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The map label for this gene is cobA [H]

Identifier: 126451772

GI number: 126451772

Start: 995296

End: 996069

Strand: Direct

Name: cobA [H]

Synonym: BURPS1106A_1018

Alternate gene names: 126451772

Gene position: 995296-996069 (Clockwise)

Preceding gene: 126455060

Following gene: 126452701

Centisome position: 24.95

GC content: 73.39

Gene sequence:

>774_bases
ATGGGTAAGGTGTATCTGATCGGCGCGGGGCCGGGTGCGGCGGACCTCATCACGGTGCGCGGCGCGCGGCTGCTCGAGCA
GGCCGACGTCGTGCTGCACGACGCGCTCGTCGAGCCCGCGATGCTCGACTATGCGCCGCGCGCGCGCAGGATCGCGGTCG
GCAAGCGCTGCGGGCAGCGCTCGAGCGCGCAGCACTTCATCAACAAGCAACTCGTCGACGCGGCGCGCGAGCACGCGGTC
GTCGTGCGGCTGAAGGGCGGCGATCCGATGCTGTTCGGCCGCGCGGACGAGGAAATGCGCGCGCTCGAAGCGGCGGGTAT
CGATTACGAGGTGGTGCCGGGCATCACGGCGGCGCTCGCGAGCGCCGCCGCGCTCAAGCGCTCGCTGACGCTGCGCGGCG
TCGCGCGCAGCGTCGCGTTCGCGACGAAGAGCCGCGCGCCCGGCAGCGACGAGATTCGCGAGCAGGTGAGCGCGGATTCG
CTCGTTTATTACATGGGGCGCGACAATGCGCCCGGCATCGCGCGGCAACTGATCGACGCCGGGCGGGCGGGCGCGACGCC
GGTCGCGATCGTCGAGGCGTGCAGCACGCCGCGCGAGCGCATGCTGACGCTCACGCTGGCCGACATGGCGGCGGGCGCCG
CGCAGGCGTGGCTCGATCCGGCGCAGCCGAGCCTGCTGATGATCGGCGACGCATTCGCCGAACGCGCGCCGCGGCTCGCG
GACGAGCCGCCGGGCGACGCAGGCGGCAAGCGCGGGATGCGCGACGCGGCTTGA

Upstream 100 bases:

>100_bases
ACACGGTCGCAGCGGGTATGATTCGTGCGTTTTCCGCGTGACGCCGCGCGCCGCATCGGCGGCGCCCGCCGGCACGTGCG
CACGAAGGGGATCGATGCGA

Downstream 100 bases:

>100_bases
CGCGGCGAGCACGGGCGGGCGTCTTCCGGCTCGAGCGTGCACGTGAGCCGCGCGGGCCGCGCGGCGCAGGCGAAAGACGC
GAACACAATGCACGACGGAC

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MGKVYLIGAGPGAADLITVRGARLLEQADVVLHDALVEPAMLDYAPRARRIAVGKRCGQRSSAQHFINKQLVDAAREHAV
VVRLKGGDPMLFGRADEEMRALEAAGIDYEVVPGITAALASAAALKRSLTLRGVARSVAFATKSRAPGSDEIREQVSADS
LVYYMGRDNAPGIARQLIDAGRAGATPVAIVEACSTPRERMLTLTLADMAAGAAQAWLDPAQPSLLMIGDAFAERAPRLA
DEPPGDAGGKRGMRDAA

Sequences:

>Translated_257_residues
MGKVYLIGAGPGAADLITVRGARLLEQADVVLHDALVEPAMLDYAPRARRIAVGKRCGQRSSAQHFINKQLVDAAREHAV
VVRLKGGDPMLFGRADEEMRALEAAGIDYEVVPGITAALASAAALKRSLTLRGVARSVAFATKSRAPGSDEIREQVSADS
LVYYMGRDNAPGIARQLIDAGRAGATPVAIVEACSTPRERMLTLTLADMAAGAAQAWLDPAQPSLLMIGDAFAERAPRLA
DEPPGDAGGKRGMRDAA
>Mature_256_residues
GKVYLIGAGPGAADLITVRGARLLEQADVVLHDALVEPAMLDYAPRARRIAVGKRCGQRSSAQHFINKQLVDAAREHAVV
VRLKGGDPMLFGRADEEMRALEAAGIDYEVVPGITAALASAAALKRSLTLRGVARSVAFATKSRAPGSDEIREQVSADSL
VYYMGRDNAPGIARQLIDAGRAGATPVAIVEACSTPRERMLTLTLADMAAGAAQAWLDPAQPSLLMIGDAFAERAPRLAD
EPPGDAGGKRGMRDAA

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=231, Percent_Identity=41.991341991342, Blast_Score=154, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6322922, Length=233, Percent_Identity=30.9012875536481, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 27007; Mature: 26876

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVYLIGAGPGAADLITVRGARLLEQADVVLHDALVEPAMLDYAPRARRIAVGKRCGQR
CCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHHHCCCC
SSAQHFINKQLVDAAREHAVVVRLKGGDPMLFGRADEEMRALEAAGIDYEVVPGITAALA
HHHHHHHHHHHHHHHHCCEEEEEECCCCEEEECCCCHHHHHHHHCCCCEEECCCHHHHHH
SAAALKRSLTLRGVARSVAFATKSRAPGSDEIREQVSADSLVYYMGRDNAPGIARQLIDA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHC
GRAGATPVAIVEACSTPRERMLTLTLADMAAGAAQAWLDPAQPSLLMIGDAFAERAPRLA
CCCCCCHHHHHHHHCCHHHHEEEHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHCCCCC
DEPPGDAGGKRGMRDAA
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GKVYLIGAGPGAADLITVRGARLLEQADVVLHDALVEPAMLDYAPRARRIAVGKRCGQR
CEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHHHCCCC
SSAQHFINKQLVDAAREHAVVVRLKGGDPMLFGRADEEMRALEAAGIDYEVVPGITAALA
HHHHHHHHHHHHHHHHCCEEEEEECCCCEEEECCCCHHHHHHHHCCCCEEECCCHHHHHH
SAAALKRSLTLRGVARSVAFATKSRAPGSDEIREQVSADSLVYYMGRDNAPGIARQLIDA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHC
GRAGATPVAIVEACSTPRERMLTLTLADMAAGAAQAWLDPAQPSLLMIGDAFAERAPRLA
CCCCCCHHHHHHHHCCHHHHEEEHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHCCCCC
DEPPGDAGGKRGMRDAA
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA