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The map label for this gene is clcA [H]

Identifier: 126452143

GI number: 126452143

Start: 2961221

End: 2962957

Strand: Direct

Name: clcA [H]

Synonym: BURPS1106A_3029

Alternate gene names: 126452143

Gene position: 2961221-2962957 (Clockwise)

Preceding gene: 126454441

Following gene: 126452766

Centisome position: 74.24

GC content: 70.01

Gene sequence:

>1737_bases
TTGTCACAACGTCGATGTCGTGCTAGCCGCGCTCGTCGCGCAACTATAATGTCACCTTTTTGCGCACCGACGCCCATGCA
ACGCCCCAGCCTGTTCCCGACTCTCACGCGCCGCACGCAGCGCATCTGGCGCCAATATGGCGTGTTCTGGCTCGGCGCGG
TCGTGGTGGGCCTGACGGCCGTGATGTACGCACGGCTCATCGACTGGGGCTACGAGGCGTTCCGTTCGCTCGGGCAAGGG
CGTCCGTGGCTGCCCTTCCTGCTGACGCCCGCCATCGCCGCGCTGTCCGTGTGGCTCACGCGCCGCTTCTTTCGCGGCGC
CGAGGGCAGCGGGATTCCTCAGGTGATCGCGACGCTGCACGCGCAGCCGAGCGCGTTCGGCTCGCGGCTGCTCACGCTGC
GCATCCTGTTCGGCAAGGTCCTGATCTCGTTGCTCGGCATCGCCGGCGGCTTCACGATCGGCCGCGAAGGGCCGACCGTG
CAGATCGGCGCGTCGCTGATGTTCAACCTGCGCCGCTTCTACCCGCGCTCGAACGCGCTGATCGAACGCCAGCTCGTGCT
CGCGGGCGCCGCCGCCGGCCTGTCCGCTGCGTTCAACACGCCGCTCGCCGGCGTCGTGTTCGCGATCGAGGAACTGAGCC
GCAGTTTTTCGGCACGCGCGAGCGGCGTGCTGATCACCGCGATCATCATCGCCGGCGTGATCGCGCTCGGCCTGAACGGC
AACTACACCTACTTCGGCACGATCGAGATCGGCCAGCATTTTCCGAAGATGCTCGCGGCCGCCGTGCTGCTGACCGCGCT
CGTCACGGGCGTCGCGGGCGGGCTGTTCGGCTGGCTGCTGCTGAACACCGGCCGCTGGCTGCCGGCGAGGCTGCTCGCGC
TCTACCGCGAGCGGCCGATCGTGTTCGCGGCGGCCTGCGGCCTCGCGATCGCCGCCGTCGGCGTCGCATCCGGCGGCACG
ACGTTCGGCAGCGGCTATGCGGAGGCGCGCGGGCTCCTCGACGGCCGCGAACAGTTGTCCGTCCTGTATCCGTTCCTGAA
AATGATCTCGATGGTCGCGTCGTACCTGCCCGGGATTCCGGGCGGGATCTTCGCGCCTTCGCTGTCGATCGGCGCGGGTT
TCGGCAATCTGCTGCACTTCGTGTTCAGCGGCATGCACCTGCCGATGCTGATCGCGCTCGCGATGGTCGGCTATCTCGCG
GCCGTCACGCAATCGCCGATCACGTCGTTCGTCATCGTGATGGAGATGATCAACGGCCACGCGCTCGTGATCTCGTTGAT
GGCCACCGCGCTGATCGCAAGCCGCGTCTCGCGCCTGTTCGTGCCGCCGCTCTACGAGACGCTCGCCGAGCGCTATCTGA
AGCCGCCGCAACCGAAGCAGGCGGCCACGGCCCCCGCGCCCGCGCACACCGGCATCGCGGCGGTCAAGATGCCCGAGGAC
GCCGAATCGGCGCCCGCCGATCCGCTCGATACGCTGCGCGACGAAGCCGCGAACGAAGCGAATGCGAACGAGCCCGATGC
GGGCGACGCCGGCGGGCATACCGGCGCGGGCGCGGCGGCGCACGCCGATGATGCGCCGTGCGGCGCGGCCGATGCCGCCC
GCGCGGGCGCGCCGCCCGACGCGAGCCCGGCATCGGCGCCCGGCGCGGCCGGCGCGTCGAACACGCGCGCGAACGACCCG
ACACCGCCGTCGGGCGACGACGAGAATCGTGAGCCGCCGCAGCGCCCCGCTCAATAG

Upstream 100 bases:

>100_bases
AGAATACGTTTCATTTTTATGTGGATGTACCCAACTCGTTAGTTGGGCATTCTAAATAGACAGAACGTCACAAACACCAC
AAATTGCGAAGAATTTACAT

Downstream 100 bases:

>100_bases
ATGACGACGGGCGCGGGCCGGTAGTACACCGGCCGCGCCGGCACGACGACGCAGCCGGCCAGCGTCAGCGCGACGAGCGC
GAGAGCGAACAAGGTCCGTT

Product: chloride channel (ClC) family protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MSQRRCRASRARRATIMSPFCAPTPMQRPSLFPTLTRRTQRIWRQYGVFWLGAVVVGLTAVMYARLIDWGYEAFRSLGQG
RPWLPFLLTPAIAALSVWLTRRFFRGAEGSGIPQVIATLHAQPSAFGSRLLTLRILFGKVLISLLGIAGGFTIGREGPTV
QIGASLMFNLRRFYPRSNALIERQLVLAGAAAGLSAAFNTPLAGVVFAIEELSRSFSARASGVLITAIIIAGVIALGLNG
NYTYFGTIEIGQHFPKMLAAAVLLTALVTGVAGGLFGWLLLNTGRWLPARLLALYRERPIVFAAACGLAIAAVGVASGGT
TFGSGYAEARGLLDGREQLSVLYPFLKMISMVASYLPGIPGGIFAPSLSIGAGFGNLLHFVFSGMHLPMLIALAMVGYLA
AVTQSPITSFVIVMEMINGHALVISLMATALIASRVSRLFVPPLYETLAERYLKPPQPKQAATAPAPAHTGIAAVKMPED
AESAPADPLDTLRDEAANEANANEPDAGDAGGHTGAGAAAHADDAPCGAADAARAGAPPDASPASAPGAAGASNTRANDP
TPPSGDDENREPPQRPAQ

Sequences:

>Translated_578_residues
MSQRRCRASRARRATIMSPFCAPTPMQRPSLFPTLTRRTQRIWRQYGVFWLGAVVVGLTAVMYARLIDWGYEAFRSLGQG
RPWLPFLLTPAIAALSVWLTRRFFRGAEGSGIPQVIATLHAQPSAFGSRLLTLRILFGKVLISLLGIAGGFTIGREGPTV
QIGASLMFNLRRFYPRSNALIERQLVLAGAAAGLSAAFNTPLAGVVFAIEELSRSFSARASGVLITAIIIAGVIALGLNG
NYTYFGTIEIGQHFPKMLAAAVLLTALVTGVAGGLFGWLLLNTGRWLPARLLALYRERPIVFAAACGLAIAAVGVASGGT
TFGSGYAEARGLLDGREQLSVLYPFLKMISMVASYLPGIPGGIFAPSLSIGAGFGNLLHFVFSGMHLPMLIALAMVGYLA
AVTQSPITSFVIVMEMINGHALVISLMATALIASRVSRLFVPPLYETLAERYLKPPQPKQAATAPAPAHTGIAAVKMPED
AESAPADPLDTLRDEAANEANANEPDAGDAGGHTGAGAAAHADDAPCGAADAARAGAPPDASPASAPGAAGASNTRANDP
TPPSGDDENREPPQRPAQ
>Mature_577_residues
SQRRCRASRARRATIMSPFCAPTPMQRPSLFPTLTRRTQRIWRQYGVFWLGAVVVGLTAVMYARLIDWGYEAFRSLGQGR
PWLPFLLTPAIAALSVWLTRRFFRGAEGSGIPQVIATLHAQPSAFGSRLLTLRILFGKVLISLLGIAGGFTIGREGPTVQ
IGASLMFNLRRFYPRSNALIERQLVLAGAAAGLSAAFNTPLAGVVFAIEELSRSFSARASGVLITAIIIAGVIALGLNGN
YTYFGTIEIGQHFPKMLAAAVLLTALVTGVAGGLFGWLLLNTGRWLPARLLALYRERPIVFAAACGLAIAAVGVASGGTT
FGSGYAEARGLLDGREQLSVLYPFLKMISMVASYLPGIPGGIFAPSLSIGAGFGNLLHFVFSGMHLPMLIALAMVGYLAA
VTQSPITSFVIVMEMINGHALVISLMATALIASRVSRLFVPPLYETLAERYLKPPQPKQAATAPAPAHTGIAAVKMPEDA
ESAPADPLDTLRDEAANEANANEPDAGDAGGHTGAGAAAHADDAPCGAADAARAGAPPDASPASAPGAAGASNTRANDPT
PPSGDDENREPPQRPAQ

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI55770840, Length=412, Percent_Identity=24.5145631067961, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI55770838, Length=412, Percent_Identity=24.5145631067961, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786350, Length=445, Percent_Identity=28.0898876404494, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87081943, Length=309, Percent_Identity=29.7734627831715, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71996455, Length=507, Percent_Identity=23.4714003944773, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71996452, Length=507, Percent_Identity=23.4714003944773, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 60604; Mature: 60473

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SQRRCRASRARRATIMSPFCAPTPMQRPSLFPTLTRRTQRIWRQYGVFWLGAVVVGLTA
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMYARLIDWGYEAFRSLGQGRPWLPFLLTPAIAALSVWLTRRFFRGAEGSGIPQVIATLH
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
AQPSAFGSRLLTLRILFGKVLISLLGIAGGFTIGREGPTVQIGASLMFNLRRFYPRSNAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEHHHHHHHHHHHCCCCCHH
IERQLVLAGAAAGLSAAFNTPLAGVVFAIEELSRSFSARASGVLITAIIIAGVIALGLNG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCC
NYTYFGTIEIGQHFPKMLAAAVLLTALVTGVAGGLFGWLLLNTGRWLPARLLALYRERPI
CEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
VFAAACGLAIAAVGVASGGTTFGSGYAEARGLLDGREQLSVLYPFLKMISMVASYLPGIP
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCC
GGIFAPSLSIGAGFGNLLHFVFSGMHLPMLIALAMVGYLAAVTQSPITSFVIVMEMINGH
CCHHCCCCHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
ALVISLMATALIASRVSRLFVPPLYETLAERYLKPPQPKQAATAPAPAHTGIAAVKMPED
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCC
AESAPADPLDTLRDEAANEANANEPDAGDAGGHTGAGAAAHADDAPCGAADAARAGAPPD
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCC
ASPASAPGAAGASNTRANDPTPPSGDDENREPPQRPAQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA