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The map label for this gene is mmlH [H]

Identifier: 126451973

GI number: 126451973

Start: 1579840

End: 1581177

Strand: Reverse

Name: mmlH [H]

Synonym: BURPS1106A_1625

Alternate gene names: 126451973

Gene position: 1581177-1579840 (Counterclockwise)

Preceding gene: 126452497

Following gene: 126453165

Centisome position: 39.64

GC content: 67.04

Gene sequence:

>1338_bases
ATGCGGGCTTTTTCTCGATCGCTGATTGAGACATCATTCTGGAGAGCGCGAGTGAACTGGTACAAAGAAATATCGCCCGT
GGAAAGACGCACGTTCAAAGGATGTTTTTCCGGCTGGGCGCTCGACGGCGTCGATACGCAGATGTTCAGCCTCGTGATTC
CGGCGCTGCTCACGGCATGGGGCATCGGCAAGGGACAGGCGGGCCTGATCGGCGGCGCGACGCTCGCCGCGGGTGCGATC
GGCGGCCTGCTCGCCGGCATGATCGCCGATCGCTTCGGCCGCGTGCGTGCGCTGCAGATCACCGTGTGCTGGTTCTCGCT
GTTCACGTTCCTCAGCGCGTTCGCGCAGAACTTCGAGCAATTGCTGGTGCTGAAGACGCTGCAAGGGCTCGGCTTCGGCG
GCGAATGGACGGCGGGCGCCGTGCTGTTGAGCGAGACGATTCGCGCGCGGCACCGCGGCAAGGCGATGGGCATCGTGCAG
AGCGCATGGGGCTTCGGCTGGGGCGGCGCGGTGCTCCTCTACACGCTCGTCTTCTCGTGGCTGCCGCCCGAATGGGCGTG
GCGCGTGCTGTTCGCGATCGGCGTGCTGCCCGCGCTGCTCGTGCTGTACATCCGGCGCGCGATTCCCGAGCCGCCGCGCG
ACGACGCACGCGTGGCCGTTTCCACATCGGCCGCGGCTGCGCAGACCGCGCCGGCACGCGCGTCGGCGAAGAGCATCTTC
GATCCGTCGGTGCTCCGGATGACGATCGTCGGCGGCCTGATCGGCGTCGGCGCGCACGGCGGCTATCATGCGATCACGAC
CTGGCTGCCGACCTACCTGAAGACCGAACGTCATCTCTCGGTGCTCGGCACGGGCGCGTATCTCGCCGTGATCATCGTCG
CGTTCATCATCGGCTGCATGACGAGCGCCTACCTGCAGGACCGCATCGGCCGCCGCAGGAATCTGATGCTGTTCTCCGCG
TGCTGCGTCGTGACGGTCAACCTGTACGTGATGCTGCCGCTCGACAACGTCGCGATGCTGCTGCTCGGCTTTCCGCTCGG
CTTCTTCGCGGCCGGCATCCCGGCCACGCTCGGCGCGCTCTTCAATGAGCTCTATCCGAGAAACGTGCGTGGCCGGGGCG
TCGGCTTTTGCTACAACTTCGGACGCGTGGCGTCGGCGATCTTCCCGGTGCTGGTCGGACACATGGGCACGTCGATGCCG
CTCGGCGTCGCGCTCGGCATCGACGCGGGCATCGCGTACGGGCTCGTGTTCGTCGCCGTGTGGTTCCTGCCCGAGACGCG
CGCGCGCGATATCCAGCCGTCGCAACCCGAGGCCCGGATCCGCGAGGCCGCGCTCTAG

Upstream 100 bases:

>100_bases
CAGTCCGACACGAGGTCCGCCATCATAATTTTCTTTTATCGATAATGCTCGCTTTCGTGATGCATATGTCGTTTACCACT
CGATAAAATATGACGATATG

Downstream 100 bases:

>100_bases
ACGCCGAGCGGCGCAACGGGCTTCCGTCATTTCGTGGGTTTTTCATGGATCAGGCATCGAACGATCCGGCAGTCGAAACG
ACAGGCCGCCCCTTCGCCAC

Product: major facilitator family transporter

Products: Proton [Cytoplasm]; N-acetylneuraminate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MRAFSRSLIETSFWRARVNWYKEISPVERRTFKGCFSGWALDGVDTQMFSLVIPALLTAWGIGKGQAGLIGGATLAAGAI
GGLLAGMIADRFGRVRALQITVCWFSLFTFLSAFAQNFEQLLVLKTLQGLGFGGEWTAGAVLLSETIRARHRGKAMGIVQ
SAWGFGWGGAVLLYTLVFSWLPPEWAWRVLFAIGVLPALLVLYIRRAIPEPPRDDARVAVSTSAAAAQTAPARASAKSIF
DPSVLRMTIVGGLIGVGAHGGYHAITTWLPTYLKTERHLSVLGTGAYLAVIIVAFIIGCMTSAYLQDRIGRRRNLMLFSA
CCVVTVNLYVMLPLDNVAMLLLGFPLGFFAAGIPATLGALFNELYPRNVRGRGVGFCYNFGRVASAIFPVLVGHMGTSMP
LGVALGIDAGIAYGLVFVAVWFLPETRARDIQPSQPEARIREAAL

Sequences:

