTCCTGCCCGCGCTCGAACGCGCGCTCGCGAGCG
GCGCGCCCGCGCTGATCGAGATCCGCGTGCCGCAAGACGCGTGCACGCCCGCCGCGACGCTCGAGCAGGTGCGCGAGCAA
GGGCTGCGCGCGCGTCGCGCTTGA

Upstream 100 bases:

>100_bases
CCGCAGCCTCGATATTAAGAAACATCGGCCATCCGCGCCTTCCGTCCCCCCTTCAACCGGCGTAAGCTGTACGTCCCGCC
ACGAAGGGAGCCCGTCTTAT

Downstream 100 bases:

>100_bases
CGATACGACCGATGAACGCTCCCATGCGATGACGCCGACCCTCGACGAAACCGCGCTGCCGCCCGCCGACGCGCTCGCCT
ACCCCGGCACGCTGCTTTCG

Product: thiamine pyrophosphate protein

Products: NA

Alternate protein names: ALS; Acetohydroxy-acid synthase [H]

Number of amino acids: Translated: 567; Mature: 566

Protein sequence:

>567_residues
MSISPDREQRATTGARLLVDALLANHVERVFCVPGESFLAVLDSLADETERIRTIVCRHEAAAANMAEAVGKLTGRPGIA
FATRGPGATHASIGVHTAFQDSTPMILFIGQCAREHLDREAFQEIDYRRMFGQLAKWVAQIDDPRRIPEYLSHAFHVAMS
GRPGPVVLALPEDVLSEPCAAQPVAPAARRVAAAPSAAQMSELRERLARAQRPLVLAGGSGWTPGACADLRTFVERWQLP
IACAFRYQDTFDNAHPQYAGDVGLGVNPELARRIREADLLFALGPRLGEATTGGYTLIDIPRPKQVLIHVHQGADELGRV
YAADLPIASGMPEIAAQLAALEPPASLAWAGSAADAHRAYLDWHAPRPMPGEVQLGDVMRQLRERLPHDAIVTNGAGNYA
AWLHRHFAYRHFRSQLAPTSGAMGYGVPAALAAKSLYPQRTVVALAGDGCFMMAGNELATAIQYGLAIIVLVVNNGHFGT
IRMHQERHYPGRVHGTGLTNPDFAAYARAFGAHGETVERTADFLPALERALASGAPALIEIRVPQDACTPAATLEQVREQ
GLRARRA

Sequences:

>Translated_567_residues
MSISPDREQRATTGARLLVDALLANHVERVFCVPGESFLAVLDSLADETERIRTIVCRHEAAAANMAEAVGKLTGRPGIA
FATRGPGATHASIGVHTAFQDSTPMILFIGQCAREHLDREAFQEIDYRRMFGQLAKWVAQIDDPRRIPEYLSHAFHVAMS
GRPGPVVLALPEDVLSEPCAAQPVAPAARRVAAAPSAAQMSELRERLARAQRPLVLAGGSGWTPGACADLRTFVERWQLP
IACAFRYQDTFDNAHPQYAGDVGLGVNPELARRIREADLLFALGPRLGEATTGGYTLIDIPRPKQVLIHVHQGADELGRV
YAADLPIASGMPEIAAQLAALEPPASLAWAGSAADAHRAYLDWHAPRPMPGEVQLGDVMRQLRERLPHDAIVTNGAGNYA
AWLHRHFAYRHFRSQLAPTSGAMGYGVPAALAAKSLYPQRTVVALAGDGCFMMAGNELATAIQYGLAIIVLVVNNGHFGT
IRMHQERHYPGRVHGTGLTNPDFAAYARAFGAHGETVERTADFLPALERALASGAPALIEIRVPQDACTPAATLEQVREQ
GLRARRA
>Mature_566_residues
SISPDREQRATTGARLLVDALLANHVERVFCVPGESFLAVLDSLADETERIRTIVCRHEAAAANMAEAVGKLTGRPGIAF
ATRGPGATHASIGVHTAFQDSTPMILFIGQCAREHLDREAFQEIDYRRMFGQLAKWVAQIDDPRRIPEYLSHAFHVAMSG
RPGPVVLALPEDVLSEPCAAQPVAPAARRVAAAPSAAQMSELRERLARAQRPLVLAGGSGWTPGACADLRTFVERWQLPI
ACAFRYQDTFDNAHPQYAGDVGLGVNPELARRIREADLLFALGPRLGEATTGGYTLIDIPRPKQVLIHVHQGADELGRVY
AADLPIASGMPEIAAQLAALEPPASLAWAGSAADAHRAYLDWHAPRPMPGEVQLGDVMRQLRERLPHDAIVTNGAGNYAA
WLHRHFAYRHFRSQLAPTSGAMGYGVPAALAAKSLYPQRTVVALAGDGCFMMAGNELATAIQYGLAIIVLVVNNGHFGTI
RMHQERHYPGRVHGTGLTNPDFAAYARAFGAHGETVERTADFLPALERALASGAPALIEIRVPQDACTPAATLEQVREQG
LRARRA

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=574, Percent_Identity=25.0871080139373, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI21361361, Length=578, Percent_Identity=24.3944636678201, Blast_Score=103, Evalue=6e-22,
Organism=Escherichia coli, GI87081685, Length=537, Percent_Identity=29.9813780260708, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1790104, Length=539, Percent_Identity=28.7569573283859, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1786717, Length=528, Percent_Identity=28.030303030303, Blast_Score=165, Evalue=9e-42,
Organism=Escherichia coli, GI1787096, Length=579, Percent_Identity=26.7702936096718, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1788716, Length=588, Percent_Identity=24.8299319727891, Blast_Score=112, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17531299, Length=565, Percent_Identity=25.4867256637168, Blast_Score=121, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17531301, Length=565, Percent_Identity=25.4867256637168, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17542570, Length=569, Percent_Identity=24.780316344464, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323755, Length=556, Percent_Identity=25.7194244604317, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6320816, Length=546, Percent_Identity=21.6117216117216, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323163, Length=493, Percent_Identity=21.9066937119675, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19922626, Length=483, Percent_Identity=27.1221532091097, Blast_Score=122, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 61204; Mature: 61073

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISPDREQRATTGARLLVDALLANHVERVFCVPGESFLAVLDSLADETERIRTIVCRHE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
AAAANMAEAVGKLTGRPGIAFATRGPGATHASIGVHTAFQDSTPMILFIGQCAREHLDRE
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHHHHH
AFQEIDYRRMFGQLAKWVAQIDDPRRIPEYLSHAFHVAMSGRPGPVVLALPEDVLSEPCA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEECCCCCCEEEECCHHHHCCCCC
AQPVAPAARRVAAAPSAAQMSELRERLARAQRPLVLAGGSGWTPGACADLRTFVERWQLP
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHCCC
IACAFRYQDTFDNAHPQYAGDVGLGVNPELARRIREADLLFALGPRLGEATTGGYTLIDI
EEEEEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCCCCCCEEEEEC
PRPKQVLIHVHQGADELGRVYAADLPIASGMPEIAAQLAALEPPASLAWAGSAADAHRAY
CCCCEEEEEEECCHHHHHHEEECCCCCCCCCHHHHHHHHHCCCCCCEEECCCCCHHHHHH
LDWHAPRPMPGEVQLGDVMRQLRERLPHDAIVTNGAGNYAAWLHRHFAYRHFRSQLAPTS
EECCCCCCCCCCEEHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCC
GAMGYGVPAALAAKSLYPQRTVVALAGDGCFMMAGNELATAIQYGLAIIVLVVNNGHFGT
CCCCCCCHHHHHHHHCCCCCEEEEEECCCEEEEECHHHHHHHHHCEEEEEEEEECCCEEE
IRMHQERHYPGRVHGTGLTNPDFAAYARAFGAHGETVERTADFLPALERALASGAPALIE
EEEECCCCCCCCEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
IRVPQDACTPAATLEQVREQGLRARRA
EECCCHHCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SISPDREQRATTGARLLVDALLANHVERVFCVPGESFLAVLDSLADETERIRTIVCRHE
CCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
AAAANMAEAVGKLTGRPGIAFATRGPGATHASIGVHTAFQDSTPMILFIGQCAREHLDRE
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHHHHH
AFQEIDYRRMFGQLAKWVAQIDDPRRIPEYLSHAFHVAMSGRPGPVVLALPEDVLSEPCA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEECCCCCCEEEECCHHHHCCCCC
AQPVAPAARRVAAAPSAAQMSELRERLARAQRPLVLAGGSGWTPGACADLRTFVERWQLP
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHCCC
IACAFRYQDTFDNAHPQYAGDVGLGVNPELARRIREADLLFALGPRLGEATTGGYTLIDI
EEEEEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCCCCCCEEEEEC
PRPKQVLIHVHQGADELGRVYAADLPIASGMPEIAAQLAALEPPASLAWAGSAADAHRAY
CCCCEEEEEEECCHHHHHHEEECCCCCCCCCHHHHHHHHHCCCCCCEEECCCCCHHHHHH
LDWHAPRPMPGEVQLGDVMRQLRERLPHDAIVTNGAGNYAAWLHRHFAYRHFRSQLAPTS
EECCCCCCCCCCEEHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCC
GAMGYGVPAALAAKSLYPQRTVVALAGDGCFMMAGNELATAIQYGLAIIVLVVNNGHFGT
CCCCCCCHHHHHHHHCCCCCEEEEEECCCEEEEECHHHHHHHHHCEEEEEEEEECCCEEE
IRMHQERHYPGRVHGTGLTNPDFAAYARAFGAHGETVERTADFLPALERALASGAPALIE
EEEECCCCCCCCEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
IRVPQDACTPAATLEQVREQGLRARRA
EECCCHHCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1512571 [H]