>Translated_445_residues
MRAFSRSLIETSFWRARVNWYKEISPVERRTFKGCFSGWALDGVDTQMFSLVIPALLTAWGIGKGQAGLIGGATLAAGAI
GGLLAGMIADRFGRVRALQITVCWFSLFTFLSAFAQNFEQLLVLKTLQGLGFGGEWTAGAVLLSETIRARHRGKAMGIVQ
SAWGFGWGGAVLLYTLVFSWLPPEWAWRVLFAIGVLPALLVLYIRRAIPEPPRDDARVAVSTSAAAAQTAPARASAKSIF
DPSVLRMTIVGGLIGVGAHGGYHAITTWLPTYLKTERHLSVLGTGAYLAVIIVAFIIGCMTSAYLQDRIGRRRNLMLFSA
CCVVTVNLYVMLPLDNVAMLLLGFPLGFFAAGIPATLGALFNELYPRNVRGRGVGFCYNFGRVASAIFPVLVGHMGTSMP
LGVALGIDAGIAYGLVFVAVWFLPETRARDIQPSQPEARIREAAL
>Mature_445_residues
MRAFSRSLIETSFWRARVNWYKEISPVERRTFKGCFSGWALDGVDTQMFSLVIPALLTAWGIGKGQAGLIGGATLAAGAI
GGLLAGMIADRFGRVRALQITVCWFSLFTFLSAFAQNFEQLLVLKTLQGLGFGGEWTAGAVLLSETIRARHRGKAMGIVQ
SAWGFGWGGAVLLYTLVFSWLPPEWAWRVLFAIGVLPALLVLYIRRAIPEPPRDDARVAVSTSAAAAQTAPARASAKSIF
DPSVLRMTIVGGLIGVGAHGGYHAITTWLPTYLKTERHLSVLGTGAYLAVIIVAFIIGCMTSAYLQDRIGRRRNLMLFSA
CCVVTVNLYVMLPLDNVAMLLLGFPLGFFAAGIPATLGALFNELYPRNVRGRGVGFCYNFGRVASAIFPVLVGHMGTSMP
LGVALGIDAGIAYGLVFVAVWFLPETRARDIQPSQPEARIREAAL

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=448, Percent_Identity=24.5535714285714, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI213021148, Length=443, Percent_Identity=21.6704288939052, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI4507005, Length=229, Percent_Identity=26.6375545851528, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87082231, Length=485, Percent_Identity=25.1546391752577, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI87082404, Length=393, Percent_Identity=24.9363867684478, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786229, Length=431, Percent_Identity=24.5939675174014, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790550, Length=401, Percent_Identity=27.431421446384, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87081723, Length=403, Percent_Identity=28.287841191067, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI87082159, Length=360, Percent_Identity=25.8333333333333, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789152, Length=345, Percent_Identity=24.0579710144928, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788942, Length=327, Percent_Identity=26.9113149847095, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1789515, Length=347, Percent_Identity=22.1902017291066, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32564663, Length=438, Percent_Identity=22.6027397260274, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922616, Length=419, Percent_Identity=25.7756563245823, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19922874, Length=383, Percent_Identity=21.4099216710183, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48039; Mature: 48039

Theoretical pI: Translated: 10.35; Mature: 10.35

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAFSRSLIETSFWRARVNWYKEISPVERRTFKGCFSGWALDGVDTQMFSLVIPALLTAW
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
GIGKGQAGLIGGATLAAGAIGGLLAGMIADRFGRVRALQITVCWFSLFTFLSAFAQNFEQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHH
LLVLKTLQGLGFGGEWTAGAVLLSETIRARHRGKAMGIVQSAWGFGWGGAVLLYTLVFSW
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHC
LPPEWAWRVLFAIGVLPALLVLYIRRAIPEPPRDDARVAVSTSAAAAQTAPARASAKSIF
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHCCCCHHHHHHCC
DPSVLRMTIVGGLIGVGAHGGYHAITTWLPTYLKTERHLSVLGTGAYLAVIIVAFIIGCM
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
TSAYLQDRIGRRRNLMLFSACCVVTVNLYVMLPLDNVAMLLLGFPLGFFAAGIPATLGAL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNELYPRNVRGRGVGFCYNFGRVASAIFPVLVGHMGTSMPLGVALGIDAGIAYGLVFVAV
HHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHH
WFLPETRARDIQPSQPEARIREAAL
HHCCCCCCCCCCCCCCHHHHHHCCC
>Mature Secondary Structure
MRAFSRSLIETSFWRARVNWYKEISPVERRTFKGCFSGWALDGVDTQMFSLVIPALLTAW
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
GIGKGQAGLIGGATLAAGAIGGLLAGMIADRFGRVRALQITVCWFSLFTFLSAFAQNFEQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHH
LLVLKTLQGLGFGGEWTAGAVLLSETIRARHRGKAMGIVQSAWGFGWGGAVLLYTLVFSW
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHC
LPPEWAWRVLFAIGVLPALLVLYIRRAIPEPPRDDARVAVSTSAAAAQTAPARASAKSIF
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHCCCCHHHHHHCC
DPSVLRMTIVGGLIGVGAHGGYHAITTWLPTYLKTERHLSVLGTGAYLAVIIVAFIIGCM
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
TSAYLQDRIGRRRNLMLFSACCVVTVNLYVMLPLDNVAMLLLGFPLGFFAAGIPATLGAL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNELYPRNVRGRGVGFCYNFGRVASAIFPVLVGHMGTSMPLGVALGIDAGIAYGLVFVAV
HHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHH
WFLPETRARDIQPSQPEARIREAAL
HHCCCCCCCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; N-acetylneuraminate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + N-acetylneuraminate [Periplasm] = Proton [Cytoplasm] + N-acetylneuraminate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]